17 July 2008 Volume 454 Number 7202, pp253-366
Visit Nature online to browse the journal.
Now available at http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0d4W0Eb
Please note that you need to be a subscriber to enjoy full text access
to Nature online. To purchase a subscription, please visit:
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Z4L0EG
Alternatively, to recommend a subscription to your library, please visit
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BRQi0EC
=====================================================================
SilenciX cell lines are novel silenced systems in HeLa cells for human
target genes. As opposed to conventional systems, SilenciX are
ready-to-use cellular models. guaranteed for a stable knock-down
(>70% RNA extinction & >500 days) no off-target effect
These unique characteristics make SilenciX a robust tool for target
discovery, cell-based assays & screening purposes.
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwc0EO
=====================================================================
The Source Event – London, 26/09/2008
Now in its 2nd successful year, The Source Event is a dedicated science
career fair from Naturejobs, combining a dynamic exhibition with
conference and workshop sessions. The programme is divided into 3
streams: Graduate, Post Doc and Non-traditional careers. Exhibitors
include a wide range of employers, recruitment agencies and governmental
institutions.
Register now at: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BwBw0Em
=====================================================================
Before the roundworm, there was the silkmoth.
CDD's next Special Issue commemorates Richard Lockshin in honor of
his 70th birthday.
Featured review articles discuss the phylogeny and regulation of
programmed cell death in a variety of model organisms. Read a selection
of FREE articles from the Richard Lockshin issue online at CDD.
View CDD'S next Special Issue
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bugw0EN
=====================================================================
----------------------
EDITORIALS
----------------------
Life after SuperBabe p253
In the 30 years since the birth of the world's first 'test tube' baby,
in vitro fertilization has become commonplace. The next three decades
could bring equally transformative technologies.
doi:10.1038/454253a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwd0EP
Templeton's legacy pp253-254
The Templeton Foundation's exploration of science and faith merits
tolerance, not outright rejection.
doi:10.1038/454253b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwe0EQ
An uneasy peace p254
Britain's 'big science' funding agency is now in a position to
regain much-needed credibility.
doi:10.1038/454254a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwf0ER
----------------------
RESEARCH HIGHLIGHTS
----------------------
Planetary science: Martian devilry p256
doi:10.1038/454256a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwg0ES
Materials science: All white p256
doi:10.1038/454256b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwh0ET
Zoology: Quick-change artists p256
doi:10.1038/454256c
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwi0EU
Genetics: Autistic details p256
doi:10.1038/454256d
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwj0EV
Virology: Collective calm p256
doi:10.1038/454256e
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwk0EW
Geoscience: Carbon sinks pp256-257
doi:10.1038/454256f
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwl0EX
Biochemistry: Cook the catalyst p257
doi:10.1038/454257a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwm0EY
Molecular imaging: A gentler touch p257
doi:10.1038/454257b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwn0EZ
Tissue engineering: To rig with oil p257
doi:10.1038/454257c
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwo0Ea
Evolution: Sea skeletons p257
doi:10.1038/454257d
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwp0Eb
----------------------
JOURNAL CLUB
----------------------
Journal club p257
Seth Putterman
doi:10.1038/454257e
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwq0Ec
----------------------
NEWS
----------------------
Russia delays Lake Vostok drill pp258-259
Antarctica's hidden water will keep its secrets for another year.
Quirin Schiermeier
doi:10.1038/454258a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwr0Ed
Pakistan finds two radioactive containers pp258-259
Discovery calls into question the country's ability to track
its nuclear material.
Zeeya Merali
doi:10.1038/454258b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzws0Ee
Autism study panned by critics p259
Plan to use chelating agents on children comes under fire.
Meredith Wadman
doi:10.1038/454259a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwt0Ef
Special Report: Making babies: the next 30 years pp260-262
Louise Brown, the first test-tube baby, was born 30 years ago this
month after being conceived outside the body using in vitro
fertilization (IVF). Helen Pearson asks what developments in
reproductive medicine could have an equivalent impact in the
next three decades.
doi:10.1038/454260a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwu0Eg
Irrawaddy may be poisoned by arsenic p263
Geological map pinpoints fresh areas of contamination in Asia.
Heidi Ledford
doi:10.1038/454263a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwv0Eh
Starting small but adding up: a free maths archive p263
Initiative aims to be one-stop shop for articles.
Jascha Hoffman
doi:10.1038/454263b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzww0Ei
Sidelines p264
Scribbles on the margins of science.
doi:10.1038/454264a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwx0Ej
Snapshot: Global wind power p264
Radar data offer clues to turbine potential.
