15 May 2008 Volume 453 Number 7193, pp257-426
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Nature Insight Regenerative Medicine
Humans lack the ability to regenerate many of our organs, and even
tissues like skin and liver which can regenerate eventually succumb
to the ravages of ageing. This Insight explores the science of
regeneration as well as the barriers to applying this science to
treating patients.
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WEB FOCUS: EPICA Dome C
The record of atmospheric carbon dioxide and methane concentrations is
extended by two complete glacial cycles in two papers in Nature this
week. The new data are from the lowest 200 metres of the EPICA Dome
C ice core in Antarctica and take our atmospheric knowledge back to
800,000 years ago.
Access the Web Focus online.
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EDITORIALS
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The next big climate challenge p257
Governments should work together to build the supercomputers needed
for future predictions that can capture the detail required to
inform policy.
doi:10.1038/453257a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3h0ER
Stuck in the mud p258
The Environmental Protection Agency must gather data on the toxicity
of spreading sewage sludge.
doi:10.1038/453258a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3i0ES
Negative results p258
Retracted papers require a thorough explanation of what went wrong in
the experiments.
doi:10.1038/453258b
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3j0ET
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RESEARCH HIGHLIGHTS
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Marine ecology: Deep-sea cheetahs p260
doi:10.1038/453260a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3k0EU
Neuroscience: Hearing what and where p260
doi:10.1038/453260b
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3l0EV
Palaeoclimate: Methane didn't act alone p260
doi:10.1038/453260c
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3m0EW
Geoscience: The dust settles p260
doi:10.1038/453260d
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3n0EX
Quantum optics: Open the box p260
doi:10.1038/453260e
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3o0EY
Neurobiology: The heart in the head pp260-261
doi:10.1038/453260f
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3p0EZ
Astronomy: A galaxy far, far away p261
doi:10.1038/453261a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3q0Ea
Ecology: Hand-me-down bacteria p261
doi:10.1038/453261b
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3r0Eb
Ecology: Hot chicks p261
doi:10.1038/453261c
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3s0Ec
Chemistry: Disulphide dichotomies p261
doi:10.1038/453261d
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3t0Ed
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JOURNAL CLUB
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Journal club p261
Carl Bergstrom
doi:10.1038/453261e
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3u0Ee
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NEWS
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Raking through sludge exposes a stink pp262-263
Environmental Protection Agency scientists accused of fabricating data
about health effects of fertilizer.
Jeff Tollefson
doi:10.1038/453262a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3v0Ef
German universities bow to public pressure over GM crops p263
Plug is pulled on maize research.
Quirin Schiermeier
doi:10.1038/453263a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3w0Eg
Flights of green fancy pp264-265
Air travel shows no sign of losing its allure but its environmental
impact is not going to go away. Katharine Sanderson looks at some of
the ways that scientists and engineers hope to reduce the carbon
wing-print of aircraft.
doi:10.1038/453264a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3x0Eh
Snapshot: Charged clouds p267
Lightning rages over Chilean volcano.
Geoff Brumfiel
doi:10.1038/453267a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3y0Ei
A side-splitting tale p267
Sex simulator sheds light on condom ruptures.
Anna Petherick
doi:10.1038/453267b
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu3z0Ej
They say they want a revolution pp268-269
Climate scientists call for major new modelling facility.
Olive Heffernan
doi:10.1038/453268a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu310EW
Sidelines p269
Scribbles on the margins of science.
doi:10.1038/453269a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu320EX
Space telescope lands new career in bomb detection p270
doi:10.1038/453270a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu330EY
Farm bill reduces support for corn ethanol p270
doi:10.1038/453270b
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu340EZ
Cosmologist quits Britain over poor physics funding p270
doi:10.1038/453270c
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu350Ea
Hefty funds lay foundations for stem-cell facilities p270
doi:10.1038/453270d
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu360Eb
Former NASA science director returns to post p270
doi:10.1038/453270e
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu370Ec
Forest clearance boosted power of Cyclone Nargis p270
doi:10.1038/453270f
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu380Ed
Nature.com wins a webby p270
doi:10.1038/453270g
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4A0En
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NEWS FEATURES
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Profile: Learning from death pp271-273
Vishva Dixit's study of cellular demise led to the discovery of a new
molecular-signalling mechanism — one with implications for
inflammation and perhaps much more, reports Melinda Wenner.
doi:10.1038/453271a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4B0Eo
Chemistry: Designer Debacle pp275-278
A high-profile scientist, a graduate student and two major retractions.
