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World Stem Cell Summit 2010

Wednesday, June 11, 2008

Leukemia Table of Contents alert Volume 22 Issue 6

LEUKEMIA

June 2008 Volume 22 Number 6, pp 1093 - 1298
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Cell Death & Differentiation presents 'Biology of hypoxia-inducible
factors'at
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BviU0Eg
as the third special issue of 2008. 'Biology of hypoxia-inducible
factors' features 10 review articles focusingon the regulators and
biological consequences of HIF activation.

To read the full selection of reviews from 'Biology of
Hypoxia-inducible factors',
please visit the Special Issues online at
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bugw0ED .

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Why Publish in Leukemia?

Efficient peer-review, hassle-free submission, recognition...

Papers benefit from wide readership through hosting on nature.com and
inclusion in the leading abstracting and indexing services.
Rapid publication is also assured through Advance Online Publication.
To read the full Guide to Authors for Leukemia, visit
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BIHy0Ey

----------------------
EDITORIAL
----------------------
Globalization of treatment strategies in leukemia: challenges and
responsibilities
A Tefferi and N M-B Killmann
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8p0EL

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REVIEW
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MicroRNAs and noncoding RNAs in hematological malignancies: molecular,
clinical and therapeutic implications
M Fabbri, R Garzon, M Andreeff, H M Kantarjian, G Garcia-Manero and G
A Calin
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8q0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8r0EN

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ORIGINAL ARTICLES
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The novel Akt inhibitor, perifosine, induces caspase-dependent
apoptosis and downregulates P-glycoprotein expression in
multidrug-resistant human T-acute leukemia cells by a JNK-dependent
mechanism
F Chiarini, M Del Sole, S Mongiorgi, G C Gaboardi, A Cappellini, I
Mantovani, M Y Follo, J A McCubrey and A M Martelli
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8s0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8t0EP

Activity of tyrosine kinase inhibitors against human
NUP214-ABL1-positive T cell malignancies
A Quintas-Cardama, W Tong, T Manshouri, F Vega, P A Lennon, J Cools, D
G Gilliland, F Lee, J Cortes, H Kantarjian and G Garcia-Manero
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8u0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8v0ER

Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and
cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia
A Habib, E Hamade, R Mahfouz, M S Nasrallah, H de The and A Bazarbachi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8w0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8x0ET

RNAi-mediated silencing of p190Bcr-Abl inactivates Stat5 and
cooperates with imatinib mesylate and
17-allylamino-17-demetoxygeldanamycin in selective killing of
p190Bcr-Abl-expressing leukemia cells
M Futami, T Hatano, Y Soda, S Kobayashi, M Miyagishi and A Tojo
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8y0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8z0EV

Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas
A L Feldman, D X Sun, M E Law, A J Novak, A D Attygalle, E C Thorland,
S R Fink, J A Vrana, B L Caron, W G Morice, E D Remstein, K L Grogg, P
J Kurtin, W R Macon and A Dogan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw810EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw820EJ

Results of the first randomized multicentre trial on childhood acute
lymphoblastic leukaemia in Russia
A Karachunskiy, R Herold, A von Stackelberg, N Miakova, A Timakow, T
Mahortih, L Bajdun, A Maschan, L Fechina, A Shamardina, S Dudkin, V
Lebedev, S Varfolomeeva, V Timofeeva, J Roumiantseva, N Chipsanova, A
Rumjanzew and G Henze
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw830EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw840EL

Thymic adult T-cell acute lymphoblastic leukemia stratified in
standard- and high-risk group by aberrant HOX11L2 expression:
experience of the German multicenter ALL study group
U Baak, N Gokbuget, H Orawa, S Schwartz, D Hoelzer, E Thiel and T
Burmeister
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw850EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw860EN

HoxA9 induces insulin-like growth factor-1 receptor expression in
B-lineage acute lymphoblastic leukemia
J T Whelan, D L Ludwig and F E Bertrand
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw870EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw880EP

T-cell receptor V[beta] CDR3 oligoclonality frequently occurs in
childhood refractory cytopenia (MDS-RC) and severe aplastic anemia
A C H de Vries, A W Langerak, B Verhaaf, C M Niemeyer, J Stary, K
Schmiegelow, E R van Wering, C M Zwaan, A Beishuizen, R Pieters and M
M van den Heuvel-Eibrink
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAA0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAB0Ej

