Signaling Gateway - 6 June 2008
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0M40EF
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TOLL-LIKE RECEPTOR SIGNALING: IRAK2 STAYS THE COURSE
The interleukin-1 receptor-associated kinase 2 (IRAK2) is dispensable
in the early phase of Toll-like receptor signaling but is required
for sustained NF-kappaB activity.
Original research paper: Nature Immunology 9, 684-691 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0vP0EO
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0HIE0Ee
Calcium-sensing receptor
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0Bww30Ez
The calcium-sensing receptor (CaSR) has a key role in calcium
homeostasis by sensing changes in the concentration of extracellular
calcium ion (Ca2+o). CaSR activates Gq/11 and Gi/o, which results in
the activation of phospholipase C, the inhibition of adenylyl cyclase,
and the modulation of the mitogen-activated protein kinases (MAPKs).
In parathyroid cells, CaSR regulates the synthesis and secretion of
parathyroid hormone (PTH), and the proliferation of parathyroid cells.
search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0BUuz0Ea
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Selected Updates
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CELL SIGNALLING: A Rac1-JNK2-beta-CATENIN DOMINO CASCADE
Wnt signaling promotes Rac1-mediated activation of Jun N-terminal
kinase-2 (JNK2), which phosphorylates beta-catenin and promotes its
nuclear translocation.
Original research paper: Cell 133, 340-353 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0Bww40E1
T-CELL RESPONSES: DCS GET KITTED OUT
Following exposure to allergens, dendritic cells stimulate a
KIT–PI3K–interleukin-6 signaling pathway that promotes TH2- and
TH17-cell responses.
Original research paper: Nature Med. 14, 565-573 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0Bww50E2
THERAPY: REVERSED PROTECTION
CBLB502 - a toll-like receptor 5 (TLR5) agonist that induces NF-kappaB
activation - inhibits apoptosis to protect hematopoietic and
gastrointestinal tract cells from the radiation damage associated with
radiotherapy.
Original research paper: Science 320, 226-230 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0Bww60E3
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0vO0EN
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Research Library
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A TWO-TIERED MECHANISM FOR STABILIZATION AND IMMOBILIZATION OF
E-CADHERIN
Nature 453, 751-756 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0Bww70E4
NANOG AND OCT4 ASSOCIATE WITH UNIQUE TRANSCRIPTIONAL REPRESSION
COMPLEXES IN EMBRYONIC STEM CELLS
Nature Cell Biology 10, 731-739 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0Bww80E5
ACTIVATION OF THE ENDOCANNABINOID SYSTEM BY ORGANOPHOSPHORUS NERVE
AGENTS
Nature Chemical Biology 4, 373-378 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0BwxA0EG
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Signaling News
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HUMAN STEM CELLS USED TO CURE BRAIN DISORDER
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0BwxB0EH
Human stem cells have been used to correct abnormal brain development
in mice with fatal brain disorders, offering hope for treating a
range of neurological disorders including some deadly childhood genetic
diseases. Those behind the new treatment hope that human clinical
trials could be just a few years away.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0Crw0E5
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Gateway Updates
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The Cell Migration Gateway - JUNE UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0wDM0EU
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles:
RNA localization: APC throws the anchor
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0BwI20EE
Integrin activation: Taking Kindlin to embryogenesis
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0BwI30EF
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0BJrg0E2
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Signaling Job of the Week
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Professor of Physiology
Employer: Rheinische Friedrich-Wilhelms-University Bonn
Location: Bonn, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0BwxC0EI
The Rheinische Friedrich-Wilhelms-University Bonn is seeking a
candidate with an outstanding track record in Physiology. Preferred
research topics include stem cell biology, regenerative medicine,
cell physiology or signal transduction. Participation in already
existing research programs at the University of Bonn is expected.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0BnjC0Et
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/elOo0Xztnp0H2W0vqs0Eq
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