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World Stem Cell Summit 2010

Wednesday, April 23, 2008

Nature 24 April 2008 Volume 452 Number 7190, pp913-1032

NATURE

24 April 2008 Volume 452 Number 7190, pp913-1032

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Nature Reviews Immunology Poster on innate immunity: sensing and
signalling

The innate immune system is the first line of defence against invading
pathogens. Detection of such pathogens is a complex business, involving
several families of pattern-recognition receptors and an array of
signalling molecules.

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----------------------
EDITORIALS
----------------------
New sources of sex cells p913
Within the next decade or so, it will become possible to derive
sperm and eggs from skin cells. The ethical and technical hurdles
need to be addressed with the scientific and therapeutic benefits
in mind.
doi:10.1038/452913a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtLs0Ek

The big ome pp913-914
It's time to make the case for proteins.
doi:10.1038/452913b
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtLt0El

Superconductors redux p914
Yet another surprise has been uncovered in the complex oxides.
doi:10.1038/452914a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtLu0Em

----------------------
RESEARCH HIGHLIGHTS
----------------------
Research highlights pp916-917
doi:10.1038/452916a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtLv0En

----------------------
JOURNAL CLUB
----------------------
Journal club p917
Vijay Kuchroo
doi:10.1038/452917a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtLw0Eo

----------------------
NEWS
----------------------
Data show extent of sexism in physics p918
Experiment at Fermilab gave women fewer opportunities to present
at conferences.
Geoff Brumfiel
doi:10.1038/452918a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtLx0Ep

Italian group claims to see dark matter — again pp918-919
Gran Sasso detector picks up unusual signal.
Geoff Brumfiel
doi:10.1038/452918b
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtLy0Eq

Swiss 'dignity' law is threat to plant biology p919
Government ethics committee guidelines could halt techniques such
as hybridization of roses.
Alison Abbott
doi:10.1038/452919a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtLz0Er

Biologists initiate plan to map human proteome pp920-921
Project aims to characterize all human proteins.
Helen Pearson
doi:10.1038/452920a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtL10Ee

Buckyballs give flash a boost p921
Eric Hand
doi:10.1038/452921a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtL20Ef

Arsenic heats up iron superconductors p922
Eric Hand
doi:10.1038/452922a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtL30Eg

Politically correct names given to flu viruses p923
World Health Organization standardizes nomenclature, but experts say
GPS sample locations should be given.
Declan Butler
doi:10.1038/452923a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtL40Eh

Sidelines p923
Scribbles on the margins of science.
doi:10.1038/452923b
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtL50Ei

Fake drugs: lessons for the world p924
Dora Akunyili is director-general of Nigeria's National Agency for
Food and Drug Administration and Control (NAFDAC). Since her appointment
in 2001, she has led a successful crusade against counterfeit pharmaceuticals,
which are responsible for millions of deaths worldwide each year. Nature
caught up with her last week in Washington DC.
Meredith Wadman
doi:10.1038/452924a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtL60Ej

Bubble-fusion engineer sues other scientists p925
doi:10.1038/452925a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtL70Ek

US biodefence agency appoints first director p925
doi:10.1038/452925b
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtL80El

Research assessment panel advised to destroy all notes p925
doi:10.1038/452925c
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMA0Ev

GlaxoSmithKline does deal to develop microRNA drugs p925
doi:10.1038/452925d
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMB0Ew

UN ruling makes Australia an even bigger country p925
doi:10.1038/452925e
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMC0Ex

Botanical art gallery opens in London p925
doi:10.1038/452925f
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMD0Ey

----------------------
NEWS FEATURES
----------------------
Biomedical science: Betting the bank pp926-929
Lyle Palmer has plans for a "ludicrously ambitious" gene–disease
research project. Bijal Trivedi reports on the trials at Joondalup.
doi:10.1038/452926a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtME0Ez

Atmospheric physics: Heating up the heavens pp930-932
Battling rumours of death beams and mind control, an ionosphere research
facility in Alaska finally brings science to the fore. Sharon Weinberger reports.
doi:10.1038/452930a
http://www.nature.com/news/2008/080423/full/452930a.html

----------------------
CORRESPONDENCE
----------------------
Media right to report small value of antidepressants p934
Olavo B. Amaral
doi:10.1038/452934a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMG0E2

Tropical farmers need productive alternatives p934
Thomas Knoke, Bernd Stimm and Michael Weber
doi:10.1038/452934b
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMH0E3

Researchers should explain why they use animals p934
doi:10.1038/452934c
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMI0E4

Truth about a plant with many names p934
Marko Kreft and Robert Zorec
doi:10.1038/452934d
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMJ0E5

----------------------
COMMENTARY
----------------------
Europe's research system must change pp935-936
Science funding in the European Union needs to be revised to better
serve economic, social and environmental goals, Luke Georghiou argues.
doi:10.1038/452935a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMK0E6

