01 May 2008 Volume 453 Number 7191, pp1-132
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A pair of Commentaries in this week's Nautre explore US and European
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EDITORIALS
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California against cronyism p1
The scale of funds set to be spent by the state on stem-cell research necessitates strong governance.
doi:10.1038/453001a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2n0Ek
A research menu p1-2
More spending on agricultural science is needed to help resolve the world's food crisis.
doi:10.1038/453001b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2o0El
A place for everything p2
More researchers must record the latitude and longitude of their data.
doi:10.1038/453002a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2p0Em
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RESEARCH HIGHLIGHTS
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Casting anchor p4
doi:10.1038/453004a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2q0En
Neurobiology: Pecking order p4
doi:10.1038/453004b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2r0Eo
Human biology: Boy appetit p4
doi:10.1038/453004c
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2s0Ep
Chemical biology: Dope hope p4
doi:10.1038/453004d
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2t0Eq
Astronomy: Galactic beginnings p4
doi:10.1038/453004e
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2u0Er
Animal behaviour: A reassuring tune pp4-5
doi:10.1038/453004f
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2v0Es
Molecular physics: Slicing the ice p5
doi:10.1038/453005a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2w0Et
Virology: Rubbish imitation p5
doi:10.1038/453005b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2x0Eu
Atmospheric science: Jetting away p5
doi:10.1038/453005c
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2y0Ev
Neuroscience: Algal vision p5
doi:10.1038/453005d
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt2z0Ew
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JOURNAL CLUB
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Journal club p5
Kristi Anseth
doi:10.1038/453005e
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt210Ej
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NEWS
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Doctors accused of doing illegal stem-cell trials p6-7
Patients in Austria may have been misled.
Alison Abbott
doi:10.1038/453006a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt220Ek
US ocean-research projects in dire economic straits p7
Multiple marine projects under threat from cash squeeze.
Rex Dalton
doi:10.1038/453007a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt230El
Food crisis spurs research spending p8
Agricultural research comes in from the cold.
Declan Butler
doi:10.1038/453008a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt240Em
Genetics bill cruises through Senate p9
Unanimous vote welcomed by personal genomics companies.
Meredith Wadman
doi:10.1038/453009a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt250En
Snapshot: Rodent round-up p9
It's been a good week for rat-catchers.
doi:10.1038/453009b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt260Eo
If you go down to the woods today … p11
Eric Hand
doi:10.1038/453011a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt270Ep
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Sidelines p12
Scribbles on the margins of science.
doi:10.1038/453012a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3A0E1
Programs promise to end PDF paper-chase p12
Software makes article control a virtual reality.
Rachel Courtland
doi:10.1038/453012b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3B0E2
Sediment cores reveal Antarctica's warmer past p13
Quirin Schiermeier
doi:10.1038/453013a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3C0E3
International consortium to tackle cancer genomes p15
doi:10.1038/453015a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3D0E4
A lift for Europe's satellites p15
doi:10.1038/453015b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3E0E5
Warming Antarctic waters begin to cool p15
doi:10.1038/453015c
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3F0E6
UK government slammed for underfunding research p15
doi:10.1038/453015d
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3G0E7
Creationists fail in bid to offer 'science' degrees p15
doi:10.1038/453015e
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3H0E8
Artist cleared over possession of bacteria p15
doi:10.1038/453015f
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3I0EA
Correction p15
doi:10.1038/453015g
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3J0EB
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COLUMN
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PARTY OF ONE
Demonstrably wrong p16
Public-private demonstration projects are a good way to test technology
in the field. But the driving force is often more political than scientific,
argues David Goldston.
doi:10.1038/453016a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3K0EC
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NEWS FEATURES
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Stem cells: The 3-billion-dollar question p18-21
Can a state do what a country cannot, and transform the way stem-cell
research is funded? Erika Check Hayden reports on the California
Institute for Regenerative Medicine.
doi:10.1038/453018a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3L0ED
Physics: Quantum all the way p22-25
How does our classical world emerge from the counterintuitive principles
of quantum theory? Can we even be sure that the world doesn't 'go quantum'
when no one is watching? Philip Ball talks to the theorists and
experimentalists trying to find out.
