June 2008 Volume 6 Number 6
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Nature Reviews Microbiology Impact Factor: 15.845*
(*Journal Citation Reports, Thomson, 2007)
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Breaking Down Memories
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T Cells Work Away from Home
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Protective medicine under the tongue
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Nature Reviews Microbiology
Poster on Metagenomics
An overview of the technology and applications of Metagenomics
Metagenomics is a powerful tool that can be used to analyze microbial communities regardless
of the ability of member organisms to be cultured in the laboratory. This technology will
likely lead to major advances in medicine, agriculture, energy production and bioremediation.
Access the Poster FREE online at
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Produced with support from:
The National Academies: Advisors to the Nation on Science, Engineering, and Medicine
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The National Science Foundation
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This month's FEATURED article:
Microbiology in the post-genomic era
Duccio Medini, Davide Serruto, Julian Parkhill, David A. Relman, Claudio Donati,
Richard Moxon, Stanley Falkow and Rino Rappuoli
p419 | doi:10.1038/nrmicro1901
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFJ0Eh
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In this issue
p409 | doi:10.1038/nrmicro1925
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFK0Ei
Editorial: Virtual networking for microbiologists
p410 | doi:10.1038/nrmicro1922
The advent of Web 2.0 applications, which enable information sharing and virtual
networking, could revolutionize science. But are microbiologists taking advantage?
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFL0Ej
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RESEARCH HIGHLIGHTS
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Cellular microbiology: Virus plays dead
p411 | doi:10.1038/nrmicro1923
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFM0Ek
DNA replication: Follow the path
p412 | doi:10.1038/nrmicro1911
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFN0El
IN BRIEF
Symbiosis | Ecology | Biofilmsp
412 | doi:10.1038/nrmicro1915
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFO0Em
Viral pathogenesis: Turning virus spread on its head
p413 | doi:10.1038/nrmicro1914
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFP0En
Techniques and applications: A model infection
p413 | doi:10.1038/nrmicro1920
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFQ0Eo
Fungal metabolism: Dissecting catalysis
p414 | doi:10.1038/nrmicro1917
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFR0Ep
Cellular microbiology: All aboard the cell-wall shuttle
p414 | doi:10.1038/nrmicro1924
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFS0Eq
Immune evasion: Overcoming defensins
p415 | doi:10.1038/nrmicro1921
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFT0Er
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NEWS AND ANALYSIS
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DISEASE WATCH
In the News
p416 | doi:10.1038/nrmicro1926
http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFU0Es
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REVIEWS
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Microbiology in the post-genomic era
Duccio Medini, Davide Serruto, Julian Parkhill, David A. Relman, Claudio Donati,
Richard Moxon, Stanley Falkow and Rino Rappuoli
p419 | doi:10.1038/nrmicro1901
Thirteen years after the first bacterial genome was sequenced, Rino Rappuoli,
Stanley Falkow and colleagues review what has changed in microbiology research
as a consequence of genomics and address the implications of the genomic era for
the future of microbiology.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFV0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFJ0Eh
Microbial diversity and the genetic nature of microbial species
Mark Achtman and Michael Wagner
p431 | doi:10.1038/nrmicro1872
This Review summarizes contemporary approaches for defining species in Bacteria
and Archaea and contrasts these approaches with various reports on microbial
population genetic patterns. The authors conclude that contemporary method-based
approaches lack a theoretical definition and new approaches are needed that should
be guided by a method-free species concept that is based on cohesive evolutionary forces.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFW0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFX0Ev
The ecology and biotechnology of sulphate-reducing bacteria
Gerard Muyzer and Alfons J. M. Stams
p441 | doi:10.1038/nrmicro1892
Sulphate-reducing bacteria (SRB) are anaerobic microorganisms that can use sulphate
as a terminal electron acceptor. These organisms are ubiquitous in anoxic habitats,
where they have an important role in both the sulphur and carbon cycles. Muyzer and
Stams provide an overview of the diversity, physiology and distribution of SRB and
their applications to environmental biotechnology.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFY0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFZ0Ex
Coordinating assembly of a bacterial macromolecular machine
Fabienne F. V. Chevance and Kelly T. Hughes
p455 | doi:10.1038/nrmicro1887
The flagellum is a beautiful structure and a fascinating model system for understanding
how genes are regulated to ensure the correct assembly of a complex structure. Chevance
and Hughes discuss the regulation of flagellar gene transcription and how it is intimately
coupled to the assembly of this exquisite bacterial nanomachine.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFa0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFb0E6
The surprisingly diverse ways that prokaryotes move
Ken F. Jarrell and Mark J. McBride
p466 | doi:10.1038/nrmicro1900
Bacteria and archaea have found many solutions to the problem of how to move in liquids
and on solid surfaces. Although the use of a rotary flagellum in bacteria is the
best-studied mode of bacterial movement, spirochaetes constrain their flagella in the
periplasm, some bacteria move using type IV pili, cyanobacteria use surface spicules and
others glide on surfaces without using appendages.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFc0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFd0E8
Mathematical models of infectious disease transmission
Nicholas C. Grassly and Christophe Fraser
p477 | doi:10.1038/nrmicro1845
The dynamics of infectious diseases are complex, so developing models that can capture
key features of the spread of infection is important. Grassly and Fraser provide an
introduction to the mathematical analysis and modelling of disease transmission, which,
in addition to informing public health disease control measures, is also important for
understanding pathogen evolution and ecology.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFe0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFf0EB
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PERSPECTIVE
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OPINION
Proteorhodopsins: an array of physiological roles?
Jed A. Fuhrman, Michael S. Schwalbach and Ulrich Stingl
p488 | doi:10.1038/nrmicro1893
The discovery of proteorhodopsin genes during metagenomic analyses of marine bacteria and
archaea challenged the notion that all solar energy is captured by microbial chlorophyll
molecules in these environments. But have subsequent studies confirmed the energy-transducing
roles of microbial proteorhodopsins? Here, the authors suggest that energy transduction might
be one of many roles for these fascinating proteins.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFg0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekvH0Xztnp0Hje0BvFh0ED
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