12 June 2008 Volume 453 Number 7197, pp823-956
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EDITORIALS
----------------------
To thwart disease, apply now p823
Translational medicine is a key addition to the biomedical research
enterprise. Policy-makers and research leaders now must build the
infrastructure to take discoveries from the bench to application.
doi:10.1038/453823a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxKx0Ej
The price isn't right p824
ITER will cost more to build than previously thought. Now is the time
to be honest about how much.
doi:10.1038/453824a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxKy0Ek
Open to interpretation p824
The use of 'dignity' as the foundation for an ethical law in
Switzerland is compromising research.
doi:10.1038/453824b
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxKz0El
----------------------
RESEARCH HIGHLIGHTS
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Palaeobiology: Remember this p826
doi:10.1038/453826a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxK10EY
Neuroscience: Shiver stoppers p826
doi:10.1038/453826b
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxK20EZ
Zoology: The skin off my back p826
doi:10.1038/453826c
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxK30Ea
Microscopy: Laser focus p826
doi:10.1038/453826d
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxK40Eb
Molecular biology: Lost in transcription p826
doi:10.1038/453826e
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxK50Ec
Animal behaviour: Best and brightest pp826-827
doi:10.1038/453826f
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxK60Ed
Nanotechnology: Golden advance p827
doi:10.1038/453827a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxK70Ee
Photonics: Cancer zapper p827
doi:10.1038/453827b
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxK80Ef
Geophysics: Mysterious mountains p827
doi:10.1038/453827c
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLA0Ep
Psychology: Not fair! p827
doi:10.1038/453827d
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLB0Eq
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JOURNAL CLUB
----------------------
Journal club p827
David Beerling
doi:10.1038/453827e
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLC0Er
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NEWS
----------------------
Egg shortage hits race to clone human stem cells pp828-829
Researchers back bid to pay donors.
Brendan Maher
doi:10.1038/453828a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQS0EE
Fusion reactor faces cost hike pp829
ITER will also be delayed by up to three years.
Geoff Brumfiel
doi:10.1038/453829a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQT0EF
The winding road from ideas to income pp830-831
Huge numbers of offices have been established over the past 30 years
to help university researchers take their discoveries from the lab to
the clinic.
Meredith Wadman assesses their success.
doi:10.1038/453830a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQU0EG
Swiss court bans work on macaque brains pp833
Universities appeal against ruling on animals' dignity.
Alison Abbott
doi:10.1038/453833a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQV0EH
Sidelines p834
Scribbles on the margins of science.
doi:10.1038/453834a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQW0EI
Near-perfect 'black' p834
Philip Ball
doi:10.1038/453834b
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQX0EJ
NIH responds to critics on peer review pp835-835
Agency sets its sights on transformative research.
Meredith Wadman
doi:10.1038/453835a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQY0EK
Beep-beep! Roadrunner breaks petaflop barrier pp837
doi:10.1038/453837a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQZ0EL
Physicist's involvement in historical race row disputed pp837
doi:10.1038/453837b
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQa0ES
Panel urges further review of controversial NIH lab pp837
doi:10.1038/453837c
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQb0ET
Publications follow policy on stem-cell research pp837
doi:10.1038/453837d
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQc0EU
Senate climate debate suffers death by hot air pp837
doi:10.1038/453837e
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQd0EV
Japanese lab installed on space station pp837
doi:10.1038/453837f
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQe0EW
Corrections pp837
doi:10.1038/453837g
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQf0EX
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COLUMN
----------------------
A delicate balance pp838-838
Near-term and long-term research are vying for attention.
David Goldston says that a fuller congressional debate is needed.
doi:10.1038/453838a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQg0EY
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NEWS FEATURES
----------------------
Translational research: Getting the message across pp839-839
doi:10.1038/453839a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQh0EZ
Translational research: Crossing the valley of death pp840-842
A chasm has opened up between biomedical researchers and the patients
who need their discoveries.
Declan Butler asks how the ground shifted and whether the US National
Institutes of Health can bridge the gap.
doi:10.1038/453840a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQi0Ea
Translational research: The full cycle pp843-845
Results can be thrust from bench to bedside, but there is also much
to be learned by pushing the other way.