doi:10.1038/453022a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3M0EE
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CORRESPONDENCE
----------------------
Biopiracy rules hinder conservation efforts p26
Valenti Rull and Teresa Vegas-Vilarrubia
doi:10.1038/453026a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3N0EF
Biopiracy: conservationists have to rebuild lost trust p26
Mariana M. Vale, Maria Alice Alves and Stuart L. Pimm
doi:10.1038/453026b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3O0EG
Spain should implement a model that's known to work p26-27
Rodrigo J. Carbajo, Jose Luis Neira and Rosa Farras
doi:10.1038/453026c
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3P0EH
Spain: leading role of scientists is heartening p27
Pere Puigdomenech
doi:10.1038/453027a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3Q0EI
Darwin-Wallace principle of natural selection p27
U. Kutschera
doi:10.1038/453027b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3R0EJ
The status of science in Muslim nations p27
K. Razi Naqvi
doi:10.1038/453027c
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3S0EK
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COMMENTARIES
----------------------
Making the grade p28-30
International testing that is used to predict the grim future of US
science and technology is being vastly misinterpreted, say Hal Salzman
and Lindsay Lowell.
doi:10.1038/453028a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3T0EL
Science teaching must evolve p31-32
Evolutionary theory, study and knowledge moved on dramatically in
the latter half of the twentieth century, but school teaching,
curricula and teacher training are still in the primeval soup era,
says Andrew Moore.
doi:10.1038/453031a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3U0EM
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BOOKS AND ARTS
----------------------
Mix and mash-up p33-34
An experimental musician explores how technology has transformed our cut-and-paste culture.
Marc Weidenbaum reviews Sound Unbound: Sampling Digital Music and Culture
doi:10.1038/453033a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3V0EN
Exemplary epidemiology p34
Mark Woolhouse reviews Modeling Infectious Diseases in Humans and
Animals by Matt J. Keeling and Pejman Rohani
doi:10.1038/453034a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3W0EO
Exhibition: Measure for measure p35
John D. Barrow reviews Beyond Measure: Conversations Across Art and Science
doi:10.1038/453035a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3X0EP
Exhibition: Changing expressions p36
Laura Spinney reviews Lovis Corinth (1858-1925): Between Impressionism
and Expressionism
doi:10.1038/453036a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3Y0EQ
Exhibition: Etching the artist's mind p36
Colin Martin reviews Scribing the Soul
doi:10.1038/453036b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3Z0ER
The Impressionists' bible p37
Ogden Rood's textbook explaining the science of optics and colour mixing
triggered an unexpectedly vivid response from the radical artists of the 1880s.
Martin Kemp
doi:10.1038/453037a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3a0EY
In retrospect: When business became biology's plague p38
A 1920s best-seller about risky campus capitalism and early phage
therapy still resonates today.
Thomas Hausler reviews Arrowsmith by Sinclair Lewis
doi:10.1038/453038a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3b0EZ
----------------------
ESSAY
----------------------
Lifting the fog from the north p39
A purist approach to wavefunctions can resolve some of quantum theory's
infamous murkiness.
Maximilian Schlosshauer
doi:10.1038/453039a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3c0Ea
----------------------
NEWS AND VIEWS
----------------------
Neuroscience: Hidden female talent p41-42
A male fruitfly serenades his female with a courtship song produced by
vibrating one wing. The female also has the neuronal circuitry to
generate a song of her own, but her brain tells her not to.
Jai Y. Yu and Barry J. Dickson
doi:10.1038/453041a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3d0Eb
Electronics: The fourth element p42-43
Almost four decades since its existence was first proposed, a fourth
basic circuit element joins the canonical three. The 'memristor' might
herald a step-change in the march towards ever more powerful circuitry.
James M. Tour and Tao He
doi:10.1038/453042a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3e0Ec
Climate change: Natural ups and downs p43-45
The effects of global warming over the coming decades will be modified
by shorter-term climate variability. Finding ways to incorporate these
variations will give us a better grip on what kind of climate change to expect.
Richard Wood
doi:10.1038/453043a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3f0Ed
Quantum physics: The squeeze goes on p45-46
After 20 years of hard labour, squeezed states -- light and matter whose
quantum fluctuations have been arduously suppressed below standard levels of
quantum noise -- are coming of age and are ripe for application.
