24 July 2008 Volume 454 Number 7203, pp367-550
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Horizons: Life, logic and information
In the latest article in Nature's Horizons series,
which are visions of the scientific future, Nobel
laureate Paul Nurse explores the agenda for treating
organisms, at any level, as information machines.
It's his belief that one great challenge for biology
is to isolate, in particular within cells, the modules
by which information of many types - whether genetic
or environmental in ultimate origin - is coded,
propagated and interpreted, and how cells are organised
so as to process such information.
To read this article and the other Horizons, visit
the Horizons web focus.
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0Bu3g0Eu
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CHINA'S CHALLENGES
A special issue of Nature this week explores
the challenges that China faces on route to
becoming a major scientific player, and the
challenges that its rapid development pose to
the rest of the world.
Click here to access the Nature News special
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0Paz0EI
Listen to this week's Nature podcast
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0nrr0Ev
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EDITORIALS
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China: China's challenges pp367-368
By almost every measure, China's growth is extraordinary. But behind
the astonishing statistics is a more complex reality.
doi:10.1038/454367a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MF0Ef
Mind the gaps p368
The incoming US administration can and should reverse the neglect of
Earth observations.
doi:10.1038/454368a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MG0Eg
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RESEARCH HIGHLIGHTS
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Zoology: Bird's-nose view p370
doi:10.1038/454370a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MH0Eh
Physics: Parting a cloud p370
doi:10.1038/454370b
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MI0Ei
Acoustics: Chuckle vision p370
doi:10.1038/454370c
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MJ0Ej
Plant sciences: Poisonous grains p370
doi:10.1038/454370d
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MK0Ek
Physics: Gravity up close pp370-371
doi:10.1038/454370e
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1ML0El
Neuroscience: Location, location, location p371
doi:10.1038/454371a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MM0Em
Astronomy: Bright origins p371
doi:10.1038/454371b
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MN0En
Infectious disease: DARC matters p371
doi:10.1038/454371c
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MO0Eo
Chemistry: Easy bonding p371
doi:10.1038/454371d
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MP0Ep
Molecular biology: WHAMM! p371
doi:10.1038/454371e
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MQ0Eq
Genetics: DNA potholes p371
doi:10.1038/454371f
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MR0Er
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NEWS
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Oil cost hits ship studies pp372-372
International Polar Year is feeling the pinch.
Quirin Schiermeier
doi:10.1038/454372a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MS0Es
Spinal cord revealed in free gene map pp373-373
Allen Institute for Brain Science releases first data set.
Meredith Wadman
doi:10.1038/454373a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MT0Et
Think tank reveals plan to manage tropical forests pp373-373
Novel way to use carbon credits to save trees.
Jeff Tollefson
doi:10.1038/454373b
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MU0Eu
China: Where have all the flowers gone? p374
At least 117 boys were being born for every 100 girls at the
beginning of this century in China.
doi:10.1038/454374a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1OM0Eo
Snapshot: Track record pp377-377
Chinese scientist takes turn with Olympic torch.
David Cyranoski
doi:10.1038/454377a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MV0Ev
Affymetrix in new patents row pp377
MIT files suit over GeneChip technology.
Heidi Ledford
doi:10.1038/454377b
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1QU0Ey
Coral isotopes show quake history p378
Eric Hand
doi:10.1038/454378a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MW0Ew
Fusion verdict: misconduct p379
Eugenie Samuel Reich
doi:10.1038/454379a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MX0Ex
Roche bids for remaining Genentech stake pp381
doi:10.1038/454381a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MY0Ey
German public–private partnership breaks ground pp381
doi:10.1038/454381b
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1MZ0Ez
Clinical trialists less likely to seek grant renewals pp381
doi:10.1038/454381c
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Ma0E7
Google Books expands its non-English resources
doi:10.1038/454381d
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mb0E8
US Senate approves $48 billion global AIDS funding pp381
doi:10.1038/454381e
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mc0EA
Ontario acts to protect its boreal forests pp381
doi:10.1038/454381f
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Md0EB
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NEWS FEATURES
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China: The great contender p382
China's performance has been remarkable in any number of fields.