Erika Check Hayden reports on a case that has rocked the chemistry
community.
doi:10.1038/453275a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4C0Ep
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CORRESPONDENCE
----------------------
Deforestation: call for justice, not militarization p280
Samuel J. Spiegel
doi:10.1038/453280a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4D0Eq
Deforestation: damage from dams adds to emissions p280
Andre Frainer Barbosa
doi:10.1038/453280b
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4E0Er
Hype around nanotubes creates unrealistic hopes p280
Kostas Kostarelos, Alberto Bianco and Maurizio Prato
doi:10.1038/453280c
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4F0Es
A case of genetic counselling for Dr Watson p281
Myra I. Roche
doi:10.1038/453281a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4G0Et
The public needs to know social benefits of vaccination p281
Anthony Robbins
doi:10.1038/453281b
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4H0Eu
Public support never has guaranteed good work p281
Neville W. Goodman
doi:10.1038/453281c
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4I0Ev
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BOOKS AND ARTS
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Big problems, big decisions pp282-283
Sustainable solutions to worldwide crises such as overpopulation and
climate change need regulating by global bodies, but whose views
should these organizations represent?
Michael Sargent reviews Fatal Misconception: The Struggle to Control
World Population by Matthew Connelly and Common Wealth: Economics
for a Crowded Planet by Jeffrey D. Sachs
doi:10.1038/453282a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4J0Ew
Enshrining the right to live or die pp284-285
Emily Jackson reviews Understanding Bioethics and the Law: The
Promises and Perils of the Brave New World of Biotechnology by
Barry R. Schaller and Easeful Death: Is There a Case for Assisted
Dying? by Mary Warnock and Elisabeth Macdonald
doi:10.1038/453284a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4K0Ex
Charting the water's edge pp285-286
Deborah Jean Warner reviews Coast Lines: How Mapmakers Frame the
World and Chart Environmental Change by Mark Monmonier
doi:10.1038/453285a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4L0Ey
Changing perceptions of light p286
Christopher Turner reviews Take Your Time: Olafur Eliasson
doi:10.1038/453286a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4M0Ez
----------------------
ESSAYS
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The evolution of music pp287-288
In the second of a nine-part essay series, Josh McDermott explores
the origins of the human urge to make and hear music.
doi:10.1038/453287a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4N0E1
OPINION
25 years of HIV pp289-290
Reflecting on how far we have come scientifically since isolating HIV
in 1983, Anthony S. Fauci urges a renewed commitment to the far
greater challenges ahead, especially that of vaccine development.
doi:10.1038/453289a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4O0E2
----------------------
NEWS AND VIEWS
----------------------
Palaeoclimate: Windows on the greenhouse pp291-292
Data laboriously extracted from an Antarctic ice core provide an
unprecedented view of temperature, and levels of atmospheric carbon
dioxide and methane, over the past 800,000 years of Earth's history.
Ed Brook
doi:10.1038/453291a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4P0E3
Signal transduction: The rhodopsin story continued pp292-293
Determination of the architecture of an invertebrate photoreceptor
protein, squid rhodopsin, is a notable event. It illuminates the
mechanism of invertebrate vision and a ubiquitous intracellular
signalling system.
Gebhard F. X. Schertler
doi:10.1038/453292a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4Q0E4
Quantum information: An integrated light circuit pp294-295
There's a long wish list for a workable quantum computer: a viable
system must be fast, compact and stable. The first integrated optical
quantum logic circuits are a step in the right direction.
Paul G. Kwiat
doi:10.1038/453294a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4R0E5
Tuberculosis: Deadly combination pp295-296
Many factors affect the severity of tuberculosis in infected
individuals. Among these are the genetic make-up of the bacterial
strain, that of the host, and the interplay between the two.
Stefan H. E. Kaufmann
doi:10.1038/453295a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4S0E6
Climate change: Attributing cause and effect pp296-297
The climate is changing, and so are aspects of the world's physical
and biological systems. It is no easy matter to link cause and effect
-- the latest attack on the problem brings the power of meta-analysis
to bear.
Francis Zwiers and Gabriele Hegerl
doi:10.1038/453296a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4T0E7
Solid-state physics: Polaritronics in view pp297-298
Polaritons are an odd cross-breed of a particle, half-matter,
half-light. They could offer an abundant crop of new and improved
optoelectronic devices -- a promise already being fulfilled.