----------------------
BOOKS AND ARTS
----------------------
Orange revolution pp937-938
Stories of seventeeth-century scientists and aristocrats show how
Dutch ingenuity benefited England. Harold Cook reviews Going Dutch:
How England Plundered Holland's Glory by Lisa Jardine.
doi:10.1038/452937a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtML0E7

Biased brains, messy memories pp938-939
Sandra Aamodt reviews Kluge: The Haphazard Construction of the Human
Mind by Gary Marcus and A Portrait of the Brain by Adam Zeman.
doi:10.1038/452938a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMM0E8

Technological twist on taxonomy p939
Kevin Kelly reviews Systematics as Cyberscience: Computers, Change,
and Continuity in Science by Christine Hine.
doi:10.1038/452939a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMN0EA

Hidden treasures: the Cajal collection in Madrid p940
The perceptive drawings, paintings, photographs and slides of Spain's
neuroanatomy pioneer record a tale of ambition and rivalry,
reports Alison Abbott.
doi:10.1038/452940a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMO0EB

----------------------
NEWS AND VIEWS
----------------------
Metabolism: Food alert pp941-942
The gut prevents nutrient overload during a meal by promoting
satiety and enhancing insulin secretion. New findings show that
nutrients in the gut also activate a neural circuit that increases
insulin sensitivity.
Joshua P. Thaler and David E. Cummings
doi:10.1038/452941a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMP0EC

Optics: Light reined in pp942-944
Light always travels at the same speed in a vacuum, no more, no less.
But in materials, there's room for manoeuvre: tweak the right material
in the right way, and exciting optoelectronic properties result.
Diederik Sybolt Wiersma
doi:10.1038/452942a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMQ0ED

50 & 100 Years Ago p943
doi:10.1038/452943a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMR0EE

Neuroscience: Current views on odour receptors p944
Insects possess refined olfactory systems that use specific receptors
on their antennae. It emerges that these receptors not only detect
odour molecules but, unexpectedly, can also act as ion channels.
Alexander Chesler and Stuart Firestein
doi:10.1038/452944a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMS0EF

Oceanography: Bottom of the top of the world p945
Tim Lincoln
doi:10.1038/452945a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMT0EG

Astrophysics: Exhaust inspection pp945-946
What do you see if you peer into the exhaust of a jet engine larger
than our Solar System? Only astronomers with the largest radio
telescopes can see the full picture -- and definitive observations
are beginning to filter through.
David L. Meier
doi:10.1038/452945b
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMU0EH

Gene transcription: Two worlds merged pp946-947
Why would two distant genes -- on separate chromosomes and from
different nuclear locations -- unite in response to signals for
gene expression? They might be seeds for the formation of
transcriptional hubs.
David M. Lonard and Bert W. O'Malley
doi:10.1038/452946a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMV0EI

Plant biology: Scent of a rose p947
Sadaf Shadan
doi:10.1038/452947a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMW0EJ

----------------------
ARTICLE
----------------------
The genome of the model beetle and pest Tribolium castaneum p949
The beetle Tribolium castaneum is a commonly used laboratory model, combining
the ease of systematic RNAi experiments like those in Caenorhabditis elegans,
with biology that is more representative of most insects than Drosophila
melanogaster. A large consortium has sequenced and analysed the genome
of the red flour beetle, creating a resource for biologists everywhere.
Tribolium Genome Sequencing Consortium
doi:10.1038/nature06784
Abstract: http://www.nature.com/nature/journal/v452/n7190/abs/nature06784.html
Article: http://www.nature.com/nature/journal/v452/n7190/full/nature06784.html

Lateral presynaptic inhibition mediates gain control in an olfactory circuit p956
A study that combines in vivo systems neuroscience with synaptic physiology
and Drosophila genetics identifies a presynaptic form of lateral inhibition
in the olfactory system. The mechanism allows for a flexible form of gain
control, which promotes coding efficiency when stimuli are strong and unambiguous,
but maximizes sensitivity when stimuli are weak and ambiguous.
Shawn R. Olsen & Rachel I. Wilson
doi:10.1038/nature06864
Abstract: http://www.nature.com/nature/journal/v452/n7190/abs/nature06864.html
Article: http://www.nature.com/nature/journal/v452/n7190/full/nature06864.html

Crystal structures of DNA/RNA repair enzymes AlkB and ABH2 bound to dsDNA pp961-965
Base lesions can be directly repaired by oxidative dealkylation
catalysed by AlkB in bacteria and by ABH2/ABH3 in man. Several
structures of AlkB and ABH2 bound to dsDNA are solved. These structures
reveal why AlkB prefers ssDNA to dsDNA substrates, and how ABH2 differs
structurally, to allow it to repair dsDNA.
Cai-Guang Yang et al.
doi:10.1038/nature06889
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMX0EK
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMY0EL