Declan Butler charts the country's scientific and economic growth.
doi:10.1038/454382a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Me0EC
China: Visions of China p384
Can the Chinese government meet its ambitious targets on space, the
environment, research, energy and health? David Cyranoski takes a look
at China today and what it hopes to be tomorrow.
doi:10.1038/454384a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mf0ED
China: Stoking the fire p388
China burns more coal than any other country; how it does so in the
future will determine our planet's climate.
Jeff Tollefson reports from Beijing.
doi:10.1038/454388a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mg0EE
Climate science: The third pole pp393-396
Climate change is coming fast and furious to the Tibetan plateau.
Jane Qiu reports on the changes atop the roof of the world.
doi:10.1038/454393a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mh0EF
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CORRESPONDENCE
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China's move to higher-meat diet hits water security p397
Junguo Liu, Hong Yang and H. H. G. Savenije
doi:10.1038/454397a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mi0EG
In the wake of two retractions, a request for investigation p397
Homme W. Hellinga
doi:10.1038/454397b
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mj0EH
Fusion needs a realistic cost assessment p397
J. H. Evans
doi:10.1038/454397c
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mk0EI
Fewer academics are not the answer to funding woes p397
Philip Strange
doi:10.1038/454397d
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Ml0EJ
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COMMENTARIES
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China: The prizes and pitfalls of progress pp398-401
Pushes to globalize science must not threaten local innovations in
developing countries, argues Lan Xue.
doi:10.1038/454398a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mm0EK
China: In their words pp399-402
Researchers and businesspeople in China, expatriates and 'returnees'
give their views of what it will take to make China a research and
innovation powerhouse.
doi:10.1038/454399a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mn0EL
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BOOKS AND ARTS
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China: How one child was deemed enough pp403-404
Scientific policy-making in China has come a long way since the 1970s,
argue Ling Chen and Gang Zhang.
Ling Chen and Gang Zhang reviews Just One Child: Science and Policy in
Deng's China by Susan Greenhalgh
doi:10.1038/454403a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mo0EM
China: A museum in every district pp404-405
Jane Qiu reviews China Science and Technology Museum
doi:10.1038/454404a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mp0EN
China: A shared view of the heavens p405
A woodcut of Ferdinand Verbiest, the Kangxi Emperor's Flemish
astronomer and mastermind of Beijing's Ancient Observatory, records a
remarkable seventeenth-century cultural exchange. Martin Kemp explains.
Martin Kemp reviews Ferdinand Verbiest: Heaven on Earth
doi:10.1038/454405a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mq0EO
Core caper p406
Emma Marris reviews Journey to the Center of the Earth
doi:10.1038/454406a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mr0EP
Geological history turned upside down pp406-407
Victor R. Baker reviews Worlds Before Adam: The Reconstruction of
Geohistory in the Age of Reform by Martin J. S. Rudwick
doi:10.1038/454406b
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Ms0EQ
Romance among robots p407
Andrew H. Knoll reviews WALL-E
doi:10.1038/454407a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mt0ER
Doctorate gets a lesson in management p408
John Kirkland reviews Toward a Global PhD? Forces and Forms in
Doctoral Education Worldwide by Maresi Nerad and Mimi Heggelund
doi:10.1038/454408a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mu0ES
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ESSAYS
----------------------
China: The man who unveiled China pp409-411
An English biochemist single-handedly changed the West's perception of
China, revealing its past scientific glories and predicting more to
come.
