29 May 2008 Volume 453 Number 7195, pp563-696
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Don't miss the Life Sciences Summit Career Fair
Come and meet employers from across New York State at the FREE Life
Sciences Summit Career Fair being held in conjunction with the Life
Sciences Summit on June 5, 2008 at the Hilton hotel, Long Island/Huntington.
Pitch your questions to the event organizers beforehand in a dedicated
forum on Nature Network:
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bugc0EU
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WEB FOCUS: Symbiosis
The enormous technological progress in recent years has made it
possible to investigate the 'simple' one-on-one interactions between
two species as well as defining the associations between complex
microbial communities and humans. The Nature web focus on symbiosis
this week reflects the broad scope of symbiosis research and
demonstrates the similarity of the underlying concepts, which are
independent of the system investigated.
Read the papers online at
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3H0EC
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EDITORIALS
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Who are we? p563
Efforts to catalogue and understand the human microbiome are opening
up a whole new research frontier. But the earlier Human Genome Project
should provide a cautionary lesson about overselling.
doi:10.1038/453563a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3I0ED
Animal tests inescapable pp563-564
The ambitious scope of Europe's chemicals legislation demands some
innovative toxicology.
doi:10.1038/453563b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3J0EE
Linking up development p564
An initiative to link scientists in the poorest nations with
colleagues around the world deserves support.
doi:10.1038/453564a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3K0EF
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RESEARCH HIGHLIGHTS
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Zoology: Pretty good p566
doi:10.1038/453566a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3L0EG
Cell biology: Bean counting p566
doi:10.1038/453566b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3M0EH
Theoretical physics: Better out than in p566
doi:10.1038/453566c
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3N0EI
Genetics: Tiger-mice p566
doi:10.1038/453566d
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3O0EJ
Nanotechnology: Nanozapped p566
doi:10.1038/453566e
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3P0EK
Physical chemistry: Growing up bigger p567
doi:10.1038/453567a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3Q0EL
Genetics: Genes with bottle p567
doi:10.1038/453567b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3R0EM
Geophysics: The heat is on p567
doi:10.1038/453567c
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3S0EN
Genetics: The sweet life p567
doi:10.1038/453567d
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3T0EO
Microbiology: Inner lives p567
doi:10.1038/453567e
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3U0EP
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JOURNAL CLUB
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Journal club p567
Nathan Wolfe
doi:10.1038/453567f
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3V0EQ
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NEWS
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Venerable institute gets a refit pp568-569
Britain's Royal Institution reopens for business.
Matt Brown
doi:10.1038/453568a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3W0ER
Climate anomaly is an artefact pp569
Glitch in the twentieth-century climate record is explained.
Quirin Schiermeier
doi:10.1038/453569a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3X0ES
Genetic testing for everyone pp570-571
Private companies are starting to test customers' DNA for gene
variants linked to an increased risk of conditions such as obesity or
Alzheimer's disease. Helen Pearson looks at whether knowledge really
is power when it comes to disease avoidance.
doi:10.1038/453570a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3Y0ET
France's research agency splits up p573
CNRS is being carved up into separate institutes.
Declan Butler
doi:10.1038/453573a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3Z0EU
The oldest pregnant mum pp575
Devonian fossilized fish contains an embryo.
Carina Dennis
doi:10.1038/453575a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv280Et
Sidelines pp575
Scribbles on the margins of science.
doi:10.1038/453575b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3a0Eb
Phoenix prepares for work after safe landing on Mars pp576
doi:10.1038/453576a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3b0Ec
Norway's first Kavlis take on Nobel prizes pp576
doi:10.1038/453576b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3c0Ed
Plug pulled on stellarator fusion project pp577
doi:10.1038/453577a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3d0Ee
Funding boost for B-cell-based HIV vaccine research pp577
doi:10.1038/453577b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3e0Ef
Japan to allow limited human embryonic cloning pp577
doi:10.1038/453577c
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3f0Eg
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CORRECTION
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Correction pp577
doi:10.1038/453577d
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3g0Eh
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NEWS FEATURES
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Microbiology: The inside story pp578-580
The human body teems with microbes. Asher Mullard looks at the global
efforts to catalogue this vast 'microbiome'.
doi:10.1038/453578a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3h0Ei
Microbiology: Straight from the gut pp581-582
Apoorva Mandavilli meets the surgeons who have a rare opportunity to
watch an ecosystem being established as they transplant guts from one
person to another.