Eugene S. Polzik
doi:10.1038/453045a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3g0Ee
Immunology: T cells hang in the balance p46-47
Equally important as the immune system's function in fighting invaders
is its ability to tolerate self. But environmental toxins could shift
the equilibrium between these activities one way or the other.
Emily A. Stevens and Christopher A. Bradfield
doi:10.1038/453046a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3h0Ef
Networks: Teasing out the missing links p47-48
Focusing on the hierarchical structure inherent in social and biological
networks might provide a smart way to find missing connections that are
not revealed in the raw data -- which could be useful in a range
of contexts.
Sid Redner
doi:10.1038/453047a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3i0Eg
Astrophysics: Rays from the dark p48-49
The origin of the cosmic rays that bombard Earth has troubled physicists
for nigh on a century. Supernova remnants are a favoured source -- but we
should keep our minds open to alternatives.
Rainer Plaga
doi:10.1038/453048a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3j0Eh
Obituary: John Wheeler (1911-2008) p50
Theoretical physicist, inspired and inspiring teacher.
P. James E. Peebles and William G. Unruh
doi:10.1038/453050a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3k0Ei
----------------------
ARTICLES
----------------------
Rapid leukocyte migration by integrin-independent flowing and squeezing p51-55
Leukocyte migration over two-dimensional surfaces is dependent on the
integrin family of adhesion receptors, which couple the contractile
force of the actomyosin cytoskeleton to the extracellular environment.
In this study, all integrin heterodimers from mouse leukocytes were
ablated and it is shown that integrins are not required for migration
in 3D environments, in vitro and in vivo. Such non-adhesive migration
renders leukocytes autonomous from the tissue environment.
Tim Lammermann et al.
doi:10.1038/nature06887
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3l0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3m0Ek
Mapping and sequencing of structural variation from eight human genomes p56-64
This paper examines eight individual genomes using a clone-based
sequencing approach, for structural variants of 8,000 nucleotides
or more. One of the first high-quality inversion maps for the human
genome is generated, and it is demonstrated that previous estimates
of variation of this sort have been too high.
Jeffrey M. Kidd et al.
doi:10.1038/nature06862
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3n0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3o0Em
Control of Treg and TH17 cell differentiation by the aryl hydrocarbon receptor p65
The aryl hydrocarbon receptor (AHR) is the cellular receptor for a number
of environment contaminants. It is shown here to induce regulatory T cells
when bound to the ligand TCCD and promote TH17 differentiation when bound
to FICZ.
Francisco J. Quintana et al.
doi:10.1038/nature06880
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3p0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3q0Eo
----------------------
LETTERS
----------------------
The sculpting of Jupiter's gossamer rings by its shadow p72-75
Jupiter has a main ring, an inner halo and two fainter and more distant
gossamer rings. Observations of dust in the outer ring region with the
surprising results of a gap in the rings interior to Thebe's orbit,
grains on highly-inclined paths, and a strong excess of submicron-sized
dust just inside Amalthea's orbit are reported. Detailed modelling shows
that the passage of ring particles through Jupiter's shadow creates the
Thebe Extension.
Douglas P. Hamilton and Harald Kruger
doi:10.1038/nature06886
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3r0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3s0Eq
Phase-slip-induced dissipation in an atomic Bose-Hubbard system p76-79
Phase slips and dissipation in a clean and well characterized system
(ultracold atoms trapped in an optical lattice) are studied. The results
clarify the role of phase slips in superfluid systems and may be of relevance
for understanding dissipation in other bosonic systems.
D. McKay, M. White, M. Pasienski and B. DeMarco
doi:10.1038/nature06920
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3t0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3u0Es
The missing memristor found p80-83
There are three fundamental passive circuit elements, resistors, capacitors,
and inductors, but it was reasoned that there should be a fourth fundamental
element, called a memristor, which has until now not been realized in a physical
system. A fresh analysis of the concept shows that memristance arises naturally
in nanoscale systems where solid state electronic and ionic transport are
coupled under an external bias voltage.
