03 April 2008 Volume 452 Number 7187, pp 503-664
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EDITORIALS
----------------------
Broken promises p503
Intense public support for clinical research can be a mixed blessing
— and the hunt for a vaccine against AIDS offers an important
lesson for many biomedical initiatives on what can go wrong.
doi:10.1038/452503a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brow0E8
Double vision pp503-504
The need to transform the world's energy technology is even greater
than many perceive.
doi:10.1038/452503b
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brox0EA
Mismanaged measures p504
Surrogate end points can be helpful in clinical trials — but
only if they are used with care.
doi:10.1038/452504a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Broy0EB
----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights pp506-507
doi:10.1038/452506a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Broz0EC
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JOURNAL CLUB
----------------------
Journal club p507
A. P. de Silva
doi:10.1038/452507a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Bro10Ex
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NEWS
----------------------
Are the IPCC scenarios 'unachievable'? pp508-509
Claim that the challenge of cutting emissions has been underestimated is debated.
Quirin Schiermeier
doi:10.1038/452508a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Bro20Ey
Carbon-trading market has uncertain future pp508-509
Clean development mechanism may be capped.
Jeff Tollefson
doi:10.1038/452508b
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Bro30Ez
Drug markers questioned pp510-511
A recent spate of worrying clinical-trial data has researchers
questioning drugs approved on the basis of how they affect biomarkers
rather than clinical endpoints. Heidi Ledford looks at surrogate markers.
doi:10.1038/452510a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Bro40E1
EPA feels heat over flame retardant pp513-513
Dismissal of toxicologist raises concerns over delayed safety report.
Brian Vastag
doi:10.1038/452513a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Bro50E2
Sidelines p514
Scribbles on the margins of science.
doi:10.1038/452514a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Bro60E3
Easy ways to other Earths pp514-515
Laser combs offer ground-based telescopes a chance to spot planetary
homes from home.
Eric Hand
doi:10.1038/452514b
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Bro70E4
Snapshot: Flirty in pink p515
Dolphins turn on the charm.
Anna Petherick
doi:10.1038/452515a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Bro80E5
Back to basics for HIV vaccine development pp516-516
doi:10.1038/452516a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpA0EG
Tasting a geyser p516
doi:10.1038/452516b
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpB0EH
US medical school to require master's degree pp516-516
doi:10.1038/452516c
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpC0EI
Too much haste in US drug approval? pp516-517
doi:10.1038/452516d
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpD0EJ
Italy to help Kenya develop space programme pp517-517
doi:10.1038/452517a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpE0EK
Muslim nations raise status of science pp517-517
doi:10.1038/452517b
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpF0EL
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CORRECTION
----------------------
Correction pp517-517
doi:10.1038/452517c
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpG0EM
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COLUMN
----------------------
Hazy reasoning behind clean air pp519-519
Science alone can't determine how regulations are written, argues David Goldston.
David Goldston
doi:10.1038/452519a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpH0EN
----------------------
NEWS FEATURES
----------------------
Architecture: Architects of a low-energy future pp520-523
Low- and zero-energy buildings could have a huge impact on energy use
and carbon emissions. We have the technologies, but if they are to
mitigate climate change, green-building design must hit the mass
market, says Declan Butler.
doi:10.1038/452520a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpI0EO
Anatomy: Truly gross anatomy pp525-526
Sometimes it is necessary to immerse yourself in a subject. Erik Vance
meets a woman whose research takes her deep — waist-deep — into
cetacean anatomy.
doi:10.1038/452525a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpJ0EP
Portugal: Navigating new waters pp528-529
Portugal's spending on research is near the lowest in western Europe.
Can a single-minded lady with half a billion euros change things,
asks Alison Abbott.
doi:10.1038/452528a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpK0EQ
----------------------
CORRESPONDENCE
----------------------
Radical rethink is needed on climate-change policy p530
Gwyn Prins
doi:10.1038/452530a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpL0ER
Comparing the legacies of Gauss, Pasteur and Darwin p530
Jurgen Schmidhuber
doi:10.1038/452530b
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpM0ES
Spanish funds will finance Bilbao's spallation bid p530
Juan Urrutia
doi:10.1038/452530c
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpN0ET
Give south Indian authors their true names p530
Nalini Puniamoorthy, Jeevananthinee Jeevanandam and Sujatha Narayanan Kutty
doi:10.1038/452530d
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpO0EU
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COMMENTARY
----------------------
Dangerous assumptions pp531-532
How big is the energy challenge of climate change? The technological
advances needed to stabilize carbon-dioxide emissions may be greater
than we think, argue Roger Pielke Jr, Tom Wigley and Christopher Green.
