August 2008 Volume 8 Number 8
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This month's FEATURED article:
The scientific contributions of M. Judah Folkman to cancer research
Bruce R. Zetter
p647 | doi:10.1038/nrc2458
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1S50EY
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From the editors
p565 | doi:10.1038/nrc2457
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1S60EZ
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RESEARCH HIGHLIGHTS
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Angiogenesis: A less bitter pill
p567 | doi:10.1038/nrc2463
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1S70Ea
Leukaemia: Mixed up
p568 | doi:10.1038/nrc2445
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1S80Eb
Tumorigenesis: PUMA strikes again
p568 | doi:10.1038/nrc2449
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TA0El
IN THE NEWS
Education, education, education
p568 | doi:10.1038/nrc2455
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TB0Em
Angiogenesis: Survival of the infected
p569 | doi:10.1038/nrc2452
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TC0En
Therapeutics: Unravelling lethality
p570 | doi:10.1038/nrc2451
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TD0Eo
Angiogenesis: Mini mediator of metastasis suppression
p570 | doi:10.1038/nrc2453
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TE0Ep
Metastasis: Delivering help
p572 | doi:10.1038/nrc2447
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TF0Eq
Angiogenesis: TGF[beta] makes a new friend
p572 | doi:10.1038/nrc2448
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TG0Er
Angiogenesis: Turning it down a Notch
p572 | doi:10.1038/nrc2450
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TH0Es
TRIAL WATCH
Targeting thyroid angiogenesis
p573 | doi:10.1038/nrc2456
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TI0Et
IN BRIEF
Angiogenesis | Nanotechnology | Biomarkers | Senescence
p574 | doi:10.1038/nrc2454
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TJ0Eu
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FOREWORD
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Limiting supply
p577 | doi:10.1038/nrc2461
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TK0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TL0Ew
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Focus on: Targeting Angiogenesis
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TN0Ey
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REVIEWS
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VEGF-targeted therapy: mechanisms of anti-tumour activity
Lee M. Ellis and Daniel J. Hicklin
p579 | doi:10.1038/nrc2403
The therapeutic benefit associated with VEGF-targeted therapy is complex, and probably
involves multiple mechanisms, several of which are covered in this Review.
Understanding these mechanisms more fully should lead to future advances in the use of
these agents in the clinic.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TO0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TP0E1
Modes of resistance to anti-angiogenic therapy
Gabriele Bergers and Douglas Hanahan
p592 | doi:10.1038/nrc2442
In both preclinical and clinical settings, the benefits of angiogenesis inhibitors
targeting the vascular endothelial growth factor signalling pathways are at best
transitory and followed by restoration of tumour growth and progression. Emerging
data support a proposition that two modes of unconventional resistance underlie
such results.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TQ0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TR0E3
Integrins in angiogenesis and lymphangiogenesis
Christie J. Avraamides, Barbara Garmy-Susini and Judith A. Varner
p604 | doi:10.1038/nrc2353
Angiogenesis and lymphangiogenesis are regulated by integrins, which are cell surface
receptors whose ligands are extracellular matrix proteins and immunoglobulin superfamily
molecules. Here, the evidence implicating integrins as regulators of angiogenesis and
lymphangiogenesis and the current state of therapeutic strategies to target them are
discussed.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TS0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TT0E5
The role of myeloid cells in the promotion of tumour angiogenesis
Craig Murdoch, Munitta Muthana, Seth B. Coffelt and Claire E. Lewis
p618 | doi:10.1038/nrc2444
Bone marrow-derived myeloid cells, such as macrophages and mast cells, have an important
role in regulating the formation and maintenance of blood vessels in tumours. How do
these cells contribute to this process?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TU0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TV0E7
The semaphorins: versatile regulators of tumour progression and tumour angiogenesis
Gera Neufeld and Ofra Kessler
p632 | doi:10.1038/nrc2404
The semaphorins and their receptors, the neuropilins and the plexins, originally
characterized as proteins involved in the guidance of axons, can either promote or
inhibit tumour progression. This Review documents their effects on tumour angiogenesis,
as well as on metastasis and cell survival.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TW0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TX0EA
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PERSPECTIVE
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TIMELINE
The scientific contributions of M. Judah Folkman to cancer research
Bruce R. Zetter
p647 | doi:10.1038/nrc2458
M. Judah Folkman is regarded by many as the father of research into the therapeutic
targeting of angiogenesis. For cancer research, what were his most notable achievements?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TY0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1S50EY
Corrigendum: Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
Mark W. Dewhirst, Yiting Cao and Benjamin Moeller
Published online: 03 July 2008
p654 | doi:10.1038/nrc2438
http://ealerts.nature.com/cgi-bin24/DM/y/emU70Xztnp0Hja0B1TZ0EC
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