April 2008 Volume 15 Number 4, pp 331 - 423
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DNA Damage Responses and Genome Maintenance
Visit the Cell Research web focus to read the latest on the genome maintenance systems involved in DNA damage detection, signaling, response and repair. Throughout this web focus featured articles encompass:
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- Recombination
- DNA damage tolerance
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EDITORIAL
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Cleaning up the EPA's act p331
On 12 March 2008, the US Environmental Protection Agency (EPA)
released its latest standards for ozone emission, along with
recommendations on how to update the Clean Air Act. This was
followed by public outcry from medical associations, nonprofit
organizations and media outlets.
doi:10.1038/nsmb0408-331
http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brnt0Ed
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NEWS AND VIEWS
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INO80 meets a fork in the road pp332 - 334
The INO80 chromatin-remodeling complex has roles in transcription,
DNA repair and replication. By studying the role of Ino80 in DNA
replication, a study now finds that the INO80 complex is essential
for replication fork progression under conditions of replicative
stress, stabilizes stalled forks and helps ensure proper restart.
Kelly M Trujillo and Mary Ann Osley
doi:10.1038/nsmb0408-332
http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brnu0Ee
Think you know how miRNAs work? Think again. pp334 - 336
Two proposed mechanisms for how microRNAs (miRNAs) and their
associated Argonaute proteins inhibit translation in mammals do
not seem to operate in Drosophila melanogaster cells, suggesting
that insights into important miRNA functions remain elusive.
However, the interaction between Argonaute and the P-body factor
GW182 may help in elucidating the biochemical basis of translational
control by miRNAs.
Joel D Richter
doi:10.1038/nsmb0408-334
http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brnv0Ef
No SIRT6 p336
Sabbi Lall
doi:10.1038/nsmb0408-336
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RESEARCH HIGHLIGHTS
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Research highlights p337
doi:10.1038/nsmb0408-337
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ARTICLES
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The Ino80 chromatin-remodeling enzyme regulates replisome function
and stability pp338 - 345
Manolis Papamichos-Chronakis and Craig L Peterson
doi:10.1038/nsmb.1413
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brny0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brnz0Ej
GW182 interaction with Argonaute is essential for miRNA-mediated
translational repression and mRNA decay pp346 - 353
Ana Eulalio, Eric Huntzinger and Elisa Izaurralde
doi:10.1038/nsmb.1405
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brn10EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brn20EX
The regulatory activity of microRNA* species has substantial
influence on microRNA and 3' UTR evolution pp354 - 363
Katsutomo Okamura et al.
doi:10.1038/nsmb.1409
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brn30EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brn40EZ
ATAC is a double histone acetyltransferase complex that stimulates
nucleosome sliding pp364 - 372
Tamaki Suganuma et al.
doi:10.1038/nsmb.1397
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brn50Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brn60Eb
The retinitis pigmentosa 2 gene product is a GTPase-activating
protein for Arf-like 3 pp373 - 380
Stefan Veltel, Raphael Gasper, Elke Eisenacher and Alfred Wittinghofer
doi:10.1038/nsmb.1396
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brn70Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0Brn80Ed
Roles of the Clr4 methyltransferase complex in nucleation, spreading
and maintenance of heterochromatin pp381 - 388
Ke Zhang, Kerstin Mosch, Wolfgang Fischle and Shiv I S Grewal
doi:10.1038/nsmb.1406
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroA0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroB0Eo
Pore-opening mechanism of the nicotinic acetylcholine receptor
evinced by proton transfer pp389 - 396
Gisela D Cymes and Claudio Grosman
doi:10.1038/nsmb.1407
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroC0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroD0Eq
Basis of altered RNA-binding specificity by PUF proteins revealed by
crystal structures of yeast Puf4p pp397 - 402
Matthew T Miller, Joshua J Higgin and Traci M Tanaka Hall
doi:10.1038/nsmb.1390
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroE0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroF0Es
Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK
channel conferred by the RCK1 domain pp403 - 410
Shangwei Hou, Rong Xu, Stefan H Heinemann and Toshinori Hoshi
doi:10.1038/nsmb.1398
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroG0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroH0Eu
MukB acts as a macromolecular clamp in DNA condensation pp411 - 418
Yuanbo Cui, Zoya M Petrushenko and Valentin V Rybenkov
doi:10.1038/nsmb.1410
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroI0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroJ0Ew
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BRIEF COMMUNICATIONS
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The ARID domain of the H3K4 demethylase RBP2 binds to a DNA CCGCCC
motif pp419 - 421
Shengjiang Tu et al.
doi:10.1038/nsmb.1400
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroK0Ex
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroL0Ey
Crystal structures of two human vitronectin, urokinase and urokinase
receptor complexes pp422 - 423
Qing Huai et al.
doi:10.1038/nsmb.1404
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroM0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej370Xztnp0Hjh0BroN0E1
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