June 2008 Volume 9 Number 6, pp 569 - 692
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Cell Shape and Polarity: Lymphocytes and Beyond
September 29, 2008
Chicago, Illinois
This mini-symposium aims to promote discussion about molecular mechanisms underlying cell polarization, synapse formation and asymmetric cell division, as well as the influence of these processes on cell fate determination and function.
Apply by June 25, 2008
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NATURE IMMUNOLOGY
FOCUS ON NATURAL KILLER CELLS
Natural killer cells influence immune responses to tumors, infections and pregnancy.
Nature Immunology presents a series of specially commissioned articles that focus on natural killer cells and their far-reaching effects on diverse cell types and biological responses. The web focus, free for six months, also includes highlights of recent research
findings, an annotated list of classic articles and links to selected NPG papers pertinent to this field.
For more information visit:
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BssN0Eo
Produced with support from Novo Nordisk and Innate Pharma
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EDITORIAL
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Assessing the status of human immunology p569
Although excellent animal model systems are available, more studies
of human immunology are needed.
doi:10.1038/ni0608-569
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIm0Eg
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ESSAY
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Positive and negative selection in Basel pp571 - 573
Harald von Boehmer describes how he used mice transgenic for T cell
receptor alpha beta to identify T cell receptor-dependent cellular
selection and lineage commitment as mechanisms responsible for
generating an effective and self-tolerant adaptive immune system.
Harald von Boehmer
doi:10.1038/ni0608-571
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIn0Eh
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COMMENTARY
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The habitual, diverse and surmountable obstacles to human immunology
research pp575 - 580
The need to translate basic research in the field of human immunology
may be much more urgent, and the rewards potentially much greater,
than is often acknowledged. Yet a commonly perceived coercion to
undertake translational research may be unhelpful. Instead, we
propose clear incentives for integrating key skill sets, together
with achievable cultural adjustments in research and medicine that
span training, recruitment and promotion.
Adrian C Hayday and Mark Peakman
doi:10.1038/ni0608-575
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIo0Ei
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NEWS AND VIEWS
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IRAK2 takes its place in TLR signaling pp581 - 582
Toll-like receptors trigger an innate immune response by activating
signaling pathways that are dependent on IRAK kinases. According
to Kawagoe et al., the least understood IRAK member, IRAK2, is
required for the perpetuation of these signals.
Etienne Meylan and Jurg Tschopp
doi:10.1038/ni0608-581
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIp0Ej
CD3 ITAMs count! pp583 - 584
The T cell receptor (TCR) is functionally coupled to a
constellation of ten immunoreceptor tyrosine-based activation
motifs (ITAMs). A new study suggests that this large number of
ITAMs is mandatory for preventing autoimmunity.
Bernard Malissen
doi:10.1038/ni0608-583
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIq0Ek
Homeostasis of dendritic cell pool in lymphoid organs pp584 - 586
A new study finds that local homeostatic expansion of conventional
dendritic cells in the spleen is regulated by Fms-related tyrosine
kinase-3 ligand.
Cedric Auffray, Yalin Emre and Frederic Geissmann
doi:10.1038/ni0608-584
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIr0El
Foxos around make B cells tolerable pp586 - 588
B cell tolerance is achieved in part through secondary rearrangements
that replace ('edit') exons encoding autoreactive antigen-receptor
chains. New findings suggest that Foxo transcription factors are
critical regulators of receptor editing by activating the
transcription of recombination-activating genes.
Marta A W Rowh and Craig H Bassing
doi:10.1038/ni0608-586
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIs0Em
Differentiation of human TH-17 cells does require TGF-beta!
pp588 - 590
Three new studies demonstrate that development of human TH-17 cells
requires transforming growth factor-beta and one or more
proinflammatory cytokines, which are the same requirements as for
mouse TH-17 development.
Anne O'Garra, Brigitta Stockinger and Marc Veldhoen
doi:10.1038/ni0608-588
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIt0En
Research Highlights p591
doi:10.1038/ni0608-591
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIu0Eo
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REVIEW
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Protein-glycan interactions in the control of innate and adaptive
immune responses pp593 - 601
Yvette van Kooyk and Gabriel A Rabinovich
doi:10.1038/ni.f.203
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIv0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIw0Eq
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ARTICLES
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Transcription factor Mef2c is required for B cell proliferation and
survival after antigen receptor stimulation pp603 - 612
Peter R Wilker et al.
doi:10.1038/ni.1609
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIx0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIy0Es
Foxo1 directly regulates the transcription of
recombination-activating genes during B cell development
pp613 - 622
Rupesh H Amin and Mark S Schlissel
doi:10.1038/ni.1612
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvIz0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvI10Eg
SLP-65 regulates immunoglobulin light chain gene recombination
through the PI(3)K-PKB-Foxo pathway pp623 - 631
Sebastian Herzog et al.
doi:10.1038/ni.1616
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvI20Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvI30Ei
A critical function for TGF-beta signaling in the development of
natural CD4+CD25+Foxp3+ regulatory T cells pp632 - 640
Yongzhong Liu et al.
doi:10.1038/ni.1607
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvI40Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvI50Ek
The differentiation of human TH-17 cells requires transforming
growth factor-beta and induction of the nuclear receptor
RORgammat pp641 - 649
Nicolas Manel, Derya Unutmaz and Dan R Littman
doi:10.1038/ni.1610
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvI60El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvI70Em
A critical function for transforming growth factor-beta,
interleukin 23 and proinflammatory cytokines in driving and
modulating human TH-17 responses pp650 - 657
Elisabetta Volpe et al.
doi:10.1038/ni.1613
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvI80En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJA0Ex
Scalable signaling mediated by T cell antigen receptor-CD3 ITAMs
ensures effective negative selection and prevents autoimmunity
pp658 - 666
Jeff Holst et al.
doi:10.1038/ni.1611
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJB0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJC0Ez
Restoration of lymphoid organ integrity through the interaction of
lymphoid tissue-inducer cells with stroma of the T cell zone
pp667 - 675
Elke Scandella et al.
doi:10.1038/ni.1605
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJD0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJE0E2
The receptor tyrosine kinase Flt3 is required for dendritic cell
development in peripheral lymphoid tissues pp676 - 683
Claudia Waskow et al.
doi:10.1038/ni.1615
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJF0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJG0E4
Sequential control of Toll-like receptor-dependent responses by
IRAK1 and IRAK2 pp684 - 691
Tatsukata Kawagoe et al.
doi:10.1038/ni.1606
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJH0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJI0E6
----------------------
CORRIGENDUM
----------------------
Corrigendum: Phosphatidylinositol-3-OH kinase and nutrient-sensing
mTOR pathways control T lymphocyte trafficking p692
Linda V Sinclair et al.
doi:10.1038/ni0608-692
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BvJJ0E7
=====================================================================
NATURE IMMUNOLOGY
FOCUS ON NATURAL KILLER CELLS
Natural killer cells influence immune responses to tumors, infections and pregnancy.
Nature Immunology presents a series of specially commissioned articles that focus on natural killer cells and their far-reaching effects on diverse cell types and biological responses. The web focus, free for six months, also includes highlights of recent research
findings, an annotated list of classic articles and links to selected NPG papers pertinent to this field.
For more information visit:
http://ealerts.nature.com/cgi-bin24/DM/y/ekv40Xztnp0HjR0BssN0Eo
Produced with support from Novo Nordisk and Innate Pharma
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