Signaling Gateway - 18 July 2008
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0M40Eh
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CELL MIGRATION: PTEN MAKES NEUTROPHILS IMMUNE TO DISTRACTION
The PI(3)K antagonist PTEN promotes efficient neutrophil migration to
sites of infection by prioritizing bacterially derived chemoattractant
cues and blocking the response to 'distracting' cues from epithelial
and immune cells.
Original research paper: Nature Immunology 9, 743-752 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0vP0Eq
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Selected Updates
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CELL MORPHOLOGY: BREAKING THE SPATIAL CODE
Two studies describe the role of actin treadmilling in generating a
specific cell shape, and uncover a relationship between cell shape and
the generation of microdomains that regulate signal transduction from
the plasma membrane to cytoplasmic signaling molecules.
Original research paper: Nature 453, 475-480 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Bz310EM
SENESCENCE: HOLD THAT THOUGHT
The expression of inflammatory mediators such as interleukin-6 (IL-6)
and IL-8 reinforces growth arrest in cells that have undergone
oncogene-induced senescence.
Original research paper: Cell 133, 1006-1018 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Bz320EN
SIGNALLING: REWARDING CHANGES IN GENE EXPRESSION
Dopamine-triggered signaling induces the accumulation of DARPP32
(dopamine- and cyclic AMP-regulated phosphoprotein with molecular
weight 32 kDa) in the nucleus of murine striatal neurons, which leads
to phosphorylation of histone H3 and affects chromatin structure and
gene expression.
Original research paper: Nature 453, 879-884 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Bz330EO
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0vO0Ep
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Research Library
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POSITIVE FEEDBACK OF G1 CYCLINS ENSURES COHERENT CELL CYCLE ENTRY
Nature 454, 291-296 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Bz340EP
GENOMIC STABILITY AND TUMOUR SUPPRESSION BY THE APC/C COFACTOR Cdh1
Nature Cell Biology 10, 802-811 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Bz350EQ
FUNCTIONAL IMMOBILIZATION OF SIGNALING PROTEINS ENABLES CONTROL OF
STEM CELL FATE
Nature Methods 5, 645-650 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Bz360ER
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Signaling News
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MOUSE miRNA LIBRARY TO OPEN
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Bzwz0Eh
Researchers at the UK Sanger Institute will create a library of
knockout mice that have been genetically engineered to inactivate
each of the known microRNA molecules. This resource, known as the
microKOMP (micro Knockout Mouse Project), will eventually be available
to all researchers studying the diverse systems affected by microRNA
expression.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Crw0EY
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - JULY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0BGyx0Eq
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and bioinformaticians
to explore, visualize and mine signaling events.
This month's update features
TNF receptor signaling pathway
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0BzOm0Eo
FOXM1 transcription factor network
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0BzOn0Ep
Bioinformatics Primer on COSMIC, the Catalogue of Somatic Mutations in Cancer
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0BzOq0Es
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0BJYy0EO
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Signaling Job of the Week
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Scientific Project Manager
Employer: Deutsches Krebsforschungszentrum
Location: Heidelberg, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0Bz370ES
The German Cancer Research Center (DKFZ) in Heidelberg invites
applications for a Scientific Project Manager in the Division of
Signaling and Functional Genomics. Researchers at the Division use
genomic and genetic approaches to identify and characterize conserved
and disease-relevant signaling pathway components. The successful
applicant will be responsible for coordinating research activities,
teaching, and writing grant applications and scientific reports.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0BnjC0EN
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0vqs0EK
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http://ealerts.nature.com/cgi-bin24/DM/y/emON0Xztnp0H2W0dIO0Ek
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