August 2008 Volume 8 Number 8
Visit Nature Reviews Immunology online to browse the journal.
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Nature Reviews Immunology Focus on Mucosal Immunology
The field of mucosal immunology is undergoing a revival. Nature Reviews
Immunology is proud to present a special Focus issue highlighting the
recent advances in this field, including insights into HIV infection,
mucosal vaccines, immune regulation and its relationship to inflammation,
inflammatory bowel disease and the immunological importance of
epithelial cells.
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Produced in collaboration with FOCIS and supported by Beckman Coulter.
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This month's FEATURED article:
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection
and autoimmune diseases
Michel Gilliet, Wei Cao and Yong-Jun Liu
p594 | doi:10.1038/nri2358
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1ZT0EB
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From the editors
p569 | doi:10.1038/nri2392
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1ZU0EC
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RESEARCH HIGHLIGHTS
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Lymphocyte responses: A new role for IL-21 revealed
p570 | doi:10.1038/nri2384
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1ZV0ED
IN BRIEF
Neuroimmunology | Immune regulation | T-cell memory
p571 | doi:10.1038/nri2385
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1ZW0EE
T-cell activation: Adaptive cholesterol
p571 | doi:10.1038/nri2389
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1ZX0EF
WEB WATCH
Teaching on the attack
p572 | doi:10.1038/nri2386
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1ZY0EG
Inflammation: A crucial cut
p572 | doi:10.1038/nri2387
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1ZZ0EH
HIV: Editing HIV entry
p572 | doi:10.1038/nri2388
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Za0EO
IN BRIEF
Tumour biology | B-cell responses | HIV
p573 | doi:10.1038/nri2391
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zb0EP
Parasite Immunity: How T cells see Toxo
p574 | doi:10.1038/nri2382
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zc0EQ
T-cell responses: The foundations of [gamma][delta] T-cell effector fate
p574 | doi:10.1038/nri2383
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zd0ER
B cells: The pre-BCR shows its negative side
p575 | doi:10.1038/nri2380
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Ze0ES
T cells: Two faces of EAE
p576 | doi:10.1038/nri2390
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zf0ET
Inflammation: Lysosomes spill the signal
p576 | doi:10.1038/nri2393
http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zg0EU
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PROGRESS
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New roles for TIM family members in immune regulation
Vijay K. Kuchroo, Valerie Dardalhon, Sheng Xiao and Ana C. Anderson
p577 | doi:10.1038/nri2366
The TIM (T-cell immunoglobulin domain and mucin domain) proteins are emerging as important regulators of immune responses. The recent identification of TIM-protein expression by antigen-presenting cells and new TIM-protein ligands is revealing new roles for these proteins.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zh0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zi0EW
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REVIEWS
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WNT signalling in the immune system: WNT is spreading its wings
Frank J. T. Staal, Tiago C. Luis and Machteld M. Tiemessen
p581 | doi:10.1038/nri2360
This Review covers the recently discovered roles of WNT proteins in the regulation of haematopoietic stem-cell fate, T- and B-cell development and activation, and dendritic-cell maturation. These new immunohaematological functions of WNT proteins have implications for the development of haematological malignancies.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zj0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zk0EY
Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Michel Gilliet, Wei Cao and Yong-Jun Liu
p594 | doi:10.1038/nri2358
By sensing viral nucleic acids and producing type I interferons, plasmacytoid dendritic cells (pDCs) are key mediators of antiviral immunity. But pDCs might also contribute to autoimmune disease by responding to self nucleic acids. Here, pDC mechanisms of action and modes of regulation are reviewed.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1ZT0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zl0EZ
The known unknowns of antigen processing and presentation
Jatin M. Vyas, Annemarthe G. Van der Veen and Hidde L. Ploegh
p607 | doi:10.1038/nri2368
The pathways of antigen processing and presentation are well known, but how do antigens gain access to MHC molecules in dendritic cells and what is the role of autophagy, endoplasmic reticulum dislocation and Toll-like receptors in these pathways?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zm0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zn0Eb
Impact of MHC class I diversity on immune control of immunodeficiency virus replication
Philip J. R. Goulder and David I. Watkins
p619 | doi:10.1038/nri2357
The outcome of HIV infection is strongly influenced by the particular HLA genes expressed by the infected individual. Here, the authors draw on this association to evaluate what might constitute an effective CD8+ T-cell response and how it might guide vaccine design.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zo0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zp0Ed
Genome-wide association studies: a new window into immune-mediated diseases
Ramnik J. Xavier and John D. Rioux
p631 | doi:10.1038/nri2361
With the identification of more disease-susceptibility genes than ever before, 2007 is thought of by many human geneticists as the year of genome-wide association studies. In this Review, the authors discuss how this powerful approach continues to reveal new information about the susceptibility and pathogenesis of several immune-mediated diseases.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zq0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zr0Ef
Innate immune modulation by RNA viruses: emerging insights from functional genomics
Michael G. Katze, Jamie L. Fornek, Robert E. Palermo, Kathie-Anne Walters and Marcus J. Korth
p644 | doi:10.1038/nri2377
By providing a global view of the host response to infection, functional genomic approaches are proving useful in deciphering complex virus-host interactions. Here, the authors reveal how such approaches are being used to better understand viral triggering and regulation of host innate immune responses.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zs0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emV20Xztnp0Hjd0B1Zt0Eh
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