doi:10.1038/453581a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3i0Ej
Origins of Death pp583-585
Programmed cell death is usually seen as the unique prerogative of
plants and animals. So how is it that photosynthetic plankton have
been killing themselves by uncannily similar methods for billions
of years? Nick Lane investigates.
doi:10.1038/453583a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3j0Ek
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CORRESPONDENCE
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Increasing use of stimulants warns of potential abuse p586
James M. Swanson and Nora D. Volkow
doi:10.1038/453586a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3k0El
Costa Rica's biotech project still on track for end of year p586
Antonieta Corrales
doi:10.1038/453586b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3l0Em
A prime problem that even quantum computing can't solve p586
Robert P. Bywater
doi:10.1038/453586c
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3m0En
Analyses support theory of stochastic regulation of fisheries p586
Joe Horwood and John Shepherd
doi:10.1038/453586d
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3n0Eo
If you don't need change, maybe you don't need sex p587
Flemming Ekelund and Regin Ronn
doi:10.1038/453587a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3o0Ep
Ancient asexuals: darwinulids not exposed p587
Koen Martens and Isa Schon
doi:10.1038/453587b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3p0Eq
Time to break the silence around virtual-water imports p587
Junguo Liu and H. H. G. Savenije
doi:10.1038/453587c
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3q0Er
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COMMENTARY
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Retiring retirement pp588-590
The United States and Australia have done away with this archaic
practice.
Peter Lawrence says it is time to end mandatory retirement worldwide.
doi:10.1038/453588a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3r0Es
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BOOKS AND ARTS
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Vivisectionists strike back pp592-593
The complex issue of animal experimentation should not be dumbed down
in the face of violent opposition, argues Andrew Read, reviewing a
new polemic on the US experience.
Andrew Read reviews The Animal Research War by P. Michael Conn
and James V. Parker
doi:10.1038/453592a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3s0Et
Moralist, meet scientist pp593-594
Nick Bostrom reviews Experiments in Ethics by Kwame Anthony Appiah
doi:10.1038/453593a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3t0Eu
Music grown from garden weeds p594
Colin Martin reviews Umbel Ballits: Dylan Martorell
doi:10.1038/453594a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3u0Ev
Reimagining the Royal Institution p595
The Royal Institution of Great Britain in London reopens this week
after two years of renovations. Architect Terry Farrell explains how
he rethought the institution's ethos.
Matt Brown
doi:10.1038/453595a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3v0Ew
Seeing the smaller picture p596
Advances in imaging techniques are transforming microbiology into a
science that is rich in visual imagery, harking back to biology's
pre-darwinian origins.
Martin Kemp
doi:10.1038/453596a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3w0Ex
Hidden treasures: Bologna's Poggi Palace p597
The exquisite obstetrics models on show in an Italian palace hint at
its former multidisciplinary glories. Alison Abbott investigates the
museum that was once home to a revolutionary institute of sciences.
doi:10.1038/453597a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3x0Ey
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ESSAY
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Science & Music: The neural roots of music pp598-599
Laurel Trainor explains how the emotional power of music depends on
the structure of the ear, and on our basic encoding of information.
doi:10.1038/453598a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3y0Ez
----------------------
NEWS AND VIEWS
----------------------
Climate Change: Hot questions of temperature bias pp601-602
An unseen measurement bias has been identified in global records of
sea surface temperature. The discrepancy will need correction, but
will not affect conclusions about an overall warming trend.
Chris E. Forest and Richard W. Reynolds
doi:10.1038/453601a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv3z0E1
Immunology: Soothing intestinal sugars pp602-604
The gut is a new frontier in microbiology, offering many opportunities
for innovative investigation. The finding of one such study is that
intestinal inflammation in mice can be tamed by bacterial sugars.
Marika C. Kullberg
doi:10.1038/453602a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv310En
Cancer: Whispering sweet somethings pp604-605
That genetic mutations contribute to cancer is undisputed. What now
emerges is that a cancer cell's microenvironment has a much stronger
hand in the course a cancer takes than previously thought.
Thea Tlsty
doi:10.1038/453604a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv320Eo
Evolutionary Biology: Sex ratios writ small pp605-606
The evolutionary theory of sex ratios should apply to all creatures,
both great and small. Experimental studies of the proportions of male
to female sex cells of malaria parasites deliver cheering results.
Jos. J. Schall
doi:10.1038/453605a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv330Ep
Mathematical Physics: Packings close and loose pp606-607
What determines how grains such as sand pack together to fill a space?
