May 2008 Volume 9 Number 5, pp 445 - 567
Visit Nature Immunology online to browse the journal.
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NATURE IMMUNOLOGY
FOCUS ON NATURAL KILLER CELLS
Natural killer cells influence immune responses to tumors, infections and
pregnancy. Nature Immunology presents a series of specially commissioned
articles that focus on natural killer cells and their far-reaching effects
on diverse cell types and biological responses. The web focus, free for
six months, also includes highlights of recent research findings, an annotated
list of classic articles and links to selected NPG papers pertinent to this field.
For more information visit:
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EDITORIAL
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Pushing the limits p445
Responding to escalating violence by extremist animal-rights groups, academics are working proactively to prevent the harassment and harm of scientists.
doi:10.1038/ni0508-445
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssO0Eu
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MEETING REPORTS
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Autoimmunity and transplantation: a meeting at the crossroads in Berlin pp447 - 449
Every 2 years, scientists interested in immunomodulation meet to discuss new opportunities arising from interactions between basic science and clinical 'translation'. This report discusses the 8th International Conference on New Trends in Immunosuppression and Immunotherapy, 2008, in Berlin.
Birgit Sawitzki et al.
doi:10.1038/ni0508-447
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssP0Ev
T cell heterogeneity: firmly fixed, predominantly plastic or merely malleable? pp450 - 453
This report highlights the lively debate and discussions on lymphocyte plasticity and/or determinism that occurred at the second Ringberg Colloquium in February 2008 in the Bavarian hills near Tegernsee, Germany.
John J O'Shea, Christopher A Hunter and Ronald N Germain
doi:10.1038/ni0508-450
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssQ0Ew
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NEWS AND VIEWS
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Moving out: mobilizing activated T cells from lymphoid tissues pp455 - 457
The intensity of cytokine-induced signaling by the kinase PI(3)K subunit p110[delta] proves to be an important regulator of T cell migration patterns. High PI(3)K activity functions through the nutrient and bioenergetic sensor mTOR to modulate the transcription factor KLF2 and thereby the repertoire of tissue-homing receptors expressed on effector T cells.
Gabriel Berstein and Robert T Abraham
doi:10.1038/ni0508-455
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssR0Ex
CD3[epsiv]: PeRuSing for positive selection pp457 - 459
How engagement of surface T cell antigen receptors 'translates' into intracellular signal cascades remains vague. Genetic and biochemical experiments now allow modification of a model linking ligation of these receptors with CD3[epsiv] and other cytoplasmic signal-transduction 'machinery'.
Jonathan S Maltzman and Gary A Koretzky
doi:10.1038/ni0508-457
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssS0Ey
'Fine tuning' TLR signaling pp459 - 461
Toll-like receptor signaling induces the production of proinflammatory cytokines and type I interferons. Inhibition of the kinase IRAK1 by the phosphatase SHP-1 provides reciprocal regulation of these pathways by dampening the former while enhancing the latter.
Luke A J O'Neill
doi:10.1038/ni0508-459
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssT0Ez
Cross-presentation: avoiding trafficking chaos? pp461 - 463
Cross-presentation of antigens is essential for the responses of cytotoxic T cells to tumors and viruses. Two new papers offer insights into the subcellular compartment and types of dendritic cells that mediate cross-presentation.
Sudhir Pai Kasturi and Bali Pulendran
doi:10.1038/ni0508-461
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssU0E1
Research Highlights p465
doi:10.1038/ni0508-465
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssV0E2
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EDITORIAL
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Outside the box p471
This Focus on natural killer cells aims to highlight what is currently known and what remains to be understood about these important innate immune cells.
doi:10.1038/ni0508-471
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssW0E3
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OVERVIEW
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Natural killer cells: diversity in search of a niche pp473 - 475
James P Di Santo
doi:10.1038/ni.f.201
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssX0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssY0E5
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ESSAY
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Natural killer cell recognition of missing self pp477 - 480
The idea that NK cells can distinguish aberrant cells by recognizing 'absence of the expected', rather than 'presence of the unexpected' emerged more than 25 years ago. Klas Karre recapitulates how the idea took shape, and the first five years of experimental work to test its general predictions.
Klas Karre
doi:10.1038/ni0508-477
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0BssZ0E6
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PERSPECTIVES
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Mistaken notions about natural killer cells pp481 - 485
Wayne M Yokoyama
doi:10.1038/ni1583
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssa0EE
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssb0EF
Natural killer cell-directed therapies: moving from unexpected results to successful strategies pp486 - 494
Magali Terme et al.
doi:10.1038/ni1580
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssc0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssd0EH
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REVIEWS
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Up on the tightrope: natural killer cell activation and inhibition pp495 - 502
Lewis L Lanier
doi:10.1038/ni1581
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bsse0EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssf0EJ
Functions of natural killer cells pp503 - 510
Eric Vivier et al.
doi:10.1038/ni1582
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssg0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssh0EL
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RESEARCH HIGHLIGHTS
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Research Highlights p511
doi:10.1038/ni0508-511
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssi0EM
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ARTICLES
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Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking pp513 - 521
Linda V Sinclair et al.
doi:10.1038/ni.1603
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssj0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssk0EO
The proline-rich sequence of CD3[epsi] controls T cell antigen receptor expression on and signaling potency in preselection CD4+CD8+ thymocytes pp522 - 532
Michael Mingueneau et al.
doi:10.1038/ni.1608
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssl0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssm0EQ
Deactivation of the kinase IKK by CUEDC2 through recruitment of the phosphatase PP1 pp533 - 541
Hui-Yan Li et al.
doi:10.1038/ni.1600
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssn0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bsso0ES
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1 pp542 - 550
Huazhang An et al.
doi:10.1038/ni.1604
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssp0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssq0EU
Direct proteasome-independent cross-presentation of viral antigen by plasmacytoid dendritic cells on major histocompatibility complex class I pp551 - 557
Tiziana Di Pucchio et al.
doi:10.1038/ni.1602
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssr0EV
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bsss0EW
Spatial and mechanistic separation of cross-presentation and endogenous antigen presentation pp558 - 566
Sven Burgdorf et al.
doi:10.1038/ni.1601
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bsst0EX
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssu0EY
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CORRIGENDUM
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Corrigendum: CD160 inhibits activation of human CD4+ T cells through interaction with herpesvirus entry mediator p567
Guifang Cai et al.
doi:10.1038/ni0508-567
http://ealerts.nature.com/cgi-bin24/DM/y/ekLc0Xztnp0HjR0Bssv0EZ
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Cell Shape and Polarity: Lymphocytes and Beyond
September 29, 2008
Chicago, Illinois
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Apply by June 25, 2008
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