Heidi Ledford tells tales of clinical trials that have prompted a
change in tack.
doi:10.1038/453843a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQj0Eb
Translational research: A case history pp846-849
The Ludwig Institute for Cancer Research is focused on translating
research into cures.
Helen Pearson investigates whether its sometimes unusual methods are
producing results.
doi:10.1038/453846a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxQk0Ec
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CORRESPONDENCE
----------------------
European research system must not go bananas p850
Andre Geim
doi:10.1038/453850a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLV0EC
Large projects can create useful partnerships p850
Josef Settele, Joachim Spangenberg and Ingolf Kuhn
doi:10.1038/453850b
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLW0ED
European research needs a dash of anarchy p850
Theo Wallimann
doi:10.1038/453850c
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLX0EE
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COMMENTARIES
----------------------
Follow the leader pp851-852
If Japan is to become a front-runner in pharmaceutical development,
it must not only speed up its approval of new drugs, but also enhance
its own research capabilities, argue Kaori Tsuji and Kiichiro Tsutani.
doi:10.1038/453851a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLY0EF
A new relationship pp853-854
Fuelling innovation requires a different kind of collaboration between
industrial and academic researchers, argues Bill Destler.
doi:10.1038/453853a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLZ0EG
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BOOKS AND ARTS
----------------------
A prescription for public health pp855-856
Will high drug prices and a lack of new medicines force the
pharmaceutical industry to restructure and take a more personalized
approach to research.
Merrill Goozner reviews Reasonable Rx: Solving the Drug Price Crisis
by Stan Finkelstein and Peter Temin
doi:10.1038/453855a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLa0EN
Complementary cures tested pp856-857
Toby Murcott reviews Trick or Treatment? Alternative Medicine on
Trial by Simon Singh and Edzard Ernst
doi:10.1038/453856a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLb0EO
Saving water p857
doi:10.1038/453857a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLc0EP
Suppressing science pp857-858
Dick Taverne reviews Doubt Is Their Product: How Industry's Assault
on Science Threatens Your Health by David Michaels
doi:10.1038/453857b
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLd0EQ
Culture dish p858
doi:10.1038/453858a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLe0ER
----------------------
ESSAY
----------------------
Science & Music: Raising the roof pp859-860
Michael Barron explores how physics, psychology and fashion have
influenced concert hall acoustics.
doi:10.1038/453859a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLf0ES
----------------------
NEWS AND VIEWS
----------------------
Biochemistry: Molecular cloaking devices pp861-862
Protease enzymes cut other proteins into pieces, but some can be
blocked by inhibitors. One such inhibitor binds to the substrate
rather than the enzyme, suggesting a new tactic for drug discovery.
Thomas Kodadek
doi:10.1038/453861a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLg0ET
Physical chemistry: Cool it, baby pp862-863
A long-sought but short-lived molecule has been made and characterized
for the first time. This compound decays at low temperatures using an
unusual trick -- a mechanism known as quantum tunnelling.
Markku Rasanen
doi:10.1038/453862a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLh0EU
Animal behaviour: Guardian caterpillars p863
Christopher Surridge
doi:10.1038/453863a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLi0EV
Huntington's disease: Genetics lends a hand pp863-864
A monkey model of Huntington's disease created by gene transfer is
only a work in progress. But as a technological feat it offers great
promise for fathoming this devastating condition.
Stephane Palfi and Bechir Jarraya
doi:10.1038/nature06365
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLj0EW
Nuclear physics: A neutrino's wobble? pp864-865
Periodic oscillations have been observed in what should be
straightforward exponential decay curves of two radioactive isotopes.
An entirely mysterious phenomenon, its proposed cause seems equally
exotic.
Philip M. Walker
doi:10.1038/453864a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLk0EX
50 & 100 Years Ago p865
doi:10.1038/453865a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLl0EY
Condensed-matter physics: Paralysed by disorder p866
In a disordered medium, a quantum particle can literally stop itself
in its tracks. This localization phenomenon can be observed directly
using the coldest known form of matter, caught in a laser trap.
Daniel A. Steck
doi:10.1038/453866a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLm0EZ
Obituary: Willis E. Lamb Jr (1913-2008) p867
Meticulous physicist and discoverer of the Lamb shift.