Benoit Deveaud-Pledran
doi:10.1038/453297a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4U0E8
Plant biology: In their neighbour's shadow pp298-299
They can't move away from shade, so plants resort to a molecular
solution to find a place in the sun. The action they take is quite
radical, and involves a reprogramming of their development.
Jiri Friml and Michael Sauer
doi:10.1038/453298a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4V0EA
50 & 100 years ago p299
doi:10.1038/453299a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4W0EB
Obituary: Edward N. Lorenz (1917-2008) p300
Meteorologist and father of chaos theory.
Edward Ott
doi:10.1038/453300a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4X0EC
----------------------
INSIGHT
----------------------
Regenerative medicine p301
Natalie DeWitt
doi:10.1038/453301a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4Y0ED
Regenerative medicine and human models of human disease pp302-305
Kenneth R. Chien
doi:10.1038/nature07037
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4Z0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4a0EL
REVIEW ARTICLE
Intrinsic and extrinsic control of haematopoietic stem-cell self-renewal pp306-313
Leonard I. Zon
doi:10.1038/nature07038
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4b0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4c0EN
Wound repair and regeneration pp314-321
Geoffrey C. Gurtner, Sabine Werner, Yann Barrandon and Michael T. Longaker
doi:10.1038/nature07039
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4d0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4e0EP
Stem-cell-based therapy and lessons from the heart pp322-329
Robert Passier, Linda W. van Laake and Christine L. Mummery
doi:10.1038/nature07040
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4f0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4g0ER
Tolerance strategies for stem-cell-based therapies pp330-337
Ann P. Chidgey, Daniel Layton, Alan Trounson and Richard L. Boyd
doi:10.1038/nature07041
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4h0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4i0ET
A chemical approach to stem-cell biology and regenerative medicine pp338-344
Yue Xu, Yan Shi and Sheng Ding
doi:10.1038/nature07042
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4j0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4k0EV
Imaging stem-cell-driven regeneration in mammals pp345-351
Timm Schroeder
doi:10.1038/nature07043
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4l0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4m0EX
----------------------
ARTICLES
----------------------
Attributing physical and biological impacts to anthropogenic climate change pp353-357
Natural physical and biological systems change in regions of
temperature increase. Such changes have occurred on all continents and
in most oceans since at least 1970. This paper presents statistical
evidence that these changes cannot be explained by natural climate
variations alone, and concludes that anthropogenic climate change is
affecting physical and biological systems globally and on some
continents.
Cynthia Rosenzweig et al.
doi:10.1038/nature06937
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4n0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4o0EZ
Nucleosome organization in the Drosophila genome p358
A map of nucleosome positions across the Drosophila genome reveals a
chromatin organization that can be compared with that of budding
yeast. The Drosophila nucleosome distribution pattern indicates that
RNA polymerase II can access the transcription start site of active
genes unimpeded by nucleosomes, but there is a nucleosome positioned
at the site where the polymerase pauses.
Travis N. Mavrich et al.
doi:10.1038/nature06929
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4p0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4q0Eb
Crystal structure of squid rhodopsin pp363-367
Invertebrate rhodopsins are light-activated G-protein-coupled
receptors, whose activity is coupled to Gq-type G-proteins. This paper
reports the crystal structure of squid rhodopsin, at 2.5 A, in which a
putative G-protein-binding site is resolved.
Midori Murakami and Tsutomu Kouyama
doi:10.1038/nature06925
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4r0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4s0Ed
----------------------
LETTERS
----------------------
True polar wander on Europa from global-scale small-circle depressions pp368-371
Paul Schenk, Isamu Matsuyama and Francis Nimmo
doi:10.1038/nature06911
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4t0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4u0Ef
A GaAs polariton light-emitting diode operating near room temperature pp372-375
Polariton lasing and nonlinearities have been demonstrated in optical
experiments, but it would be of considerable technological interest to
demonstrate electrically driven polariton light emitting devices.
Emission from polariton states at near room temperature, 235K is
reported. The electro luminescence data reveal characteristic
signatures of strong coupling between excitons and photons.
