Signaling Gateway - 13 June 2008
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0M40Eg
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CELL CYCLE: SPINNING A TRANSCRIPTION FACTOR WEB
A cyclin-CDK-independent network involving successive waves of
transcription factor activity regulates the periodic expression of a
significant proportion of cell cycle genes.
Original research paper: Nature 453, 944-947 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0vP0Ep
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Signaling Survey
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SIGNALING GATEWAY SURVEY: WHAT DO YOU THINK?
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bvd80ED
The Signaling Gateway team invites you to complete a brief online
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Touch or two-year subscription to Nature. Your feedback will help
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click here.
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0HIE0E6
GABA A receptor alpha 6 subunit
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxam0E4
The alpha6 subunit is one of 19 subunits that can assemble to form
gamma-aminobutyric acid (GABAA) receptors. These heteropentameric
ligand-gated ion channels mediate many of the actions of GABA, the major
inhibitory neurotransmitter in the central nervous system of mature
mammals. GABAA receptors with different subunit compositions exist
in different brain regions and neuronal populations. alpha6
subunit-containing receptors are found primarily in cerebellar granule
neurons.
search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0BUuz0E2
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Selected Updates
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T-CELL SIGNALLING: ITAMS: QUANTITY OVER QUALITY
A systematic analysis of the CD3 immunoreceptor tyrosine-based activation
motifs (ITAMs), which transmit intracellular signals following T-cell
receptor (TCR) ligation, illuminates the requirement for multiple ITAMs
in T-cell development and function.
Original research paper: Nature Immunol. 9, 658-666 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxav0EE
METASTASIS: TRADING IN MITOCHONDRIA
Exchanging the mitochondrial DNA (mtDNA) between mouse tumor cell lines
has revealed mtDNA mutations that increase the metastatic potential of
tumor cells by mediating the generation of reactive oxygen species (ROS).
Original research paper: Science 320, 661-664 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxan0E5
MICROSCOPY: MOTIONLESS FAST 3D SCANNING
A 3D laser scanning microscopy method that requires no moving parts
promises to expand the in vivo study of fast neuronal signaling
at cellular and subcellular levels
Original research paper: Nature Neurosci. 11, 713-720 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxaw0EF
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0vO0Eo
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Research Library
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REGULATION OF AUTOPHAGY BY CYTOPLASMIC P53
Nature Cell Biology 10, 676-687 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxao0E6
SUMOYLATION OF KRUPPEL-LIKE TRANSCRIPTION FACTOR 5 ACTS AS A
MOLECULAR SWITCH IN TRANSCRIPTIONAL PROGRAMS OF LIPID METABOLISM
INVOLVING PPAR-DELTA
Nature Medicine 14, 656-666 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxap0E7
CELL-SURFACE PROTEIN-PROTEIN INTERACTION ANALYSIS WITH TIME-RESOLVED
FRET AND SNAP-TAG TECHNOLOGIES: APPLICATION TO GPCR OLIGOMERIZATION
Nature Methods 5, 561-567 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxaq0E8
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Signaling News
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TRANSLATIONAL RESEARCH: THE FULL CYCLE
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0BxQj0Ek
Many scientists are now challenging the idea that translational research
is just about carrying results from bench to bedside, arguing that the
reverse process - using clinical trials and patients' unexpected
responses to refine the experiment in its next iteration - provides
valuable information. These studies have already helped explain why the
EGFR inhibitor gefitinib failed to improve lung cancer patient survival
and illuminated the link between leukemia and IL2RG gene therapy.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Crw0EX
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - JUNE UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0BGyx0Ep
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and bioinformaticians
to explore, visualize and mine signaling events.
This month's update features:
IL1-mediated signaling events
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0BxDZ0EH
FoxO family signaling
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0BxDa0EO
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0BJYy0EN
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Signaling Job of the Week
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Postdoctoral Position
Employer: Clinical Sciences Centre, Medical Research Council
Location: London, UK
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxar0EA
A postdoctoral position is available in Professor Vasso Episkopou's
laboratory in the Mammalian Neurogenesis group of the MRC Clinical
Sciences Centre. The research project will focus on the role of
intracellular molecules (repressors, activators, de-repressors) in
regulating the strength and duration of TGF-beta signaling to achieve
different cell fates in embryonic stem cells and early embryos.
Applications for this job should be made online at
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0Bxas0EB
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0BnjC0EM
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/elZC0Xztnp0H2W0vqs0EJ
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