Signaling Gateway - 11 July 2008
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0M40EC
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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OVARIAN STEM CELLS: MEI ACTS LIKE A BRAT
Mei-P26 suppresses cell growth and differentiation and downregulates
microRNA expression in the Drosophila ovarian stem-cell lineage.
Original research paper: Nature 454, 241-245 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0vP0EL
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0HIE0Eb
C5a receptor
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdd0EV
The complement factor 5a receptor (C5aR) is a G protein-coupled
receptor (GPCR) that has an important role in the innate immune
response. C5aR is activated by the potent chemoattractant C5a. Upon
activation, the receptor binds to heterotrimeric G proteins, which
leads to inhibition of adenylyl cyclase, activation of MAP kinase,
phosphoinositol accumulation and calcium mobilization. Targeting C5aR
appears to be a promising avenue for novel anti-inflammatory
therapeutics.
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0BUuz0EX
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Selected Updates
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CELL SIGNALLING: HOW TO LEAD A DOUBLE LIFE
The focal adhesion protein kindlin-2 binds to integrin tails and
regulates integrin bidirectional signaling.
Original research paper: J. Cell Biol. 181, 439-446 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzde0EW
TUMORIGENESIS: COMBINED EFFORT
Oncogenic mutations perturb the expression of many downstream pathway
genes, and researchers have now shown that blocking these synergistic
changes in gene expression can suppress tumor formation.
Original research paper: Nature 453, 1112-1116 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdf0EX
PROTEOMICS: LIVE-CELL MAP QUEST
A high-resolution interactome map describes how proteins interact in
living yeast cells.
Original research paper: Science 320, 1465-1470 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdg0EY
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0vO0EK
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Research Library
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CRYSTAL STRUCTURE OF THE LIGAND-FREE G-PROTEIN-COUPLED RECEPTOR OPSIN
Nature 454, 183-187 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdh0EZ
WAVE AND Arp2/3 JOINTLY INHIBIT FILOPODIUM FORMATION BY ENTERING INTO
A COMPLEX WITH mDia2
Nature Cell Biology 10, 849-857 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdi0Ea
AUTOMATED ON-CHIP RAPID MICROSCOPY, PHENOTYPING AND SORTING OF
C. ELEGANS
Nature Methods 5, 637-643 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdj0Eb
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Signaling News
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NATURE NEWS: BOYZ 2 PIPETTEMEN
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0BzU80EW
Compare Networks Production Group (CNPG) aims to put the 'sex' back
into 'Scientific EXperiments' with a music-video viral marketing
campaign. The ads feature tongue-in-cheek spoofs of boy bands singing
about Eppendorf's epMotion system and a PCR machine from Bio-Rad, and
include lyrics such as "Girl you need epMotion (yeah girl it's time
to automate)" and "PCR, when you need to find out who the daddy is
(who's your daddy?)".
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdk0Ec
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdl0Ed
More News
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Crw0E2
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Gateway Updates
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THE CELL MIGRATION GATEWAY - JULY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0uLB0EM
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles:
Notch signalling: The long road to the aorta
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0BzCu0EF
Actin nucleation: To CAP it off
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0BzCv0EG
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0BJrg0Ey
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Signaling Job of the Week
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Postdoctoral Position
Employer: US Food and Drug Administration
Location: Bethesda, Maryland
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0Bzdm0Ee
A postdoctoral position is available in the Laboratory of Molecular
and Developmental Immunology at the US Food and Drug Administration.
Ongoing research projects are focused on the role of Fc receptor-like
(FCRL) proteins in tumor development and autoimmune diseases, with an
aim to identify tumor-associated viruses and oncogenes that perturb
the expression of FCRL genes.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0BnjC0Eq
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0vqs0En
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http://ealerts.nature.com/cgi-bin24/DM/y/emFt0Xztnp0H2W0dIO0EF
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