May 15 2008
Visit Nature Reports Stem Cells online.
Now available at: http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BU280E1
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THIS MONTH IN NATURE REPORTS STEM CELLS
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What's now and what's next for regenerative medicine? This month's newsletter complements Nature Insight: Regenerative Medicine by including frank and forward-thinking interviews with prominent scientists. Additionally, news features describe what scientists plan to do with induced pluripotent stem cells and how the California Institute of Regenerative Medicine plans to shape the future of stem cell science.
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuvF0Eu
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OUR TOP STORIES
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Our collection of interviews on what's now and what's next for stem cell therapies.
Ken Chien: the road ahead for regenerative medicine
Human models of human disease are likely to be the first benefits of stem cells to medicine.
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxH0Ey
Christine Mummery: regenerating the heart
Scientists search for the best ways to make therapies from embryonic stem cells and adult tissues.
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxI0Ez
Richard Boyd and Ann Chidgey: protecting cells from immune attack
Inducing tolerance to transplanted cells could make stem-cell therapy more enduring and versatile.
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxJ0E1
Sheng Ding: small molecules for stem cells
A chemical approach to regenerative medicine provides practical solutions and scientific insight
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxK0E2
Timm Schroeder: stem cell tracking and imaging technology
Visualization techniques are improving, but stem cells are still tough to watch.
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxL0E3
Interviews with Michael Longaker on wound regeneration and Leonard Zon on controlling hematopoetic stem cell self-renewal will be published at the beginning of June. Meanwhile, see our commentaries from both.
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxM0E4
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxN0E5
Embryonic stem cells 2.0
Scientists have grand plans for induced pluripotency
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxO0E6
Stem cells: The 3-billion-dollar question
Can the California Institute of Regenerative Medicine transform the state of stem cell funding?
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxP0E7
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Research highlights and news stories keying off recent publications
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Beating heart tissue grown in lab
Test-tube recipe produces three types of cardiac cell
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BtZr0EB
Yang, L. Nature advance online publication, doi:10.1038/nature06894 (23 April 2008).
Balances in blood
Studies re-examine what keeps haematopoietic stem cells quiet
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxQ0E8
Maillard, I. et al. Cell Stem Cell 2, 356-366 (2008).
Min, I. M. et al. Cell Stem Cell 2, 380-391 (2008).
Haug, J. S. et al. Cell Stem Cell 2, 367-379 (2008).
Reprogramming turns an end into a beginning
Mature B cells from reprogramming-ready mice become pluripotent
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxR0EA
Hanna, J. et al. Cell 133, 250-264 (2008).
A mutant Methuselah for blood-making progenitors
Cells that regenerate blood increase tenfold in mutant mice
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxS0EB
Akala, O. et al. Nature advance online publication, doi:10.1038/nature06869 (17 April 2008).
Cancer and embryonic stem cells share genetic fingerprints
At least two modules of genes promote stemness
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxT0EC
Wong, D. J. et al. Cell Stem Cell 2, 333-344 (2008).
Stem cells improve Parkinson's disease symptoms
Reprogrammed mice cells show promise as a cell replacement therapy but safety issues need to be addressed
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxU0ED
Kordower, J. H., Chu, Y., Hauser, R. A., Freeman, T. B. & Olanow, C. W. Nat. Med. 14, 504-506 (2008).
Li, J-Y. et al. Nat. Med. 14, 501-503 (2008).
Mendez, I. et al. Nat. Med. 14, 507-509 (2008).
Tabar, V. et al. Nat. Med. 14, 379-381 (2008).
Wernig, M. et al. Proc. Natl. Acad. Sci. USA 105, 5856-5861 (2008).
Answering age-old questions
Progerin hijacks the Notch signalling pathway to disrupt mesenchymal stem cell differentiation
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxV0EE
Scaffidi, P. & Misteli, T. Nat. Cell Biol. 10, 452-459 (2008).
An artificial sweetener for studying development
A new technique allows both cells and sugar synthesis to be tracked in growing zebrafish embryos
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxW0EF
Laughlin, S. T. et al. Science 320, 664-667 (2008).
Pituitary stem cells found using a general stem cell marker
Genetic approaches identify a distinct, postnatal stem cell population
http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BuxX0EG
Gleiberman, A. et al. Proc. Natl. Acad. Sci. USA 105, 6332-6337 (2008).
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PRINCIPAL SPONSOR
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Nature Reports Stem Cells is pleased to acknowledge financial support from our Principal Sponsor.
Advanced Cell Technology
Advanced Cell Technology, Inc. (OTCBB: ACTC) is a biotechnology company applying human embryonic stem ("ES") cell technology in the field of regenerative medicine with the goal of bringing effective, patient-specific therapies to the bedside. The company owns or licenses over 300 patents and patent applications and plans to use its proprietary technology to develop treatments for indications including dermal injuries, macular degeneration, and blood and cardiovascular diseases.
Sponsor profile: http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BU5o0Ey
Sponsor's article: http://ealerts.nature.com/cgi-bin24/DM/y/ekrF0Xztnp0JEp0BU5p0Ez
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