Roger Pielke, Jr, Tom Wigley and Christopher Green
doi:10.1038/452531a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpP0EV
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BOOKS AND ARTS
----------------------
From spies to servers p533
Fastidious history chronicles how a suburb of Washington DC became
home to the Internet.
Joel Shurkin reviews Internet Alley: High Technology in Tysons Corner,
1945-2005 by Paul E. Ceruzzi
doi:10.1038/452533a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpQ0EW
Theatre: Ten years of science off Broadway p534
Alan Packer reviews
doi:10.1038/452534a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpR0EX
History: An astrolabe for the people p534
Philip Ball
doi:10.1038/452534b
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpS0EY
Film: Celluloid explores life of graduate student killer p535
Emma Marris
doi:10.1038/452535a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpT0EZ
----------------------
NEWS AND VIEWS
----------------------
Genomics: When the smoke clears ... pp537-538
Three studies identify an association between genetic variation at
a location on chromosome 15 and risk of lung cancer. But they disagree
on whether the link is direct or mediated through nicotine dependence.
Stephen J. Chanock and David J. Hunter
doi:10.1038/452537a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpU0Ea
Extrasolar planets: With a coarse-tooth comb pp538-539
The search for Earth-like planets outside our Solar System is bedevilled
by the lack of an adequate frequency standard for calibrating starlight.
Tweaking existing laser 'frequency combs' could be a way forward.
Gordon Walker
doi:10.1038/452538a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpV0Eb
Geophysics: Humming a different tune pp539-541
Earth breathes in and out, murmuring gently to itself as it does so.
The habit has been ascribed to the tickling effects of ocean waves — but
a new-found twisting oscillation might reopen the search for the source.
Toshiro Tanimoto
doi:10.1038/452539a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpW0Ec
Drug resistance: The fight against fungi pp541-542
Although several drugs are available to combat often-deadly fungal
infections, many of these pathogens have acquired multidrug resistance.
Discerning how they have achieved this could help us hit back.
Andre Goffeau
doi:10.1038/452541a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpX0Ed
Condensed-matter physics: Opposite of a superconductor pp542-543
Magnetism and superconductivity are caused by spontaneous ordering
on a macroscopic scale. Studies of a two-dimensional superconductor
reveal another striking example of such behaviour -- superinsulation.
Rosario Fazio
doi:10.1038/452542a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpY0Ee
RNA interference: Generic block on angiogenesis pp543-545
A virtue of using small interfering RNAs as therapeutics is their
exquisite specificity. But when it comes to inhibiting blood-vessel
growth, it seems that they can act generically without even entering
a cell.
Raghu Kalluri and Keizo Kanasaki
doi:10.1038/452543a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrpZ0Ef
Obituary: Arthur C. Clarke (1917-2008) p546
Visionary science-fiction author.
Gregory Benford
doi:10.1038/452546a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpa0Em
----------------------
INSIGHT
----------------------
Molecular cancer diagnostics p547
Barbara Marte, Alex Eccleston and Deepa Nath
doi:10.1038/452547a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpb0En
OVERVIEW ARTICLE
The cancer biomarker problem pp548-552
Charles L. Sawyers
doi:10.1038/nature06913
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpc0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpd0Ep
REVIEW ARTICLE
Translating insights from the cancer genome into clinical practice pp553-563
Lynda Chin and Joe W. Gray
doi:10.1038/nature06914
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpe0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpf0Er
Enabling personalized cancer medicine through analysis of gene-expression patterns pp564-570
Laura J. van 't Veer and Rene Bernards
doi:10.1038/nature06915
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpg0Es
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brph0Et
Mining the plasma proteome for cancer biomarkers pp571-579
Samir M. Hanash, Sharon J. Pitteri and Vitor M. Faca
doi:10.1038/nature06916
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpi0Eu
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpj0Ev
Imaging in the era of molecular oncology pp580-589
Ralph Weissleder and Mikael J. Pittet
doi:10.1038/nature06917
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpk0Ew
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpl0Ex
----------------------
ARTICLE
----------------------
Sequence- and target-independent angiogenesis suppression by siRNA via TLR3 pp591-597
The antiangiogenic effect of siRNAs does not depend on the target of
the siRNA, or on intraocular administration. Rather, the siRNAs activate
TLR3, a cell surface receptor for long viral dsRNAs, and innate immunity.
