Uterine Stem Cells Create New Neurons That Can Curb Parkinson's
Disease
Article Date: 28 Mar 2008 - 14:00 PDT
The injection of uterine stem cells trigger growth of new brain cells
in mice with Parkinson's disease, Yale School of Medicine researchers
report in an abstract presented at the 2008 Society for Gynecologic
Investigation (SGI) Annual Scientific Meeting held March 26-29 in San
Diego, California. "Previously, we were able to coax these
multipotent stem cells to differentiate into cartilage cells," said
lead author Hugh S. Taylor, M.D., professor in the Department of
Obstetrics, Gynecology & Reproductive Sciences at Yale School of
Medicine and section chief of Reproductive Endocrinology and
Infertility at Yale School of Medicine. "Now we have found that we
can turn uterine stem cells into neurons that can boost dopamine
levels and partially correct the problem of Parkinson's disease."
Parkinson's disease is a degenerative disorder of the central nervous
system that often impairs the sufferer's motor skills and speech. The
primary symptoms are the results of decreased stimulation of the
motor cortex by the basal ganglia, which is normally caused by the
insufficient formation and action of dopamine.
The stem cells in this study were derived from human endometrial
stromal cells that were cultured under conditions that induce the
creation of neurons. These cells then developed axon-like projections
and cell bodies with a pyramid shape typical of neurons.
"The dopamine levels in the mice increased once we transferred the
stem cells into their brains," Taylor said. "The implications of our
findings are that women have a ready supply of stem cells that are
easily obtained, are differentiable into other cell types, and have
great potential use for other purposes."
Other authors include Erin Wolff, M.D., who will present the abstract
at SGI, Zane B. Andrews, Xiao-Bing Gao and Katherine V. Yao. This
abstract is an SGI Trainee Plenary Session Selection and winner of
the SGI President's Presenter Award.
http://www.yale.
http://www.medicaln
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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