May 2008 Volume 8 Number 5
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This month's FEATURED article:
Getting to the stem of chronic myeloid leukaemia
Michael Savona and Moshe Talpaz
p341 | doi:10.1038/nrc2368
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK70EK
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From the editors
p319 | doi:10.1038/nrc2388
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKq0EI
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RESEARCH HIGHLIGHTS
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Carcinogenesis: Predisposing to behaviour?
p321 | doi:10.1038/nrc2383
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKr0EJ
Tumorigenesis: Ready and waiting
p322 | doi:10.1038/nrc2379
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKs0EK
Signalling: Follow your eNOS
p322 | doi:10.1038/nrc2382
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKt0EL
TRIAL WATCH
Don't stop now!
p322 | doi:10.1038/nrc2387
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKu0EM
Therapy: Bad to the bone
p323 | doi:10.1038/nrc2376
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKv0EN
Tumour microenvironment: No changes necessary
p324 | doi:10.1038/nrc2384
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKw0EO
Oncogenes: Sibling rivalry explained
p324 | doi:10.1038/nrc2385
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKx0EP
IN THE NEWS
The devil with the details
p324 | doi:10.1038/nrc2386
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKy0EQ
Signalling: Stress and disease connect at mTORC1
p325 | doi:10.1038/nrc2381
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtKz0ER
Tumour suppressors: Motoring on down
p326 | doi:10.1038/nrc2377
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK10EE
Metastasis: Bringing up the rear
p326 | doi:10.1038/nrc2380
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK20EF
Signalling: An oncogene becomes RESTless
p327 | doi:10.1038/nrc2378
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK30EG
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REVIEWS
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Detection, clinical relevance and specific biological properties of disseminating tumour cells
Klaus Pantel, Ruud H. Brakenhoff and Burkhard Brandt
p329 | doi:10.1038/nrc2375
Most cancer deaths are caused by metastatic spread and subsequent growth of tumour cells at distant organs. How are disseminating tumour cells relevant to the biology of early metastatic spread and how might they be used to improve cancer treatment?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK40EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK50EI
Getting to the stem of chronic myeloid leukaemia
Michael Savona and Moshe Talpaz
p341 | doi:10.1038/nrc2368
Imatinib has been an extremely successful treatment for chronic myeloid leukaemia. However, we need to know about the stem cells involved in the disease to understand why relapse is so common when imatinib is stopped.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK60EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK70EK
Immunotherapy of established (pre)malignant disease by synthetic long peptide vaccines
Cornelis J.M. Melief and Sjoerd H. van der Burg
p351 | doi:10.1038/nrc2373
This Review discusses the recent progress in the treatment of established (pre)malignant disease of viral or non-viral origin with synthetic long peptide vaccines that are capable of inducing robust T-cell responses.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtK80EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLA0EV
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival
H. Llewelyn Roderick and Simon J. Cook
p361 | doi:10.1038/nrc2374
Changes in the levels of the second messenger Ca2+ can result in the activation of broadly proliferative or cytotoxic responses. As reviewed here, to tip the balance in their favour, cancer cells often remodel the expression or activity of their Ca2+ signalling apparatus.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLB0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLC0EX
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PERSPECTIVES
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OPINION
Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis
John M. Pawelek and Ashok K. Chakraborty
p377 | doi:10.1038/nrc2371
The causes of metastasis remain elusive. Could the fusion of cancer cells with macrophages or other migratory bone marrow-derived cells (BMDCs) provide an explanation?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLD0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLE0EZ
TIMELINE
Wnt signalling and its impact on development and cancer
Alexandra Klaus and Walter Birchmeier
p387 | doi:10.1038/nrc2389
The Wnt signalling pathway has a crucial role in the development of all animal species, and mutations or deregulated expression of components of the Wnt pathway can result in cancer. This Timeline examines the past 25 years of crucial discoveries - from a variety of disciplines - about the components and functions of this pathway.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLF0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLG0Eb
SCIENCE AND SOCIETY
The challenge of cancer control in Africa
Rebecca J. Lingwood, Peter Boyle, Alan Milburn, Twalib Ngoma, John Arbuthnott, Ruth McCaffrey, Stewart H. Kerr and David J. Kerr
p398 | doi:10.1038/nrc2372
The developing world is set to be ravaged by an impending cancer epidemic. How can we help to ensure that cancer patients get the treatment they need in Africa?
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLH0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLI0Ed
Corrigendum: Prostate-specific antigen and prostate cancer: prediction, detection and monitoring (Corrigendum)
Hans Lilja, David Ulmert and Andrew J. Vickers
p403 | doi:10.1038/nrc2395
http://ealerts.nature.com/cgi-bin24/DM/y/ekSh0Xztnp0Hja0BtLJ0Ee
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