A thoroughgoing investigation of how geometry and friction interact in
such systems is a step towards a more general understanding.
Francesco Zamponi
doi:10.1038/453606a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv340Eq
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ARTICLES
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Sex ratio adjustment and kin discrimination in malaria parasites pp609-614
Malaria parasites must reproduce sexually to transmit to vectors, but
very little is understood about their reproductive strategies. This
paper details that malaria parasites adjust their sex ratios in
response to unrelated conspecifics, as predicted by evolutionary
theory.
Sarah E. Reece, Damien R. Drew and Andy Gardner
doi:10.1038/nature06954
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv350Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv360Es
The genomic and epidemiological dynamics of human influenza A virus p615-619
Current debate on the selection of strains for the influenza vaccine
highlights the need for epidemiological understanding of human
influenza A virus. This paper analyses genomic sequences from global
viral isolates, and hypothesizes that the virus follows a 'sink source'
model, where new lineages keep arising from some areas and dying out
in other areas.
Andrew Rambaut, Oliver G. Pybus, Martha I. Nelson, Cecile Viboud,
Jeffery K. Taubenberger & Edward C. Holmes
doi:10.1038/nature06945
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv370Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv380Eu
A microbial symbiosis factor prevents intestinal inflammatory disease pp620-625
Bacteroides fragilis is a member of the human intestinal microbiota.
It is reported that a single molecule produced by this bacterium,
polysaccharide A, can suppress the intestinal inflammatory response
and thus protect from experimental colitis.
Sarkis K. Mazmanian, June L. Round and Dennis L. Kasper
doi:10.1038/nature07008
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4A0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4B0E6
----------------------
LETTERS
----------------------
An infrared ring around the magnetar SGR 1900+14 pp626-628
This paper reports the discovery of an infrared elliptical ring or
shell surrounding the magnetar SGR 1900+14. It is suggested that a
dust free cavity was produced in the magnetar environment by the giant
flare emitted by the source in August 1998 and concludes that SGR
1900+14 is unambiguously associated with a cluster of massive stars.
S. Wachter et al.
doi:10.1038/nature06987
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4C0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4D0E8
A phase diagram for jammed matter pp629-632
This paper presents a statistical description of jammed states in
which random close packing can be interpreted as the ground state of
the ensemble of jammed matter. The approach demonstrates that random
packings of hard spheres in three dimensions cannot exceed a limit of
~ 63.4 per cent. A phase diagram provides a common view of the hard
sphere packing problem and illuminates various data, including the
random loose packing state.
Chaoming Song, Ping Wang and Hernan A. Makse
doi:10.1038/nature06981
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4E0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4F0EB
Quantum phase transition in a single-molecule quantum dot pp633-637
In contrast to bulk materials with complex electronic structure,
artificial nanoscale devices could offer a new and simpler vista to
the understanding of quantum phase transitions. This paper
demonstrates this possibility in a single molecule quantum dot, where
the quantum phase transition consists of a crossing of singlet and
triplet electron spin states at zero magnetic field. The quantum dot
is operated in the Kondo regime, where an uncompensated electron spin
on the quantum dot is screened by metallic electrodes. This strong
electronic coupling between the quantum dot and the metallic contacts
provides the necessary strong electron correlations to observe quantum
critical behaviour.
Nicolas Roch et al.
doi:10.1038/nature06930
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4G0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4H0ED
Anatase TiO2 single crystals with a large percentage of reactive facets pp638-641
Extensive first principles calculations carried out show that the
relative stability of facets of anatase can be switched by terminating
the surfaces with fluorine. It is then demonstrated that uniform
anatase single crystals with a high percentage of {001} facets can be
generated using hydrofluoric acid as a structure directing agent.
Subsequently, surfaces can be freed of fluorine using a simple heat
treatment.
Hua Gui Yang et al.
doi:10.1038/nature06964
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4I0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4J0EF
Snowball Earth termination by destabilization of equatorial permafrost
methane clathrate pp642-645
This paper reports the broadest range of oxygen isotope values yet
measured in marine sediments in methane seeps in Marinoan deglacial
sediments underlying a thin interval of carbonate; these deposits are
thought to record widespread oceanic carbonate precipitation during
postglacial sea level rise. The range of values is likely the result
of mixing between ice sheet derived meteoric waters and clathrate
derived fluids during the flushing and destabilization of a clathrate
field by glacial meltwater.
