ReNeuron reports promising data from retinal stem cell therapy program
24 Apr 2008
ReNeuron's ReN003 human retinal progenitor cells were tested in a
rodent model of damaged retina. Between 14 and 28 days after
transplantation into the sub-retinal space, the cells were seen to
integrate with the host retinal tissue. A sub-population of these
integrated cells differentiated into cells exhibiting the
characteristics of photoreceptors, expressing the proteins rhodopsin
and recoverin, markers for the light-sensitive rod cells found in
healthy retina.
These results therefore indicate the potential utility of ReNeuron's
prototype ReN003 cell line as a therapy for blindness-causing
diseases characterized by damage to the retina, such as retinitis
pigmentosa, age-related macular degeneration and diabetic
retinopathy.
John Sinden, chief scientific officer of ReNeuron, said: "There is
still much work to do before this cell line can be taken into the
clinic, but these early pre-clinical results give us the confidence
to move the programme in that direction as quickly as possible."
http://www.pharmace
guid=0E1D4746-
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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