Signaling Gateway - 11 April 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0M40E4
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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AGING: NOTCHING UP STEM CELL DIFFERENTIATION
A mutant form of lamin A activates the Notch signaling pathway to
promote precocious mesenchymal stem cell differentiation.
Original research paper: Nature Cell Biology 10, 452-459 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0vP0EE
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0HIE0EU
Relaxin family peptide receptor 3
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWf0E5
The relaxin family peptide receptor 3 (RXFP3) is the cognate receptor
for the peptide hormone relaxin 3, which is a member of the
relaxin/insulin family of peptides. RXFP3 is a rhodopsin-like GPCR
(family A) that is mainly coupled the Gi/o class of G proteins. It is
suggested to be important in sensory perception and the processing of
audio, visual, tactile and somatosensory information, particularly
under stressful conditions.
Also published this week:
DFCP1
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWg0E6
Relaxin family peptide receptor 4
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWh0E7
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BUuz0EQ
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Selected Updates
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INNATE IMMUNITY: TLR4 SIGNALLING
The TIRAP-MyD88 and TRAM-TRIF signaling pathways are induced
sequentially, with the TRAM-TRIF pathway only being operational from
early endosomes following Toll-like receptor 4 endocytosis.
Original research paper: Nature Immunol. 9, 361-368 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWi0E8
TUMORIGENESIS: TURNING THE HANDS OF TIME
The discovery of a link between DNA damage response (DDR) signaling
and the scheduling of circadian rhythms may help us discover why there
is an increase in tumorigenesis when circadian rhythms are altered.
Original research paper: Curr. Biol. 18, 286-291 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWj0EA
OLFACTORY PROCESSING: LIGHTING UP THE PATH TO ROMANCE
The neural circuit activated by the pheromone cis-vaccenyl acetate
(cVA) differs subtly between males and females, explaining how it can
both suppress and promote mating with males in Drosophila males and
females, respectively.
Original research paper: Nature 452, 473-477 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWk0EB
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0vO0ED
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Research Library
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A PLANT PATHOGEN VIRULENCE FACTOR INHIBITS THE EUKARYOTIC PROTEASOME
BY A NOVEL MECHANISM
Nature 452, 755-758 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWl0EC
PHOSPHOREGULATION AND DEPOLYMERIZATION-DRIVEN MOVEMENT OF THE DAM1
COMPLEX DO NOT REQUIRE RING FORMATION
Nature Cell Biology 10, 407-414 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWv0EM
ROBO4 STABILIZES THE VASCULAR NETWORK BY INHIBITING PATHOLOGIC
ANGIOGENESIS AND ENDOTHELIAL HYPERPERMEABILITY
Nature Medicine 14, 448-453 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWn0EE
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Signaling News
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FDA TO VET EMBRYONIC STEM CELLS' SAFETY
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsKP0EW
Investors, biotech companies and other stem-cell stakeholders are
meeting in Gaithersburg, Maryland, this week for the US Food and Drug
Administration's (FDA's) first public hearing on the safety of
therapies that use human embryonic stem cells. No decisions will be
made at the meeting, but the process should eventually lead to
guidelines from the FDA about required preclinical studies, trial
design and patient follow-up.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0Crw0Eu
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Gateway Updates
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NCI-NATURE PATHWAY INTERACTION DATABASE - APRIL UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BGyx0EE
The Pathway Interaction Database is a free, high-quality resource of
signaling pathways in human cells for biologists and bioinformaticians
to explore, visualize and mine signaling events.
This month's update features the
cytoplasmic and nuclear SMAD2/3 regulation signaling pathway
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsEM0EN
and the
amb2 integrin signaling pathway
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BkuP0E5
Sign up here to receive the monthly update alert for the
NCI-Nature Pathway Interaction Database.
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BJYy0Ek
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Signaling Job of the Week
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Zebrafish Cardiovascular Biologist
Employer: The Victor Chang Cardiac Research Institute
Location: Sydney, Australia
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BsWo0EF
Applications are invited from scientists or clinician-scientists
working on aspects of the cardiovascular system in the zebrafish
model. The position will be at the Assistant, Associate Professor or
Full Professor level. Candidates with a distinguished record in any
area of zebrafish cardiovasacular biology, including signal
transduction, computational biology or other aspects will be given
serious consideration.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0BnjC0Ej
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ekFo0Xztnp0H2W0vqs0Eg
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