Simon Winchester investigates the ongoing legacy of Joseph Needham.
doi:10.1038/454409a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mv0ET
China: The end of the science superpowers pp412-413
Could the end of US world dominance over research mark the passing of
national science giants, ask J. Rogers Hollingsworth, Karl H. Muller
and Ellen Jane Hollingsworth.
doi:10.1038/454412a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mw0EU
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NEWS AND VIEWS
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Environmental science: Poisoned waters traced to source pp415-416
South Asia's well-water is widely polluted with arsenic, but no one
has located the source. A study on the Mekong River finds that
contamination begins in pond sediments, and is spread by groundwater
flow to wells.
Charles F. Harvey
doi:10.1038/454415a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mx0EV
Physiology: Myoglobin's new clothes pp416-417
Nitric oxide generated from the nitrite ion limits the tissue damage
caused by restricted blood flow. Gene knockout experiments in mice now
reveal that myoglobin is the mediator of this effect.
Andrew Cossins and Michael Berenbrink
doi:10.1038/454416a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1My0EW
Molecular computing: A layer of logic pp417-418
Silicon chips have thousands of electronic logic gates etched on them.
But there are other ways to decorate monolithic surfaces with logic
gates, as a system using metal complexes secured to glass slides shows.
A. Prasanna de Silva
doi:10.1038/454417a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Mz0EX
Alzheimer's disease: Moving towards a vaccine pp418-420
An agent that clears disease-associated amyloid aggregates from the
brains of patients with Alzheimer's disease does not alleviate disease
progression. Yet this disappointing news should not rule out such
potential therapies.
David M. Holtzman
doi:10.1038/454418a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1M10EK
50 & 100 Years Ago p419
doi:10.1038/454419a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1M20EL
Materials science: A tale of two tilings pp420-421
What do you get when you cross a crystal with a quasicrystal? The
answer is a structure that links the ancient tiles of Archimedes, the
iconic Fibonacci sequence of numbers and a book from the seventeenth
century.
Sharon C. Glotzer and Aaron S. Keys
doi:10.1038/454420a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1M30EM
Genomics: Thoroughly modern meiosis pp421-422
Meiotic recombination shuffles the genome, so each generation inherits
a new combination of parental traits. Combining traditional and modern
approaches, new work pinpoints where recombination occurs genome-wide.
Michael Lichten
doi:10.1038/454421a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1M40EN
Ecology: Forest air conditioning pp422-423
During the growing season, with photosynthesis at its peak, leaf
temperatures remain constant over a wide latitudinal range. This is a
finding that overturns a common assumption and has various
ramifications.
F. I. Woodward
doi:10.1038/454422a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1M50EO
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HORIZONS
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Life, logic and information pp424-426
Focusing on information flow will help us to understand better how
cells and organisms work.
Paul Nurse
doi:10.1038/454424a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1M60EP
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INSIGHT
----------------------
EDITORIAL
Inflammation p427
Ursula Weiss
doi:10.1038/454427a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1M70EQ
REVIEW ARTICLE
Origin and physiological roles of inflammation pp428-435
Ruslan Medzhitov
doi:10.1038/nature07201
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1M80ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NA0Eb
Cancer-related inflammation pp436-444
Alberto Mantovani, Paola Allavena, Antonio Sica and Frances Balkwill
doi:10.1038/nature07205
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NB0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NC0Ed
The development of allergic inflammation pp445-454
Stephen J. Galli, Mindy Tsai and Adrian M. Piliponsky
doi:10.1038/nature07204
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1ND0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NE0Ef
From endoplasmic-reticulum stress to the inflammatory response pp455-462
Kezhong Zhang and Randal J. Kaufman
doi:10.1038/nature07203
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NF0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NG0Eh
HYPOTHESIS ARTICLE
The role of exercise and PGC1[alpha] in inflammation and chronic disease pp463-469
Christoph Handschin and Bruce M. Spiegelman
doi:10.1038/nature07206
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NH0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NI0Ej
REVIEW ARTICLE
Integration of metabolism and inflammation by lipid-activated nuclear receptors pp470-477
Steven J. Bensinger and Peter Tontonoz
doi:10.1038/nature07202
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NJ0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NK0El
----------------------
ARTICLES
----------------------
High-resolution mapping of meiotic crossovers and non-crossovers
in yeast p479
This study presents a landmark high resolution map of all the
recombination products, both crossover and non crossover, in meiosis
in the yeast Saccharomyces cerevisiae.
