Signaling Gateway - 23 May 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0M40Eh
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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COLON CANCER: ANALYZING RAS SPECIFICITY
Active N-Ras and K-Ras have different effects in colon cancer: K-Ras
promotes proliferation and suppresses differentiation, whereas N-Ras
protects cells from chemically induced apoptosis.
Original research paper: Nature Genetics 40, 600-608 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0vP0Eq
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0HIE0E7
Rasgrf2
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0BvGB0Et
Rasgrf2 is a member of the mammalian Rasgrf family of guanosine
nucleoside exchange factors (GEFs), showing dual specificity towards
H-Ras and Rac1. Through its ability to activate Rac1, Rasgrf2 has been
reported to have important functional interactions with the
cytoskeleton. Rasgrf2 has also been shown to display significant
synaptic functionality in neural contexts including the hippocampus
and cortical neurons.
Also published this week:
Fgf20
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvdz0EK
search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0BUuz0E3
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Selected Updates
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TUMORIGENESIS: READY AND WAITING
MYC is required for the interaction between the E2F1 transcription
factor and its target gene promoters, which promotes activation of
the E2F network and leads to cell proliferation.
Original research paper: Oncogene published online 17 March 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvd10E6
MICROGLIA: GIVING OUT DANGEROUS SIGNALS
The release of heat-shock protein HSP60 from injured neurons activates
Toll-like receptor 4 (TLR4) signaling, which stimulates microglia and
facilitates neurodegeneration.
Original research paper: J. Neurosci. 27, 2320-2331 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvd20E7
GENE REGULATION: FOLLOW THE UBIQUITIN
When used in chromatin immunoprecipitation (ChIP) experiments, an
antibody to monoubiquitinated histone H2B (ubH2B) can map
ubiquitination patterns across the genome or follow the modification
of individual genes.
Original research paper: Nat. Cell Biol. 10, 483-488 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvd30E8
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0vO0Ep
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Research Library
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PROTEASOME SUBUNIT Rpn13 IS A NOVEL UBIQUITIN RECEPTOR
Nature 453, 481-488 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvd40EA
FUNCTIONAL IDENTIFICATION OF SENSORY MECHANISMS REQUIRED FOR
DEVELOPMENTAL SONG LEARNING
Nature Neuroscience 11, 579-586 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvd50EB
LIVE-CELL PHOTOACTIVATED LOCALIZATION MICROSCOPY OF NANOSCALE
ADHESION DYNAMICS
Nature Methods 5, 417-423 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvd60EC
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Signaling News
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NATURE NEWS: CARBON NANOTUBES: THE NEW ASBESTOS?
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvd70ED
Nanotechnology experts are calling for prompt government action to
ensure that carbon nanotubes are properly regulated, after researchers
discovered that some carbon nanotubes can cause precancerous growths.
When injected into the lung mesothelium of mice, long, straight,
multi-walled carbon nanotubes can cause granulomas that are similar
to those caused by asbestos fibers.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Crw0EY
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Gateway Updates
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SIGNALING GATEWAY SURVEY: WHAT DO YOU THINK?
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0Bvd80EE
The Signaling Gateway team invites you to complete a brief online
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Touch or two-year subscription to Nature. Your feedback will help
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click here.
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Signaling Job of the Week
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Postdoctoral Position
Employer: University of Miami Miller School of Medicine
Location: Miami, FL
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0BveA0EO
A postdoctoral position is available at the University of Miami to
study Notch signaling in melanoma using in vitro and in vivo
techniques. The successful candidate must have research experience in
signal transduction and tumor biology, including familiarity with gene
mutagenesis, RNAi, quantitative RT-PCR, flow cytometry and
immunohistochemistry.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0BnjC0EN
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ek210Xztnp0H2W0vqs0EK
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