Murray Sargent
doi:10.1038/453867a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLn0Ea
----------------------
REVIEW
----------------------
What we can do and what we cannot do with fMRI pp869-878
Nikos K. Logothetis
doi:10.1038/nature06976
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLo0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLp0Ec
----------------------
ARTICLES
----------------------
A phosphatase cascade by which rewarding stimuli control nucleosomal
response p879
The phosphorylation of dopamine and cAMP regulated phosphoprotein 32
(DARPP 32) in the striatum is a regulator of dopamine signalling. A
signal transduction cascade involving nuclear accumulation of DARPP 32
that is induced by both drugs of abuse and natural stimuli, such as
food, has been discovered. Disruption of this cascade alters the
behavioural effects of the drugs and decreases motivation for food,
suggesting the importance of this mechanism in the in vivo actions of
dopamine signalling.
Alexandre Stipanovich et al.
doi:10.1038/nature06994
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLq0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLr0Ee
Structural basis for the regulated protease and chaperone function of
DegP p885
DegP is a protease chaperone in the bacterial envelope that is
involved in protein quality control and outer membrane protein
biogenesis. Binding of misfolded proteins transforms hexameric DegP
into 12 and 24 meric multimers. Structural analysis of these
particles uncovered a protein packaging device whose central
compartment is adaptable to the size and concentration of substrate.
Tobias Krojer, Justyna Sawa, Eva Schäfer, Helen R. Saibil,
Michael Ehrmann & Tim Clausen
doi:10.1038/nature07004
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLs0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLt0Eg
----------------------
LETTERS
----------------------
Direct observation of Anderson localization of matter waves in a
controlled disorder pp891-894
Anderson localization is a phenomenon in wave physics that occurs when
interference between multiple scattering paths causes diffusion to
cease. This paper reports Anderson localization in a Bose–Einstein
condensate as it expands in a one dimensional disordered optical
potential. The atomic density profiles are imaged directly as a
function of time, and it is found that weak disorder can stop the
expansion and lead to the formation of a stationary exponentially
localized wave function, a direct signature of Anderson localization.
Juliette Billy et al.
doi:10.1038/nature07000
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLu0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLv0Ei
Anderson localization of a non-interacting Bose-Einstein condensate pp895-898
A non interacting Bose Einstein condensate of ultracold atoms is used
to study Anderson localization. The effect is clearly demonstrated
through investigations of the transport properties and spatial and
momentum distributions. The highly controllable nature of the system
may render it useful for investigations of the interplay between
disorder and interaction, and to uncover exotic quantum phases.
Giacomo Roati et al.
doi:10.1038/nature07071
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLw0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLx0Ek
Magnetic order close to superconductivity in the iron-based layered
LaO1-xFxFeAs systems p899
This paper reports neutron scattering experiments demonstrating that
LaOFeAs undergoes an abrupt structural distortion below ~150 K,
followed by the development of long range spin density wave type AF
order at ~137 K with a small moment but simple magnetic structure.
Doping the system with fluorine suppresses both the magnetic order
and structural distortion in favor of superconductivity. Therefore,
like high Tc copper oxides, the superconducting regime in these Fe
based materials occurs in close proximity to a long range ordered AF
ground state.
Clarina de la Cruz et al.
doi:10.1038/nature07057
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLy0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxLz0Em
Two-band superconductivity in LaFeAsO0.89F0.11 at very high magnetic
fields p903
This paper reports very high field resistance measurements of
LaFeAsO0.89F0.11 up to 45 T, which show a remarkable enhancement of
the upper critical field Bc2 as compared to values expected from the
slopes dBc2/dT 2 T K near Tc, particularly at low temperatures
where the deduced Bc2(0) 63–65 T exceeds the paramagnetic limit.
F. Hunte et al.
doi:10.1038/nature07058
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxL10EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxL20Ea
Capture of hydroxymethylene and its fast disappearance through
tunnelling pp906-909
Many carbenes are highly reactive and have long been considered too
short lived for direct observations, especially hydroxymethylene,
which has attracted much attention but never been observed. This paper
reports that it can be trapped in an argon matrix kept at 11 K and
characterized. It may be trapped, but in the end hydroxymethylene
still evades all snares through unexpectedly fast hydrogen
tunnelling that transforms it into its tautomer formaldehyde.
