Ovarian Cancer Stem Cells Identified, Characterized
ScienceDaily (Apr. 18, 2008) — Researchers at Yale School of Medicine
have identified, characterized and cloned ovarian cancer stem cells
and have shown that these stem cells may be the source of ovarian
cancer's recurrence and its resistance to chemotherapy.
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Health & Medicine
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Ovarian Cancer
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"These results bring us closer to more effective and targeted
treatment for epithelial ovarian cancer, one of the most lethal forms
of cancer," said Gil Mor, M.D., associate professor in the Department
of Obstetrics, Gynecology & Reproductive Sciences at Yale School of
Medicine.
Mor presented his findings recently at the annual meeting of the
American Association for Cancer Research (AACR) Meeting in San Diego,
California.
Cancerous tumors are made up of cells that are both cancerous and non-
cancerous. Within cancerous cells, there is a further subclass
referred to as cancer stem cells, which can replicate indefinitely.
"Present chemotherapy modalities eliminate the bulk of the tumor
cells, but cannot eliminate a core of these cancer stem cells that
have a high capacity for renewal," said Mor, who is also a member of
the Yale Cancer Center. "Identification of these cells, as we have
done here, is the first step in the development of therapeutic
modalities."
Mor and colleagues isolated cells from 80 human samples of either
peritoneal fluid or solid tumors. The cancer stem cells that were
identified were positive for traditional cancer stem cell markers
including CD44 and MyD88. These cells also showed a high capacity for
repair and self-renewal.
The isolated cells formed tumors 100 percent of the time. Within
those tumors, 10 percent of the cells were positive for cancer stem
cell marker CD44, while 90 percent were CD44 negative.
Mor and his team were able to isolate and clone the ovarian cancer
stem cells. They found that these cells were highly resistant to
conventional chemotherapy while the non-cancer stem cells responded
to treatment. "Isolating and cloning these cells will lead to
development of new treatments to target and eliminate the cancer stem
cells and hopefully prevent recurrence," said Mor.
Adapted from materials provided by Yale University.
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MLA Yale University (2008, April 18). Ovarian Cancer Stem Cells
Identified, Characterized. ScienceDaily. Retrieved April 22, 2008,
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