22 May 2008 Volume 453 Number 7194, pp427-562
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EDITORIALS
----------------------
Two symbols, one solution p427
Saving a handful of photogenic species -- or iconic rainforests
-- is no substitute for a comprehensive plan that deals with climate,
economics and the environment together.
doi:10.1038/453427a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVo0Ep
Trials on trial pp427-428
The Food and Drug Administration should rethink its rejection of the
Declaration of Helsinki.
doi:10.1038/453427b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVp0Eq
The Universe at home p428
The digitization of astronomy is a transformation and a delight for
both amateurs and professionals.
doi:10.1038/453428a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVq0Er
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RESEARCH HIGHLIGHTS
----------------------
Geology: Fjord focus p430
doi:10.1038/453430a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVr0Es
Microscopy: Enter, the nanoscope p430
doi:10.1038/453430b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVs0Et
Zoology: Less than slothful p430
doi:10.1038/453430c
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVt0Eu
Chemistry: Up close and structural p430
doi:10.1038/453430d
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVu0Ev
Molecular biology: AAAAnswers p430
doi:10.1038/453430e
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVv0Ew
Population biology: Keep off the grass pp430-431
doi:10.1038/453430f
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVw0Ex
Genetics: Self defence p431
doi:10.1038/453431a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVx0Ey
Inorganic chemistry: Towards a noble line p431
doi:10.1038/453431b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVy0Ez
Plant science: Monster fruit p431
doi:10.1038/453431c
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvVz0E1
Human reproduction: Fertile tones p431
doi:10.1038/453431d
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvV10En
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JOURNAL CLUB
----------------------
Journal club p431
Andrea Manica
doi:10.1038/453431e
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvV20Eo
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NEWS
----------------------
Polar bear numbers set to fall pp432-433
Climate-change icon gains 'threatened' status from United States.
Rachel Courtland
doi:10.1038/453432a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvV30Ep
Whales are on the rise p433
Humpback population shows signs of recovery.
Rex Dalton
doi:10.1038/453433a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvV40Eq
Meeting urges scientists into politics p434
Advice on how to ditch the lab for elected office.
Gene Russo
doi:10.1038/453434a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvV50Er
Sterile mosquitoes near take-off p435
Malaysia prepares to fight dengue with GM insects.
David Cyranoski
doi:10.1038/453435a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvV60Es
Sidelines p435
Scribbles on the margins of science.
doi:10.1038/453435b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvV70Et
No star left behind p437
An open-source software project could help unify every existing
astronomical image into a single data set.
Eric Hand
doi:10.1038/453437a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvV80Eu
Q&A
Poland tackles science like a business p438
Science minister Barbara Kudrycka talks reform.
doi:10.1038/453438a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWA0E5
US plans more primate research p439
HIV and clinical research drive up demand for experiments.
Erika Check Hayden
doi:10.1038/453439a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWB0E6
Parkinson's researchers join forces with gene tester p441
doi:10.1038/453441a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWC0E7
Europe considers plans for manned spacecraft p441
doi:10.1038/453441b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWD0E8
British parliament backs hybrid embryos p441
doi:10.1038/453441c
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWE0EA
Cosmic dust hides true brightness of Universe p441
doi:10.1038/453441d
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWF0EB
NOAA chief backs bid for climate-change agency p441
doi:10.1038/453441e
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWG0EC
Cancer forces Tasmanian devil onto endangered list p441
doi:10.1038/453441f
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWH0ED
----------------------
NEWS FEATURES
----------------------
Eyewitness identification: Line-ups on trial pp442-444
A major, but flawed, study of identity parades, or line-ups, has set
science and the police at odds. Laura Spinney investigates.
doi:10.1038/453442a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWI0EE
Language: The language barrier pp446-448
Some researchers think that the evolution of languages can be
understood by treating them like genomes — but many linguists don't
want to hear about it. Emma Marris reports.
