Volume 99 Number 3
Published online 29 July 2008 (385 - 556)
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EDITORIAL
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Promises and caveats of in silico biomarker discovery
L Pusztai and B Leyland-Jones
http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tZ0Ew
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MINIREVIEWS
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Resistance to chemotherapy: new treatments and novel insights into an
old problem
S Raguz and E Yague
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1ta0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tb0E5
Tumour-targeted nanomedicines: principles and practice
T Lammers, W E Hennink and G Storm
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tc0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1td0E7
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CLINICAL STUDIES
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PRAME expression and clinical outcome of breast cancer
M T Epping, A A M Hart, A M Glas, O Krijgsman and R Bernards
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1te0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tf0EA
High-risk human papillomavirus infections in breast cancer in Syrian
women and their association with Id-1 expression: a tissue microarray
study
N Akil, A Yasmeen, A Kassab, L Ghabreau, A D Darnel and A-E Al
Moustafa
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tg0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1th0EC
Human papillomavirus detected in female breast carcinomas in Japan
N A Khan, A Castillo, C Koriyama, Y Kijima, Y Umekita, Y Ohi, M
Higashi, Y Sagara, H Yoshinaka, T Tsuji, S Natsugoe, T Douchi, Y
Eizuru and S Akiba
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1ti0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tj0EE
Implementing a system of quality-of-life diagnosis and therapy for
breast cancer patients: results of an exploratory trial as a
prerequisite for a subsequent RCT
M Klinkhammer-Schalke, M Koller, C Ehret, B Steinger, B Ernst, J C
Wyatt, F Hofstadter and W Lorenz
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tk0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tl0EG
Effectiveness of service screening: a case-control study to assess
breast cancer mortality reduction
D Puliti, G Miccinesi, N Collina, V De Lisi, M Federico, S Ferretti, A
C Finarelli, F Foca, L Mangone, C Naldoni, M Petrella, A Ponti, N
Segnan, A Sigona, M Zarcone, M Zorzi, M Zappa and E Paci
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tm0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tn0EI
Target and reality of adjuvant endocrine therapy in postmenopausal
patients with invasive breast cancer
U Guth, D J Huang, A Schotzau, R Zanetti-Dallenbach, W Holzgreve, J
Bitzer and E Wight
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1to0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tp0EK
Dietary glycaemic index, glycaemic load and endometrial and ovarian
cancer risk: a systematic review and meta-analysis
H G Mulholland, L J Murray, C R Cardwell and M M Cantwell
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tq0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tr0EM
Phase III randomised trial of doxorubicin-based chemotherapy compared
with platinum-based chemotherapy in small-cell lung cancer
S Baka, R Califano, R Ferraldeschi, L Aschroft, N Thatcher, P Taylor,
C Faivre-Finn, F Blackhall and P Lorigan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1ts0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tt0EO
The clinical implications of sunitinib-induced hypothyroidism: a
prospective evaluation
P Wolter, C Stefan, B Decallonne, H Dumez, M Bex, P Carmeliet and P
Schoffski
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tu0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tv0EQ
Biweekly cetuximab and irinotecan in advanced colorectal cancer
patients progressing after at least one previous line of chemotherapy:
results of a phase II single institution trial
P Martin-Martorell, S Rosello, E Rodriguez-Braun, I Chirivella, A
Bosch and A Cervantes
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tw0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tx0ES
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TRANSLATIONAL THERAPEUTICS
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Reciprocal relationship between expression of hypoxia inducible factor
1[alpha] (HIF-1[alpha]) and the pro-apoptotic protein Bid in ex vivo
colorectal cancer
M M Seenath, D Roberts, C Cawthorne, M P Saunders, G R Armstrong, S T
O'Dwyer, I J Stratford, C Dive and A G Renehan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1ty0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1tz0EU
The xc- cystine//glutamate antiporter: a mediator of pancreatic cancer
growth with a role in drug resistance
M Lo, V Ling, Y Z Wang and P W Gout
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1t10EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1t20EI