Emma Marris
doi:10.1038/454264b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwy0Ek
Mouse miRNA library to open p264
Biologists launch knockout resource.
Amber Dance
doi:10.1038/454264c
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzwz0El
Court victory for subject of experimental therapy p265
doi:10.1038/454265a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzw10EY
Drug firms join forces to boost discovery pipeline p265
doi:10.1038/454265b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzw20EZ
Chemical giant seeks route into speciality market p265
doi:10.1038/454265c
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzw30Ea
'Fundamentally flawed' US pollution law thrown out pp265
doi:10.1038/454265d
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzw40Eb
FDA aims for neutral tone in drug-rejection letters p265
doi:10.1038/454265e
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzw50Ec
Lionfish not a roaring success for coral reefs p265
doi:10.1038/454265f
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzw60Ed
----------------------
NEWS FEATURES
----------------------
The long summer begins pp266-269
A research vessel embedded in the thinning Arctic sea ice has a
front-row seat for the cryospheric show of the century.
Quirin Schiermeier reports from Darnley Bay, Canada.
doi:10.1038/454266a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzw70Ee
From the desert to the edge of space pp270-273
Not all NASA launches need rockets and countdowns.
Eric Hand sees the alternative in Fort Sumner, New Mexico.
doi:10.1038/454270a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzw80Ef
----------------------
CORRESPONDENCE
----------------------
Reverse translation: clearing a path from bedside to bench p274
David R. Moore
doi:10.1038/454274a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxA0Ep
Translational research: don't neglect basic science p274
Stephen Moss
doi:10.1038/454274b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxB0Eq
Health science: from bench to bedside to trench and back p274
Simon J. Craddock Lee
doi:10.1038/454274c
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxC0Er
----------------------
BOOKS AND ARTS
----------------------
Missing links in food-chain story pp275-276
Our actions have driven top predators from much of the world,
resulting in complex consequences for many ecosystems, explains
Stuart Pimm.
Stuart Pimm reviews Where the Wild Things Were: Life, Death and
Ecological Wreckage of Vanishing Predators By William Stolzenburg
doi:10.1038/454275a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxD0Es
Science wars revisited pp276-277
N. David Mermin reviews Beyond the Hoax: Science, Philosophy,
and Culture by Alan Sokal
doi:10.1038/454276a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxE0Et
To know or not to know? pp277-278
Sarah Franklin reviews Blood Matters: From Inherited Illness to
Designer Babies, How the World and I Found Ourselves in the
Future of the Gene by Masha Gessen
doi:10.1038/454277a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxF0Eu
Science artists draw together pp278-279
Nick Thomas
doi:10.1038/454278a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxG0Ev
Climate comedy falls flat p279
Emma Marris reviews Sizzle
doi:10.1038/454279a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxH0Ew
Culture dish p279
doi:10.1038/454279b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxI0Ex
----------------------
ESSAY
----------------------
30 years: from IVF to stem cells pp280-281
Ruth Deech, former chair of Britain's Human Fertilisation and
Embryology Authority, reflects on how the science that gave an
infertile couple a baby has been extended to saving lives.
doi:10.1038/454280a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxJ0Ey
----------------------
NEWS AND VIEWS
----------------------
Developmental biology: Serpent clocks tick faster pp282-283
Snakes have graceful, elongated bodies containing hundreds of
vertebrae. This extreme of morphology stems from evolutionary
changes in a developmental clock that regulates body patterning.
Freek J. Vonk and Michael K. Richardson
doi:10.1038/454282a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxK0Ez
Microscopy: Spot the atom pp283-284
Heavy atoms can be detected by electron microscopy, but lighter atoms,
such as carbon or hydrogen, are more elusive. These bashful atoms can
now be pinpointed if they are adsorbed to a single layer of graphite.
John Silcox
doi:10.1038/454283a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxL0E1
Motor neuron disease: The curious ways of ALS pp284-285
That mutations in the SOD1 enzyme underlie inherited forms of a
motor neuron disease known as ALS is clear. But the question of what
the consequences of such mutations are seems to have more than one answer.
Magdalini Polymenidou and Don W. Cleveland
doi:10.1038/454284a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxM0E2
Earth science: Volcanic cause of catastrophe pp285-287
From the timing, it looks as if an episode of marked oceanic oxygen
deficiency during the Cretaceous was the result of undersea volcanism.
Studies of such events are relevant to the warming world of today.
