June 2008 Volume 22 Number 6, pp 1093 - 1298
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Cell Death & Differentiation presents 'Biology of hypoxia-inducible
factors'at
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BviU0Eg
as the third special issue of 2008. 'Biology of hypoxia-inducible
factors' features 10 review articles focusingon the regulators and
biological consequences of HIF activation.
To read the full selection of reviews from 'Biology of
Hypoxia-inducible factors',
please visit the Special Issues online at
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bugw0ED .
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EDITORIAL
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Globalization of treatment strategies in leukemia: challenges and
responsibilities
A Tefferi and N M-B Killmann
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8p0EL
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REVIEW
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MicroRNAs and noncoding RNAs in hematological malignancies: molecular,
clinical and therapeutic implications
M Fabbri, R Garzon, M Andreeff, H M Kantarjian, G Garcia-Manero and G
A Calin
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8q0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8r0EN
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ORIGINAL ARTICLES
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The novel Akt inhibitor, perifosine, induces caspase-dependent
apoptosis and downregulates P-glycoprotein expression in
multidrug-resistant human T-acute leukemia cells by a JNK-dependent
mechanism
F Chiarini, M Del Sole, S Mongiorgi, G C Gaboardi, A Cappellini, I
Mantovani, M Y Follo, J A McCubrey and A M Martelli
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8s0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8t0EP
Activity of tyrosine kinase inhibitors against human
NUP214-ABL1-positive T cell malignancies
A Quintas-Cardama, W Tong, T Manshouri, F Vega, P A Lennon, J Cools, D
G Gilliland, F Lee, J Cortes, H Kantarjian and G Garcia-Manero
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8u0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8v0ER
Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and
cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia
A Habib, E Hamade, R Mahfouz, M S Nasrallah, H de The and A Bazarbachi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8w0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8x0ET
RNAi-mediated silencing of p190Bcr-Abl inactivates Stat5 and
cooperates with imatinib mesylate and
17-allylamino-17-demetoxygeldanamycin in selective killing of
p190Bcr-Abl-expressing leukemia cells
M Futami, T Hatano, Y Soda, S Kobayashi, M Miyagishi and A Tojo
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8y0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw8z0EV
Overexpression of Syk tyrosine kinase in peripheral T-cell lymphomas
A L Feldman, D X Sun, M E Law, A J Novak, A D Attygalle, E C Thorland,
S R Fink, J A Vrana, B L Caron, W G Morice, E D Remstein, K L Grogg, P
J Kurtin, W R Macon and A Dogan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw810EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw820EJ
Results of the first randomized multicentre trial on childhood acute
lymphoblastic leukaemia in Russia
A Karachunskiy, R Herold, A von Stackelberg, N Miakova, A Timakow, T
Mahortih, L Bajdun, A Maschan, L Fechina, A Shamardina, S Dudkin, V
Lebedev, S Varfolomeeva, V Timofeeva, J Roumiantseva, N Chipsanova, A
Rumjanzew and G Henze
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw830EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw840EL
Thymic adult T-cell acute lymphoblastic leukemia stratified in
standard- and high-risk group by aberrant HOX11L2 expression:
experience of the German multicenter ALL study group
U Baak, N Gokbuget, H Orawa, S Schwartz, D Hoelzer, E Thiel and T
Burmeister
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw850EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw860EN
HoxA9 induces insulin-like growth factor-1 receptor expression in
B-lineage acute lymphoblastic leukemia
J T Whelan, D L Ludwig and F E Bertrand
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw870EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20Bw880EP
T-cell receptor V[beta] CDR3 oligoclonality frequently occurs in
childhood refractory cytopenia (MDS-RC) and severe aplastic anemia
A C H de Vries, A W Langerak, B Verhaaf, C M Niemeyer, J Stary, K
Schmiegelow, E R van Wering, C M Zwaan, A Beishuizen, R Pieters and M
M van den Heuvel-Eibrink