Dmitri B. Strukov, Gregory S. Snider, Duncan R. Stewart and R. Stanley Williams
doi:10.1038/nature06932
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3v0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3w0Eu
Advancing decadal-scale climate prediction in the North Atlantic sector p84-88
Detailed knowledge of the North Atlantic Ocean state is not strictly
necessary for producing useful predictions of climate fluctuations on
decadal timescales. Instead, this approach makes use of existing sea
surface temperature observations to improve the forecasting skill of
climate models to predict that natural climate variations in the North
Atlantic and tropical Pacific oceans will, over the coming decade,
temporarily offset the projected anthropogenic warming.
N. S. Keenlyside et al.
doi:10.1038/nature06921
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3x0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3y0Ew
Origin of a `Southern Hemisphere' geochemical signature in the Arctic upper mantle p89-93
An abrupt mantle compositional boundary exists on the the Gakkel ridge,
with basalts from west of the boundary displaying affinities to the 'Dupal'
isotopic province, previously observed only in the Southern Hemisphere.
It is concluded that the source of the Dupal signature is subcontinental
lithospheric mantle that delaminated and became integrated into the
convecting Arctic asthenosphere.
Steven L. Goldstein et al.
doi:10.1038/nature06919
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt3z0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt310Ek
Hydatellaceae are water lilies with gymnospermous tendencies p94
Hydatellaceae is a group of water plants that are now discovered to
be part of the initial emergence of flowering plants back in the
Mesozoic Era. The plant shows a number of rare embryological
features which, in combination, are found only in members of the
equally primitive Nymphaeales (water lilies). But Hydatella
has one additional feature, the provisioning of the seed from
maternal rather than embryonic tissue, which is unique among
flowering plants, but relatively common among gymnosperms.
William E. Friedman
doi:10.1038/nature06733
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt320El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt330Em
Hierarchical structure and the prediction of missing links in networks p98-101
Networks have recently emerged as a powerful tool to describe and
quantify many complex systems, with applications in engineering,
communications, ecology, biochemistry and genetics. A general
technique to divide network vertices in groups and sub-groups
is reported. Revealing such underlying hierarchies in turn allows
the predicting of missing links from partial data with higher
accuracy than previous methods.
Aaron Clauset, Cristopher Moore and M. E. J. Newman
doi:10.1038/nature06830
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt340En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt350Eo
Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision p102-105
The mammalian retina has three types of light sensing cells: rods, cones
and melanopsin containing cells. Rods and cones are involved in vision
but have also been shown to contribute to light entrainment of the
circadian clock. Rods and cones must signal through melanopsin
containing cells for the latter.
Ali D. Güler et al.
doi:10.1038/nature06829
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt360Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt370Eq
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins p106-114
Activation of the aryl hydrocarbon receptor with the ligand FICZ
regulates IL 22 expression in TH17 cells.
Marc Veldhoen et al.
doi:10.1038/nature06881
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt380Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4A0E2
BCR–ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros p110
This paper reports the identification of high-frequency deletions in the
Ikaros gene in acute lymphoblastic leukaemia cases that are characterized
by BCR ABL1 translocations. In contrast, BCR ABL1 CML is not associated
with Ikaros deletions in chronic phase patients, but are often acquired
during progression to blast crisis. These deletions lead to expression
of altered transcripts. In contrast to previous models suggesting that
these transcripts result from aberrant alternative splicing, it is
shown that the deletions found are due to aberrant RAG mediated
recombination.
Charles G. Mullighan et al.
doi:10.1038/nature06866
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4B0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4C0E4
Genome-wide screen reveals APC-associated RNAs enriched in cell protrusions p115-119
RNA localization is important in diverse biological process including
establishment of polarity. This study has focused on migrating
fibroblasts that polarize to form a leading edge and tail, in
a process that involves assymetric distribution of RNAs. On a
genome-wide scale RNAs that are localized to cell protrusions
are identified. Through their 3' UTRs, these transcripts are
anchored in granules concentrated at the plus end of microtubules
and associate with the APC tumour suppressor.
Stavroula Mili, Konstadinos Moissoglu and Ian G. Macara
doi:10.1038/nature06888
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4D0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4E0E6
Life without RNase P p120-123
Transfer RNAs are synthesized as longer forms that need to be processed,
and ribonuclease P (RNase P) is the ribonuclease that clips off excess
RNA to give the mature 5' end. It is found universally, except in
Nanoarchaeum equitans, and this paper uncovers how rearrangements
in the promoters of this archaeon's tRNA genes seem to have facilitated
the generation of 'leaderless' tRNAs that no longer required RNase P processing.