Enzastaurin inhibits tumours sensitive and resistant to anti-EGFR
drugs
T Gelardi, R Caputo, V Damiano, G Daniele, S Pepe, F Ciardiello, M
Lahn, R Bianco and G Tortora
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1t30EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1t40EK
[lsqb]18F[rsqb]FDG and [lsqb]18F[rsqb]FLT uptake in human breast
cancer cells in relation to the effects of chemotherapy: an in vitro
study
W G E Direcks, S C Berndsen, N Proost, G J Peters, J Balzarini, M D
Spreeuwenberg, A A Lammertsma and C F M Molthoff
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1t50EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1t60EM
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MOLECULAR DIAGNOSTICS
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The transforming mutation E17K//AKT1 is not a major event in
B-cell-derived lymphoid leukaemias
I S Mahmoud, M A Sughayer, H A Mohammad, A A Eshtayeh, A S Awidi, M S
EL-Khateeb and S I Ismail
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1t70EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1t80EO
Identification of claudin-4 as a marker highly overexpressed in both
primary and metastatic prostate cancer
K A Landers, H Samaratunga, L Teng, M Buck, M J Burger, B Scells, M F
Lavin and R A Gardiner
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uA0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uB0EZ
Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor
in colon cancer cells
G O'Callaghan, J Kelly, F Shanahan and A Houston
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uC0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uD0Eb
Genomic instability and proliferative activity as risk factors for
distant metastases in breast cancer
L Li, K Mu, G Zhou, L Lan, G Auer and A Zetterberg
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uE0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uF0Ed
MUC4 activates HER2 signalling and enhances the motility of human
ovarian cancer cells
M P Ponnusamy, A P Singh, M Jain, S Chakraborty, N Moniaux and S K
Batra
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uG0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uH0Ef
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EPIDEMIOLOGY
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Obesity and risk of pancreatic cancer among postmenopausal women: the
Women's Health Initiative (United States)
J Luo, K L Margolis, H-O Adami, A LaCroix and W Ye
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uI0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uJ0Eh
Should colorectal cancer screening start at the same age in European
countries? Contributions from descriptive epidemiology
H Brenner, M Hoffmeister and U Haug
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uK0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uL0Ej
Modification of second cancer risk after malignant melanoma by
parental history of cancer
H Zhang, J Lorenzo Bermejo, J Sundquist and K Hemminki
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uM0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uN0El
Second breast cancers in a Tuscan case series: characteristics,
prognosis, and predictors of survival
S Ciatto, N Houssami, F Martinelli, R Bonardi, F H Cafferty and S W
Duffy
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uO0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uP0En
Childhood cancer in the offspring born in 1921-1984 to US radiologic
technologists
K J Johnson, B H Alexander, M M Doody, A J Sigurdson, M S Linet, L G
Spector, R W Hoffbeck, S L Simon, R M Weinstock and J A Ross
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uQ0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uR0Ep
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LETTERS TO THE EDITOR
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Clinical interest of KRAS mutation detection in blood for anti-EGFR
therapies in metastatic colorectal cancer
F Di Fiore, F Charbonnier, B Lefebure, M Laurent, F Le Pessot, P
Michel and T Frebourg
http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uS0Eq
Is serum matrix metalloproteinase 9 a useful biomarker in detection of
colorectal cancer? Considering pre-analytical interference that may
influence diagnostic accuracy
K Jung
http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uT0Er
Reply: Is serum matrix metalloproteinase 9 a useful biomarker in
detection of colorectal cancer[quest] Considering pre-analytical
interference that may influence diagnostic accuracy
N G Hurst
http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uU0Es
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CORRIGENDUM
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Reply: Elevated serum matrix metalloproteinase 9 (MMP-9) concentration
predicts the presence of colorectal neoplasia in symptomatic patients
N G Hurst, D D Stocken, S Wilson, C Keh, M J O Wakelam and T Ismail
http://ealerts.nature.com/cgi-bin24/DM/y/embn0Xztnp0Hhi0B1uV0Et
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