doi:10.1038/453446a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWJ0EF
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CORRESPONDENCE
----------------------
Acceptance of peer review will free Italy's research slaves p449
Ignazio R. Marino
doi:10.1038/453449a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWK0EG
Mimicking photosynthesis, but just the best bits p449
A. William Rutherford and Thomas A. Moore
doi:10.1038/453449b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWL0EH
Standard identifier could mobilize data and free time pp449-450
Dave Roberts and Vishwas Chavan
doi:10.1038/453449c
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWM0EI
Name variations can hit citation rankings p450
Biji T. Kurien
doi:10.1038/453450a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWN0EJ
Names: dropped to avoid prejudice, now useful again p450
Prabhu B. Patil
doi:10.1038/453450b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWO0EK
Open-access more harm than good in developing world p450
Raghavendra Gadagkar
doi:10.1038/453450c
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWP0EL
A 3D revolution in communicating science p450
Jerome Murienne, Alexander Ziegler and Bernhard Ruthensteiner
doi:10.1038/453450d
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWQ0EM
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BOOKS AND ARTS
----------------------
Security in an uncertain world pp451-452
Biological protection systems that have evolved over billions of years
could be the key to strengthening national defences against unforeseen
threats. Jessica Flack reviews Natural Security: A Darwinian Approach
to a Dangerous World
doi:10.1038/453451a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWR0EN
Genetic medicine at the bedside pp452-453
Hugh Young Rienhoff Jr reviews Heredity and Hope: The Case for Genetic
Screening by Ruth Schwartz Cowan
doi:10.1038/453452a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWS0EO
A rough guide to Titan pp453-454
Henry Roe reviews Titan Unveiled: Saturn's Mysterious Moon Explored
by Ralph Lorenz and Jacqueline Mitton
doi:10.1038/453453a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWT0EP
Culture dish p453
doi:10.1038/453453b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWU0EQ
How science hit the small screen pp454-455
Colin Martin reviews Films of Fact
doi:10.1038/453454a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWV0ER
Super clothes with special powers p455
Josie Glausiusz reviews Superheroes: Fashion and Fantasy
doi:10.1038/453455a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWW0ES
----------------------
ESSAY
----------------------
Science & Music: Lost in music pp456-457
Music provides unique opportunities for understanding both brain and
culture. But globalization means that time is running out, warns
David Huron, for the quest to encounter the range of possible musical
minds.
doi:10.1038/453456a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWX0ET
----------------------
NEWS AND VIEWS
----------------------
Laser Technology: Over the rainbow pp459-460
Many laser diodes provide light in only a limited range of the visible
spectrum. A hybrid laser made out of plastic, driven by a high-power
light-emitting diode, looks to offer a more flexible approach.
John M. Lupton
doi:10.1038/453459a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWY0EU
Cell Biology: Two hands for degradation pp460-461
Living cells must do away with regulatory proteins that are not
needed. News comes of a considerable advance in understanding how the
main agent of destruction, the proteasome, catches its targets.
Yasushi Saeki and Keiji Tanaka
doi:10.1038/453460a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWZ0EV
Biophysics: Cells get in shape for a crawl pp461-462
A cell's shape changes as it moves along a surface. The
forward-thinking cytoskeletal elements are all for progress, but the
conservative cell membrane keeps them under control by physically
opposing their movement.
Jason M. Haugh
doi:10.1038/453461a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWa0Ec
Astronomy: Supernova bursts onto the scene pp462-463
The stellar explosions known as supernovae are spectacular but common
cosmic events. A satellite telescope's chance observation of a burst
of X-ray light might be the first record of a supernova's earliest
minutes.
Roger Chevalier
doi:10.1038/453462a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWb0Ed
Structural Biology: Snapshots of DNA repair pp463-466
In recombinational DNA repair, nearly identical sequences in
chromosomes are found and swapped. Structures of the RecA-DNA
complexes involved provide insight into the mechanism and energetics
of this universal process.