The immunophenotype of different immature, myeloid and B-cell
lineage-committed CD34+ hematopoietic cells allows discrimination
between normal//reactive and myelodysplastic syndrome precursors
S Matarraz, A Lopez, S Barrena, C Fernandez, E Jensen, J Flores, P
Barcena, A Rasillo, J M Sayagues, M L Sanchez, P Hernandez-Campo, J M
Hernandez Rivas, C Salvador, N Fernandez-Mosteirin, M Giralt, L
Perdiguer and A Orfao
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAC0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAD0El

Characterization of BCR-ABL deletion mutants from patients with
chronic myeloid leukemia
D W Sherbenou, O Hantschel, L Turaga, I Kaupe, S Willis, T Bumm, R D
Press, G Superti-Furga, B J Druker and M W Deininger
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAE0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAF0En

Effective killing of Gleevec-resistant CML cells with T315I mutation
by a natural compound PEITC through redox-mediated mechanism
H Zhang, D Trachootham, W Lu, J Carew, F J Giles, M J Keating, R B
Arlinghaus and P Huang
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAG0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAH0Ep

Dasatinib induces durable cytogenetic responses in patients with
chronic myelogenous leukemia in chronic phase with resistance or
intolerance to imatinib
A Hochhaus, M Baccarani, M Deininger, J F Apperley, J H Lipton, S L
Goldberg, S Corm, N P Shah, F Cervantes, R T Silver, D Niederwieser, R
M Stone, H Dombret, R A Larson, L Roy, T Hughes, M C Muller, R
Ezzeddine, A M Countouriotis and H M Kantarjian
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAI0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAJ0Er

CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are
leukemia-initiating cells with self-renewal capacity in human
B-precursor ALL
Y Kong, S Yoshida, Y Saito, T Doi, Y Nagatoshi, M Fukata, N Saito, S M
Yang, C Iwamoto, J Okamura, K Y Liu, X J Huang, D P Lu, L D Shultz, M
Harada and F Ishikawa
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAK0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAL0Et

Dose-dependent repression of T-cell and natural killer cell genes by
PU.1 enforces myeloid and B-cell identity
M B Kamath, I B Houston, A J Janovski, X Zhu, S Gowrisankar, A G Jegga
and R P DeKoter
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAM0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAN0Ev

Sorafenib inhibits activation of human peripheral blood T cells by
targeting LCK phosphorylation
W Zhao, Y H Gu, R Song, B Q Qu and Q Xu
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAO0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAP0Ex

Increase sensitivity to chemotherapeutical agents and cytoplasmatic
interaction between NPM leukemic mutant and NF-[kappa]B in AML
carrying NPM1 mutations
D Cilloni, F Messa, V Rosso, F Arruga, I Defilippi, S Carturan, R
Catalano, M Pautasso, C Panuzzo, P Nicoli, E Messa, A Morotti, I
Iacobucci, G Martinelli, E Bracco and G Saglio
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAQ0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAR0Ez

AML1-Evi-1 specifically transforms hematopoietic stem cells through
fusion of the entire Evi-1 sequence to AML1
M Takeshita, M Ichikawa, E Nitta, S Goyama, T Asai, S Ogawa, S Chiba
and M Kurokawa
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAS0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAT0E2

Impact of genetic abnormalities on survival after allogeneic
hematopoietic stem cell transplantation in multiple myeloma
G Schilling, T Hansen, A Shimoni, T Zabelina, J-A Simon-Perez, N C
Gutierrez, W Bethge, P Liebisch, R Schwerdtfeger, M Bornhauser, S
Otterstetter, E M M Penas, J Dierlamm, F Ayuk, D Atanackovic, U
Bacher, C Bokemeyer, A Zander, J S Miguel, A Nagler and N Kroger
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAU0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAV0E4

----------------------
LETTERS TO THE EDITOR
----------------------
Third party mesenchymal stromal cell infusions fail to induce tissue
repair despite successful control of severe grade IV acute
graft-versus-host disease in a child with juvenile myelo-monocytic
leukemia
L Ball, R Bredius, A Lankester, J Schweizer, M van den Heuvel-Eibrink,
H Escher, W Fibbe and M Egeler
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAW0E5

Synthetic triterpenoids have cytotoxicity in pediatric acute
lymphoblastic leukemia cell lines but cytotoxicity is independent of
induced ceramide increase in MOLT-4 cells
G Kong, D Wang, H Wang, J Wu, J Bielawski, M Konopleva, M Andreeff, P
P Ruvolo and B J Maurer
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAX0E6

t(3;7)(q27;q32) fuses BCL6 to a non-coding region at FRA7H near miR-29
B Schneider, S Nagel, M Kaufmann, S Winkelmann, J Bode, H G Drexler
and R A F MacLeod
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAY0E7

