Signaling Gateway - 16 May 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0M40EH
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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CALCIUM SIGNALING: COMPOUNDED AGGREGATION
A screen for compounds that regulate autophagy has identified a
cyclical inhibitory pathway in which cyclic AMP (cAMP) signaling
increases intracellular calcium levels and stimulates calpain-mediated
activation of Galphas, which raises cAMP levels.
Original research paper: Nature Chemical Biology 4, 295-305 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0vP0EQ
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0HIE0Eg
VAChT
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BvGA0ES
The vesicular acetylcholine transporter (VAChT) is responsible for
packaging acetylcholine (ACh) into synaptic vesicles. This transporter
is rate limiting for ACh release from the nerve terminal. The amount
of VAChT expression regulates filling of vesicles, physical endurance
and cognitive behavior in mice. In mammals, VAChT is present in
cholinergic cell bodies, fibers and terminals. VAChT also is in
non-neural tissues, including the immune system.
search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BUuz0Ec
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Selected Updates
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MEMBRANE TRAFFICKING: A MATURING INFLUENCE
A fluorescence resonance energy transfer (FRET) probe shows that
Rab5 and its activator Gapex5 have key roles in phagosome maturation,
potentially by mediating the fusion between phagosomes and early
endosomes.
Original research paper: Nature 453, 241-245 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BvGC0EU
TUMOUR SUPPRESSORS: MOTORING ON DOWN
Kinesin family member 1B (KIF1B) induces apoptosis in neurons in
response to nerve growth factor withdrawal and is deleted in many
different types of neuronal tumors.
Original research paper: Genes Dev. 22, 884–893 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BvGD0EV
NEUROPROTECTION: STAYING ACTIVE = STAYING ALIVE
Activation of NMDA receptors in synapses, but not at extra-synaptic
sites, has neuroprotective effects through stimulation of the
antioxidant thioredoxin–peroxiredoxin enzyme system.
Original research paper: Nature Neurosci. 11, 476-487 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BvGE0EW
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0vO0EP
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Research Library
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GENETIC EVIDENCE THAT FGFs HAVE AN INSTRUCTIVE ROLE IN LIMB
PROXIMAL-DISTAL PATTERNING
Nature 453, 401-405 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0Bu5B0EA
DEACTIVATION OF THE KINASE IKK BY CUEDC2 THROUGH RECRUITMENT OF THE
PHOSPHATASE PP1
Nature Immunology 9, 533-541 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BvGF0EX
FUNCTIONAL ROLES FOR C5a RECEPTORS IN SEPSIS
Nature Medicine 14, 551-557 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BvGG0EY
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Signaling News
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NATURE NEWS: LEARNING FROM DEATH
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0Bu4B0E8
Nature News talks to Vishva Dixit about his research career - from
studying apoptosis and elucidating the function of the 'inflammasome'
to developing anti-cancer therapeutics. The UCSD-Nature Signaling
Gateway is pleased to have Dr. Dixit, the vice-president of research
at Genentech, as a member of our advisory board.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0Crw0E7
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Gateway Updates
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NATURE PROTOCOLS - RECIPES FOR RESEARCHERS
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W04a70EW
Nature Protocols is a comprehensive online resource of laboratory
protocols, including authoritative, peer-reviewed 'Nature Protocols'
and an interactive 'Protocols Network'.
This month's featured protocols include:
Southwestern blotting in investigating transcriptional regulation
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BljL0E3
Detecting protein-protein interactions by far western blotting
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0Bjio0Ea
and
Ambient Molecular Imaging by Desorption Electrospray Ionization (DESI) Mass Spectrometry
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0Bpjd0EW
Sign up to receive the table of contents e-alert for Nature Protocols.
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W02Bg0El
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Signaling Job of the Week
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Research Investigator
Employer: Novartis Pharma
Location: Basel, Switzerland
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BvGH0EZ
A Research Investigator position is available at Novartis Pharma for
an experienced immunologist. The successful applicant will investigate
key signaling pathways involved in inflammation and autoimmune
diseases. This work will support ongoing drug discovery programs aimed
at the identification of novel therapies.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0BnjC0Ev
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0vqs0Es
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http://ealerts.nature.com/cgi-bin24/DM/y/ekvK0Xztnp0H2W0dIO0EK
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