Eugenio Mancera, Richard Bourgon, Alessandro Brozzi, Wolfgang Huber
& Lars M. Steinmetz
doi:10.1038/nature07135
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NL0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NM0En
Structure of a beta1-adrenergic G-protein-coupled receptor p486
A crystal structure of the beta1 adrenergic G protein coupled receptor
in inactive state has been determined using a mutagenesis approach to
thermostabilize the receptor for crystallization. The structure reveals
the binding mode of a ligand and insights into the G-protein binding
interface.
Tony Warne et al.
doi:10.1038/nature07101
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NN0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NO0Ep
----------------------
LETTERS
----------------------
The characteristic blue spectra of accretion disks in quasars as uncovered
in the infrared pp492-494
Quasars are thought to be powered by supermassive black holes accreting
surrounding gas through a putative accretion disk. The most extensively
studied disk model predicts a specific blue spectral shape from the
visible to near infrared. Observations of polarized light interior to
the dust emitting region are reported that reveal that the near infrared
disk spectrum is as blue as predicted.
Makoto Kishimoto et al.
doi:10.1038/nature07114
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NP0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NQ0Er
Medium-scale carbon nanotube thin-film integrated circuits on flexible
plastic substrates pp495-500
Forming integrated circuits on flexible sheets of plastic enables
attributes that are difficult to achieve with rigid substrates, the
most widely explored types of semiconductors suitable for such flexible
integrated circuits being organic small molecules and polymers.
An alternative approach is to use carbon based nanomaterials.
This paper reports small to medium scale integrated digital circuits
with more than 100 transistors made from random networks of single
walled carbon nanotubes on plastic substrates.
Qing Cao et al.
doi:10.1038/nature07110
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NR0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NS0Et
Archimedean-like tiling on decagonal quasicrystalline surfaces pp501-504
This paper describes interactions between highly charged colloidal
particles and a surface with a quasiperiodic patterned potential on it.
When the charges on the colloids are shielded, the colloidal monolayer
templates the order from the patterned potential to form a two-dimensional
quasicrystal. However, when the colloidal interactions are not shielded,
a transition to Archimedean tiling is achieved, where order is still
locally commensurate with quasicrystalline structure but now exhibits
long range periodicity.
Jules Mikhael, Johannes Roth, Laurent Helden and Clemens Bechinger
doi:10.1038/nature07074
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NT0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NU0Ev
Near-surface wetland sediments as a source of arsenic release to ground water
in Asia pp505-508
Hydrologic and biogeochemical measurements are used to show that on the
minimally disturbed Mekong Delta of Cambodia, arsenic is released from
near surface, river derived sediments and transported, on a centennial
time scale, through the underlying aquifer back to the river.
The results represent a model for understanding pre disturbance
conditions for other major deltas in Asia.
Matthew L. Polizzotto et al.
doi:10.1038/nature07093
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NV0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NW0Ex
Stress changes from the 2008 Wenchuan earthquake and increased hazard
in the Sichuan basin p509
On the 12th May 2008, a 7.9 magnitude earthquake struck the eastern
edge of the Tibetan Plateau. The Sichuan basin and surroundings are
crossed by other active strike slip and thrust faults. This paper now
calculates co seismic stress changes on those faults that resulted
from the 12th May event. It is found that many of the surrounding
faults show significant stress increases, which leads to them having
relatively higher odds of producing large aftershocks.