BMI1 as oncogenic candidate in a novel TCRB-associated chromosomal
aberration in a patient with TCR[gamma][delta]+ T-cell acute
lymphoblastic leukemia
N S D Larmonie, W A Dik, H B Beverloo, E R van Wering, J J M van
Dongen and A W Langerak
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAZ0E8

The prevalence of IG translocations and 7q32 deletions in splenic
marginal zone lymphoma
E D Remstein, M Law, M Mollejo, M A Piris, P J Kurtin and A Dogan
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAa0EG

Treatment of relapsed acute myeloid leukemia with MLL//AF6 fusion
after allogeneic hematopoietic stem cell transplantation with
gemtuzumab ozogamicin with a long interval followed by donor
lymphocyte infusion
H Tamai, Y Shioi, H Yamaguchi, M Okabe, S Wakita, T Mizuki, K
Nakayama, K Inokuchi, K Tajika and K Dan
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAb0EH

MicroRNA expression profiles of human leukemias
S Takada, Y Yamashita, E Berezikov, H Hatanaka, S-i Fujiwara, K
Kurashina, H Watanabe, M Enomoto, M Soda, Y L Choi and H Mano
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAc0EI

Fusion of ZMIZ1 to ABL1 in a B-cell acute lymphoblastic leukaemia with
a t(9;10)(q34;q22.3) translocation
G Soler, I Radford-Weiss, R Ben-abdelali, N Mahlaoui, J F Ponceau, E A
Macintyre, M Vekemans, O A Bernard and S P Romana
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAd0EJ

Effect of lenalidomide therapy on mobilization of peripheral blood
stem cells in previously untreated multiple myeloma patients
A Mazumder, J Kaufman, R Niesvizky, S Lonial, D Vesole and S Jagannath
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAe0EK

Reply to /`Effect of lenalidomide therapy on mobilization of
peripheral blood stem cells in previously untreated multiple myeloma
patients/'
S Kumar and M A Gertz
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAf0EL

Compromised stem cell mobilization following induction therapy with
lenalidomide in myeloma
H Paripati, A K Stewart, S Cabou, A Dueck, V J Zepeda, N Pirooz, C
Ehlenbeck, C Reeder, J Slack, J F Leis, J Boesiger, A S Torloni, R
Fonseca and P L Bergsagel
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAg0EM

Use of pegylated recombinant filgrastim (Pegfilgrastim) in patients
with acute myeloid leukemia: pharmacokinetics and impact on leukocyte
recovery
M Fiegl, W Hiddemann and J Braess
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAh0EN

In human genome, generation of a nuclear export signal through
duplication appears unique to nucleophosmin (NPM1) mutations and is
restricted to AML
A Liso, A Bogliolo, V Freschi, M P Martelli, S A Pileri, M
Santodirocco, N Bolli, M F Martelli and B Falini
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAi0EO

JAK2 Mutations are present in all cases of polycythemia vera
Y L Wang, K Vandris, A Jones, N C P Cross, P Christos, F Adriano and R
T Silver
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAj0EP

Fresh frozen plasma contains free asparagine and may replace the
plasma asparagine pool during L-asparaginase therapy
M Steiner, A Attarbaschi, O A Haas, U Kastner, H Gadner and G Mann
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAk0EQ

Low MCL-1 mRNA expression correlates with prolonged survival in B-cell
chronic lymphocytic leukemia
L Veronese, O Tournilhac, P Verrelle, F Davi, G Dighiero, E Chautard,
R Veyrat-Masson, F Kwiatkowski, C Goumy, P Vago, P Travade and A
Tchirkov
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAl0ER

Methylation analysis of the von Hippel-Lindau gene in acute myeloid
leukaemia and myelodysplastic syndromes
L Benetatos, A Dasoula, N Syed, E Hatzimichael, T Crook and K L
Bourantas
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAm0ES

Prognostic interaction between thrombocytosis and JAK2 V617F mutation
in the WHO subcategories of myelodysplastic//myeloproliferative
disease-unclassifiable and refractory anemia with ringed sideroblasts
and marked thrombocytosis
E Atallah, R Nussenzveig, C C Yin, C Bueso-Ramos, C Tam, T Manshouri,
S Pierce, H Kantarjian and S Verstovsek
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAn0ET

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