----------------------
LETTERS
----------------------
The inner jet of an active galactic nucleus as revealed by a radio-to-gamma-ray outburst pp966-969
Sequences of high-resolution radio images and optical polarization
measurements of the blazar BL Lacertae are reported. The data reveal
a bright feature in the jet that causes a double flare of radiation
from optical frequencies to TeV gamma-ray energies. It is concluded
that the event starts in a region with a helical magnetic field as
envisaged by the theories.
Alan P. Marscher et al.
doi:10.1038/nature06895
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMZ0EM
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMa0ET

A topological Dirac insulator in a quantum spin Hall phase pp970-974
In the conventional quantum Hall effect, a two-dimensional electronic
system in the presence of a magnetic field forms metallic conduction
paths at the edge of the sample. This paper experimentally demonstrates
a sought-after three-dimensional and spontaneous version of this effect;
the bulk of a Bi0.9Sb0.1 crystal is shown to be insulating, while
two-dimensional metallic conduction paths exist at the surface, without
any applied magnetic field.
D. Hsieh et al.
doi:10.1038/nature06843
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMb0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMc0EV

Small phonon contribution to the photoemission kink in the copper oxide superconductors pp975-978
This paper reports first-principles calculations of the role of phonons
in La2-xSrxCuO4 (LSCO). It is demonstrated that the phonon-induced
renormalization of the electron energies and the Fermi velocity is
almost one order of magnitude smaller than the effect observed in
photoemission experiments. Therefore the present finding rules out
electron-phonon interaction in bulk LSCO as the exclusive origin
of the measured kink.
Feliciano Giustino, Marvin L. Cohen and Steven G. Louie
doi:10.1038/nature06874
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMd0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMe0EX

Eocene/Oligocene ocean de-acidification linked to Antarctic glaciation by sea-level fall pp979-982
A global biogeochemical box model is used to test competing hypotheses
put forward to explain the Eocene/Oligocene transition. It is found that
only shelf-to-deep-sea carbonate partitioning is capable of explaining
the observed changes in both carbon isotope composition and calcium carbonate
accumulation at the sea floor. This work sheds new light on the mechanisms
linking glaciation and ocean acidity change across the climate transition of
the Cenozoic.
Agostino Merico, Toby Tyrrell and Paul A. Wilson
doi:10.1038/nature06853
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMf0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMg0EZ

Hydrous silicate melt at high pressure pp983-986
The results of first-principles molecular dynamics simulations of hydrous
silicate melt is reported, showing that pressure has a profound influence
on speciation of the water component. It is inferred that the
speciation changes from being dominated by hydroxyls and water molecules
at low pressure to extended structures at high pressure. This change in
structure is linked to the finding that the water-silicate system becomes
increasingly ideal at high pressure, indicating complete miscibility of
water and silicate melt throughout almost the entire mantle pressure regime.
Mainak Mookherjee, Lars Stixrude and Bijaya Karki
doi:10.1038/nature06918
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMh0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMi0Eb

Mountain pine beetle and forest carbon feedback to climate change pp987-990
It is reported that the current severe outbreak of the mountain pine
beetle (Dendroctonus ponderosae) in British Columbia is likely to
convert the forest from a small net carbon sink to a large net
carbon source, something, it is argued, should be taken into
account when modelling the impact of climate change on carbon cycling.
W. A. Kurz et al.
doi:10.1038/nature06777
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMj0Ec
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMk0Ed

The draft genome of the transgenic tropical fruit tree papaya (Carica papaya Linnaeus) pp991-996
Researchers from Hawaii and an international consortium have produced a
draft genome assembly for 'SunUp', the first commercial virus-resistant
transgenic fruit tree. Comparison of this plant genome to those of
Arabidopsis and others sheds light on evolution of characteristics
such as biosynthesis, starch deposition, control of photosynthesis
and pathways for creating volatile compounds.
Ray Ming et al.
doi:10.1038/nature06856
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMl0Ee
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMm0Ef

Genetic variation in human NPY expression affects stress response and emotion p997-1001
Across human populations, individual ability to deal with stress and anxiety
spans a wide range. The causes of emotional resilience are complex; this paper
shows the contribution of genetic variance in expression of neuropeptide Y (NPY),
an anxiolytic peptide released in emotion related neural circuitry. Genetic
variants were predictive of not only NPY levels, but also fMRI and PET
activation in response to emotional stimuli and pain induced stress.
Zhifeng Zhou et al.
doi:10.1038/nature06858
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMn0Eg
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMo0Eh