Timothy J. Bralower
doi:10.1038/454285a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxN0E3
Signal transduction: Linking nutrients to growth pp287-288
How cells sense nutrients to control growth is largely unknown. One
missing link involved in conveying the nutrient signal to the TOR
protein, which regulates growth, seems to be the Rag proteins.
Vittoria Zinzalla and Michael N. Hall
doi:10.1038/454287a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxO0E4
Systems biology: On the cell cycle and its switches pp288-289
For the cell-division cycle to progress, hundreds of genes and proteins
must be coordinately regulated. Systems-level studies of this cycle show
that positive-feedback loops help to keep events in sync.
Silvia D. M. Santos and James E. Ferrell
doi:10.1038/454288a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxP0E5
Obituary: John Templeton (1912-2008) p290
Philanthropist at the interface of religion and science.
Andrew Brown
doi:10.1038/454290a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxQ0E6
=====================================================================
Quality Web resources at your fingertips
With millions of people now actively publishing on the Web, how do you
find resources that are right for you?
Use Intute - a free online service, created by subject specialists,
guiding you to the very best Web resources for education and research in
all subject areas including the health and life sciences.
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0By6S0E1
=====================================================================
----------------------
ARTICLE
----------------------
Positive feedback of G1 cyclins ensures coherent cell cycle entry pp291-296
In budding yeast, the Start checkpoint in the G1 cell cycle phase is
a point after which cells are irreversibly committed to cell division.
Previous work has identified a linear pathway that triggers the
Start transition. In contrast, analyses of single cells reveal that
Start represents a positive feedback dependent sharp switch that
coordinates the simultaneous transcription of a large group of cell
cycle genes and the budding of a daughter cell.
Jan M. Skotheim, Stefano Di Talia, Eric D. Siggia and Frederick R. Cross
doi:10.1038/nature07118
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxR0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxS0E8
The cohesin ring concatenates sister DNA molecules p297
During mitosis, the two copies of each chromosome pair are held together
by cohesin. Three subunits of cohesin form a ring structure and it has
been proposed that the sister chromatids are tethered together by
being encircled by cohesin rings. This paper provides the most direct
evidence to date that cohesin rings topologically entrap two DNA molecules.
Christian H. Haering, Ana-Maria Farcas, Prakash Arumugam,
Jean Metson & Kim Nasmyth
doi:10.1038/nature07098
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxT0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxU0EB
----------------------
LETTERS
----------------------
Strong magnetic fields in normal galaxies at high redshift pp302-304
The origin and growth of magnetic fields in galaxies is still something
of an enigma. Quasars with strong MgII absorption lines are unambiguously
associated with larger rotation measures, which requires that organized
fields of surprisingly high strength are associated with normal galaxies
when the Universe was only about half its present age.
Martin L. Bernet et al.
doi:10.1038/nature07105
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxV0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxW0ED
Hydrated silicate minerals on Mars observed by the Mars Reconnaissance
Orbiter CRISM instrument pp305-309
Results from the Compact Reconnaissance Imaging Spectrometer for Mars
(CRISM) of phyllosilicate rich regions are reported. It is discovered
that stratigraphic relationships show olivine rich materials overlying
phyllosilicate bearing units, indicating cessation of aqueous alteration
before emplacement of the olivine bearing unit. It is also found
phyllosilicates in sedimentary deposits clearly laid by water, pointing
to a rich diversity of Noachian environments conducive to habitability.
John F. Mustard et al.
doi:10.1038/nature07097
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxX0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxY0EF
Generation of Fock states in a superconducting quantum circuit pp310-314
A 'circuit' quantum electrodynamics system where a superconducting
qubit acts as an atom like two energy level system and is embedded in
a microwave transmission circuit (acting as the optical cavity) is
studied. In this system, it is demonstrated that the creation of pure
quantum states, known as Fock states, which give specific numbers of
energy quanta, in this case photons. Fock states with up to six photons
are prepared and analysed.
Max Hofheinz et al.
doi:10.1038/nature07136
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BzxZ0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxa0EN
Climbing the Jaynes-Cummings ladder and observing its nonlinearity
in a cavity QED system pp315-318
This paper shows spectroscopic features in a particular solid state
cavity quantum electrodynamics system that agree with a theoretically
predicted relation between energy and number of photons, and which is
purely based on quantum mechanics. This system is also dubbed circuit
QED and is based on a superconducting qubit (acting as the atom
like emitter) and a microwave transmission line (the optical cavity).
