June 12 2008
Visit Nature Reports Stem Cells online.
Now available at: http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BU280E8
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THIS MONTH IN NATURE REPORTS STEM CELLS
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As stem cell scientists gather in Philadelphia, Nature Reports Stem Cells chronicles how researchers plan to address issues of stem cell tourism, clinical trial design and human volunteers. Interviews with prominent scientists explore self-renewal in blood and the molecular underpinnings of healing, and peer reviewers weigh in on the random forces affecting cell fate.
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OUR TOP STORIES
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Stem cell researchers face down stem cell tourism
A variety of international efforts hope to warn patients of unregulated treatments
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYc0E5
Questioning the self cell
A surprising study indicates that non-self mesenchymal stem cells might be just as therapeutic as one's own stem cells
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYd0E6
Egg shortage hits race to clone human stem cells
Researchers back bid to pay donors
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYG0Ec
Q&A: Leonard Zon: unlocking stemness in haematopoiesis
After decades of study, blood still holds secrets and lessons of self-renewal
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYe0E7
Zon, L. I. Nature 453, 306-313 (2008).
Geoff Gurtner: learning healing from scars
For its power to be harnessed, wound repair must reveal its molecular secrets
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYH0Ed
Gurtner, G. et al. Nature 453, 314-321 (2008).
Inside the paper: Metarandom states push cell fate
See peer reviews on a paper showing that gene expression noise in multipotent progenitors may be crucial for cell differentiation
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0Bw6U0EG
Chang, H. H. Nature 453, 544-547 (2008).
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Research highlights and news stories keying off recent publications
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Chance and the single cell
Fully multipotent cells fluctuate slowly between states with varying likelihoods of differentiation
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0Bw6V0EH
Chang, H. H. Nature 453, 544-547 (2008).
Off with differentiation
Embryonic stem cells can be grown without the complex biological ingredients that normally activate self-renewal
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0Bw6W0EI
Ying, Q.-L. et al. Nature 453, 519-523 (2008).
Glucose restriction blocks skeletal muscle cell differentiation
Aging pathways allow muscle progenitors to respond to nutrients
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYf0E8
Fulco, M. et al. Dev. Cell 14, 661-673 (2008).
Stem cell research: more support brings more papers
Publication rates in human embryonic stem cell research reflect government policies
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYg0EA
Levine, A. Cell Stem Cell 2, 521-524 (2008).
Human transplants stop the shivers
Injected human glial progenitor cells grow into functional myelin sheaths in shiverer mice
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYh0EB
Levine, A. Cell Stem Cell 2, 521-524 (2008).
Unlocking reprogramming
New strategy could lead to changes in the quality, quantity of induced pluripotent cells
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0BxYi0EC
Mikkelsen, T. S. et al. Nature advance online publication, doi:10.1038/nature07056 (28 May 2008).
Mali, P. et al. Stem Cells doi:10.1634/stemcells.2008-0346 (published online 29 May 2008).
Also, editor Monya Baker attended the Cold Spring Harbor Symposium on controlling and regulating stem cells, which took place May 28 - June 2. Read her thoughts here:
http://ealerts.nature.com/cgi-bin24/DM/y/elSk0Xztnp0JEp0Bw6b0ET
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