April 2008 Volume 14 Number 4, pp 351 - 465
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Nature Reviews Stem Cell Collection
Free online access
Stem-cell research has a history of more than 20 years, and has made some outstanding contributions to our understanding of haematopoiesis and embryology. The Nature Reviews journals present a Stem Cell Collection, which includes Research Highlights, Reviews and Perspectives articles from Nature Reviews Cancer, Nature Reviews Immunology and Nature Reviews Molecular Cell Biology.
All these articles will be available free online for six months at:
www.nature.com/reviews/focus/stemcells
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LICR Singapore Branch Director
The international Ludwig Institute for Cancer Research seeks
outstanding physician-scientist to develop new translational and
clinical research branch in Singapore, in conjunction with Agency
for Science, Technology and Research (A*STAR), National University
of Singapore (NUS) Yong-Loo Lin School of Medicine and Duke-NUS
Graduate Medical School.
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrsU0EI
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Nature Reviews Stem Cell Collection
Free online access
Stem-cell research has a history of more than 20 years, and has made some outstanding contributions to our understanding of haematopoiesis and embryology. The Nature Reviews journals present a Stem Cell Collection, which includes Research Highlights, Reviews and Perspectives articles from Nature Reviews Cancer, Nature Reviews Immunology and Nature Reviews Molecular Cell Biology.
All these articles will be available free online for six months at:
www.nature.com/reviews/focus/stemcells
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Unleash the full potential of real-time PCR:
Discover the next-generation LightCycler(R) 480 System and its broad range of analysis capabilities. Join us this year to celebrate a decade of PCR innovation and
cutting-edge performance.
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT01RQ0EU
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EDITORIAL
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A metareview at the NIH p351
Science funding in the United States is tight, and the application process is arduous. A recent study of NIH peer-review recommends a major overhaul of the system. Will the changes prove cosmetic or curative?
doi:10.1038/nm0408-351
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrsV0EJ
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NEWS
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Search for potential autism treatments turns to 'trust hormone' p353
Alisa Opar
doi:10.1038/nm0408-353
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrsW0EK
After microbicide failures, hope that antiviral approach will gel p354
T V Padma
doi:10.1038/nm0408-354a
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrsX0EL
Gates Foundation looks to fund unconventional health solutions p354
Apoorva Mandavilli
doi:10.1038/nm0408-354b
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrsY0EM
Gut instincts drive next generation of diabetes medications p355
Genevive Bjorn
doi:10.1038/nm0408-355
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrsZ0EN
News in brief pp356 - 357
Timeline of events...a brief look at the headlines from the past month
doi:10.1038/nm0408-356
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsa0EU
Immune to the high pp358 - 361
Current medications used to treat drug addiction help to some extent by easing withdrawal symptoms, but these treatments cannot curb the high that people receive when they relapse and take a hit of the drug. Emma Marris explores how researchers are working on a way to make these tempting drug highs history for recovering addicts.
Emma Marris
doi:10.1038/nm0408-358
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsb0EV
Q & A: Samir Khleif p362
In 1999, Hussein bin Talal, the king of Jordan, died after a long battle with non-Hodgkin's lymphoma. Since then, his eldest son and successor, King Abdullah II bin Al Hussein, has sought to improve cancer treatment in his country as part of an effort to boost healthcare and technological development. The country's capital, Amman, now boasts a world-class cancer treatment center, which draws patients from throughout the region. To lead that effort, the king tapped Samir Khleif, chief of the cancer vaccine section at the US National Cancer Institute in Bethesda, Maryland. Khleif, who received his medical degree in Jordan, now has an even bigger mandate from the king: to build an internationally renowned institute devoted to cancer research and biotechnology. Construction on The King Hussein Institute for Cancer and Biotechnology is scheduled to begin on the outskirts of Amman this month, with an expected completion in 2010.
Charlotte Schubert
doi:10.1038/nm0408-362
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsc0EW
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BOOK REVIEW
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A history of malaria p363
Brian Greenwood reviews The Making of a Tropical Disease: A Short History of MalariaRandall M Packard
doi:10.1038/nm0408-363
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsd0EX
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NEWS AND VIEWS
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New drugs for an ancient parasite pp365 - 367
Only one drug is widely used to treat schistosomiasis, a chronic, neglected tropical disease caused by parasitic blood flukes. Fears of potential drug resistance have accelerated the search for new classes of antischistosome drugs. A promising candidate has now emerged (pages 407-412).
Alex Loukas and Jeffrey M Bethony
doi:10.1038/nm0408-365
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brse0EY
Dropping acid to help cystic fibrosis pp367 - 369
Vesicular accumulation of the membrane component ceramide may underlie key aspects of lung pathology in cystic fibrosis (pages 382-391).
