5 June 2008 Volume 453 Number 7196, pp697-822
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EDITORIALS
----------------------
This time it's personal p697
The next head of the US National Human Genome Research Institute will
need to be equipped to deal with the scientific, political and
societal challenges presented by the burgeoning era of personal
genomics.
doi:10.1038/453697a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhj0E7
On the campaign trail pp697-698
It is less specific policies and more the approach to science that
will distinguish the next US president.
doi:10.1038/453697b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhk0E8
A flood of hard data p698
Social scientists have a new handle on group behaviour -- but its
causes remain a challenge.
doi:10.1038/453698a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhl0EA
----------------------
RESEARCH HIGHLIGHTS
----------------------
Atmospheric science: Blow by blow p700
doi:10.1038/453700a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhm0EB
Biotechnology: Genetic dexterity p700
doi:10.1038/453700b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhn0EC
Plant science: Mossy management p700
doi:10.1038/453700c
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwho0ED
Evolution: Genetic bric-a-brac p700
doi:10.1038/453700d
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhp0EE
Astronomy: Meal deal p700
doi:10.1038/453700e
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhq0EF
Chemical biology: Reducing power pp700-701
doi:10.1038/453700f
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhr0EG
Nanotechnology: Sheet change p701
doi:10.1038/453701a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhs0EH
Chemical sensing: Molecular mapping p701
doi:10.1038/453701b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwht0EI
Zoology: Mid-ocean wanderer p701
doi:10.1038/453701c
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhu0EJ
Correction p701
doi:10.1038/453701d
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhv0EK
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JOURNAL CLUB
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Journal club p701
Uri Alon
doi:10.1038/453701e
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhw0EL
----------------------
NEWS
----------------------
Russian science academy rejects Putin ally pp702-703
No change at the top as old guard keeps its grip on power.
Quirin Schiermeier
doi:10.1038/453702a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhx0EM
Mars reveals early mysteries p703
Planet's surface proves a puzzle for Phoenix probe.
Eric Hand
doi:10.1038/453703a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhy0EN
Japanese nuclear plant in quake risk pp704
Reprocessing facility may be built on active fault.
David Cyranoski
doi:10.1038/453704a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwhz0EO
UN decision puts brakes on ocean fertilization p704
Countries agree on moratorium for commercial schemes.
Jeff Tollefson
doi:10.1038/453704b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwh10EB
Physicists to target neutrinos pp705
US switches focus from colliders.
Eric Hand
doi:10.1038/453705a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwh20EC
Sidelines pp705
Scribbles on the margins of science.
doi:10.1038/453705b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwh30ED
The four-year fight for biological art pp707
Steven Kurtz talks about the court battle to clear his name of
bioterror links
Rachel Courtland
doi:10.1038/453707a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwh40EE
Here's looking at you, kid pp708
Software promises to identify blockbuster scripts.
Zeeya Merali
doi:10.1038/453708a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwh50EF
Biological tools revamp disease classification pp709
The role of gene interactions is explored.
Erika Check Hayden
doi:10.1038/453709a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwh60EG
US genomics leader bows out from institute pp710
doi:10.1038/453710a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwh70EH
Merck scores victory in three Vioxx appeals pp710
doi:10.1038/453710b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwh80EI
Indian coral islands under threat from algae pp710-711
doi:10.1038/453710c
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiA0ES
Donation breathes life into Fermilab's balance sheet pp711
doi:10.1038/453711a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiB0ET
Researchers kidnapped near Atacama telescope p711
doi:10.1038/453711b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiC0EU
Correction pp711
doi:10.1038/453711c
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiD0EV
----------------------
NEWS FEATURES
----------------------
Planetary science: Stranger in a strange land pp712-713
Snapshot from Mars captures Phoenix landing.
Eric Hand
doi:10.1038/453712a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiE0EW
Ecological modelling: The mathematical mirror to animal nature pp714-716
Animal behaviour is an endless challenge to mathematical modellers.