Stephen C. Kowalczykowski
doi:10.1038/453463a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWc0Ee
50 & 100 years ago p465
doi:10.1038/453465a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWd0Ef
Cell Biology: Viruses in camouflage pp466-467
The vaccinia virus acts like a Trojan Horse to enter its host cells:
it envelops itself in the membrane of a dying cell, and is then taken
up by healthy cells.
Kirsten Sandvig and Bo van Deurs
doi:10.1038/453466a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWe0Eg
Correction p467
doi:10.1038/453467a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWf0Eh
=====================================================================
Stem Cell Sciences
==================
Culticell iSTEM is the new serum and feeder-free media available from
SCS to maintain stem cells in their ground state.
By blocking exogenous signals (to pERK) rather than providing exogenous
signals to STAT3, this breakthrough may represent the way to culture
authentic ES cells of great purity. Click the link below to read more:
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWg0Ei
=====================================================================
----------------------
ARTICLES
----------------------
An extremely luminous X-ray outburst at the birth of a supernova pp469-474
Supernovae are usually discovered through their 'delayed' light, which
becomes visible some hours after the actual event. Now
Soderberg et al. report the discovery of a supernova at the time of
the explosion, marked by an extremely luminous X-ray outburst.
A. M. Soderberg et al.
doi:10.1038/nature06997
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWh0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWi0Ek
Mechanism of shape determination in motile cells pp475-480
Theriot and colleagues use fish keratocytes to study variations in
cell shape that occur during motility. They report a model that
quantitatively accounts for their experimental measurements and
provides an explanation for the observed morphology of motile cells.
Kinneret Keren et al.
doi:10.1038/nature06952
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWj0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWk0Em
Proteasome subunit Rpn13 is a novel ubiquitin receptor pp481-488
The 26S proteasome is a multisubunit complex that selectively degrades
ubiquitin conjugated proteins. Two studies (this Article and the
Letter Dikic doi:10.1038/nature06924) show that a known component of
the proteasome, Rpn13, functions as a novel ubiquitin binding
receptor, and structural studies reveal a novel mode of ubiquitin
recognition. Rpn13 is also a receptor for a deubiquitinating enzyme,
suggesting a linkage between ubiquitin chain recognition and
disassembly.
Koraljka Husnjak et al.
doi:10.1038/nature06926
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWl0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWm0Eo
Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures p489
DNA damage can be reversed by the homologous pairing of an undamaged
DNA with a damaged DNA. Pavletich and colleagues report the structure
of the E. coli strand-exchange protein, RecA, bound to DNA, offering
new insight into the process by which homologous DNAs are paired.
Zhucheng Chen, Haijuan Yang and Nikola P. Pavletich
doi:10.1038/nature06971
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWn0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWo0Eq
----------------------
LETTERS
----------------------
A Levy flight for light pp495-498
An extension of the concept of a random walk is the Levy flight, in
which the moving entity can occasionally take unusually large steps.
Pierre Barthelemy and colleagues show how such behaviour can be
engineered into an optical material.
Pierre Barthelemy, Jacopo Bertolotti and Diederik S. Wiersma
doi:10.1038/nature06948
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWp0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWq0Es
Gelation of particles with short-range attraction pp499-503
Solid-like behaviour arises in a wide variety of complex fluids upon
gelation -- aggregation of particles to form mesoscopic clusters and
networks. The authors show that gelation of spherical particles with
isotropic, short-range attractions is initiated by spinodal
decomposition.
Peter J. Lu et al.
doi:10.1038/nature06931
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWr0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWs0Eu
Triple oxygen isotope evidence for elevated CO2 levels after a
Neoproterozoic glaciation pp504-506
Historical information about the atmosphere is scarce. Huiming Bao and
colleagues show that the triple oxygen isotope composition of sulphate
from ancient evaporites and barites exhibits variable negative
oxygen-17 isotope anomalies over the past 750 million years.
