April 2008 Volume 22 Number 4, pp 673 - 890
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EDITORIALS
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A kinder, gentler way: control of the proliferative tumor compartment,
not cosmetic complete response, should be the goal of myeloma therapy
P L Bergsagel
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoQ0En
C/EBP[alpha], do not forget your TIP60
C W E So and B A van der Reijden
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoR0Eo
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REVIEWS
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The role of CALM-AF10 gene fusion in acute leukemia
D Caudell and P D Aplan
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoS0Ep
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoT0Eq
Contributions of the Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and
Jak/STAT pathways to leukemia
L S Steelman, S L Abrams, J Whelan, F E Bertrand, D E Ludwig, J
Basecke, M Libra, F Stivala, M Milella, A Tafuri, P Lunghi, A Bonati,
A M Martelli and J A McCubrey
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoU0Er
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoV0Es
Targeting survival cascades induced by activation of
Ras/Raf/MEK/ERK, PI3K/PTEN/Akt/mTOR and Jak/STAT pathways for
effective leukemia therapy
J A McCubrey, L S Steelman, S L Abrams, F E Bertrand, D E Ludwig, J
Basecke, M Libra, F Stivala, M Milella, A Tafuri, P Lunghi, A Bonati
and A M Martelli
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoW0Et
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoX0Eu
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ORIGINAL ARTICLES
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E2A-ZNF384 and NOL1-E2A fusion created by a cryptic t(12;19)(p13.3;
p13.3) in acute leukemia
C-h Zhong, V Prima, X Liang, C Frye, L McGavran, L Meltesen, Q Wei, T
Boomer, M Varella-Garcia, J Gump and S P Hunger
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoY0Ev
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BsoZ0Ew
MDM2 antagonist nutlin-3 is a potent inducer of apoptosis in pediatric
acute lymphoblastic leukemia cells with wild-type p53 and
overexpression of MDM2
L Gu, N Zhu, H W Findley and M Zhou
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoa0E4
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsob0E5
The histone deacetylase inhibitor ITF2357 selectively targets cells
bearing mutated JAK2V617F
V Guerini, V Barbui, O Spinelli, A Salvi, C Dellacasa, A Carobbio, M
Introna, T Barbui, J Golay and A Rambaldi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoc0E6
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsod0E7
Enhanced BCR-ABL kinase inhibition does not result in increased
inhibition of downstream signaling pathways or increased growth
suppression in CML progenitors
H Konig, M Holtz, H Modi, P Manley, T L Holyoake, S J Forman and R
Bhatia
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoe0E8
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsof0EA
Low JAK2V617F allele burden in primary myelofibrosis, compared to
either a higher allele burden or unmutated status, is associated with
inferior overall and leukemia-free survival
A Tefferi, T L Lasho, J Huang, C Finke, R A Mesa, C Y Li, W Wu, C A
Hanson and A Pardanani
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsog0EB
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoh0EC
Cooperative genetic defects in TLX3 rearranged pediatric T-ALL
P Van Vlierberghe, I Homminga, L Zuurbier, J Gladdines-Buijs, E R van
Wering, M Horstmann, H B Beverloo, R Pieters and J P P Meijerink
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoi0ED
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoj0EE
Minimal residual disease-directed risk stratification using real-time
quantitative PCR analysis of immunoglobulin and T-cell receptor gene
rearrangements in the international multicenter trial AIEOP-BFM ALL
2000 for childhood acute lymphoblastic leukemia
T Flohr, A Schrauder, G Cazzaniga, R Panzer-Grumayer, V van der
Velden, S Fischer, M Stanulla, G Basso, F K Niggli, B W Schafer, R
Sutton, R Koehler, M Zimmermann, M G Valsecchi, H Gadner, G Masera, M
Schrappe, J J M van Dongen, A Biondi and C R Bartram
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsok0EF
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsol0EG
High titer autoantibodies to GM-CSF in patients with AML, CML and MDS
are associated with active disease
A Sergeeva, Y Ono, R Rios and J J Molldrem
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsom0EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bson0EI
BCR-ABL mutants spread resistance to non-mutated cells through a
paracrine mechanism
J Liu, S Joha, T Idziorek, S Corm, D Hetuin, N Philippe, C Preudhomme
and B Quesnel
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoo0EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsop0EK
Proteomic identification of the MYST domain histone acetyltransferase
TIP60 (HTATIP) as a co-activator of the myeloid transcription factor
C/EBP[alpha]
D Bararia, A K Trivedi, A A Peer Zada, P A Greif, M A Mulaw, M
Christopeit, W Hiddemann, S K Bohlander and G Behre
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoq0EL
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsor0EM
Sorafenib induces apoptosis of AML cells via Bim-mediated activation
of the intrinsic apoptotic pathway
W Zhang, M Konopleva, V R Ruvolo, T McQueen, R L Evans, W G Bornmann,
J McCubrey, J Cortes and M Andreeff
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsos0EN
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsot0EO
Downregulation of Mcl-1 potentiates HDACi-mediated apoptosis in
leukemic cells
S Inoue, R Walewska, M J S Dyer and G M Cohen
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsou0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsov0EQ
KSHV-transformed primary effusion lymphoma cells induce a
VEGF-dependent angiogenesis and establish functional gap junctions
