Allogeneic Stem Cell Transplants May Be Best Option for T-Cell
Lymphoma
Researchers from France affiliated with the Societe Francaise de
Greffe de Moelle et de Therapies Cellulaire have reported that
allogeneic stem cell transplants are effective therapy for patients
with NK/T–cell lymphomas. The details of this study appeared in an
early online publication in the Journal of Clinical Oncology on April
7, 2008.1
T-cell lymphomas are a relatively uncommon form of non-Hodgkin'
lymphoma (NHL) that generally respond less well to treatment than B-
cell NHL. And while patients with B-cell NHL benefited significantly
from Rituxan® (rituximab) therapy over the past decade, there is no
comparable T-cell antibody for treatment of T-cell lymphomas. High-
dose chemotherapy with autologous stem cell rescue has been used with
some success for the treatment of patients with T-cell lymphoma.
However, even after autologous stem cell transplantation, the
probability of recurrent disease is high. Allogeneic stem cell
transplantation offers a more curative approach, but transplant-
related mortality is high.
The current study reviewed the outcomes of 77 patients with
aggressive T-cell or NK/T cell lymphoma who were treated with an
allogeneic stem cell transplant. Fifty-seven patients received a
myeloablative treatment regimen, and the remainder a reduced-
intensity treatment regimen. Sixty patients received transplants from
related donors and the remainder from unrelated donors. Fifty-seven
of these patients were in complete or partial remission at the time
of transplant. The five-year treatment-related mortality was 33%,
overall survival was 57%, and event-free survival was 53%. Better
outcomes were achieved in patients in complete or partial remission.
Graft-versus host disease also increased mortality, especially in
recipients of mismatched stem cells.
Comments: These are relatively good results in a very poor risk group
of patients who were expected to do poorly with conventional
chemotherapy or high-dose chemotherapy with autologous stem cell
transplantation.
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Cord Blood Registry
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The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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