August 2008 Volume 9 Number 8
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Cell Signaling Review Series and Web Focus -
brought to you by Cell Research
Since March 2008, Cell Research has featured many articles about the recent
advances in cell signaling. This review series and accompanying web focus
highlights articles from Cell Research as well as Nature and explores the
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This month's FEATURED article:
ATR: an essential regulator of genome integrity
Karlene A. Cimprich & David Cortez
p517 | doi:10.1038/nrm2438
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EG0Eb
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From the editors
p583 | doi:10.1038/nrm2465
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EH0Ec
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RESEARCH HIGHLIGHTS
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Cell signalling: AKTing in Wnt pathway
p584 | doi:10.1038/nrm2462
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EI0Ed
Membrane trafficking: All cisternae are not created equal
p585 | doi:10.1038/nrm2448
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EJ0Ee
IN BRIEF
Cell polarity | Membrane trafficking | Chromatin
p585 | doi:10.1038/nrm2464
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EK0Ef
Cell signalling: Sensing nutrient availability
p586 | doi:10.1038/nrm2452
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EL0Eg
IN THE NEWS
Building muscle
p586 | doi:10.1038/nrm2463
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EM0Eh
Cell cycle: Achieving entry
p587 | doi:10.1038/nrm2454
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EN0Ei
Stem cells: A samurai without a master
p587 | doi:10.1038/nrm2459
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EO0Ej
Nuclear envelope: The power of two
p588 | doi:10.1038/nrm2449
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EP0Ek
Chromosomes: One ring to bind them
p588 | doi:10.1038/nrm2461
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EQ0El
Small RNAs: Roundworm joins the piRNA club
p589 | doi:10.1038/nrm2456
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1ER0Em
AN INTERVIEW WITH...
Stanley Cohen
p590 | doi:10.1038/nrm2458
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1ES0En
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REVIEWS
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Building the cell: design principles of cellular architecture
Susanne M. Rafelski and Wallace F. Marshall
p593 | doi:10.1038/nrm2460
Cells are highly complex structures, but where does this complexity come from?
Self-organization principles combined with simple physical constraints seem to
control organelle size, number, shape and position. These factors then combine
to give rise to the overall cell architecture.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1ET0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EU0Ep
Nectins and nectin-like molecules: roles in contact inhibition of cell movement
and proliferation
Yoshimi Takai, Jun Miyoshi, Wataru Ikeda and Hisakazu Ogita
p603 | doi:10.1038/nrm2457
Nectins and nectin-like molecules (Necls) are transmembrane cell adhesion molecules
that have recently been shown to have a variety of cellular functions. They have
roles in cell-cell adhesion, differentiation, polarization and survival, as well
as in contact inhibition of cell movement and proliferation.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EV0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EW0Er
ATR: an essential regulator of genome integrity
Karlene A. Cimprich and David Cortez
p616 | doi:10.1038/nrm2450
ATR kinase and the related ATM kinase have overlapping but non-redundant functions
in the DNA-damage response that maintains genome integrity. ATR signals to regulate
DNA replication, cell-cycle transitions and DNA repair through the phosphorylation
of various substrates.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EX0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EY0Et
Cancer as an overhealing wound: an old hypothesis revisited
Matthias Schafer and Sabine Werner
p628 | doi:10.1038/nrm2455
The hypothesis that [ldquo]tumor production is a possible overhealing[rdquo] has
recently been verified in several studies. In vivo analysis of genes that are involved
in tissue repair combined with gene-expression analysis in wounds and tumours
have highlighted remarkable similarities between wound healing and cancer.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1EZ0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Ea0E2
Shaping cups into phagosomes and macropinosomes
Joel A. Swanson
p639 | doi:10.1038/nrm2447
The ingestion of particles or cells by phagocytosis and of fluids by macropinocytosis
requires cup-shaped invaginations of the plasma membrane. Common signalling mechanisms
and distinct signalling patterns characterize the different stages of the formation
of phagocytic and macropinocytic cups.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Eb0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Ec0E4
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PERSPECTIVES
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TIMELINE
From the first protein structures to our current knowledge of protein folding:
delights and scepticisms
Alan R. Fersht
p650 | doi:10.1038/nrm2446
The determination of the first three-dimensional structure of a protein 50 years
ago initiated the field of protein folding research. Technological and experimental
advances, which were sometimes met with initial scepticism, have led to our present
understanding of protein folding.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Ed0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Ee0E6
OPINION
Regulation of TNFR1 and CD95 signalling by receptor compartmentalization
Stefan Schutze, Vladimir Tchikov and Wulf Schneider-Brachert
p655 | doi:10.1038/nrm2430
Tumour-necrosis factor receptor-1 (TNFR1) and CD95 can transduce pro-apoptotic
and anti-apoptotic signals, but what determines the specificity of signalling events?
It is possible that the endosomal compartment functions as a signalling organelle
that selectively transmits death signals from TNFR1 and CD95.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Ef0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Eg0E8
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CORRESPONDENCE
----------------------
Correspondence: Chemotaxis and the cell surface-area problem
Maurice B. Hallett, Christopher J. von Ruhland and Sharon Dewitt
p662 | doi:10.1038/nrm2419-c1
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Eh0EA
Author Reply: Surface area regulation: underexplored yet crucial in cell motility
Robert R. Kay, Paul Langridge, David Traynor and Oliver Hoeller
p662 | doi:10.1038/nrm2419-c2
http://ealerts.nature.com/cgi-bin24/DM/y/emR40Xztnp0Hjf0B1Ei0EB
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