July 17 2008
Visit Nature Reports Stem Cells online.
Now available at: http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0BU280Ed
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THIS MONTH IN NATURE REPORTS STEM CELLS
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July newsletter: notes from ISSCR
In a Q&A, the new president of the International Society for Stem Cell Research describes career prospects for new scientists as "buoyant." An expert commentary warns about what scientists hunting epigenetic mechanisms might overlook. Several articles come straight from the annual meeting of ISSCR. There, experts discussed how to set standards for clinical trials and cell identities; the notions of cancer stem cells, cell fate, and transdifferentiation came up for re-examination.
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OUR TOP STORIES
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Fiona Watt: expanding niches for stem cell researchers
The new president of the ISSCR explains why young scientists should think twice before making induced pluripotent stem cells
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzsx0EP
Stem cell meeting 2008: in with the old, in with the new
Natalie DeWitt and Monya Baker explore the growing resolution on mechanisms of cellular memory, the emerging questions on how cells can flit straight from one differentiated fate to another and whether cancer stem cells exist
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzsy0EQ
How do you know a reprogrammed cell is reprogrammed?
Scientists consider minimum standards for induced pluripotent stem cells
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzsz0ER
Stem cell society condemns unproven treatments
Guidelines describing what is considered ethical behaviour for stem cell practitioners
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzs10EE
Related story: Scientists face down stem cell tourism
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzs20EF
How to assess a stem cell genome
In a commentary, Michael Teitell, of the University of California, Los Angeles, argues that to pick the best cell line for the job, genetic variation should be better understood
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzs30EG
California's new lines: what got funded
The California Institute of Regenerative Medicine awarded $23 million for 16 grants to create pluripotent stem cell lines. Of the 50 submissions, 29 proposed creating lines from reprogrammed adult cells; 17 from IVF embryos; 3 from nuclear transfer. Twelve proposals came from for-profit companies; Find out how many of each were funded. (You'll need to scroll to the end.)
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzs40EH
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Research highlights and news stories keying off recent publications
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Pluripotency
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The latest pluripotency factor is a lone warrior
Ronin takes a place beside Oct4, Nanog and Sox2
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzs50EI
Dejosez, M. et al. Cell 133, 1162-1174 (2008).
Small molecules boost reprogramming rates
Induced pluripotent stem cells edge away from viruses
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzs60EJ
Shi, Y. et al. Cell Stem Cell 2, 525-528 (2008).
Huangfu, D. et al. Nature Biotechnol. advance online publication, doi:10.1038/nbt1418 (22 June 2008).
Easing out the viruses in induced pluripotency
In neural stem cells, only two transgenes are necessary for reprogramming
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzs70EK
Kim, J. B. et al. Nature advance online publication, doi:10.1038/nature07061 (29 June 2008).
Two networks of pluripotency
An analysis of transcription factor binding sites finds clusters that clarify cooperative binding
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0Bzs80EL
Chen, X. et al. Cell 133, 1106-1117 (2008).
'Reprogramming-ready' mice
Transgenic mice offer a source of genetically identical induced pluripotent stem cells
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0BztA0EV
Wernig, M. et al. Nature Biotechnol. advance online publication, doi:10.1038/nbt1483 (1 July 2008).
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Muscle, money, mind, blood and more
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Embryonic stem cells answer questions about breast cancer
A cell-based assay identifies deleterious mutations in BRCA2
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0BztB0EW
Kuznetsov, S., Liu, P. & Sharan, S. Nature Med. advance online publication, doi:10.1038/nm.1719 (6 July 2008).
A metasignalling network makes muscles age
Regeneration is actively repressed in a metasignalling network between TGF-beta and Notch
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0BztC0EX
Carlson, M. E., Hsu, M. & Conboy, I. M. Nature advance online publication, doi:10.1038/nature07034 (15 June 2008).
Finding new muscle in cardiac stem cells
Researchers discover a new type of stem cell in the heart's protective layer
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0BztD0EY
Zhou, B. et al. Nature advance online publication, doi:10.1038/nature07060 (22 June 2008).
Cai, C.-L. et al. Nature advance online publication, doi:10.1038/nature06969 (14 May 2008).
US stem cell scientists consider relocating
Survey shows state policies and resources influence decisions
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0BztE0EZ
Levine, A. Public Admin. Rev. 68, 681-694 (2008).
Growing blood in a dish
New models for generating functional haematopoietic stem cells ex vivo
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0BztF0Ea
Ledran, M. H. et al. Cell Stem Cell 3, 85-98 (2008).
Taoudi, S. et al. Cell Stem Cell 3, 99-108 (2008).
Mind control
Overexpression of single genes directs neural progenitors to adopt specific fates
http://ealerts.nature.com/cgi-bin24/DM/y/emLS0Xztnp0JEp0BztG0Eb
Li, Z. et al. J. Neurosci. 28, 6557-6568 (2008).
Li, H. et al. Proc. Natl. Acad. Sci. USA doi:10.1073/pnas.0802876105 (published online 30 June 2008).
Jessberger, S. et al. Nature Neurosci. advance online publication, doi:10.1038/nn.2148 (29 June 2008).
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