J. M. Fink et al.
doi:10.1038/nature07112
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxb0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxc0EP
Imaging and dynamics of light atoms and molecules on graphene
pp319-322
Detecting individual low atomic number atoms is extremely challenging
using conventional transmission electron microscopy. This paper reports
the direct imaging in a transmission electron microscope (TEM) of
atomic carbon and hydrogen using graphene as a substrate which
provides a near invisible background. The approach could be used for
the direct study at the atomic level of organic species such
as biomolecules.
Jannik C. Meyer, C. O. Girit, M. F. Crommie and A. Zettl
doi:10.1038/nature07094
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxd0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxe0ER
Cretaceous oceanic anoxic event 2 triggered by a massive magmatic episode
pp323-326
Oceanic anoxic events (OAEs) were episodes of widespread marine anoxia
during which large amounts of organic carbon were buried on the ocean
floor under oxygen-deficient bottom waters, and OAE2 is the most
widespread and best defined OAE of the mid-Cretaceous. It is found
that that the marine osmium isotope record changes abruptly just at
or before the onset of the OAE2 at two distant sites, and it is
calculated that over 97 per cent of the total osmium content at both
sites is magmatic in origin, indicative of a widespread magmatic
pulse at the onset of OAE2.
Steven C. Turgeon and Robert A. Creaser
doi:10.1038/nature07076
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxf0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxg0ET
A unifying framework for dinitrogen fixation in the
terrestrial biosphere p327
In contrast to marine environments, the occurrence of nitrogen fixation
in terrestrial environments does not seem to be dependent on nitrogen
availability. An alternative framework is proposed, based on the
assumptions that enhanced phosphate acquisition by nitrogen fixing
plants provides an advantage in phosphate limited environments and
that temperature limits nitrogen fixation in high latitudes.
Benjamin Z. Houlton, Ying-Ping Wang, Peter M. Vitousek & Christopher B. Field
doi:10.1038/nature07028
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxh0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxi0EV
Coherent ecological dynamics induced by large-scale disturbance pp331-334
This paper shows that disturbance, in this case experimental
acidification of a whole lake, can cause communities to shift from
seemingly random incoherent dynamics to strongly synchronous dynamics.
Timothy H. Keitt
doi:10.1038/nature06935
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxj0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxk0EX
Control of segment number in vertebrate embryos p335
The vertebrate body axis is divided into a number of segments or
'somites', such as the number of vertebrae. But what controls vertebra
number, and its variation between species? This paper postulates that
the number depends on a balance between the division of the body into
somites (the segmentation clock rate) and the overall rate of development,
as established by showing that the large number of vertebrae in snakes
comes from a much greater segmentation clock speed in snakes, relative
to development as a whole, than in other vertebrates.
Céline Gomez, Ertug breverul M. Özbudak, Joshua Wunderlich, Diana Baumann,
Julian Lewis & Olivier Pourquié
doi:10.1038/nature07020
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxl0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxm0EZ
The role of the orbitofrontal cortex in the pursuit of happiness
and more specific rewards p340
The effect of conditioned reinforcement in rats is studied using an
experimental paradigm that differentiated between cues evoking thoughts
of specific outcomes or cues that evoked general stimulus–emotion
representations. It is reported that rats were willing to work for
either form of cue, but that the orbitofrontal cortex was important
for only conditioned reinforcement involving cues that evoked
thoughts of specific outcomes.
Kathryn A. Burke, Theresa M. Franz, Danielle N. Miller &
Geoffrey Schoenbaum
doi:10.1038/nature06993
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxn0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxo0Eb
IGFBP-4 is an inhibitor of canonical Wnt signalling required
for cardiogenesis p345
This study reports a function for IGFBP 4 as a cardiogenic growth
factor, showing that IGFBP 4 enhances cardiomyocyte differentiation
in vitro, and knockdown of IGFBP 4 attenuated cardiomyogenesis both
in vitro and in vivo. The effect was independent of IGF binding, and
was mediated by canonical Wnt signalling. IGFBP 4 physically
interacted with a Wnt receptor Frizzled 8 (Frz8) and a Wnt co receptor
low density lipoprotein receptor related protein 6 (LRP6), and
inhibited Wnt3A binding to Frz8 and LRP6.
Weidong Zhu et al.
doi:10.1038/nature07027
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxp0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxq0Ed
IL-21 and TGF-beta are required for differentiation of human
TH17 cells p350
The TH17 pathway is thought to contribute to the pathogenesis of a
number of human autoimmune diseases. This study examines which
cytokines are required for the production of IL-17A by memory
and naive human CD4+ T cells.