with endothelial cells
L Haddad, H El Hajj, R Abou-Merhi, Y Kfoury, R Mahieux, M El-Sabban
and A Bazarbachi
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsow0ER
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsox0ES
Histone acetylation and DNA demethylation of B cells result in a
Hodgkin-like phenotype
A Ehlers, E Oker, S Bentink, D Lenze, H Stein and M Hummel
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoy0ET
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bsoz0EU
Efficacy and safety of bortezomib in patients with renal impairment:
results from the APEX phase 3 study
J F San-Miguel, P G Richardson, P Sonneveld, M W Schuster, D Irwin, E
A Stadtmauer, T Facon, J-L Harousseau, D Ben-Yehuda, S Lonial, H
Goldschmidt, D Reece, J Blade, M Boccadoro, J D Cavenagh, R Neuwirth,
A L Boral, D-L Esseltine and K C Anderson
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bso10EH
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bso20EI
Suppression of abnormal karyotype predicts superior survival in
multiple myeloma
V Arzoumanian, A Hoering, J Sawyer, F van Rhee, C Bailey, J Gurley, J
D Shaughnessy, E Anaissie, J Crowley and B Barlogie
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bso30EJ
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bso40EK
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LETTERS TO THE EDITOR
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A new case with rare e6a2 BCR-ABL fusion transcript developing two new
resistance mutations during imatinib mesylate, which were replaced by
T315I after subsequent dasatinib treatment
S Schnittger, U Bacher, W Kern, T Haferlach, B Hertenstein and C
Haferlach
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bso50EL
Validation of NG2 antigen in identifying BP-ALL patients with MLL
rearrangements using qualitative and quantitative flow cytometry: a
prospective study
A Zangrando, F Intini, G te Kronnie and G Basso
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bso60EM
Clonal expansion of non-leukemic cells expressing two novel MLL-ELL
variants differing in transforming activity
M Takeuchi, C Nakaseko, S Miyagi, Y Takeda, S Ozawa, C Ohwada, R Cho,
M Nishimura, Y Saito and A Iwama
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bso70EN
Re: Essential thrombocythemia in young individuals: frequency and risk
factors for vascular events and evolution to myelofibrosis in 126
patients. Alvarez-Larran A et al.
D Westerman and S Juneja
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20Bso80EO
Reply to 'Re: Essential thrombocythemia in young individuals:
frequency and risk factors for vascular events and evolution to
myelofibrosis in 126 patients. Alvarez-Larran A et al.' by Westerman
et al.
A Alvarez-Larran, F Cervantes and C Besses
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspA0EY
Reply to 'Re: Essential thrombocythemia in young individuals:
frequency and risk factors for vascular events and evolution to
myelofibrosis in 126 patients. Alvarez-Larran et al. Leukemia 2007;
21: 1218-1223'
D Westerman and S Juneja
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspB0EZ
Reply to Westerman et al.: 'Re: Essential thrombocythemia in young
individuals: frequency and risk factors for vascular events and
evolution to myelofibrosis in 126 patients. Alvarez-Larran A et al.
Leukemia 2007; 21: 1218-1223'
A Alvarez-Larran, F Cervantes and C Besses
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspC0Ea
Erythroid variant of chronic myelogenous leukemia
N Talreja, H Abdulhaq, R K Shadduck, J Rossetti, A Jalil, A Makary and
J Lister
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspD0Eb
Two novel JAK2 exon 12 mutations in JAK2V617F-negative polycythaemia
vera patients
C M Butcher, U Hahn, L B To, J Gecz, E J Wilkins, H S Scott, P G Bardy
and R J D'Andrea
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspE0Ec
Contribution of GM-CSF and IL-8 to the CD44-induced differentiation of
acute monoblastic leukemia
J Delaunay, N Lecomte, S Bourcier, J Qi, Z Gadhoum, L Durand, C
Chomienne, J Robert-Lezenes and F Smadja-Joffe
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspF0Ed
Association of 3q21q26 syndrome and late-appearing Philadelphia
chromosome in acute myeloid leukemia
A Quintas-Cardama, D L Gibbons, J Cortes, D Bobadilla, M L Slovak, H
Kantarjian and L V Abruzzo
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspG0Ee
Effect of parental history of cancer on the development of second
neoplasms after lymphoma at the same site than the parents
J Lorenzo Bermejo, J Sundquist and K Hemminki
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspH0Ef
The genetic characterization of acute promyelocytic leukemia with
cryptic t(15;17) including a new recurrent additional cytogenetic
abnormality i(17)(q10)
M Kim, J Lim, Y Kim, K Han, D H Lee, N G Chung, B Cho, H K Kim, K S
Eom, C-K Min and W-S Min
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspI0Eg
Proteasome inhibition therapies in childhood cancer
F Zaman, B Fadeel and L Savendahl
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspJ0Eh
Reply to 'Proteasome inhibition therapies in childhood cancer' by
Zaman et al.
E Terpos and O Sezer
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspK0Ei
Sequencing of subcloned PCR products facilitates earlier detection of
BCR-ABL1T315I and other mutants compared to direct sequencing of the
ABL1 kinase domain
A Quintas-Cardama, D L Gibbons, H Kantarjian, M Talpaz, N Donato and J
Cortes
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspL0Ej
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CORRIGENDUM
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Expression and mutation status of candidate kinases in multiple
myeloma
J O Claudio, F Zhan, L Zhuang, R Khaja, Y X Zhu, K Sivananthan, S
Trudel, E Masih-Khan, R Fonseca, P L Bergsagel, S W Scherer, J
Shaughnessy and A K Stewart
http://ealerts.nature.com/cgi-bin24/DM/y/ekKD0Xztnp0Hi20BspM0Ek
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