Mark Buchanan looks at how a mathematical principle from physics might
be able to explain patterns of movement.
doi:10.1038/453714a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiF0EX
Palaeobiology: The Cambrian smorgasbord pp717-718
Arran Frood asks what current models can teach us about ecological
networks half a billion years old.
doi:10.1038/453717a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiG0EY
----------------------
CORRESPONDENCE
----------------------
Evolutionary theory: it's on the school syllabus in Mexico p719
Antonio Lazcano, Arturo Becerra and Juli Pereto
doi:10.1038/453719a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiH0EZ
Evolutionary theory: don't skimp on teaching its history p719
David M. Williams and Malte C. Ebach
doi:10.1038/453719b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiI0Ea
Learning to navigate the geography of citation indexes p719
Debbie Chaves
doi:10.1038/453719c
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiJ0Eb
Vaccine failure is not a 'crisis' for HIV research pp719-720
Richard Jefferys
doi:10.1038/453719d
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiK0Ec
Fixing hiring practices means asking the right question p720
Emilio Artacho
doi:10.1038/453720a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiL0Ed
Germline modification carries risk of major social harm p720
Marcy Darnovsky
doi:10.1038/453720b
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiM0Ee
Global database is needed to support adaptation science p720
Elvira S. Poloczanska, Alistair J. Hobday and Anthony J. Richardson
doi:10.1038/453720c
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiN0Ef
----------------------
BOOKS AND ARTS
----------------------
Command and control pp721-722
A biography of botanist Joseph Dalton Hooker illustrates how science
switched in the nineteenth century from being a hobby of aristocrats
to a profession paid for by governments.
Sandra Knapp reviews Imperial Nature: Joseph Hooker and the Practices
of Victorian Science by Jim Endersby
doi:10.1038/453721a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiO0Eg
Staving off the global food crisis pp722-723
C. Peter Timmer reviews The End of Food by Paul Roberts
doi:10.1038/453722a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiP0Eh
Horse power unbridled p723
Josie Glausiusz reviews The Horse
doi:10.1038/453723a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiQ0Ei
How the car became king pp724-725
Marcial Echenique reviews Fighting Traffic: The Dawn of the Motor Age
in the American City by Peter D. Norton
doi:10.1038/453724a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiR0Ej
In Retrospect: The chromosome trail p725
A new translation of Theodor Boveri's 1914 monograph brings the early
origins of contemporary cancer research to a wider readership,
contends Robert A. Weinberg.
Robert A. Weinberg reviews Concerning the Origin of Malignant Tumours
by Theodor Boveri
doi:10.1038/453725a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiS0Ek
----------------------
ESSAY
----------------------
Science & Music: Talk of the tone pp726-727
To appreciate how our species makes sense of sound we must study the
brain's response to a wide variety of music, languages and musical
languages, urges Aniruddh D. Patel.
doi:10.1038/453726a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiT0El
----------------------
NEWS AND VIEWS
----------------------
Genomics: Protein fossils live on as RNA pp729-731
Pseudogenes constitute many of the non-coding DNA sequences that make
up large parts of genomes. Once considered merely protein fossils, it
now emerges that some of them have active regulatory roles.
Rajkumar Sasidharan and Mark Gerstein
doi:10.1038/453729a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiU0Em
Attosecond physics: An easier route to high harmony pp731-733
The generation of ultrashort light pulses by atomic ionization and
recombination doesn't come cheap. But by niftily exploiting the play
of light on a nanostructured surface, it can be done on a table-top.
Mark I. Stockman
doi:10.1038/453731a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiV0En
Developmental biology: Order in the lung pp733-735
Given the lung's thousands of branching airways, its development might
be expected to be a highly complex process. Yet a surprisingly simple
picture now emerges of when, where and in what order these branches
form.
David Warburton
doi:10.1038/453733a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiW0Eo
50 & 100 years ago p734
doi:10.1038/453734a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiX0Ep
Physical chemistry: Charge states in transition p735
Transition metals come in different oxidation states with different
electric charges. So at least we are told at school. Detailed
calculations lead to a heretical conclusion -- those variable charge
states are a myth.
Raffaele Resta
doi:10.1038/453735a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiY0Eq
----------------------
NEWS AND VIEWS Q&A
----------------------
Condensed-matter physics: Optical lattices pp736-738
Optical lattices have rapidly become a favoured tool of atomic and
condensed-matter physicists. These crystals made of light can be used
to trap atoms at very low temperatures, creating a workshop in which
to pore over and tinker with fundamental properties of matter.