Tom Parsons, Chen Ji & Eric Kirby
doi:10.1038/nature07177
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NX0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NY0Ez
Subtropical to boreal convergence of tree-leaf temperatures p511
This paper reveals why climate doesn't have as great an impact on
leaf morphology and physiology as one might think. During periods
in which plants assimilate carbon, temperatures within leaves remain
at around 21.4 degrees C, whether the leaf is in the subtropics or the polar
regions, a range of 50 degrees of latitude. This goes against the received
wisdom that the temperature and relative humidity in an actively
photosynthesizing leaf is the same as that of the surrounding air.
Brent R. Helliker & Suzanna L. Richter
doi:10.1038/nature07031
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1NZ0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Na0E8
Ecosystem energetic implications of parasite and free-living biomass
in three estuaries pp515-518
This paper quantifies the biomass of free living and parasitic species
in three estuaries on the Pacific coast of California and Baja,
California. It shows that parasites have substantial biomass in these
ecosystems, even exceeding that of top predators, implying an important
role for infectious processes in these estuaries.
Armand M. Kuris et al.
doi:10.1038/nature06970
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nb0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nc0EB
Evidence for the evolutionary nascence of a novel sex determination
pathway in honeybees p519
edsumms2 goes here
Martin Hasselmann, Tanja Gempe, Morten Schiøtt,
Carlos Gustavo Nunes-Silva, Marianne Otte & Martin Beye
doi:10.1038/nature07052
This paper describes a new component of the sex determining pathway in
honey bees, called 'feminizer', as it is required for female development.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nd0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Ne0ED
Innate immunity induced by composition-dependent RIG-I recognition of
hepatitis C virus RNA p523
The RNA helicases RIG I and MDA5 signal activation of interferon
dependent innate immunity through detection of viral RNA in the cytosol
of infected cells. The conserved polyuridine motif in the 3' non
transcribed region of the HCV genome is the relevant PAMP for
detection by RIG I.
Takeshi Saito, David M. Owen, Fuguo Jiang, Joseph Marcotrigiano
& Michael Gale Jr.
doi:10.1038/nature07106
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nf0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Ng0EF
Imbalance between pSmad3 and Notch induces CDK inhibitors in
old muscle stem cells p528
This paper shows that aged muscle produces high levels of TGF-beta,
which leads to overactivation of pSmad3 in satellite cells and block
regeneration. The activity of Smad3 is antagonized by Notch, which is
inactivated in ageing muscle, also contributing to loss of regenerative
capacity. It is shown that the balance of Notch and Smad3 controls the
regulation of cyclin dependent kinases, which are negative regulators of
cell cycle progression, with Notch controlling whether Smad3 can bind
to these negative regulators of cell cycle.
Morgan E. Carlson, Michael Hsu & Irina M. Conboy
doi:10.1038/nature07034
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nh0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Ni0EH
Switch of rhodopsin expression in terminally differentiated
Drosophila sensory neurons p533
Blue sensitive neurons in a fruitfly's larval eye switch pigment
during metamorphosis to become green sensitive and form the adult
eyelets, little organs on the top of the fly's head, which reset its
circadian clock. The work opens the way to the genetic investigation
of gene regulatory mechanisms controlling such rare fate switching
events in post mitotic neurons.
Simon G. Sprecher & Claude Desplan
doi:10.1038/nature07062
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nj0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nk0EJ
Oligomerization of STIM1 couples ER calcium depletion to
CRAC channel activation p538
STIM1 is the messenger that signals endoplasmic reticulum Ca2+ store
depletion and subsequently activates the store operated channel ORAI.
However, its precise mechanism of action is unclear. This paper shows
that STIM oligomerzation, not the concentration of Ca2+ in the
endoplasmic reticulum, is the key event that triggers ORAI activation.
Riina M. Luik, Bin Wang, Murali Prakriya, Minnie M. Wu & Richard S. Lewis
doi:10.1038/nature07065
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nl0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nm0EL
Saccharomyces cerevisiae ATM orthologue suppresses break-induced
chromosome translocations pp543-546
A system to replicate chromosomal translocation event in yeast has
been devised. Using this system it is found that Tel1, the yeast
homologue of the kinase ATM which is mutated in ataxia telangiectasia,
is a key factor in suppressing non homologous end joining of
interchromosomal DNA ends.