Li Yang et al.
doi:10.1038/nature07021
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxr0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxs0Ef
Positive feedback sharpens the anaphase switch p353
Chromosomes separate abruptly during anaphase of mitosis, but how this
switch like behaviour is achieved is unclear. Cohesion between sister
chromatids is dissolved by the protease separase, which is held in
check by securin. In this paper, a positive feedback loop regulating
the ubiquitination and destruction of securin is proposed to make
anaphase more switch like.
Liam J. Holt, Andrew N. Krutchinsky & David O. Morgan
doi:10.1038/nature07050
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxt0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxu0Eh
Structural basis of specific tRNA aminoacylation by a small
in vitro selected ribozyme p358
Flexizyme is an in vitro evolved ribozyme which can specifically add
an amino acid onto the terminal 3'OH of a tRNA. The structure of
flexizyme joined to a tRNA mimic is solved. Interestingly, the RNA
displays many of the known aminoacyl tRNA synthetase–tRNA interactions,
approaches the tRNA in a similar manner, and exhibits an induced fit
conformation that enhances specificity.
Hong Xiao, Hiroshi Murakami, Hiroaki Suga & Adrian R. Ferré-D'Amaré
doi:10.1038/nature07033
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxv0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxw0Ej
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p363
On being and becoming a maverick scientist.
Gene Russo
doi:10.1038/nj7202-363a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxx0Ek
Career View
Ernst-Ludwig Winnacker, secretary-general,
Human Frontier Science Program Organization, Strasbourg, France p364
New leadership coming to Human Frontier Science Program Organization.
Virginia Gewin
doi:10.1038/nj7202-364a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxy0El
Recruiting by rail p364
Max Planck Society hits the rails in India in search of talent.
Paul Smaglik
doi:10.1038/nj7202-364b
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzxz0Em
Taking steps p364
The random walk of my career.
Jon Yearsley
doi:10.1038/nj7202-364c
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzx10EZ
----------------------
FUTURES
----------------------
Ignorantia juris p366
Beware the long arm of the law.
Gareth Owens
doi:10.1038/454366a
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzx20Ea
----------------------
ADVANCE ONLINE PUBLICATION
----------------------
16 July 2008
Article
On the nature of partial agonism in the nicotinic receptor superfamily
Remigijus Lape, David Colquhoun & Lucia G. Sivilotti
doi:10.1038/nature07139
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzx30Eb
Letters
Acetylcholine contributes through muscarinic receptors to attentional
modulation in V1
J. L. Herrero, M. J. Roberts, L. S. Delicato, M. A. Gieselmann,
P. Dayan & A. Thiele
doi:10.1038/nature07141
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzx40Ec
Molecular basis of the copulatory plug polymorphism in
Caenorhabditis elegans
Michael F. Palopoli et al.
doi:10.1038/nature07171
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzx50Ed
Internal brain state regulates membrane potential synchrony in barrel
cortex of behaving mice
James F. A. Poulet & Carl C. H. Petersen
doi:10.1038/nature07150
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzx60Ee
The behaviour of Drosophila adult hindgut stem cells is controlled
by Wnt and Hh signalling
Shigeo Takashima, Marianna Mkrtchyan, Amelia Younossi-Hartenstein,
John R. Merriam & Volker Hartenstein
doi:10.1038/nature07156
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Bzx70Ef
=====================================================================
Laboratory Investigation presents:
'Understanding the development of human bladder cancer by using a
whole-organ genomic mapping strategy'
Can this disease be detected earlier? Genome-wide mapping of human
bladder cancer has identified key genetic risk areas for cancer
development and provides new insight into early genetic origins of cancer.
View the complete article online
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0BvKH0E8
Laboratory Investigation
www.laboratoryinvestigation.org
=====================================================================
You have been sent this Table of Contents Alert because you have opted in to
receive it. You can change or discontinue your e-mail alerts at any time,
by modifying your preferences on your nature.com account at:
http://ealerts.nature.com/cgi-bin24/DM/y/emMm0Xztnp0HjB0Zzu0E6
(You will need to log in to be recognised as a nature.com registrant).
For further technical assistance, please contact our registration department:
registration@nature.com
For print subscription enquiries, please contact our subscription department:
subscriptions@nature.com
For other enquiries, please contact our customer feedback department:
feedback@nature.com
Nature Publishing Group | 75 Varick Street, 9th Floor | New York |
NY 10013-1917 | USA
Nature Publishing Group's worldwide offices:
London - Paris - Munich - New Delhi - Tokyo - Melbourne -
San Diego - San Francisco - Washington - New York - Boston
(c) Copyright 2008 Nature Publishing Group
=====================================================================
