Signaling Gateway - 30 May 2008
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0M40Eg
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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ANGIOGENESIS: PI3K SUBUNITS BRANCH OUT
The catalytic subunits of class IA phosphoinositide 3-kinases (PI3K)
are activated by distinct signals and have discrete roles in
angiogenesis and vascular remodeling.
Original research paper: Nature 453, 662-666 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0vP0Ep
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Signaling Survey
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SIGNALING GATEWAY SURVEY: WHAT DO YOU THINK?
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0Bvd80ED
The Signaling Gateway team invites you to complete a brief online
survey on the usability of the site for the chance to win a FREE iPod
Touch or two-year subscription to Nature. Your feedback will help
ensure that we continue to present content and information that meet
your needs. To complete the survey and enter the prize draw, please
click here.
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Selected Updates
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MECHANISMS OF DISEASE: STRESS AND DISEASE CONNECT AT mTORC1
Loss of tuberous sclerosis complex (Tsc) genes causes constitutive
activation of mTOR, leading to endoplasmic reticulum (ER) stress and
dysregulation of insulin receptor signaling.
Original research paper: Mol. Cell 29, 541-551 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BwKR0EF
SIGNALLING: AN ONCOGENE BECOMES RESTLESS
The abundance of the protein REST (repressor-element-1 silencing
transcription factor) is regulated by a cell cycle-dependent
ubiquitin pathway.
Original research paper: Nature 452, 365-369 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BwKS0EG
CELL FATE: THE PATH TO NEUROGENESIS
In mice, oxidative conditions increase the interaction between the
histone deacetylase Sirt1 and the transcription factor Hes1, which
represses expression of the pro-neuronal-fate transcription factor
Mash1 and promotes differentiation of neural progenitor cells.
Original research paper: Nature Cell Biol. 10, 385-394 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BwKT0EH
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0vO0Eo
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Research Library
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p53 REGULATES GLUCOSE METABOLISM THROUGH AN IKK-NF-kappaB PATHWAY
AND INHIBITS CELL TRANSFORMATION
Nature Cell Biology 10, 611-618 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BwKU0EI
SPHEROID-BASED ENGINEERING OF A HUMAN VASCULATURE IN MICE
Nature Methods 5, 439-445 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BwKV0EJ
IDENTIFICATION OF RIP1 KINASE AS A SPECIFIC CELLULAR TARGET OF
NECROSTATINS
Nature Chemical Biology 4, 313-321 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BwKW0EK
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Signaling News
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MARINE MICROBIOLOGY: ORIGINS OF DEATH
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0Bv3j0EE
Programmed cell death is usually seen as the unique prerogative of
plants and animals. However, plankton and photosynthetic cyanobacteria
undergo a process strikingly similar to apoptosis. Plankton diatoms
that contain high levels of nitric oxide grow slowly and are highly
sensitive to stress, and activate as many as six metacaspases during
their cell-death program.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0Crw0EX
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - MAY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BGyx0Ep
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and bioinformaticians
to explore, visualize and mine signaling events.
This month's update features:
Cardiovascular signaling mediated by endothelins,
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0Buvs0ET
BMP receptor signaling
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0Buvt0EU
and a
Bioinformatics primer on GenMAPP
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BsEP0E2
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BwKX0EL
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BJYy0EN
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Signaling Job of the Week
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Professorship positions
Employer: The University of Vienna
Location: Vienna, Austria
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BwKY0EM
The Centre for Molecular Biology at The University of Vienna invites
applications for Full Professorships in Cell Signaling and in
Molecular Microbiology. The cell signaling candidate should focus on
signal transduction processes in multicellular organisms. The
molecular microbiology candidate should study the post-transcriptional
regulation of microbial genomes. Applicants for either position should
have experience in university teaching and in directing major research
projects.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0BnjC0EM
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/elEX0Xztnp0H2W0vqs0EJ
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