April 2008 Volume 26 Number 4, pp 357 - 474
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EDITORIALS
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Doing better at doing good p357
Global health initiatives should place greater emphasis on mechanisms for encouraging small and medium-sized biotech enterprises to participate in the fight against neglected diseases.
doi:10.1038/nbt0408-357
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBJ0Ef
A voice with no words p358
The first blog from a biotech company goes live.
doi:10.1038/nbt0408-358
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBK0Eg
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NEWS
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US credit crunch impacts biotech across the globe pp359 - 360
Peter Mitchell
doi:10.1038/nbt0408-359
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBL0Eh
Dynogen's SPAC p360
Randy Osborne
doi:10.1038/nbt0408-360
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBM0Ei
Can 'double blockbuster' strengthen Amgen's backbone? pp361 - 363
Cormac Sheridan
doi:10.1038/nbt0408-361
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBN0Ej
Four rebuffs for Cabilly p362
Emily Waltz
doi:10.1038/nbt0408-362a
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBO0Ek
India's IP snub p362
KS Jayaraman
doi:10.1038/nbt0408-362b
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBP0El
Companies line up for hereditary angioedema market pp364 - 365
Brady Huggett
doi:10.1038/nbt0408-364
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBQ0Em
Tear-free onions p365
Susan Aldridge
doi:10.1038/nbt0408-365a
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBR0En
Thumbs up for Avastin p365
BJ Spalding
doi:10.1038/nbt0408-365b
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBS0Eo
Bush tails follow-ons p366
Jeff Fox
doi:10.1038/nbt0408-366a
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBT0Ep
Amgen's Japan deal p366
Mark Ratner
doi:10.1038/nbt0408-366b
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBU0Eq
Drug makers chase cancer stem cells pp366 - 367
Charlie Schmidt
doi:10.1038/nbt0408-366c
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBV0Er
PROFILE
Dan Ravicher p369
A patent attorney relies on guts, smarts and 'deep throats' to take on what he considers a broken patent system.
Crispin Littlehales
doi:10.1038/nbt0408-369
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBW0Es
NEWS FEATURE
A mid-life crisis for aging theory pp371 - 374
From yeast to mice, limiting food intake slows aging and extends lifespan. Activators of the sirtuins, enzymes famously linked to this process, promise a wealth of new drugs[mdash]but the sirtuin hypothesis is now coming under fire. Ken Garber reports.
Ken Garber
doi:10.1038/nbt0408-371
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBX0Et
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BIOENTREPRENEUR
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BUILDING A BUSINESS
The seven deadly sins of business development pp375 - 377
Striking partnerships is a key ingredient to building a biotech company. In this article, we discuss seven common mistakes that you should avoid during business development.
Jeffrey J Stewart and Ben Bonifant
doi:10.1038/bioe.2008.3
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBY0Eu
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OPINION AND COMMENT
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CORRESPONDENCE
An inconvenient version of events p379
Giovanni Monastra
doi:10.1038/nbt0408-379a
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBZ0Ev
Response to An inconvenient version of events pp379 - 380
doi:10.1038/nbt0408-379b
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBa0E3
Transendothelial movement and caveolae pp380 - 381
Richard G W Anderson
doi:10.1038/nbt0408-380
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBb0E4
Response to Transendothelial movement and caveolae pp381 - 382
doi:10.1038/nbt0408-381
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBc0E5
Expanding YIC status pp382 - 383
Philippe Pouletty
doi:10.1038/nbt0408-382
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBd0E6
Bt corn in Spain - the performance of the EU's first GM crop pp384 - 386
Manuel Gomez-Barbero, Julio Berbel and Emilio Rodriguez-Cerezo
doi:10.1038/nbt0408-384
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBe0E7
COMMENTARY
Newtons of the leaves of grass pp387 - 389
Joachim Boldt and Oliver Muller
doi:10.1038/nbt0408-387
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBf0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBg0EA
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BOOK REVIEW
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A bio-friendly future p391
Linda MacDonald Glenn reviews A Many-Colored Glass: Reflections on the Place of Life in the Universe By Freeman J. Dyson
doi:10.1038/nbt0408-391
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBh0EB
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FEATURES
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PATENTS
Patenting pluripotence: the next battle for stem cell intellectual property pp393 - 395
What will be the impact of induced pluripotent stem cell discoveries on the current stem cell patent landscape?