S. I. Tsintzos et al.
doi:10.1038/nature06979
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4v0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4w0Eh
Superconductivity at 43 K in an iron-based layered compound
LaO1-xFxFeAs p376
The application of pressure can raise the superconducting transition
temperature of oxypnictide (a pnicogen being a group V element)
substantially, to a maximum value of about 43 K. This is the highest
transition temperature yet reported for a non copper based material,
but this record is unlikely to last for long: the material system
offers considerable flexibility for chemical modification, and we
can reasonably anticipate that this record will soon be superseded.
Hiroki Takahashi, Kazumi Igawa, Kazunobu Arii, Yoichi Kamihara,
Masahiro Hirano & Hideo Hosono
doi:10.1038/nature06972
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4x0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4y0Ej
High-resolution carbon dioxide concentration record 650,000-800,000
years before present pp379-382
Changes in past atmospheric carbon dioxide concentrations can be
determined by measuring the composition of air trapped in ice cores
from Antarctica. Thomas Stocker and colleagues now extend the
previously published atmospheric carbon dioxide concentration record
by two complete glacial cycles to 800,000 years before present. The
authors find that atmospheric carbon dioxide is strongly correlated
with Antarctic temperature throughout eight glacial cycles but with
significantly lower concentrations between 650,000 and 750,000 years
before present. Carbon dioxide levels are below 180ppmv for a period
of 3000 years during Marine Isotope Stage 16, possibly reflecting more
pronounced oceanic carbon storage. They report the lowest carbon
dioxide concentration measured in an ice core, which extends the
range of carbon dioxide concentrations during the late Quaternary by
about 10 ppmv to 172 300 ppmv.
Dieter Luthi et al.
doi:10.1038/nature06949
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu4z0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu410EX
Orbital and millennial-scale features of atmospheric CH4 over the past
800,000 years pp383-386
A detailed atmospheric methane record from the EPICA Dome C ice core
that extends the history of atmospheric methane to 800,000 years
before present is detailed. Spectral analyses indicate that the
long-term variability in atmospheric methane levels is dominated by
~100,000 year glacial-interglacial cycles up to ~400,000 years ago
with an increasing contribution of the precessional component during
the four more recent climatic cycles.
Laetitia Loulergue et al.
doi:10.1038/nature06950
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu420EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu430EZ
Chemical compass model of avian magnetoreception p387
Animals of many kinds can orient themselves with respect to the
Earth's magnetic field. Magnetic orientation seems to be through the
eye, possibly by the magnetic modulation of a photochemical reaction.
The problem is that nobody knows whether such modulation is even
possible, for any chemical system, as that the Earth's magnetic field
is relatively weak. This paper presents evidence that weak magnetic
fields can modulate photochemical reactions in the expected manner.
The model system is entirely artificial, and the temperature rather
low, but the point has been made.
Kiminori Maeda et al.
doi:10.1038/nature06834
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu440Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu450Eb
Evolution of metal hyperaccumulation required cis-regulatory changes
and triplication of HMA4 p391
Strains of the model plant Arabidopsis vary in their ability to thrive
in heavy metal environments, presumably due to adaptations throughout
evolution. This paper demonstrates that the strain A. halleri has
accumulated multiple copies of the gene HMA4 and changes to the
regulatory elements for these genes to survive in extreme conditions.
Their results should be useful in bioremediation for metal
contaminated soils
Marc Hanikenne et al.
doi:10.1038/nature06877
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu460Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu470Ed
Human metabolic phenotype diversity and its association with diet and
blood pressure p396
This paper presents a large scale, multi national population-based
urinary metabolic profiling analysis from individuals participating
in the InterMap study.
Elaine Holmes et al.
doi:10.1038/nature06882
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu480Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5A0Eo
Genetic evidence that FGFs have an instructive role in limb
proximal–distal patterning p401
Genetic techniques have been used to delete different combinations of
fibroblast growth factors (FGFs) from the mouse limb, to study the
contribution that each FGF makes to the total apical ectodermal ridge
(AER)–FGF signal. Out of the four AER–FGFs, it is shown that only one
of them, Fgf8 is sufficient for normal limb development. This dispels
a longstanding notion that there is a positive feedback loop between
the three other FGF genes expressed in the posterior AER, and the
sonic hedgehog gene.
Francesca V. Mariani, Christina P. Ahn & Gail R. Martin
doi:10.1038/nature06876
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5B0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5C0Eq
Free choice activates a decision circuit between frontal and parietal
cortex p406
In primates, planning movements to selected targets involves a number
of areas in anatomically connected frontal and parietal cortex, but
how these areas interact is poorly understood. This paper
simultaneously records spikes and local field potentials in dorsal
pre-motor and parietal reach region and find that correlations between
the two areas increase when monkeys choose which movement among
several alternatives to make, rather than when they are following
instructions.