Insect olfactory receptors are heteromeric ligand-gated ion channels p1002-1006
Olfactory cues are detected by large families of seven transmembrane
spanning receptors, which have until now been classified as G-protein
coupled receptors. In insects, these odorant receptors require a second
protein (Or83b) for correct function. These heteromeric receptors form
ligand gated cation channels that are not dependent on G protein coupled
second messengers and it is speculated that seven other transmembrane
spanning proteins may show similar ion channel activity.
Koji Sato et al.
doi:10.1038/nature06850
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMp0Ei
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMq0Ej

Drosophila odorant receptors are both ligand-gated and cyclic-nucleotide-activated cation channels p1007-1011
Olfactory cues are detected by large families of seven transmembrane
spanning receptors, which have until now been classified as G-protein
coupled receptors. In insects, these odorant receptors require a second
protein (Or83b) for correct function. The second of two related papers
shows that, in addition to direct channel activation, ligand binding to
odorant receptors causes G-protein coupled channel activation.
Koji Sato et al.
doi:10.1038/nature06861
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMr0Ek
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMs0El

Upper intestinal lipids trigger a gut–-brain–-liver axis to regulate glucose production p1012-1016
The presence of lipids in the intestine causes a reduction in nutrient
intake, but it is now shown that lipids present in the intestine also
regulate endogenous nutrient production. According to the data, putative
intra intestinal lipid sensors signal the presence of ingested lipids,
via the brain, to the liver, which reduces the endogenous glucose
production accordingly.
Penny Y. T. Wang et al.
doi:10.1038/nature06852
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMt0Em
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMu0En

A deadenylation negative feedback mechanism governs meiotic metaphase arrest p1017-1021
A genome wide screen for mRNAs that were polyadenylated at meiotic
transitionsnoted that many contained an ARE, a deadenylation element,
as well as a cytoplasmic polyadenylation element (CPE). One such mRNA
encodes C3H 4, a protein that promotes shortening of polyA tails. The
data suggest a model in which the early extension of polyadenylation
through the CPE element leads to expression of C3H 4, which then acts
in a negative feedback loop to deadenylate, and deactivate, those mRNAs
that also contain an ARE, thereby allowing exit from metaphase.
Eulàlia Belloc & Raúl Méndez
doi:10.1038/nature06809
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMv0Eo
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMw0Ep

Crystal structure of the (lambda) repressor and a model for pairwise cooperative operator binding pp1022-1025
A crystal structure of the intact, dimeric phage (lambda) cI repressor
bound to a DNA operator site reveals an unusual architecture allowing
the repressor to adopt a conformation that facilitates cooperative
binding to adjacent operator sites.
Steven Stayrook et al.
doi:10.1038/nature06831
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMx0Eq
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMy0Er

----------------------
NATUREJOBS
----------------------
Prospect
Prospects p1027
Even as science and engineering in China ascends, its graduate students
and postdocs often struggle.
Gene Russo
doi:10.1038/nj7190-1027a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtJr0Eh

Special Report
China's challenge p1028
Young researchers in China face stiff competition as they strive to
establish labs or find other scientific careers. Wei Zeng explores what
it takes to succeed as a Chinese scientist.
doi:10.1038/nj7190-1028a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtJu0Ek


Marja Makarow, chief executive, European Science Foundation, Strasbourg, France p1030
New European Science Foundation chief executive brings varied experience.
Jill U. Adams
doi:10.1038/nj7190-1030a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtJv0El


A guiding COMPASS p1030
From a student's struggles, a new mentor programme for minority students
blossoms.
Betty Mbom
doi:10.1038/nj7190-1030b
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In the name of science p1030
I sacrifice an awful lot in the name of science.
Aliza le Roux
doi:10.1038/nj7190-1030c
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtJt0Ej

----------------------
FUTURES
----------------------
SETI for profit p1032
A capital idea.
Gregory Benford
doi:10.1038/4521032a
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtMz0Es

----------------------
ADVANCE ONLINE PUBLICATIONS
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23 April 2008
Melanopsin cells are the principal conduits for rod–cone input to non-image-forming vision
Ali D. Güler et al.
doi:10.1038/nature06829
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtM10Ef

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population
Lei Yang et al.
doi:10.1038/nature06894
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtM20Eg


Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
Jennifer S. Ziegenfuss et al.
doi:10.1038/nature06901
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtM30Eh

NF-(kappa)B links innate immunity to the hypoxic response through transcriptional regulation of HIF-1(alpha)
Jordi Rius et al.
doi:10.1038/nature06905
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtM40Ei

Superconductivity at 43K in an iron-based layered compound LaO1-x F x FeAs
Hiroki Takahashi et al.
doi:10.1038/nature06972
http://ealerts.nature.com/cgi-bin24/DM/y/ekSd0Xztnp0HjB0BtM50Ej


20 April 2008
Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4
Marc Hanikenne et al.
doi:10.1038/nature06877
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Human metabolic phenotype diversity and its association with diet and blood pressure
Elaine Holmes et al.
doi:10.1038/nature06882
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