Signaling Gateway - 2 May 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0M40Es
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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ONCOGENIC TRANSFORMATION: INVASION OF THE MICROVESICLES
Glioma cells that express the oncogenic receptor EGFRvIII form
microvesicles that fuse with neighboring, non-transformed cells to
promote their oncogenic transformation.
Original research paper: Nature Cell Biology 10, 619-624 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0vP0E2
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0HIE0EJ
Rac2
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuEQ0EI
Rac2 is a member of the Rho family of small GTPases. Rac2 regulates
a number of cellular functions by cycling between its inactive
GDP-bound state and its active GTP-bound state. Rac2 has been shown
to preferentially regulate phagocyte NADPH oxidase by directly
interacting with it and the regulatory protein p67-phox. The Rac2
knockout mouse exhibits chemotaxis defects due to interactions with
unknown cytoskeletal effectors.
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BUuz0EF
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Selected Updates
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CELL MIGRATION: GROUP VOYAGE
Collective cell migration - the movement of cells in clusters,
strands, sheets and tubes - is regulated by an evolutionarily
conserved cascade that involves the Jun N-terminal kinase (JNK)
signaling pathway.
Original research paper: Curr. Biol. 18, 532–537 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuER0EJ
TUMOUR IMMUNOLOGY: TUMOUR SURVEILLANCE BY NKG2D
The expression of natural-killer group 2, member D (NKG2D) stimulatory
receptor ligands is known to render tumor cells susceptible to NK-cell
killing, and NKG2D has now been found to have an important role in
tumor surveillance in spontaneous cancer models in vivo.
Original research paper: Immunity 28, 571–580 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuES0EK
THERAPY: BAD TO THE BONE
Suppressing the hedgehog signaling pathway in cancers has potential
therapeutic value; however, suppressing this pathway in young mice
results in permanent and detrimental skeletal changes.
Original research paper: Cancer Cell 13, 249–260 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuET0EL
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0vO0E1
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Research Library
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HIERARCHICAL STRUCTURE AND THE PREDICTION OF MISSING LINKS IN
NETWORKS
Nature 453, 98-101 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuEU0EM
ANGIOPOIETINS ASSEMBLE DISTINCT Tie2 SIGNALLING COMPLEXES IN
ENDOTHELIAL CELL-CELL AND CELL-MATRIX CONTACTS
Nature Cell Biology 10, 527-537 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuEV0EN
BAC TRANSGENEOMICS: A HIGH-THROUGHPUT METHOD FOR EXPLORATION OF
PROTEIN FUNCTION IN MAMMALS
Nature Methods 5, 409-415 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuEW0EO
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Signaling News
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UCSD-NATURE SIGNALING GATEWAY: SUPPORT THE SITE!
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Help keep the Signaling Gateway free! We would like to apply for
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More News
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0Crw0Ej
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Gateway Updates
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THE CELL MIGRATION GATEWAY - MAY UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0ll80EH
The Cell Migration Update is a comprehensive FREE online resource to
keep you abreast of the latest findings in the field.
This month's update features
Mammary development: Collective migration without protrusions
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuEX0EP
and
Differential signalling: For quiescence or for migration?
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuEY0EQ
Sign up to receive the monthly table of contents e-alert for the
Cell Migration Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BJrg0Eg
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Signaling Job of the Week
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Science Manager and Postdoctoral Scientist
Employer: Otto von Guericke University Magdeburg
Location: Magdeburg, Germany
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BuEZ0ER
A Science Manager position and a Postdoctoral position are available
at the Institute of Experimental Internal Medicine at the Otto von
Guericke University, Magdeburg. The Science Manager will contribute to
patent and grant applications, lab management and the development of
innovative research strategies. The Postdoctoral scientist will use
mathematical models of signal transduction to study NF-kappaB
signaling in inflammation and tumor biology.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0BnjC0EY
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0vqs0EV
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http://ealerts.nature.com/cgi-bin24/DM/y/ekdF0Xztnp0H2W0dIO0Ev
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