Signaling Gateway - 4 April 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0M40Em
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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TUMORIGENESIS: eNOS IS ENOUGH
Oncogenic KRas initiates and maintains tumor growth by stimulating
the PI3K-AKT-eNOS signaling pathway, which activates wild-type HRas
and NRas.
Original research paper: <i>Nature</i> <b>452</b>, 646-649 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0vP0Ev
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0HIE0ED
Ubc9
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Br4d0EB
Ubc9 is an E2-conjugating enzyme for the small, ubiquitin-related
modifier (SUMO). Attachment of SUMO to a lysine residue(s) in target
proteins can alter protein function through changes in protein
stability, transcriptional activity or subcellular localization.
Although ubiquitination requires an E3 ligase, Ubc9 is sufficient for
SUMOylation, as certain substrates can be modified in vitro using
only E1 (Uba2/Aos1), Ubc9, mature SUMO and ATP.
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0BUuz0E8
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Selected Updates
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NUCLEAR TRANSPORT: SIGNALLING AND TRANSPORT CONVERGE
RSK- and AKT-mediated phosphorylation of Ran-binding protein-3
(RanBP3) increases the efficiency of nuclear import.
Original research paper: Mol. Cell 29, 362-375 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Br4e0EC
ADDICTION: DAMPING DOWN ALCOHOL DEPENDENCE
Alcohol cravings are suppressed by pharmacological inhibition of the
stress and anxiety response mediator neurokinin 1 receptor (NK1R),
thus providing a biological explanation for the link between stress
and alcoholism relapse.
Original research paper: Science 319, 1536-1539 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Br4f0ED
CHEMICAL BIOLOGY: DNA SYNTHESIS LIGHTS UP
Researchers have developed a method for detecting DNA synthesis in
proliferating cells that uses small-molecule fluorophores rather than
antibodies, which improves resolution and signal strength.
Original research paper: Proc. Natl. Acad. Sci. USA 105, 2415–2420 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Br4g0EE
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0vO0Eu
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Research Library
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CUTANEOUS CANCER STEM CELL MAINTENANCE IS DEPENDENT ON beta-CATENIN
SIGNALLING
Nature 452, 650-653 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Br4h0EF
DROSOPHILA SHORT NEUROPEPTIDE F SIGNALLING REGULATES GROWTH BY
ERK-MEDIATED INSULIN SIGNALLING
Nature Cell Biology 10, 468-475 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Br4i0EG
SYNAPTIC NMDA RECEPTOR ACTIVITY BOOSTS INTRINSIC ANTIOXIDANT DEFENSES
Nature Neuroscience 11, 476-487 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Br4j0EH
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Signaling News
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NATURE INSIGHT: MOLECULAR CANCER DIAGNOSTICS
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Brpb0E8
Recent technological advances have helped researchers to characterize
the molecular basis of cancer. This FREE Nature Insight highlights
key approaches for the discovery and validation of cancer biomarkers
and diagnostic approaches, and examines how imaging technologies and
serum biomarkers can be used to monitor responses to treatment.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Crw0Ed
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Gateway Updates
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THE CELL MIGRATION GATEWAY - APRIL UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0wDM0E2
The Cell Migration Gateway is a comprehensive FREE online resource
for news, highlights and research on cell migration.
This month's featured articles include
Intravasation and metastasis: Bringing up the rear
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0BrvM0Es
Cell migration: Nudel-ity turns Cdc42 on
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0BrvN0Et
Sign up to receive the table of contents e-alert for the
Cell Migration Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0BJrg0Ea
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Signaling Job of the Week
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Associate Editor
Employer: Nature Publishing Group
Location: Boston, New York or London
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0Br4k0EI
Nature Publishing Group is looking for an Associate Editor to join
the editorial team of the Pathway Interaction Database. The
successful applicant will share responsibility for the site's content
and high scientific quality and will contribute to the curation of
the database content.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0BnjC0ES
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ej6o0Xztnp0H2W0vqs0EP
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