Lennart Randau, Imke Schroder and Dieter Soll
doi:10.1038/nature06833
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4F0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4G0E8
Structural analysis of the essential self-cleaving type III secretion proteins EscU and SpaS p124-127
A type II beta-turn in the Escherichia coli protein EscU undergoes auto-cleavage
via a mechanism involving cyclization of a conserved asparagine residue.
Structural and in vivo analysis of point and deletion mutations illustrates
the subtle conformational effects of auto-cleavage in modulating the molecular
features of a highly conserved surface region of EscU, a potential point
of interaction with other T3SS components at the inner membrane.
Raz Zarivach et al.
doi:10.1038/nature06832
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4H0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4I0EB
----------------------
CORRIGENDUM
----------------------
Direct estimation of per nucleotide and genomic deleterious mutation rates in Drosophila p128
Cathy Haag-Liautard et al.
doi:10.1038/nature06946
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4J0EC
----------------------
NATUREJOBS
----------------------
Prospect
Prospects p129
US National Postdoctoral Association campaigns for stipend boost.
Gene Russo
doi:10.1038/nj7191-129a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4K0ED
Career View
Eaton E. Lattman, chief executive and executive director of the
Hauptman-Woodward Medical Research Institute, Buffalo, New York p130
Crystallographer takes over at Buffalo's Hauptman-Woodward Medical
Research Institute.
Virginia Gewin
doi:10.1038/nj7191-130a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4L0EE
Crossing borders p130
Training programme links Stockholm and New York.
Paul Smaglik
doi:10.1038/nj7191-130b
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4M0EF
Meeting our targets p130
Evaluating the metrics of my own 'success'.
Amanda Goh
doi:10.1038/nj7191-130c
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4N0EG
Highlights
Opportunities: The National Institutes of Health
doi:10.1038/nj0206
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4O0EH
----------------------
FUTURES
----------------------
Build your own time machine p132
It's a unique set of experiences.
Igor Teper
doi:10.1038/453132a
http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4P0EI
---------------------------
ADVANCE ONLINE PUBLICATION
---------------------------
30 April 2008
Chemical compass model of avian magnetoreception
Kiminori Maeda et al.
doi:10.1038/nature06834
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4Q0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4R0EK
Genetic evidence that FGFs have an instructive role in limb proximal–distal patterning
Francesca V. Mariani, Christina P. Ahn and Gail R. Martin
doi:10.1038/nature06876
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4S0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4T0EM
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
Derek J. Richard et al.
doi:10.1038/nature06883
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4U0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4V0EO
Rapid cloning of high-affinity human monoclonal antibodies against influenza virus
Jens Wrammert et al.
doi:10.1038/nature06890
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4W0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4X0EQ
Angiogenesis selectively requires the p110-alpha isoform of PI3K to control endothelial cell migration
Mariona Graupera et al.
doi:10.1038/nature06892
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4Y0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4Z0ES
3.88-Aring structure of cytoplasmic polyhedrosis virus by cryo-electron microscopy
Xuekui Yu, Lei Jin and Z. Hong Zhou
doi:10.1038/nature06893
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4a0EZ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4b0Ea
A novel route for ATP acquisition by the remnant mitochondria of Encephalitozoon cuniculi
Anastasios D. Tsaousis et al.
doi:10.1038/nature06903
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4c0Eb
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4d0Ec
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
Robert K. McGinty et al.
doi:10.1038/nature06906
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4e0Ed
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4f0Ee
The Cl-/H+ antiporter ClC-7 is the primary chloride permeation pathway in lysosomes
Austin R. Graves, Patricia K. Curran, Carolyn L. Smith and Joseph A. Mindell
doi:10.1038/nature06907
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4g0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4h0Eg
RNA toxicity is a component of ataxin-3 degeneration in Drosophila
Ling-Bo Li, Zhenming Yu, Xiuyin Teng and Nancy M. Bonini
doi:10.1038/nature06909
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4i0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4j0Ei
27 April 2008
HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
Nabieh Ayoub, Anand D. Jeyasekharan, Juan A. Bernal and Ashok R. Venkitaraman
doi:10.1038/nature06875
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4k0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekb80Xztnp0HjB0Bt4l0Ek
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