May 2008 Volume 9 Number 5
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Nature Reviews Stem Cell Collection
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Stem-cell research has a history of more than 20 years, and has made
some outstanding contributions to our understanding of haematopoiesis
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which includes Research Highlights, Reviews and Perspectives articles
from Nature Reviews Cancer, Nature Reviews Immunology and
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This month's FEATURED article:
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
Adilson Guilherme, Joseph V. Virbasius, Vishwajeet Puri and Michael P. Czech
p367 | doi:10.1038/nrm2391
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFv0EK
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From the editors
p345 | doi:10.1038/nrm2398
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFi0E6
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RESEARCH HIGHLIGHTS
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Cell migration: Group voyage
p346 | doi:10.1038/nrm2405
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFj0E7
Membrane trafficking: A maturing influence
p347 | doi:10.1038/nrm2397
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFk0E8
IN BRIEF
Epigenetics | Gene expression | Ageing
p347 | doi:10.1038/nrm2403
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFl0EA
Membrane trafficking: Polar express
p348 | doi:10.1038/nrm2400
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFm0EB
Protein degradation: Ribophagy: selective ribosome 'eating'
p348 | doi:10.1038/nrm2401
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFn0EC
Mechanisms of disease: Stress and disease connect at mTORC1
p349 | doi:10.1038/nrm2396
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFo0ED
Protein translocation: Dancing the two-step with SAM
p350 | doi:10.1038/nrm2402
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFp0EE
Chromosomes: Introducing HAC
p351 | doi:10.1038/nrm2392
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFq0EF
TECHNOLOGY WATCH
Introducing BAC transgeneomics | Noninvasive live imaging
p351 | doi:10.1038/nrm2404
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFr0EG
AN INTERVIEW WITH...
Paul Berg
p352 | doi:10.1038/nrm2385
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFs0EH
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REVIEWS
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Mechanisms of asymmetric cell division: flies and worms pave the way
Pierre Gonczy
p355 | doi:10.1038/nrm2388
Asymmetric cell division, which occurs when a mother cell gives rise to two daughter cells with different fates, is crucial for generating diversity during development and for the function of stem cells. Studies in flies and worms have provided important advances for understanding this process.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFt0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFu0EJ
Article series: Mechanisms of disease
http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf02b30ET
Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes
Adilson Guilherme, Joseph V. Virbasius, Vishwajeet Puri and Michael P. Czech
p367 | doi:10.1038/nrm2391
Adipose tissue controls whole-body lipid flux, thereby modulating both glucose and lipid homeostasis in humans. Discovery of new targets that regulate fatty acids in adipocytes might lead to therapeutic modalities that can prevent insulin resistance and type 2 diabetes.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFv0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFh0E5
Expansion and evolution of cell death programmes
Alexei Degterev and Junying Yuan
p378 | doi:10.1038/nrm2393
Cell death has historically been divided into regulated (apoptotic) and unregulated (necrotic) mechanisms. Emerging evidence, however, suggests that these two categories do not adequately explain all cell death mechanisms. How and why might non-apoptotic, regulated cell death mechanisms have evolved?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFw0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFx0EM
Non-hexameric DNA helicases and translocases: mechanisms and regulation
Timothy M. Lohman, Eric J. Tomko and Colin G. Wu
p391 | doi:10.1038/nrm2394
DNA helicases and translocases have essential roles in nucleic acid metabolism. Processive helicases must translocate along DNA; however, enzyme self assembly and/or interactions with accessory proteins can regulate the separate translocase and helicase activities of some of these enzymes.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFy0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtFz0EO
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ANALYSIS
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Transcriptional control of human p53-regulated genes
Todd Riley, Eduardo Sontag, Patricia Chen and Arnold Levine
p402 | doi:10.1038/nrm2395
The p53 protein regulates the transcription of many target genes in response to a wide variety of stress signals. This Analysis article presents the most comprehensive list so far of human p53-regulated genes and their experimentally validated, functional binding sites that confer p53 regulation.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtF10EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtF20EC
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PERSPECTIVES
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ESSAY
How to succeed in science: a concise guide for young biomedical scientists. Part I: taking the plunge
Jonathan W. Yewdell
p413 | doi:10.1038/nrm2389
Although biomedical research has never been more intellectually exciting or practically important to society, pursuing a career as a biomedical scientist has never been more difficult. This article provides advice and gives tips on finding the right laboratory for Ph.D. and postdoctoral training.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtF30ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtF40EE
SCIENCE AND SOCIETY
The European Research Council -- a new opportunity for European science
Carl-Henrik Heldin
p417 | doi:10.1038/nrm2374
During recent decades, the lack of appropriate funding has made it difficult for European basic research to compete with research in North America and parts of Asia. The establishment of the European Research Council promises new opportunities to boost European science.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtF50EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekRf0Xztnp0Hjf0BtF60EG
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Nature Reviews Neuroscience
Poster on Alzheimer's
Two key proteins - amyloid-beta and tau - are thought to contribute to
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potential drug targets for the treatment of AD.
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