Martin Kennedy, David Mrofka and Chris von der Borch
doi:10.1038/nature06961
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4K0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4L0EH
A large discontinuity in the mid-twentieth century in observed
global-mean surface temperature pp646-649
A pronounced discontinuity in the record of global sea-surface
temperatures has been identified. The marked drop in global sea
surface temperature in 1945 coincides with a significant change in
the shipboard instrumentation that was used to collect the source data
at that time. This discontinuity is 40% as large as the century-long
upward trend in temperatures, so correcting for it is likely to change
the overall record and its interpretation, particularly in the middle
20th century.
David W. J. Thompson, John J. Kennedy, John M. Wallace and Phil D. Jones
doi:10.1038/nature06982
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4M0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4N0EJ
Live birth in the Devonian period pp650-652
The placoderms were a large and diverse group of distinctive fossil
fishes, now thought to be the most primitive known vertebrates with
jaws. Placoderm fossils from the Late Devonian Gogo Formation of
Australia (about 380 million years ago) show a new species of
placoderm, the specimen preserved with a single, large embryo
connected to the adult by a mineralized remnant of an umbilical cord.
John A. Long, Kate Trinajstic, Gavin C. Young and Tim Senden
doi:10.1038/nature06966
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4O0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4P0EL
Abundance and diversity of microbial life in ocean crust pp653-656
Little is known about microbial life in the basaltic ocean crust, but
this paper details a survey from two sites that reveals unexpected
microbial abundance and diversity.
Cara M. Santelli et al.
doi:10.1038/nature06899
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4Q0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4R0EN
Functional genomic screen reveals genes involved in lipid-droplet
formation and utilization p657-661
Eukaryotic cells store neutral lipids in cytoplasmic lipid droplets.
Processes regulating the formation of these organelles are at present
unknown. A genome wide RNAi screen in Drosophila cells identifies
genes involved in lipid droplet formation and utilization, finding
that 1% of all genes are involved in these processes. This study will
lead to an understanding of human diseases involving excessive lipid
storage.
Yi Guo et al.
doi:10.1038/nature06928
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4S0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4T0EP
Angiogenesis selectively requires the p110alpha isoform of PI3K to
control endothelial cell migration p662-666
The p110alpha isoform of phosphoinositide 3 kinase has a critical role
in angiogenesis. In particular, it is needed to mediate the migration
of endothelial cells downstream of VEGF receptor activation, acting
upstream of RhoA. The results suggest that pharmacological inhibition
of the p110alpha isoform may be useful in anti angiogenesis therapy of
cancer.
Mariona Graupera et al.
doi:10.1038/nature06892
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4U0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4V0ER
Rapid cloning of high-affinity human monoclonal antibodies against
influenza virus p667-671
This paper demonstrates the efficient generation of high-affinity
human monoclonal antibodies after booster vaccination with a
conventional influenza vaccine.
Jens Wrammert et al.
doi:10.1038/nature06890
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4W0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4X0ET
CLEC5A is critical for dengue-virus-induced lethal disease p672-676
Dengue hemorrhagic fever is transmitted by the bite of a mosquito
infected with dengue virus. The dengue virus interacts with the C type
lectin CLEC45A. The interaction promotes the production of pro
inflammatory cytokines and contributes to lethal disease in a mouse
model.
Szu-Ting Chen et al.
doi:10.1038/nature07013
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4Y0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4Z0EV
Single-stranded DNA-binding protein hSSB1 is critical for genomic
stability p677-681
Single stranded DNA (ssDNA) in a cell is highly prone to degradation,
so cells shield ssDNA from nucleases by coating it with single strand
DNA binding proteins (SSBs). In eukaryotes, the canonical SSB is a
heterotrimer known as RPA. This paper characterizes a second SSB from
human cells, which is called hSSB1. Unlike RPA, hSSB1 is a single
protein. Its primary function seems to be in the cellular response to
DNA damage.
Derek J. Richard et al.
doi:10.1038/nature06883
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4a0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4b0Ed
HP1-beta mobilization promotes chromatin changes that initiate the DNA
damage response p682-686
A phosphorylation step carried out by casein kinase 2, coupled with
mobilization of the chromatin factor HP1-beta, helps to initiate the
DNA damage response by promoting phosphorylation of histone H2AX.
