New Insights into Genetic Variation
In a recent article published in Nature, Dr. Evan Eichler and
colleagues present the first high-resolution sequence map of
structural variation across eight human genomes, revealing gaps in the
reference genome and refining our understanding of CNVs. Learn more
and download this important paper now.
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1CZ0EC
The EMBO Journal
Table of contents
Volume 27, Number 14 (23 July 2008)
In this issue...
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates
oligonucleotides that stimulate ATM activity
The MRN complex promotes ATM activity by unknown mechanisms. Vincenzo
Costanzo and colleagues now report that 'byproducts' of MRN's known
task, the processing of DNA double strand breaks, function in inducing
and sustaining ATM activation.
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Ca0EJ
Articles
Essential function of TORC2 in PKC and Akt turn motif
phosphorylation, maturation and signalling.
Tsuneo Ikenoue, Ken Inoki, Qian Yang, Xiaoming Zhou and Kun-Liang Guan
The EMBO Journal (2008) 27, 14, 1919-1931
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Cb0EK
Published online: 19 June 2008
The mammalian target of rapamycin complex 2 controls folding and
stability of Akt and protein kinase C.
Valeria Facchinetti, Weiming Ouyang, Hua Wei, Nelyn Soto, Adam
Lazorchak, Christine Gould, Carolyn Lowry, Alexandra C Newton, Yuxin
Mao, Robert Q Miao, William C Sessa, Jun Qin, Pumin Zhang, Bing Su
and Estela Jacinto
The EMBO Journal (2008) 27, 14, 1932-1943
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Cc0EL
Published online: 19 June 2008
Molecular basis for maintenance of fidelity during the CCA-adding
reaction by a CCA-adding enzyme.
Yukimatsu Toh, Tomoyuki Numata, Kazunori Watanabe, Daijiro Takeshita,
Osamu Nureki and Kozo Tomita
The EMBO Journal (2008) 27, 14, 1944-1952
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Cd0EM
Published online: 26 June 2008
Mre11-Rad50-Nbs1-dependent processing of DNA breaks generates
oligonucleotides that stimulate ATM activity.
Ali Jazayeri, Alessia Balestrini, Elizabeth Garner, James E Haber and
Vincenzo Costanzo
The EMBO Journal (2008) 27, 14, 1953-1962
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Ca0EJ
Published online: 3 July 2008
Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression
by ATR in response to replication stress.
Zhao-Hui Wu and Shigeki Miyamoto
The EMBO Journal (2008) 27, 14, 1963-1973
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Ce0EN
Published online: 26 June 2008
Stress-protective signalling of prion protein is corrupted by scrapie
prions.
Angelika S Rambold, Veronika Müller, Uri Ron, Nir Ben-Tal, Konstanze
F Winklhofer and Jorg Tatzelt
The EMBO Journal (2008) 27, 14, 1974-1984
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Cf0EO
Published online: 19 June 2008
Small-molecule inhibition and activation-loop trans-phosphorylation
of the IGF1 receptor.
Jinhua Wu, Wanqing Li, Barbara P Craddock, Kenneth W Foreman, Mark J
Mulvihill, Qun-sheng Ji, W Todd Miller and Stevan R Hubbard
The EMBO Journal (2008) 27, 14, 1985-1994
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Cg0EP
Published online: 19 June 2008
Novel type of Ras effector interaction established between tumour
suppressor NORE1A and Ras switch II.
Benjamin Stieglitz, Christine Bee, Daniel Schwarz, Ozkan Yildiz, Anna
Moshnikova, Andrei Khokhlatchev and Christian Herrmann
The EMBO Journal (2008) 27, 14, 1995-2005
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Ch0EQ
Published online: 3 July 2008
Regulation of the transcription factor Ets-1 by DNA-mediated
homo-dimerization.
Ekaterina P Lamber, Laurent Vanhille, Larissa C Textor, Galina S
Kachalova, Michael H Sieweke and Matthias Wilmanns
The EMBO Journal (2008) 27, 14, 2006-2017
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Ci0ER
Published online: 19 June 2008
Implementing the LIM code: the structural basis for cell
type-specific assembly of LIM-homeodomain complexes.
Mugdha Bhati, Christopher Lee, Amy L Nancarrow, Mihwa Lee, Vanessa J
Craig, Ingolf Bach, J Mitchell Guss, Joel P Mackay and Jacqueline M
Matthews
The EMBO Journal (2008) 27, 14, 2018-2029
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Cj0ES
Published online: 26 June 2008
Corrigendum
Structure of Escherichia coli tyrosine kinase Etk reveals a novel
activation mechanism.
Daniel C Lee, Jimin Zheng, Yi-Min She and Zongchao Jia
The EMBO Journal (2008) 27, 14, 2030
http://ealerts.nature.com/cgi-bin24/DM/y/emRy0Xztnp0Hh50B1Ck0ET
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