Huiming Bao, J. R. Lyons and Chuanming Zhou
doi:10.1038/nature06959
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWt0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWu0Ew
Seismogenic lavas and explosive eruption forecasting pp507-510
Lavallee and colleagues have performed rheological experiments on the
lavas involved in volcanic dome-building eruptions. They find that
these dome lavas are seismogenic, the nature of the seismicity
changing across the ductile-to-brittle transition, and conclude that
monitoring such magma seismicity may lead to improved forecasting for
some volcanic eruptions.
Y. Lavallee et al.
doi:10.1038/nature06980
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWv0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWw0Ey
Evidence for seismogenic fracture of silicic magma pp511-514
Tuffen and colleagues present experiments in which high-temperature
silica-rich magmas are deformed under simulated volcanic conditions.
Acoustic emissions recorded during the experiments indicate that
seismogenic rupture may occur in both crystal-rich and crystal-free
silicic magmas at eruptive temperatures, extending the range of known
conditions for seismogenic faulting.
Hugh Tuffen, Rosanna Smith and Peter R. Sammonds
doi:10.1038/nature06989
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWx0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWy0E1
A stem batrachian from the Early Permian of Texas and the origin of
frogs and salamanders pp515-518
Anderson and colleagues describe a fossil amphibian from the Early
Permian of Texas that has the chassis of a temnospondyl but with the
addition of many features seen in modern frogs, toads and salamanders.
A phylogenetic analysis splits modern Amphibia into two groups, with
frogs, toads and salamanders related to temnospondyls, and caecilians
to leopspndyls.
Jason S. Anderson et al.
doi:10.1038/nature06865
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvWz0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvW10Eo
The ground state of embryonic stem cell self-renewal pp519-523
Smith and colleagues show that embryonic stem cell self-renewal does
not rely on extrinsic instruction, and can be enabled by the
elimination of factors that induce differentiation and by inhibition
of glycogen synthase kinase 3. They interpret the data as showing the
ground state of the embryonic stem cell in the absence of extrinsic
instruction is self renewal.
Qi-Long Ying et al.
doi:10.1038/nature06968
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvW20Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvW30Eq
Human cardiovascular progenitor cells develop from a KDR+
embryonic-stem-cell-derived population p524
Keller and colleagues report a method for differentiation and
isolation of one of the earliest human cardiac progenitors from human
ES cells. They show that these cardiac progenitors can form cardiac,
endothelial and vascular smooth muscle in vivo and in vitro, and can
form a population of contracting cardiomyocytes when plated in culture.
Lei Yang et al.
doi:10.1038/nature06894
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvW40Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvW50Es
Multi-genetic events collaboratively contribute to Pten-null leukaemia
stem-cell formation p529
The loss of the Pten tumour suppressor in haematopoietic stem cells
can lead to acute T lymphoblastic leukemia. This study illustrates how
multi-genetic alterations can dictate hyperproliferative disorders and
the progression to cancer.
Wei Guo et al.
doi:10.1038/nature06933
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvW60Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvW70Eu
Pseudogene-derived small interfering RNAs regulate gene expression in
mouse oocytes p534
Over evolutionary time genes can undergo duplication, and may
accumulate mutations that render them non-functional pseudogenes,
which are thought to be uninteresting. This study (and that of the
group of Sasaki) shows that pseudogenes can in fact influence gene
expression.
Oliver H. Tam et al.
doi:10.1038/nature06904
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvW80Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXA0E6
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in
mouse oocytes p539
Over evolutionary time genes can undergo duplication, and may
accumulate mutations that render them non-functional pseudogenes,
which are thought to be uninteresting. This study (and that of the
group of Hannon) shows that pseudogenes can in fact influence gene
expression.
Toshiaki Watanabe et al.
doi:10.1038/nature06908
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXB0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXC0E8
Transcriptome-wide noise controls lineage choice in mammalian
progenitor cells pp544-547
Even in clonal populations of cells, there is significant phenotypic
variation from cell to cell: Huang and colleagues analyse the
behaviour of an 'outlier', which had very high expressions of the stem
cell marker Sca-1, and conclude that clonal heterogeneity of gene
expression level is a manifestation of metastable states of a slowly
fluctuating transcriptome. These fluctuations may govern the
reversible, stochastic priming of multipotent progenitor cells in cell
fate decision. (See Nature Reports Stem Cells).
