April 2008 Volume 10 Number 4, pp 371 - 497
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EDITORIAL
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Good review p371
Much has been said about alternatives and enhancements to
'single-blind' peer review; but what actually constitutes a good
referee report?
doi:10.1038/ncb0408-371
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brih0Ed
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NEWS AND VIEWS
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Neurogenesis directed by Sirt1 pp373 - 374
Differentiation of neuronal stem cells into astrocytes or neurons is
important in maintaining brain function. Oxidative stress and
inflammation are now shown to bias differentiation toward astrocytes
by modulating activity of the anti-ageing gene Sirt1. These findings
link a longevity gene to the activity of neuronal stem cells and
their response to stress.
Sergiy Libert, Dena Cohen and Leonard Guarente
doi:10.1038/ncb0408-373
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brii0Ee
Sophistications of cell sorting pp375 - 377
The self-sorting of early embryonic cells is mediated not only by
pure differential adhesion but also involves other processes. Direct
force measurements reveal the role of cell-cortical tension, whereas
epithelial-wrapping dominates the sorting of enclosed mesenchymal
cells.
Jeremy B.A. Green
doi:10.1038/ncb0408-375
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brij0Ef
BRCA1 and stem cells: tumour typecasting pp377 - 379
Phenotypic variation between tumour types is likely to reflect the
nature of the cell of origin and the genes involved in pathogenesis.
Compared with most sporadic breast cancers, those arising in carriers
of BRCA1 mutations usually have distinctive pathological
characteristics. A new study suggests that a role for BRCA1 in the
determination of stem-cell fate may explain this phenomenon.
Matthew J. Smalley, Jorge S. Reis-Filho and Alan Ashworth
doi:10.1038/ncb0408-377
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brik0Eg
Dam1 complexes go it alone on disassembling
microtubules pp379 - 381
Kinetochores maintain a mechanical grip on disassembling microtubule
plus ends, possibly through a 16-member Dam1 ring that acts as a
sliding clamp. It turns out, however, that a ring is not required
for maintaining grip: individual Dam1 complexes in vitro can diffuse
on the microtubule lattice and track shortening microtubule tips.
Melissa K. Gardner and David J. Odde
doi:10.1038/ncb0408-379
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bril0Eh
Securin' M-phase entry pp381 - 383
The anaphase-promoting complex (APC) mediates the ubiquitination and
degradation of key M-phase regulators, including cyclins and the
anaphase inhibitor securin. Intriguingly, securin can also inhibit
the degradation of cyclin B. This competition between substrates
permits the accumulation of enough cyclin to drive entry into M
phase.
Mark J. Solomon and Janet L. Burton
doi:10.1038/ncb0408-381
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brim0Ei
STIM1 tracks growing microtubule ends p384
Andrew Jermy
doi:10.1038/ncb0408-384
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brin0Ej
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ARTICLES
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Sirt1 contributes critically to the redox-dependent fate of neural
progenitors pp385 - 394
Timour Prozorovski et al.
doi:10.1038/ncb1700
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brio0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brip0El
Inn1 couples contraction of the actomyosin ring to membrane ingression
during cytokinesis in budding yeast pp395 - 406
Alberto Sanchez-Diaz et al.
doi:10.1038/ncb1701
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Briq0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brir0En
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LETTERS
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Phosphoregulation and depolymerization-driven movement of the Dam1
complex do not require ring formation pp407 - 414
Daniel R. Gestaut et al.
doi:10.1038/ncb1702
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bris0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brit0Ep
EB1 regulates microtubule dynamics and tubulin sheet closure
in vitro pp415 - 421
Benjamin Vitre et al.
doi:10.1038/ncb1703
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Briu0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Briv0Er
The NHL-domain protein Wech is crucial for the integrin-cytoskeleton
link pp422 - 428
Birgit Loer et al.
doi:10.1038/ncb1704
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Briw0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Brix0Et
Tensile forces govern germ-layer organization in
zebrafish pp429 - 436
M. Krieg et al.
doi:10.1038/ncb1705
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Briy0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Briz0Ev
elipsa is an early determinant of ciliogenesis that links the IFT
particle to membrane-associated small GTPase Rab8 pp437 - 444
Yoshihiro Omori et al.
doi:10.1038/ncb1706
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bri10Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bri20Ej
Securin regulates entry into M-phase by modulating the stability
of cyclin B pp445 - 451
Petros Marangos and John Carroll
doi:10.1038/ncb1707
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bri30Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bri40El
Lamin A-dependent misregulation of adult stem cells associated with
accelerated ageing pp452 - 459
Paola Scaffidi and Tom Misteli
doi:10.1038/ncb1708
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bri50Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bri60En
Functional interaction between FOXO3a and ATM regulates DNA damage
response pp460 - 467
Wen-Bin Tsai et al.
doi:10.1038/ncb1709
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bri70Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0Bri80Ep
Drosophila short neuropeptide F signalling regulates growth by
ERK-mediated insulin signalling pp468 - 475
Kyu-Sun Lee et al.
doi:10.1038/ncb1710
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjA0Ez
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjB0E1
A bistable Rb-E2F switch underlies the restriction
point pp476 - 482
Guang Yao et al.
doi:10.1038/ncb1711
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjC0E2
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjD0E3
Monoubiquitinated H2B is associated with the transcribed region of
highly expressed genes in human cells pp483 - 488
Neri Minsky et al.
doi:10.1038/ncb1712
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjE0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjF0E5
Drosophila STAT is required for directly maintaining HP1 localization
and heterochromatin stability pp489 - 496
Song Shi et al.
doi:10.1038/ncb1713
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjG0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjH0E7
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ERRATUM
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Erratum p497
doi:10.1038/ncb0408-497a
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjI0E8
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CORRIGENDUM
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Corrigendum p497
doi:10.1038/ncb0408-497b
http://ealerts.nature.com/cgi-bin24/DM/y/ej210Xztnp0HjD0BrjJ0EA
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