Mark E. Kleinman et al.
doi:10.1038/nature06765
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpm0Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpn0Ez
Following translation by single ribosomes one codon at a time pp598-603
Use of a single molecule approach finds that translation by the ribosome
occurs through a reiterative process of translocation and pausing. A
single translocation event covers three nucleotides, in which three
substeps are detected, and is rapid. The pauses, which are longer
and whose length depends on the mRNA's secondary structure, are rate
determining and are composed of at least two processes.
Jin-Der Wen et al.
doi:10.1038/nature06716
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpo0E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpp0E2
A nuclear receptor-like pathway regulating multidrug resistance in fungi pp604-609
Fungal Pdr1p family proteins bind directly to diverse drugs and xenobiotics,
resulting in activation of transcription and induction of multidrug
resistance. The mechanism has analogy to regulation of multidrug resistance
in vertebrates by nuclear receptors.
Jitendra K. Thakur et al.
doi:10.1038/nature06836
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpq0E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpr0E4
----------------------
LETTERS
----------------------
A laser frequency comb that enables radial velocity measurements with a
precision of 1 cm s-1 pp610-612
Searches for extrasolar planets using the periodic Doppler shift of stellar
spectral lines have recently achieved a precision of 60 cm s 1, sufficient
to find a 5-Earth mass planet in a Mercury-like orbit around a Sun like star.
The fabrication of an 'astro comb' that should allow a precision as high
as 1 cm s 1 in astronomical radial velocity measurements is reported
Chih-Hao Li et al.
doi:10.1038/nature06854
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brps0E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpt0E6
Superinsulator and quantum synchronization pp613-615
This paper shows that at a certain finite temperature, a Cooper pair
insulator undergoes a transition to a superinsulating state with
infinite resistance. Experimental evidence of this transition in
titanium nitride films is presented and it is demonstrated that
the superinsulating state is dual to the superconducting state:
it is destroyed by a sufficiently strong critical magnetic field,
and breaks down at some critical voltage which is analogous to the
critical current in superconductors.
Valerii M. Vinokur et al.
doi:10.1038/nature06837
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpu0E7
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpv0E8
Dust-climate couplings over the past 800,000 years from the EPICA Dome C
ice core pp616-619
It has been suggested that production, transport, and deposition of dust
is influenced by climatic changes on glacial interglacial timescales.
This paper presents a high resolution record of aeolian dust from the
EPICA Dome C ice core in East Antarctica, which suggests that dust is
increasingly correlated with Antarctic temperature as the climate becomes
colder, indicative of a progressive coupling of the climates of Antarctica
and lower latitudes.
F. Lambert et al.
doi:10.1038/nature06763
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpw0EA
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpx0EB
Absolute plate motions and true polar wander in the absence of hotspot tracks pp620-623
The observed motion of continents relative to the Earth's spin axis may
be due either to rotation of the entire Earth relative to its spin
axis ('true polar wander'), or to the motion of individual tectonic
plates. To distinguish between these processes, the global average
of continental motion and rotation in a palaeomagnetic reference frame
over the past 320 Myr was computed and two components were identified:
a steady northward motion and, during certain time intervals, clockwise
and counterclockwise rotations, which they interpret as true polar wander.
Bernhard Steinberger and Trond H. Torsvik
doi:10.1038/nature06824
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpy0EC
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brpz0ED
Localization and functionality of microsporidian iron–sulphur cluster assembly proteins pp624-628
Microsporidia contain a tiny mitochondrial remnant called a mitosome,
but the function of this organelle is unknown. Microsporidian genomes
encode several components of the mitochondrial iron–sulphur cluster
machinery. This paper describes the cloning, characterization and
subcellular localization of several Fe–S cluster components for two
microsporidia. Although some components localize to the mitosome,
others are cytosolic, raising questions about how their function
is coordinated.