Hannah H. Chang et al.
doi:10.1038/nature06965
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXD0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXE0EB
Ubiquitin docking at the proteasome through a novel pleckstrin-homology
domain interaction pp548-552
The 26S proteasome is a multisubunit complex that selectively degrades
ubiquitin conjugated proteins. Two studies (this Letter and the
Article Dikic doi:10.1038/nature06926) show that a known component of
the proteasome, Rpn13, functions as a novel ubiquitin binding
receptor, and structural studies reveal a novel mode of ubiquitin
recognition. Rpn13 is also a receptor for a deubiquitinating enzyme,
suggesting a linkage between ubiquitin chain recognition and
disassembly.
Patrick Schreiner et al.
doi:10.1038/nature06924
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXF0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXG0ED
A novel route for ATP acquisition by the remnant mitochondria of
Encephalitozoon cuniculi p553
The parasite Encephalitozoon cuniculi contains mitosomes instead of
functional mitochondria. Although mitochondrial carrier proteins are
known to be responsible for ATP transport from the mitochondria to the
cytosol, Hirt et al. now show this process to be reversed in
E. cuniculi, where ATP appears to be transported from the cytosol to
the organelle.
Anastasios D. Tsaousis, Edmund R. S. Kunji, Alina V. Goldberg,
John M. Lucocq, Robert P. Hirt & T. Martin Embley
doi:10.1038/nature06903
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXH0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXI0EF
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p557
Energy-related jobs could be on the rise for years to come.
Paul Smaglik
doi:10.1038/nj7194-557a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXJ0EG
Region
Westernizing Eastern-bloc science p558
Scientists in newer member countries are learning how to use what the
European Union offers.
Quirin Schiermeier
doi:10.1038/nj7194-558a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXK0EH
Career View
Frank Torti, chief scientist, US Food and Drug Administration p560
New FDA science chief faces serious challenges.
Virginia Gewin
doi:10.1038/nj7194-560a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXL0EI
Upping student numbers and diversity p560
Undergraduate research awardees emphasize diversity.
Virginia Gewin
doi:10.1038/nj7194-560b
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXM0EJ
An impassive observation p560
An impassioned observer.
Aliza le Roux
doi:10.1038/nj7194-560c
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXN0EK
----------------------
FUTURES
----------------------
The Neanderthal correlation p562
A question of breeding.
Jeff Hecht
doi:10.1038/453562a
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXO0EL
----------------------
ADVANCE ONLINE PUBLICATION
----------------------
21 May 2008
Crucial role for the Nalp3 inflammasome in the immunostimulatory
properties of aluminium adjuvants
Stephanie C. Eisenbarth et al.
doi:10.1038/nature06939
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXP0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXQ0EN
A phosphatase cascade by which rewarding stimuli control nucleosomal response
Alexandre Stipanovich et al.
doi:10.1038/nature06994
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXR0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXS0EP
Structural basis for the regulated protease and chaperone function of DegP
Tobias Krojer et al.
doi:10.1038/nature07004
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXT0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXU0ER
CLEC5A is critical for dengue-virus-induced lethal disease
Szu-Ting Chen et al.
doi:10.1038/nature07013
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXV0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXW0ET
18 May 2008
Huntington's disease: Genetics lends a hand
A monkey model of Huntington's disease created by gene transfer is
only a work in progress. But as a technological feat it offers great
promise for fathoming this devastating condition.
Stephane Palfi and Bechir Jarraya
doi:10.1038/nature06365
http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXX0EU
Towards a transgenic model of Huntington's disease in a non-human primate
Shang-Hsun Yang et al.
doi:10.1038/nature06975
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXY0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXZ0EW
Dynamic repertoire of a eukaryotic transcriptome surveyed at
single-nucleotide resolution
Brian T. Wilhelm et al.
doi:10.1038/nature07002
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXa0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekzv0Xztnp0HjB0BvXb0Ee
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