May 2008 Volume 15 Number 5, pp 425 - 536
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EDITORIAL
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Promoting creativity and innovation p425
If the United States is losing its competitive edge in science and
technology, how can we begin to reverse that trend?
doi:10.1038/nsmb0508-425
http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuL50Ez
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NEWS AND VIEWS
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Modifications target spliceosome dynamics pp426 - 428
The splicing pathway is dominated by ATP-dependent RNA rearrangements
promoted by DEAD-box helicases. Post-translational modifications have
now been implicated in the regulation of two DEAD-box proteins that
are required for catalytic activation of the spliceosome.
Corina Maeder and Christine Guthrie
doi:10.1038/nsmb0508-426
http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuL60E1
The type II secretion arrowhead: the structure of GspI-GspJ-GspK
pp428 - 430
A heterotrimeric complex of minor pseudopilins from the type II
secretion system has been identified and its crystal structure
solved. Although each subunit shares the same overall alpha-beta
fold as other characterized (pseudo)pilins, GspK has a unique large
alpha-helical domain inserted between two canonical beta-strands.
The structure constrains models for pseudopilus assembly.
Katrina T Forest
doi:10.1038/nsmb0508-428
http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuL70E2
DNA damage: a histone-code mediator leaves the stage pp430 - 432
Chromosomal breaks destabilize the genome and can cause developmental
defects and diseases such as cancer. New work suggests that, shortly
after DNA damage, dissociation of the histone binding protein
HP1beta from chromatin facilitates restoration of genome integrity.
Jiri Lukas and Jiri Bartek
doi:10.1038/nsmb0508-430
http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuL80E3
New clues to actin function in chromatin regulation pp432 - 433
Since the discovery that actin and actin-related proteins (ARPs)
reside in the nucleus as integral subunits of chromatin-modifying
and chromatin-remodeling complexes, efforts to uncover their roles
in chromatin regulation have met with limited success. In a new
study, the previously mysterious helicase-SANT-associated (HSA)
domain found in many chromatin regulatory complexes is shown to
act as a module that directs recruitment and contributes to the
action of actin and ARPs in chromatin regulation.
Aaron J Gottschalk, Ronald C Conaway and Joan Weliky Conaway
doi:10.1038/nsmb0508-432
http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMA0EE
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RESEARCH HIGHLIGHTS
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Research highlights p434
doi:10.1038/nsmb0508-434
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ARTICLES
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Phosphorylation of human PRP28 by SRPK2 is required for integration
of the U4/U6-U5 tri-snRNP into the spliceosome pp435 - 443
Rebecca Mathew et al.
doi:10.1038/nsmb.1415
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMC0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMD0EH
A role for ubiquitin in the spliceosome assembly pathway
pp444 - 451
Priya Bellare et al.
doi:10.1038/nsmb.1401
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuME0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMF0EJ
Membrane-dependent signal integration by the Ras activator Son of
sevenless pp452 - 461
Jodi Gureasko et al.
doi:10.1038/nsmb.1418
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMG0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMH0EL
Structure of the GspK-GspI-GspJ complex from the enterotoxigenic
Escherichia coli type 2 secretion system pp462 - 468
Konstantin V Korotkov and Wim G J Hol
doi:10.1038/nsmb.1426
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMI0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMJ0EN
The HSA domain binds nuclear actin-related proteins to regulate
chromatin-remodeling ATPases pp469 - 476
Heather Szerlong et al.
doi:10.1038/nsmb.1403
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMK0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuML0EP
ATP-dependent chromatin remodeling shapes the DNA replication
landscape pp477 - 484
Jack A Vincent, Tracey J Kwong and Toshio Tsukiyama
doi:10.1038/nsmb.1419
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMM0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMN0ER
Sequence-directed DNA export guides chromosome translocation during
sporulation in Bacillus subtilis pp485 - 493
Jerod L Ptacin et al.
doi:10.1038/nsmb.1412
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMO0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMP0ET
Signal sequence-independent membrane targeting of ribosomes
containing short nascent peptides within the exit tunnel
pp494 - 499
Thomas Bornemann, Johannes Jockel, Marina V Rodnina and Wolfgang
Wintermeyer
doi:10.1038/nsmb.1402
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMQ0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMR0EV
The structural basis for cap binding by influenza virus polymerase
subunit PB2 pp500 - 506
Delphine Guilligay et al.
doi:10.1038/nsmb.1421
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMS0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMT0EX
Aminoacylation of tRNA with phosphoserine for synthesis of
cysteinyl-tRNACys pp507 - 514
Chun-Mei Zhang, Cuiping Liu, Simon Slater and Ya-Ming Hou
doi:10.1038/nsmb.1423
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMU0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMV0EZ
DNA apurinic-apyrimidinic site binding and excision by endonuclease
IV pp515 - 522
Elsa D Garcin et al.
doi:10.1038/nsmb.1414
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMW0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMX0Eb
Mouse Eri1 interacts with the ribosome and catalyzes 5.8S rRNA
processing pp523 - 530
K Mark Ansel et al.
doi:10.1038/nsmb.1417
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMY0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMZ0Ed
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BRIEF COMMUNICATIONS
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The exonuclease ERI-1 has a conserved dual role in 5.8S rRNA
processing and RNAi pp531 - 533
Harrison W Gabel and Gary Ruvkun
doi:10.1038/nsmb.1411
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMa0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMb0El
A conserved rRNA methyltransferase regulates ribosome biogenesis
pp534 - 536
Zhili Xu, Heather C O'Farrell, Jason P Rife and Gloria M Culver
doi:10.1038/nsmb.1408
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMc0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekgv0Xztnp0Hjh0BuMd0En
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