Peter R. Schreiner et al.
doi:10.1038/nature07010
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxL30Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxL40Ec
Continental mantle signature of Bushveld magmas and coeval diamonds pp910-913
Sulphide inclusions in ~2 billion year old diamonds from opposite
sides of the Bushveld complex have initial Os isotope ratios even more
radiogenic than those of Bushveld sulphide ore minerals. Sulphide
Re–Os and silicate Sm–Nd and Rb–Sr isotope compositions indicate that
components of the continental mantle most likely contributed to the
genesis of both the diamonds and the Bushveld Complex. Coeval diamonds
provide key evidence that the main source of Bushveld platinum group
elements is the mantle rather than the crust.
Stephen H. Richardson and Steven B. Shirey
doi:10.1038/nature07073
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxL50Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxL60Ee
Ultrasonic frogs show hyperacute phonotaxis to female courtship
calls p914
Ultrasonic communication in the Chinese torrent frog, Odorrana
tormota, which lives in the noisy environment of rushing streams, was
reported in 2006. The story deepens further with the discovery that
female frogs emit ultrasonic signals when they are ovulating, a
reversal of the usual way of things, in which it is males that
advertise their virility — and that male frogs can locate their
signals with an acuity of one or two degrees.
Jun-Xian Shen et al.
doi:10.1038/nature06719
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxL70Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxL80Eg
Perceptual accuracy and conflicting effects of certainty on
risk-taking behaviour pp917-920
According to the certainty effect, people and even animals tend to
select the safer of two prospects if this ensures a good outcome with
certainty. But under certain circumstances, humans prefer the risky
option -- the reversed certainty effect. This paper shows the
differences in perceptual accuracy that underlie these findings and
shows experimentally that both the certainty and the reversed
certainty effects can occur in animals.
Sharoni Shafir et al.
doi:10.1038/nature06841
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMA0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMB0Er
Towards a transgenic model of Huntington's disease in a non-human
primate p921
The progress towards developing a non-human primate model for the
severely disabling and lethal neurodegenerative disorder
Huntington's disease is reported. The paper establishes expression of
the first exon of the human Huntington gene with a disease typical
polyglutamine expansion, and observes some hallmark features of
Huntington's disease in the monkeys. These data suggest that it will
be feasible to generate valuable non-human primate models for
Huntington's disease.
Shang-Hsun Yang et al.
doi:10.1038/nature06975
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMC0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMD0Et
Substrate-targeting gamma-secretase modulators pp925-929
One therapeutic approach for Alzheimer's disease is to diminish
depostition of amyloid beta peptide (Abeta42) by curbing its generation.
Some non steroidal anti inflammatory drugs have this capacity. But
rather than binding the enzyme complex that carves the peptide out of
the precursor protein, these drugs bind the susbstrate itself. Binding
of the drug not only alters the production of Abeta42 but also prevents
its aggregation.
Thomas L. Kukar et al.
doi:10.1038/nature07055
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxME0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMF0Ev
Sex determination involves synergistic action of SRY and SF1 on a
specific Sox9 enhancer p930
The testis determining factor SRY, which is encoded on the Y
chromosome, forms a complex with an orphan nuclear receptor SF1, and
together they bind to an enhancer regulating Sox 9. Sox9 controls the
expression of genes involved in male development. Earlier work had
suggested that Sox9 is a target of SRY. However, this study identifies
a direct regulatory interaction at the level of transcriptional
regulation, and identifies the enhancer element responsible.
Ryohei Sekido & Robin Lovell-Badge
doi:10.1038/nature06944
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMG0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMH0Ex
Draper-dependent glial phagocytic activity is mediated by Src and Syk
family kinase signalling p935
Rapid clearance of apoptotic cells is essential to prevent
inflammtion. Glial cell phagocytosis in Drosophila requires the
interaction of the engulfment receptor Draper with the non receptor
tyrosine kinase Shark through ITAM-like motifs. The Src family kinase
Src42a phosphorylates Draper and is thought to promote Shark binding.
Jennifer S. Ziegenfuss et al.
doi:10.1038/nature06901
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMI0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMJ0Ez
Magnetic resonance imaging of pH in vivo using hyperpolarized
13C-labelled bicarbonate p940
The pH value of tissues in a living organism can vary, and alterations
in tissue pH have been implicated in a variety of diseases, including
cancer. A non invasive method has now been devised that allows the
monitoring of the extracellular pH in living mice. The findings also
confirm that the pH in a tumour is lower that the one of normal tissue
and it is hoped that this technique can be exploited in humans to
diagnose and monitor disease processes.