Bijan Pesaran, Matthew J. Nelson & Richard A. Andersen
doi:10.1038/nature06849
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5D0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5E0Es
Vascular normalization in Rgs5-deficient tumours promotes immune
destruction p410
RGS5, a signalling protein that regulates the activity of G proteins,
is shown to be an important regulator of the tumour vasculature.
Deletion of RGS5 leads to normalization of blood vessels of tumours,
making them less leady and improving their coverage with pericytes. As
a consequence, more immune cells that can target the tumour cells
reach the tumour, which enhances the survival of tumour bearing mice.
Juliana Hamzah et al.
doi:10.1038/nature06868
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5F0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5G0Eu
3.88 Å structure of cytoplasmic polyhedrosis virus by cryo-electron
microscopy p415
This paper presents a high resolution structure of the cytoplasmic
polyhedroasis virus (CPV) obtained by single particle cryo electron
microscopy, and shows that the polypeptide backbone can be traced
without the need of making a crystal.
Xuekui Yu, Lei Jin & Z. Hong Zhou
doi:10.1038/nature06893
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5H0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5I0Ew
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p421
Aspiring interdisciplinarians should think beyond academia.
Gene Russo
doi:10.1038/nj7193-421a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5J0Ex
Postdocs and Students
Assembly work p422
Graduate students can be key links in interdisciplinary science, but
training them for this role is a challenge, says Brian Vastag.
Brian Vastag
doi:10.1038/nj7193-422a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5K0Ey
Career View
Craig Hogan, director, Center for Particle Astrophysics, Fermi
National Accelerator Laboratory and professor of astronomy and
astrophysics, University of Chicago, Illinois p424
Incoming director at Fermilab plans fresh focus.
Virginia Gewin
doi:10.1038/nj7193-424a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5L0Ez
The postdoc interview p424
Consider asking these questions during your next postdoc interview.
Kryste Ferguson & Ivonne Vidal Pizarro
doi:10.1038/nj7193-424b
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5M0E1
Judging me, judging you p424
Conducting a lecture, hoping for a lectureship.
Jon Yearsley
doi:10.1038/nj7193-424c
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5N0E2
----------------------
FUTURES
----------------------
Sanctity p426
All life is here.
Heather Bradshaw
doi:10.1038/453426a
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5O0E3
---------------------------
ADVANCE ONLINE PUBLICATION
---------------------------
14 May 2008
Article
A two-tiered mechanism for stabilization and immobilization of
E-cadherin
Matthieu Cavey, Matteo Rauzi, Pierre-François Lenne & Thomas Lecuit
doi:10.1038/nature06953
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5P0E4
Letters
A myocardial lineage derives from Tbx18 epicardial cells
Chen-Leng Cai et al.
doi:10.1038/nature06969
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5Q0E5
Crystal structures of oseltamivir-resistant influenza virus neuraminidase mutants
Patrick J. Collins et al.
doi:10.1038/nature06956
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5R0E6
Hippocampus-independent phase precession in entorhinal grid cells
Torkel Hafting, Marianne Fyhn, Tora Bonnevie, May-Britt Moser
& Edvard I. Moser
doi:10.1038/nature06957
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5S0E7
11 May 2008
Article
PML targeting eradicates quiescent leukaemia-initiating cells
Keisuke Ito et al.
doi:10.1038/nature07016
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5T0E8
Letters
Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is
associated with pre-eclampsia
Keizo Kanasaki et al.
doi:10.1038/nature06951
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5U0EA
Ultrasonic frogs show hyperacute phonotaxis to female courtship calls
Jun-Xian Shen et al.
doi:10.1038/nature06719
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5V0EB
Rapid strengthening of thalamo-amygdala synapses mediates cue–reward
learning
Kay M. Tye, Garret D. Stuber, Bram de Ridder, Antonello Bonci
& Patricia H. Janak
doi:10.1038/nature06963
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5W0EC
IL-21 and TGF-beta are required for differentiation of human TH17 cells
Li Yang et al.
doi:10.1038/nature07021
http://ealerts.nature.com/cgi-bin24/DM/y/eksT0Xztnp0HjB0Bu5X0ED
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