Nabieh Ayoub, Anand D. Jeyasekharan, Juan A. Bernal
& Ashok R. Venkitaraman
doi:10.1038/nature06875
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4c0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4d0Ef
----------------------
TECHNOLOGY FEATURES
----------------------
Metagenomics: Exploring unseen communities pp687-690
Advances in sequencing technology and tools for analysis are allowing
researchers to unravel the environmental diversity of microbes faster
and in greater detail than ever before. Nathan Blow reports.
doi:10.1038/453687a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4e0Eg
Metagenomics: Benchmarks and standards p687
doi:10.1038/453687b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4f0Eh
Metagenomics: The human environment p689
doi:10.1038/453689a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4g0Ei
Metagenomics: Table of suppliers pp691-692
doi:10.1038/453691a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4h0Ej
----------------------
NATUREJOBS
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Prospect
Prospects p693
Contemplating the contributions of, and discrimination against,
scientists who are senior citizens.
Gene Russo
doi:10.1038/nj7195-693a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4i0Ek
Career View
Larry McKinney, director, Harte Research Institute for Gulf of Mexico
Studies, Texas A&M University, Corpus Christi, Texas p694
Oceanographer heads to an institute in the Gulf of Mexico to look
after 'America's third coast.
Virginia Gewin
doi:10.1038/nj7195-694a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4j0El
The softer side of science p694
Mastering soft skills helps master one's career.
Bernhard Sabel
doi:10.1038/nj7195-694b
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4k0Em
Singapore's happiest person p694
Aspiring to emulate Singapore's happiest person.
Amanda Goh
doi:10.1038/nj7195-694c
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4l0En
----------------------
FUTURES
----------------------
Morpho sanguinalis p696
Beauty is in the eye of the beholder.
Julie Jansen
doi:10.1038/453696a
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4m0Eo
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ADVANCE ONLINE PUBLICATION
----------------------
28 May 2008
Articles
Dissecting direct reprogramming through integrative genomic analysis
Tarjei S. Mikkelsen et al.
doi:10.1038/nature07056
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4n0Ep
Letters
Magnetic resonance imaging of pH in vivo using hyperpolarized
13C-labelled bicarbonate
Ferdia A. Gallagher et al.
doi:10.1038/nature07017
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4o0Eq
Two-band superconductivity in LaFeAsO0.89F0.11 at very high magnetic fields
F. Hunte et al.
doi:10.1038/nature07058
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4p0Er
Analysis of a spatial orientation memory in Drosophila
Kirsa Neuser, Tilman Triphan, Markus Mronz, Burkhard Poeck
& Roland Strauss
doi:10.1038/nature07003
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4q0Es
Cortical control of a prosthetic arm for self-feeding
Meel Velliste, Sagi Perel, M. Chance Spalding, Andrew S. Whitford
& Andrew B. Schwartz
doi:10.1038/nature06996
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4r0Et
Induced ncRNAs allosterically modify RNA-binding proteins in cis to
inhibit transcription
Xiangting Wang et al.
doi:10.1038/nature06992
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4s0Eu
Hydrogen sulphide release to surface waters at the
Precambrian/Cambrian boundary
Martin Wille, Thomas F. Nägler, Bernd Lehmann, Stefan Schröder
& Jan D. Kramers
doi:10.1038/nature07072
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4t0Ev
Magnetic order close to superconductivity in the iron-based layered
LaO1-xFxFeAs systems
Clarina de la Cruz et al.
doi:10.1038/nature07057
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4u0Ew
25 May 2008
Letters
Superconductivity at 43 K in SmFeAsO1-xFx
X. H. Chen, T. Wu, G. Wu, R. H. Liu, H. Chen & D. F. Fang
doi:10.1038/nature07045
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4v0Ex
Formation of accumbens GluR2-lacking AMPA receptors mediates
incubation of cocaine craving
Kelly L. Conrad et al.
doi:10.1038/nature06995
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4w0Ey
Modest stabilization by most hydrogen-bonded side-chain interactions
in membrane proteins
Nathan HyunJoong Joh et al.
doi:10.1038/nature06977
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4x0Ez
Imaging the biogenesis of individual HIV-1 virions in live cells
Nolwenn Jouvenet, Paul D. Bieniasz & Sanford M. Simon
doi:10.1038/nature06998
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4y0E1
Structural basis for EGFR ligand sequestration by Argos
Daryl E. Klein, Steven E. Stayrook, Fumin Shi, Kartik Narayan
& Mark A. Lemmon
doi:10.1038/nature06978
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv4z0E2
Synergistic response to oncogenic mutations defines gene class
critical to cancer phenotype
Helene R. McMurray et al.
doi:10.1038/nature06973
http://ealerts.nature.com/cgi-bin24/DM/y/elBX0Xztnp0HjB0Bv410Eo
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