June 2008 Volume 10 Number 6, pp 629 - 752
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Submit an abstract now for this AACR Special Conference in Cancer Research:
Chemical and Biological Aspects of Inflammation and Cancer Oct. 14-17, 2008 --
Ko Olina, HI -- Abstracts due by Aug. 10, 2008
http://www.aacr.org/page13193.aspx
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Cell Shape and Polarity: Lymphocytes and Beyond
September 29, 2008
Chicago, Illinois
This mini-symposium aims to promote discussion about molecular mechanisms
underlying cell polarization, synapse formation and asymmetric cell division,
as well as the influence of these processes on cell fate determination and function.
Apply by June 25, 2008
Attendance at this meeting is free on acceptance of application.
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EDITORIAL
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Missing the boat: a loophole in start-up funding? p629
Funding agencies have set up dedicated schemes to help the plight of
young principal investigators. But is the playing field level for all
qualified scientists?
doi:10.1038/ncb0608-629
http://www.nature.com/ncb/journal/v10/n6/full/ncb0608-629.html
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MEETING REPORT
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Small RNAs tell big stories in Whistler pp630 - 633
Amy C. Seila and Phillip A. Sharp
doi:10.1038/ncb0608-630
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb0608-630.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb0608-630.html
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NEWS AND VIEWS
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SUMO amplifies TGF-beta signalling pp635 - 637
Transforming growth factor-beta (TGF-beta) stimulates phosphorylation
of TGF-beta type I receptor. This receptor is now shown to be
sumoylated, leading to enhanced activation and modulation of the
downstream Smad signalling pathway.
Kohei Miyazono, Yuto Kamiya and Keiji Miyazawa
doi:10.1038/ncb0608-635
http://www.nature.com/ncb/journal/v10/n6/full/ncb0608-635.html
p53: The Janus of autophagy? pp637 - 639
The autophagy pathway functions in adaptation to nutrient stress and
tumour suppression. The p53 tumour suppressor, previously thought to
positively regulate autophagy, may also inhibit it. This dual
interplay between p53 and autophagy regulation is enigmatic, but may
underlie key aspects of metabolism and cancer biology.
Beth Levine and John Abrams
doi:10.1038/ncb0608-637
http://www.nature.com/ncb/journal/v10/n6/full/ncb0608-637.html
Skeletal muscle dressed in SOCs pp639 - 641
Store-operated Ca2+ channels (SOCs) are activated in response to Ca2+
release from the endoplasmic reticulum (ER). The stromal interaction
molecule 1 (STIM1) is the ER sensor that transmits the stored Ca2+
content to the pore-forming SOCs Orai and TRPC channels. Recent studies
reveal high levels of Orai1 and STIM1 in skeletal muscle, and a
prominent role of SOCs in muscle development and function.
Dong Min Shin and Shmuel Muallem
doi:10.1038/ncb0608-639
http://www.nature.com/ncb/journal/v10/n6/full/ncb0608-639.html
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RESEARCH HIGHLIGHTS
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Research highlights p642
doi:10.1038/ncb0608-642
http://www.nature.com/ncb/journal/v10/n6/full/ncb0608-642.html
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ARTICLES
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The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation
and proliferation by destabilizing the N-Myc oncoprotein
pp643 - 653
Xudong Zhao et al.
doi:10.1038/ncb1727
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1727.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1727.html
The type I TGF-beta receptor is covalently modified and regulated
by sumoylation pp654 - 664
Jong Seok Kang, Elise F. Saunier, Rosemary J. Akhurst and Rik Derynck
doi:10.1038/ncb1728
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1728.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1728.html
Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase
is necessary for proper assembly of the mitotic spindle pp665 - 675
Karen Crasta et al.
doi:10.1038/ncb1729
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1729.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1729.html
Regulation of autophagy by cytoplasmic p53 pp676 - 687
Ezgi Tasdemir et al.
doi:10.1038/ncb1730
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1730.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1730.html
STIM1 signalling controls store-operated calcium entry required for
development and contractile function in skeletal muscle pp688 - 697
Jonathan Stiber et al.
doi:10.1038/ncb1731
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1731.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1731.html
----------------------
LETTERS
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Netrin-1 mediates neuronal survival through PIKE-L interaction with
the dependence receptor UNC5B pp698 - 706
Xiaoling Tang et al.
doi:10.1038/ncb1732
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1732.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1732.html
Yeast Ataxin-7 links histone deubiquitination with gene gating and
mRNA export pp707 - 715
Alwin Kohler et al.
doi:10.1038/ncb1733
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1733.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1733.html
beta1 Integrin deletion from the basal compartment of the mammary
epithelium affects stem cells pp716 - 722
Ilaria Taddei et al.
doi:10.1038/ncb1734
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1734.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1734.html
p53-Driven apoptosis limits centrosome amplification and genomic
instability downstream of NPM1 phosphorylation pp723 - 730
Maria Emanuela Cuomo et al.
doi:10.1038/ncb1735
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1735.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1735.html
Nanog and Oct4 associate with unique transcriptional repression
complexes in embryonic stem cells pp731 - 739
Jiancong Liang et al.
doi:10.1038/ncb1736
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1736.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1736.html
An agonist-induced conformational change in the growth hormone
receptor determines the choice of signalling pathway pp740 - 747
Scott W. Rowlinson et al.
doi:10.1038/ncb1737
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1737.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1737.html
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BRIEF COMMUNICATION
----------------------
Extra centrosomes and/or chromosomes prolong mitosis in human cells
pp748 - 751
Zhenye Yang, Jadranka Loncarek, Alexey Khodjakov and Conly L. Rieder
doi:10.1038/ncb1738
Abstract: http://www.nature.com/ncb/journal/v10/n6/abs/ncb1738.html
Article: http://www.nature.com/ncb/journal/v10/n6/full/ncb1738.html
----------------------
ERRATUM
----------------------
Erratum p752
doi:10.1038/ncb0608-752
http://www.nature.com/ncb/journal/v10/n6/full/ncb0608-752.html
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