Markus Greiner and Simon Folling
doi:10.1038/453736a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwiZ0Er
----------------------
ARTICLE
----------------------
The determination of the structure of Saturn's F ring by nearby
moonlets pp739-744
A report giving direct evidence of moonlets embedded in the bright
core of Saturn's F ring, and showing that most of the F ring's
morphology results from the continual gravitational and collisional
effects of small satellites, often combined with the perturbing
effect of Prometheus.
Carl D. Murray et al.
doi:10.1038/nature06999
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwia0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwib0Ez
The branching programme of mouse lung development p745
A complete three dimensional branching pattern and lineage of the
mouse bronchial tree, reconstructed from an analysis of hundreds of
developmental intermediates, is described. The branching process is
stereotyped and generated by three simple modes of branching used in
three different orders throughout the lung.
Ross J. Metzger, Ophir D. Klein, Gail R. Martin & Mark A. Krasnow
doi:10.1038/nature07005
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwic0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwid0E2
A two-tiered mechanism for stabilization and immobilization of
E-cadherin p751
A study showing that homophilic E-cadherin complexes partition in very
stable microdomains. Stability and lateral mobility of these
microdomains depend on two distinct actin populations: small, stable
actin patches stabilize homophilic E cadherin clusters, whereas a
rapidly turning over, contractile network constrains lateral diffusion
by a tethering mechanism.
Matthieu Cavey, Matteo Rauzi, Pierre-Francois Lenne & Thomas Lecuit
doi:10.1038/nature06953
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwie0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwif0E4
----------------------
LETTERS
----------------------
High-harmonic generation by resonant plasmon field enhancement pp757-760
A paper demonstrating high harmonic generation that requires no extra
amplifier cavities. This is achieved by exploiting the local field
enhancement induced by resonant plasmons within a metallic
nanostructure consisting of bow-tie-shaped gold elements on a sapphire
substrate.
Seungchul Kim et al.
doi:10.1038/nature07012
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwig0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwih0E6
Superconductivity at 43 K in SmFeAsO1-xFx p761
A report on the discovery of bulk superconductivity in samarium
arsenide oxides SmFeAsO1-xFx with a transition temperature as high as
43 K.
X. H. Chen, T. Wu, G. Wu, R. H. Liu, H. Chen & D. F. Fang
doi:10.1038/nature07045
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwie0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwif0E4
Charge self-regulation upon changing the oxidation state of transition
metals in insulators pp763-766
A paper looking at the response of hybrid bonds, formed between the
transition-metal atom and its host crystal, to the addition or removal
of electrons. A self-regulating process is identified that shifts the
energy levels of these bonds in such a way that the local charge on
the transition-metal atom remains approximately constant.
Hannes Raebiger, Stephan Lany and Alex Zunger
doi:10.1038/nature07009
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwii0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwij0E8
Hydrogen sulphide release to surface waters at the
Precambrian/Cambrian boundary p767
This paper reports molybdenum isotope signatures of black shales from
two stratigraphically correlated sample sets with a depositional age
of around 542 million years. The findings suggest that the Early
Cambrian animal radiation may have been triggered by a major change
in ocean circulation, terminating a long period during which the
Proterozoic ocean was stratified, with sulphidic deep water.
Martin Wille, Thomas F. Nägler, Bernd Lehmann, Stefan Schröder
& Jan D. Kramers
doi:10.1038/nature07072
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwik0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwil0EB
Simultaneous teleseismic and geodetic observations of the stick-slip
motion of an Antarctic ice stream pp770-774
This report combines long-period surface-wave observations with
simultaneous GPS measurements of ice displacement to study the tidally
modulated stick-slip motion of the Whillans Ice Stream in West
Antarctica. Such long period seismic waves are useful for detecting
and studying sudden ice movement, but are insensitive to the total
amount of slip.
Douglas A. Wiens, Sridhar Anandakrishnan, J. Paul Winberry and Matt A. King
doi:10.1038/nature06990
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwim0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwin0ED
Cladistic analysis of continuous modularized traits provides
phylogenetic signals in Homo evolution p775
This paper adopts a new approach to phylogenetic analysis that
captures large scale, biologically meaningful shape variation, treats
the data using conventional statistical approaches and uses the
output to inform a cladistic analysis. Their test case, applied to
the human lineage, could provide a benchmark for future studies of the
evolutionary relationships of groups in which there are many similar
members.