Gerald B Pier
doi:10.1038/nm0408-367
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsf0EZ
Getting personal about treating HIV pp369 - 370
Genetic variants have been identified that may predict the response to HIV treatment (pages 413-420).
James D Neaton and H Clifford Lane
doi:10.1038/nm0408-369
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsg0Ea
Bacteria fight back against Toll-like receptors pp370 - 372
A strain of Escherichia coli that causes urinary tract infections seems to take hold in the body by interfering with signaling through Toll-like receptors (TLRs). The mechanism involves a secreted bacterial protein that is taken up by cells and clogs up the TLR signaling mechanism (pages 399-406).
Luke A J O'Neill
doi:10.1038/nm0408-370
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsh0Eb
Robo4 counteracts VEGF signaling pp372 - 373
Robo4 expression in emerging blood vessels can neutralize signaling through the angiogenic factor vascular endothelial growth factor (VEGF) and maintain vessel integrity. The findings could lead to new therapeutic targets for angiogenesis and vascular leakage (pages 448-453).
Lisette M Acevedo, Sara M Weis and David A Cheresh
doi:10.1038/nm0408-372
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsi0Ec
Cancer's source in the peripheral nervous system pp373 - 375
Two studies examine the cellular origins of peripheral nervous system tumors in mouse models of neurofibromatosis type 1 and conclude that stem cells may not be the culprits. Instead, more differentiated cells may give rise to and drive the tumors.
Peter B Dirks
doi:10.1038/nm0408-373
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsj0Ed
Research highlights pp376 - 377
doi:10.1038/nm0408-376
http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsk0Ee
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BRIEF COMMUNICATION
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Therapeutic cloning in individual parkinsonian mice pp379 - 381
Viviane Tabar et al.
doi:10.1038/nm1732
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsl0Ef
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsm0Eg
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ARTICLES
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Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis pp382 - 391
Volker Teichgraber et al.
doi:10.1038/nm1748
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsn0Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brso0Ei
Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis pp392 - 398
Adrian M Piliponsky et al.
doi:10.1038/nm1738
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsp0Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsq0Ek
Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins pp399 - 406
Christine Cirl et al.
doi:10.1038/nm1734
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsr0El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brss0Em
Identification of oxadiazoles as new drug leads for the control of schistosomiasis pp407 - 412
Ahmed A Sayed et al.
doi:10.1038/nm1737
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brst0En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsu0Eo
CCL3L1-CCR5 genotype influences durability of immune recovery during antiretroviral therapy of HIV-1-infected individuals pp413 - 420
Sunil K Ahuja et al.
doi:10.1038/nm1741
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsv0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsw0Eq
Simian immunodeficiency virus-induced mucosal interleukin-17 deficiency promotes Salmonella dissemination from the gut pp421 - 428
Manuela Raffatellu et al.
doi:10.1038/nm1743
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsx0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsy0Es
Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4+ T cells pp429 - 436
Kathryn S Jones et al.
doi:10.1038/nm1745
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brsz0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brs10Eg
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LETTERS
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Interferon-[gamma] is a therapeutic target molecule for prevention of postoperative adhesion formation pp437 - 441
Hisashi Kosaka et al.
doi:10.1038/nm1733
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brs20Eh
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brs30Ei
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy pp442 - 447
Douglas P Millay et al.
doi:10.1038/nm1736
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brs40Ej
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brs50Ek
Robo4 stabilizes the vascular network by inhibiting pathologic angiogenesis and endothelial hyperpermeability pp448 - 453
Christopher A Jones et al.
doi:10.1038/nm1742
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brs60El
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brs70Em
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TECHNICAL REPORTS
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Detection of colonic dysplasia in vivo using a targeted heptapeptide and confocal microendoscopy pp454 - 458
Pei-Lin Hsiung et al.
doi:10.1038/nm1692
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0Brs80En
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrtA0Ex
Simultaneous PET-MRI: a new approach for functional and morphological imaging pp459 - 465
Martin S Judenhofer et al.
doi:10.1038/nm1700
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrtB0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej4O0Xztnp0HjT0BrtC0Ez
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Nature Reviews Immunology Poster on innate immunity: sensing and signalling
The innate immune system is the first line of defence against invading pathogens. Detection of such pathogens is a complex business, involving several families of pattern-recognition receptors and an array of signalling molecules.
This poster provides an overview of the components and networks involved in pathogen sensing and signalling in the innate immune system.
Access the Poster FREE online!
www.nature.com/nri/posters/innate
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