Kihoon Lee, Yu Zhang and Sang Eun Lee
doi:10.1038/nature07054
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Nn0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1No0EN
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p547
National Academies panel endorses professional master's degree.
Gene Russo
doi:10.1038/nj7203-547a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Pr0ES
Career View
Brent Reynolds, director of the Adult Stem Cell Engineering and
Therapeutic Core, McKnight Brain Center, University of Florida,
Gainesville p548
Stem-cell scientist embraces Eastern philosophy — and a return
to science.
Paul Smaglik
doi:10.1038/nj7203-548a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Pt0EU
Vitae for postgraduate development p548
New organization pledges to fight for postgraduate student issues
in Britain.
Virginia Gewin
doi:10.1038/nj7203-548b
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Pv0EW
An unwelcome intrusion p548
It's not the workload that worries me, it's the reverse culture shock.
Aliza le Roux
doi:10.1038/nj7203-548c
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Px0EY
----------------------
FUTURES
----------------------
Hillcrest v. Velikovsky p550
An act of God?
Peter Watts
doi:10.1038/454550a
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Pz0Ea
----------------------
ADVANCE ONLINE PUBLICATION
----------------------
23 July 2008
Letters
Structural mechanism of WASP activation by the enterohaemorrhagic
E. coli effector EspFU
Hui-Chun Cheng, Brian M. Skehan, Kenneth G. Campellone, John M. Leong
& Michael K. Rosen
doi:10.1038/nature07160
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1QY0E3
Spatio-temporal correlations and visual signalling in a complete
neuronal population
Jonathan W. Pillow et al.
doi:10.1038/nature07140
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1QZ0E4
The pathogen protein EspFU hijacks actin polymerization using
mimicry and multivalency
Nathan A. Sallee et al.
doi:10.1038/nature07170
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Qa0EC
Cell-specific ATP7A transport sustains copper-dependent tyrosinase
activity in melanosomes
Subba Rao Gangi Setty, Danièle Tenza, Elena V. Sviderskaya,
Dorothy C. Bennett, Graça Raposo & Michael S. Marks
doi:10.1038/nature07163
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Qb0ED
A blend of small molecules regulates both mating and development in
Caenorhabditis elegans
Jagan Srinivasan et al.
doi:10.1038/nature07168
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Qc0EE
20 July 2008
Letters
Cryptochrome mediates light-dependent magnetosensitivity in Drosophila
Robert J. Gegear, Amy Casselman, Scott Waddell & Steven M. Reppert
doi:10.1038/nature07183
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Qd0EF
Significant contribution of Archaea to extant biomass in marine
subsurface sediments
Julius S. Lipp, Yuki Morono, Fumio Inagaki & Kai-Uwe Hinrichs
doi:10.1038/nature07174
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Qe0EG
Single-nucleotide mutation rate increases close to insertions/deletions
in eukaryotes
Dacheng Tian et al.
doi:10.1038/nature07175
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Qf0EH
Multipotent somatic stem cells contribute to the stem cell niche
in the Drosophila testis
Justin Voog, Cecilia D'Alterio & D. Leanne Jones
doi:10.1038/nature07173
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0B1Qg0EI
=====================================================================
Nature Insight Inflammation
Inflammation is our body's immediate response to damage
to its tissues and cells by pathogens or noxious stimuli
such as chemicals or physical injury. While initiation
and the process of acute inflammation are reasonably well
defined, much less is known about the causes and pathways
associated with chronic inflammation. This Insight highlights
recent advances in our knowledge of the exogenous and endogenous
inducers of chronic inflammation, the inflammatory mediators
and the cells that carry out the response.
Read the Insight in the 24th July issue of Nature or access it online.
http://ealerts.nature.com/cgi-bin24/DM/y/emUR0Xztnp0HjB0BuvF0EU
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