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAA0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAB0Ej
The immunophenotype of different immature, myeloid and B-cell
lineage-committed CD34+ hematopoietic cells allows discrimination
between normal//reactive and myelodysplastic syndrome precursors
S Matarraz, A Lopez, S Barrena, C Fernandez, E Jensen, J Flores, P
Barcena, A Rasillo, J M Sayagues, M L Sanchez, P Hernandez-Campo, J M
Hernandez Rivas, C Salvador, N Fernandez-Mosteirin, M Giralt, L
Perdiguer and A Orfao
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAC0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAD0El
Characterization of BCR-ABL deletion mutants from patients with
chronic myeloid leukemia
D W Sherbenou, O Hantschel, L Turaga, I Kaupe, S Willis, T Bumm, R D
Press, G Superti-Furga, B J Druker and M W Deininger
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAE0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAF0En
Effective killing of Gleevec-resistant CML cells with T315I mutation
by a natural compound PEITC through redox-mediated mechanism
H Zhang, D Trachootham, W Lu, J Carew, F J Giles, M J Keating, R B
Arlinghaus and P Huang
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAG0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAH0Ep
Dasatinib induces durable cytogenetic responses in patients with
chronic myelogenous leukemia in chronic phase with resistance or
intolerance to imatinib
A Hochhaus, M Baccarani, M Deininger, J F Apperley, J H Lipton, S L
Goldberg, S Corm, N P Shah, F Cervantes, R T Silver, D Niederwieser, R
M Stone, H Dombret, R A Larson, L Roy, T Hughes, M C Muller, R
Ezzeddine, A M Countouriotis and H M Kantarjian
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAI0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAJ0Er
CD34+CD38+CD19+ as well as CD34+CD38-CD19+ cells are
leukemia-initiating cells with self-renewal capacity in human
B-precursor ALL
Y Kong, S Yoshida, Y Saito, T Doi, Y Nagatoshi, M Fukata, N Saito, S M
Yang, C Iwamoto, J Okamura, K Y Liu, X J Huang, D P Lu, L D Shultz, M
Harada and F Ishikawa
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAK0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAL0Et
Dose-dependent repression of T-cell and natural killer cell genes by
PU.1 enforces myeloid and B-cell identity
M B Kamath, I B Houston, A J Janovski, X Zhu, S Gowrisankar, A G Jegga
and R P DeKoter
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAM0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAN0Ev
Sorafenib inhibits activation of human peripheral blood T cells by
targeting LCK phosphorylation
W Zhao, Y H Gu, R Song, B Q Qu and Q Xu
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAO0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAP0Ex
Increase sensitivity to chemotherapeutical agents and cytoplasmatic
interaction between NPM leukemic mutant and NF-[kappa]B in AML
carrying NPM1 mutations
D Cilloni, F Messa, V Rosso, F Arruga, I Defilippi, S Carturan, R
Catalano, M Pautasso, C Panuzzo, P Nicoli, E Messa, A Morotti, I
Iacobucci, G Martinelli, E Bracco and G Saglio
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAQ0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAR0Ez
AML1-Evi-1 specifically transforms hematopoietic stem cells through
fusion of the entire Evi-1 sequence to AML1
M Takeshita, M Ichikawa, E Nitta, S Goyama, T Asai, S Ogawa, S Chiba
and M Kurokawa
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAS0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAT0E2
Impact of genetic abnormalities on survival after allogeneic
hematopoietic stem cell transplantation in multiple myeloma
G Schilling, T Hansen, A Shimoni, T Zabelina, J-A Simon-Perez, N C
Gutierrez, W Bethge, P Liebisch, R Schwerdtfeger, M Bornhauser, S
Otterstetter, E M M Penas, J Dierlamm, F Ayuk, D Atanackovic, U
Bacher, C Bokemeyer, A Zander, J S Miguel, A Nagler and N Kroger
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAU0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAV0E4
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LETTERS TO THE EDITOR
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Third party mesenchymal stromal cell infusions fail to induce tissue
repair despite successful control of severe grade IV acute
graft-versus-host disease in a child with juvenile myelo-monocytic
leukemia
L Ball, R Bredius, A Lankester, J Schweizer, M van den Heuvel-Eibrink,
H Escher, W Fibbe and M Egeler
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAW0E5
Synthetic triterpenoids have cytotoxicity in pediatric acute
lymphoblastic leukemia cell lines but cytotoxicity is independent of