Katja Triller Vrtovec and Christopher Thomas Scott
doi:10.1038/nbt0408-393
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBi0EC
Recent patent applications in drug discovery automation p396
doi:10.1038/nbt0408-396
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBj0ED
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NEWS AND VIEWS
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Toward a renewable source of pancreatic [beta]-cells pp397 - 398
Insulin-producing cells generated from human embryonic stem cells protect mice from diabetes.
Camillo Ricordi and Helena Edlund
doi:10.1038/nbt0408-397
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBk0EE
Targeting siRNA to arrest fibrosis pp399 - 400
Vitamin A-mediated targeting of small interfering (si)RNA to stellate cells reverses liver cirrhosis.
Scott L Friedman
doi:10.1038/nbt0408-399
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBl0EF
Cancer biomarker profiling with microRNAs pp400 - 401
MicroRNAs define tissues of origin in cancer.
Stefanie S Jeffrey
doi:10.1038/nbt0408-400
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBm0EG
The oldest antibodies newly discovered pp402 - 403
Lamprey monoclonal antibodies provide stable and high-avidity alternatives to immunoglobulins.
Zeev Pancer and Roy A Mariuzza
doi:10.1038/nbt0408-402
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBn0EH
siRNAs with guts pp403 - 405
Leukocyte-directed, small interfering (si)RNA against cyclin D1 shows promise for treatment of inflammatory bowel disease.
Ian MacLachlan
doi:10.1038/nbt0408-403
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBo0EI
Research highlights p406
doi:10.1038/nbt0408-406
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBp0EJ
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COMPUTATIONAL BIOLOGY
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ANALYSIS
Discovering microRNAs from deep sequencing data using miRDeep pp407 - 415
Marc R Friedlander et al.
doi:10.1038/nbt1394
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBq0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBr0EL
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RESEARCH
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PERSPECTIVE
Making it stick: convection, reaction and diffusion in surface-based biosensors pp417 - 426
Todd M Squires, Robert J Messinger and Scott R Manalis
doi:10.1038/nbt1388
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBs0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBt0EN
BRIEF COMMUNICATIONS
Detecting native folds in mixtures of proteins that contain disulfide bonds pp427 - 429
Mahesh Narayan et al.
doi:10.1038/nbt1380
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBu0EO
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBv0EP
ARTICLES
Resolution of liver cirrhosis using vitamin A-coupled liposomes to deliver siRNA against a collagen-specific chaperone pp431 - 442
Yasushi Sato et al.
doi:10.1038/nbt1396
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBw0EQ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBx0ER
Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo pp443 - 452
Evert Kroon et al.
doi:10.1038/nbt1393
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBy0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsBz0ET
Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors pp453 - 461
Johannes L Zakrzewski et al.
doi:10.1038/nbt1395
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsB10EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsB20EH
MicroRNAs accurately identify cancer tissue origin pp462 - 469
Nitzan Rosenfeld et al.
doi:10.1038/nbt1392
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsB30EI
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsB40EJ
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ERRATUM
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Erratum: Vintage genetic engineering p470
Laura DeFrancesco
doi:10.1038/nbt0408-470a
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsB50EK
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CORRIGENDUM
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Corrigendum: Fluorogen-activating single-chain antibodies for imaging cell surface proteins p470
Christopher Szent-Gyorgyi et al.
doi:10.1038/nbt0408-470b
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsB60EL
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NATUREJOBS
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CAREERS AND RECRUITMENT
Almost in bloom pp471 - 472
St. Louis wants to become a hub of agricultural biotechnology. All it needs is more start-ups and funds.
Emma Marris
doi:10.1038/nbt0408-471
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsB70EM
PEOPLE
People p474
doi:10.1038/nbt0408-474
http://ealerts.nature.com/cgi-bin24/DM/y/ekAh0Xztnp0HjC0BsB80EN
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