Rolando Gonzalez-Jose, Ignacio Escapa, Walter A. Neves, Ruben Cuneo
& Hector M. Pucciarelli
doi:10.1038/nature06891
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwio0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwip0EF
Understanding individual human mobility patterns pp779-782
This study used a sample of 100,000 mobile phone users whose
trajectory was tracked for six months to study human mobility
patterns. Displacements across all users suggest behaviour close to
the Levy-flight-like pattern observed previously based on the motion
of marked dollar bills, but with a cutoff in the distribution. The
origin of the Levy patterns observed in the aggregate data appears to
be population heterogeneity and not Levy patterns at the level of the
individual.
Marta C. Gonzalez, Cesar A. Hidalgo and Albert-Laszlo Barabasi
doi:10.1038/nature06958
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwiq0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwir0EH
Dynamics of fat cell turnover in humans p783
This paper finds that the number of fat cells is set during childhood
and adolescence, and adipocyte numbers for lean or obese individuals
are subject to little variation during adulthood. Even after
significant weight loss in adulthood and reduced adipocyte volume,
adipocyte number remains the same.
Kirsty L. Spalding et al.
doi:10.1038/nature06902
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwis0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwit0EJ
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway
in lysosomes p788
This paper shows that ClC 7 is a Cl-/H+ antiporter in lysosomal
membranes, the activity of which maintains the correct membrane
voltage during acidification of the organelle. This work reinforces
the idea that plasma membrane CLCs are Cl- channels whereas
'intracellular' CLCs are antiporters.
Austin R. Graves, Patricia K. Curran, Carolyn L. Smith
& Joseph A. Mindell
doi:10.1038/nature06907
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwiu0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwiv0EL
Drosophila endogenous small RNAs bind to Argonaute 2 in somatic
cells p793
The identification of esiRNAs, a class of small RNAs, many of which
are expressed from (and repress) retrotransposons, but in somatic
cells. esiRNAs and piRNAs interact with different subfamilies of
Argonaute proteins involved in RNAi.
Yoshinori Kawamura et al.
doi:10.1038/nature06938
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwiw0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwix0EN
An endogenous small interfering RNA pathway in Drosophila p798
This paper identifies a class of small RNAs in fly: endogenous siRNAs
(endo siRNAs). These RNAs are present in both somatic and gonadal
cells, and their processing is different than that of miRNAs or piRNAs.
Benjamin Czech et al.
doi:10.1038/nature07007
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwiy0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwiz0EP
The Drosophila hairpin RNA pathway generates endogenous short
interfering RNAs p803
This paper shows that the Drosophila genome encodes endogenous siRNAs.
Derived from long hairpin RNA genes, these siRNAs downregulate protein
expression. Their processing pathway from the hairpin into the mature
~21-nucleotide siRNA involves factors of two pathways thought to be
distinct.
Katsutomo Okamura, Wei-Jen Chung, J. Graham Ruby, Huili Guo,
David P. Bartel & Eric C. Lai
doi:10.1038/nature07015
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwi10EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwi20ED
NF-kappaB links innate immunity to the hypoxic response through
transcriptional regulation of HIF-1alpha p807
The cellular response to hypoxia is regulated by the hypoxia inducible
factor (HIF) pathway. This paper shows that HIF-1alpha transcription
is regulated by basal IKK-beta dependent NF-kappaB signalling, thus
linking the hypoxic response to innate immunity and inflammation.
Jordi Rius et al.
doi:10.1038/nature06905
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwi30EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwi40EF
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated
intranucleosomal methylation p812
An approach is described to synthesize chemically a protein that is
ubiquitylated on a specific residue. Insight is provided into how
ubiquitylated histone H2B regulates methylation of histone H3 in a
trans histone crosstalk pathway.
Robert K. McGinty, Jaehoon Kim, Champak Chatterjee, Robert G. Roeder
& Tom W. Muir
doi:10.1038/nature06906
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwi50EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwi60EH
----------------------
NATUREJOBS
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Prospect
Prospects p817
Europe aims for more flexibility and job security for researchers.