Ferdia A. Gallagher et al.
doi:10.1038/nature07017
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMK0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxML0E2
Global control of cell-cycle transcription by coupled CDK and network
oscillators p944
During the cell cycle, many genes are transcribed in a periodic
manner. A study in Saccharomyces cerevisiae shows that a significant
proportion of these genes continues to cycle in the absence of the
major cell cycle regulatory cyclin/CDK complexes that control the G1–S
transition. This suggests the existence additional period regulators
responsible for the periodic transcription of genes during the cell
cycle.
David A. Orlando et al.
doi:10.1038/nature06955
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMM0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMN0E4
Domain organization of human chromosomes revealed by mapping of
nuclear lamina interactions p948
A high resolution map of the sites of the human genome that are in
close proximity to the nuclear lamina reveals interactions through
large domains with low gene expression levels. The borders of these
domains are demarcated by various features including binding sites
for the transcription insulator protein CTCF.
Lars Guelen et al.
doi:10.1038/nature06947
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMO0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMP0E6
----------------------
CORRIGENDUM
----------------------
Lethargus is a Caenorhabditis elegans sleep-like state p952
David M. Raizen et al.
doi:10.1038/nature07044
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMQ0E7
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p953
US universities may have to chip in more for researchers' salaries.
Gene Russo
doi:10.1038/nj7197-953a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMR0E8
Career View
Cato Laurencin, vice-president for health affairs, University of
Connecticut Health Center, and dean, University of Connecticut
School of Medicine, Farmington p954
Cato Laurencin brings medicine and engineering expertise to
his new post.
Virginia Gewin
doi:10.1038/nj7197-954a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMS0EA
A route to postdoc diversity p954
Postdoc diversity programme shows signs of success.
Jill U. Adams
doi:10.1038/nj7197-954b
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMT0EB
Winning a plant campaign p954
Going to battle, with vegetables.
Zachary Lippman
doi:10.1038/nj7197-954c
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMU0EC
----------------------
FUTURES
----------------------
Permanent position p956
A lesson from history.
John Gilbey
doi:10.1038/453956a
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxMV0ED
----------------------
ADVANCE ONLINE PUBLICATION
----------------------
11 June 2008
Article
SMAD proteins control DROSHA-mediated microRNA maturation
Brandi N. Davis, Aaron C. Hilyard, Giorgio Lagna & Akiko Hata
doi:10.1038/nature07086
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxPK0E4
Letters
Osteoclast size is controlled by Fra-2 through LIF/LIF-receptor
signalling and hypoxia
Aline Bozec et al.
doi:10.1038/nature07019
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxPL0E5
An internal thermal sensor controlling temperature preference in
Drosophila
Fumika N. Hamada et al.
doi:10.1038/nature07001
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxPM0E6
Subtropical to boreal convergence of tree-leaf temperatures
Brent R. Helliker & Suzanna L. Richter
doi:10.1038/nature07031
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxPN0E7
Innate immunity induced by composition-dependent RIG-I recognition of
hepatitis C virus RNA
Takeshi Saito, David M. Owen, Fuguo Jiang, Joseph Marcotrigiano
& Michael Gale
doi:10.1038/nature07106
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxPO0E8
Structural basis of specific tRNA aminoacylation by a small in vitro
selected ribozyme
Hong Xiao, Hiroshi Murakami, Hiroaki Suga & Adrian R. Ferré-D'Amaré
doi:10.1038/nature07033
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxPP0EA
08 June 2008
Letter
Volcanic carbon dioxide vents show ecosystem effects of ocean acidification
Jason M. Hall-Spencer et al.
doi:10.1038/nature07051
http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BxPQ0EB
=====================================================================
Cell Death & Differentiation presents 'Biology of hypoxia-inducible
factors' at http://ealerts.nature.com/cgi-bin24/DM/y/elWV0Xztnp0HjB0BviU0Ec as the
third special issue of 2008. 'Biology of hypoxia-inducible factors'
features 10 review articles focusing on the regulators and biological
consequences of HIF activation. To read the full selection of reviews
from 'Biology of Hypoxia-inducible factors'
please visit the Special Issues online at www.nature.com/cdd/special.
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