Alina V. Goldberg et al.
doi:10.1038/nature06606
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brp10Ey
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brp20Ez
Functional metagenomic profiling of nine biomes pp629-632
Nearly 17 million sequences were used in a comparative metagenomic
approach of 45 microbiomes and viriomes from distinct environments.
Although core metabolic traits were represented in microbial genomes
from all environments, differences could be correlated with biogeochemical
condition. The analysis also revealed a surprising array of viral
metabolic capabilities, suggesting that viruses may serve as a gene pool.
Elizabeth A. Dinsdale et al.
doi:10.1038/nature06810
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brp30E1
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brp40E2
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor
subunit genes on 15q25 pp633-637
A genome wide association study for lung cancer finds that genetic sequences
in the nicotinic acetylcholine receptor subunit gene cluster contribute
susceptibility. Interestingly, this susceptibility is not related to
smoking status or frequency, and seems to come from a change in an amino
acid in the receptor itself.
Rayjean J. Hung et al.
doi:10.1038/nature06885
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brp50E3
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brp60E4
A variant associated with nicotine dependence, lung cancer and peripheral
arterial disease pp638-642
Thorgeir E. Thorgeirsson et al.
doi:10.1038/nature06846
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brp70E5
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0Brp80E6
A neural representation of depth from motion parallax in macaque visual cortex pp642-645
It is shown that in addition to the well documented representation of
retinal motion, primate area middle temporal area neurons are sensitive
to the relative depth of stimuli defined by motion parallax. Motion
parallax is a powerful depth cue that arises when the observer is moving
due to near and far objects moving across the retina at different speeds.
Jacob W. Nadler et al.
doi:10.1038/nature06814
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqA0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqB0EI
Tumour maintenance is mediated by eNOS pp646-649
Endothelial nitric oxide synthase (eNOS) is shown to have a role in
cellular transformation and tumour maintenance downstream of Ras–AKT
signalling. eNOS exerts its effect through nitrosylation and activation
of endogenous wild-type Ras proteins.
Kian-Huat Lim et al.
doi:10.1038/nature06778
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqC0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqD0EK
Cutaneous cancer stem cell maintenance is dependent on [beta] catenin signalling pp650-653
In a mouse model for skin cancer, [beta] catenin signalling is shown to be
important to specifically maintain a population of cancer stem cells.
These cancer stem cells share properties with normal bulge stem cells
and may therefore be derived from those cell. As catenin signalling
isn't required for normal skin homeostasis, it may be a suitable new
target for skin cancer therapy.
Ilaria Malanchi et al.
doi:10.1038/nature06835
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqE0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqF0EM
Dendritic cell PAR1–S1P3 signalling couples coagulation and inflammation pp654-658
This paper examines the link between coagulation and systematic inflammation,
and shows that coagulation proteases signal to dendritic cells by
activating PAR1, resulting in activation of the shingolipid signalling
component and dissemination of inflammation from the lymph nodes to the lungs.
Frank Niessen et al.
doi:10.1038/nature06663
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqG0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqH0EO
----------------------
NATURE JOBS
----------------------
Prospect
Prospects p659
The startling contrasts of Bangalore
Gene Russo
doi:10.1038/nj7187-659a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqI0EP
Region
Biotech in Bangalore p660
Bangalore has a growing biotech sector, supported by a tradition of
academic science. But there are still challenges in committing to
discovery science and retaining top talent. Gene Russo reports.
Gene Russo
doi:10.1038/nj7187-660a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqJ0EQ
Career View
Dave Tapolczay, chief executive, MRC Technology, London p662
Tapolczay looking to bolster MRC tech transfer
Jill U. Adams
doi:10.1038/nj7187-662a
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqK0ER
Göttingen bridges the gap p662
Max Planck gets complex with new degree programme.
Virginia Gewin
doi:10.1038/nj7187-662b
http://ealerts.nature.com/cgi-bin24/DM/y/ejx20Xztnp0HjB0BrqL0ES
Getting that lucky break p662
My project isn't working. Is it OK to quit?
Amanda Goh
doi:10.1038/nj7187-662c
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