Paul Smaglik
doi:10.1038/nj7196-817a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwi70EI
Region
Beyond rocket science p818
Huntsville, Alabama, the original home of NASA and of military weapons
development, makes a move into biology.
Paul Smaglik reports from Rocket City.
doi:10.1038/nj7196-818a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bwi80EJ
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FUTURES
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The invisible hand p822
A granted wish.
Allan M. Lees
doi:10.1038/453822a
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwjA0ET
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ADVANCE ONLINE PUBLICATION
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04 June 2008
Letters
A BCS-like gap in the superconductor SmFeAsO0.85F0.15
T. Y. Chen, Z. Tesanovic, R. H. Liu, X. H. Chen & C. L. Chien
doi:10.1038/nature07081
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwjB0EU
Template-directed synthesis of a genetic polymer in a model protocell
Sheref S. Mansy, Jason P. Schrum, Mathangi Krishnamurthy, Sylvia Tobé,
Douglas A. Treco & Jack W. Szostak
doi:10.1038/nature07018
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwjC0EV
Mei-P26 regulates microRNAs and cell growth in the Drosophila ovarian
stem cell lineage
Ralph A. Neumüller et al.
doi:10.1038/nature07014
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwjD0EW
IGFBP-4 is an inhibitor of canonical Wnt signalling required for
cardiogenesis
Weidong Zhu et al.
doi:10.1038/nature07027
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwjE0EX
28 May 2008
Article
Dissecting direct reprogramming through integrative genomic analysis
Tarjei S. Mikkelsen et al.
doi:10.1038/nature07056
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bv4n0EJ
Letters
Magnetic resonance imaging of pH in vivo using hyperpolarized
13C-labelled bicarbonate
Ferdia A. Gallagher et al.
doi:10.1038/nature07017
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bv4o0EK
Two-band superconductivity in LaFeAsO0.89F0.11 at very high magnetic
fields
F. Hunte et al.
doi:10.1038/nature07058
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bv4p0EL
Analysis of a spatial orientation memory in Drosophila
Kirsa Neuser, Tilman Triphan, Markus Mronz, Burkhard Poeck
& Roland Strauss
doi:10.1038/nature07003
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bv4q0EM
Cortical control of a prosthetic arm for self-feeding
Meel Velliste, Sagi Perel, M. Chance Spalding, Andrew S. Whitford
& Andrew B. Schwartz
doi:10.1038/nature06996
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bv4r0EN
See also: News and Views by Kalaska
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwjF0EY
Induced ncRNAs allosterically modify RNA-binding proteins in cis to
inhibit transcription
Xiangting Wang et al.
doi:10.1038/nature06992
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bv4s0EO
Hydrogen sulphide release to surface waters at the
Precambrian/Cambrian boundary
Martin Wille, Thomas F. Nägler, Bernd Lehmann, Stefan Schröder
& Jan D. Kramers
doi:10.1038/nature07072
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bv4t0EP
Magnetic order close to superconductivity in the iron-based layered
LaO1-xFxFeAs systems
Clarina de la Cruz et al.
doi:10.1038/nature07057
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0Bv4u0EQ
News and Views
Neuroscience: Brain control of a helping hand
Paralysed patients would benefit if their thoughts could become
everyday actions. The demonstration that monkeys can use brain
activity for precise control of an arm-like robot is a step towards
that end.
John F. Kalaska
doi:10.1038/nature06366
http://ealerts.nature.com/cgi-bin24/DM/y/elLj0Xztnp0HjB0BwjF0EY
=====================================================================
Nature Methods focus on Single Molecule Analysis - June 2008
Biologists are becoming increasingly interested in methodologies that
can examine the mechanism of action of fundamental biological processes
at the molecular level. This focus will consist of four review-type
articles that provide practical guidance for some of the techniques
that are most integral to in vitro single-molecule experiments. These
will cover single-molecule fluorescence methods, microfluidic flow cells
to manipulate experimental conditions during experiments, and force
spectroscopy techniques such as atomic force microscopy (AFM) and optical
traps to manipulate individual molecules themselves.
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