induced ceramide increase in MOLT-4 cells
G Kong, D Wang, H Wang, J Wu, J Bielawski, M Konopleva, M Andreeff, P
P Ruvolo and B J Maurer
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAX0E6
t(3;7)(q27;q32) fuses BCL6 to a non-coding region at FRA7H near miR-29
B Schneider, S Nagel, M Kaufmann, S Winkelmann, J Bode, H G Drexler
and R A F MacLeod
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAY0E7
BMI1 as oncogenic candidate in a novel TCRB-associated chromosomal
aberration in a patient with TCR[gamma][delta]+ T-cell acute
lymphoblastic leukemia
N S D Larmonie, W A Dik, H B Beverloo, E R van Wering, J J M van
Dongen and A W Langerak
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAZ0E8
The prevalence of IG translocations and 7q32 deletions in splenic
marginal zone lymphoma
E D Remstein, M Law, M Mollejo, M A Piris, P J Kurtin and A Dogan
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAa0EG
Treatment of relapsed acute myeloid leukemia with MLL//AF6 fusion
after allogeneic hematopoietic stem cell transplantation with
gemtuzumab ozogamicin with a long interval followed by donor
lymphocyte infusion
H Tamai, Y Shioi, H Yamaguchi, M Okabe, S Wakita, T Mizuki, K
Nakayama, K Inokuchi, K Tajika and K Dan
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAb0EH
MicroRNA expression profiles of human leukemias
S Takada, Y Yamashita, E Berezikov, H Hatanaka, S-i Fujiwara, K
Kurashina, H Watanabe, M Enomoto, M Soda, Y L Choi and H Mano
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAc0EI
Fusion of ZMIZ1 to ABL1 in a B-cell acute lymphoblastic leukaemia with
a t(9;10)(q34;q22.3) translocation
G Soler, I Radford-Weiss, R Ben-abdelali, N Mahlaoui, J F Ponceau, E A
Macintyre, M Vekemans, O A Bernard and S P Romana
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAd0EJ
Effect of lenalidomide therapy on mobilization of peripheral blood
stem cells in previously untreated multiple myeloma patients
A Mazumder, J Kaufman, R Niesvizky, S Lonial, D Vesole and S Jagannath
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAe0EK
Reply to /`Effect of lenalidomide therapy on mobilization of
peripheral blood stem cells in previously untreated multiple myeloma
patients/'
S Kumar and M A Gertz
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAf0EL
Compromised stem cell mobilization following induction therapy with
lenalidomide in myeloma
H Paripati, A K Stewart, S Cabou, A Dueck, V J Zepeda, N Pirooz, C
Ehlenbeck, C Reeder, J Slack, J F Leis, J Boesiger, A S Torloni, R
Fonseca and P L Bergsagel
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAg0EM
Use of pegylated recombinant filgrastim (Pegfilgrastim) in patients
with acute myeloid leukemia: pharmacokinetics and impact on leukocyte
recovery
M Fiegl, W Hiddemann and J Braess
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAh0EN
In human genome, generation of a nuclear export signal through
duplication appears unique to nucleophosmin (NPM1) mutations and is
restricted to AML
A Liso, A Bogliolo, V Freschi, M P Martelli, S A Pileri, M
Santodirocco, N Bolli, M F Martelli and B Falini
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAi0EO
JAK2 Mutations are present in all cases of polycythemia vera
Y L Wang, K Vandris, A Jones, N C P Cross, P Christos, F Adriano and R
T Silver
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAj0EP
Fresh frozen plasma contains free asparagine and may replace the
plasma asparagine pool during L-asparaginase therapy
M Steiner, A Attarbaschi, O A Haas, U Kastner, H Gadner and G Mann
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAk0EQ
Low MCL-1 mRNA expression correlates with prolonged survival in B-cell
chronic lymphocytic leukemia
L Veronese, O Tournilhac, P Verrelle, F Davi, G Dighiero, E Chautard,
R Veyrat-Masson, F Kwiatkowski, C Goumy, P Vago, P Travade and A
Tchirkov
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAl0ER
Methylation analysis of the von Hippel-Lindau gene in acute myeloid
leukaemia and myelodysplastic syndromes
L Benetatos, A Dasoula, N Syed, E Hatzimichael, T Crook and K L
Bourantas
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAm0ES
Prognostic interaction between thrombocytosis and JAK2 V617F mutation
in the WHO subcategories of myelodysplastic//myeloproliferative
disease-unclassifiable and refractory anemia with ringed sideroblasts
and marked thrombocytosis
E Atallah, R Nussenzveig, C C Yin, C Bueso-Ramos, C Tam, T Manshouri,
S Pierce, H Kantarjian and S Verstovsek
http://ealerts.nature.com/cgi-bin24/DM/y/elTn0Xztnp0Hi20BxAn0ET
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