Fat-derived stem cells could aid percutaneous spine therapies
1st on the web (March 6, 2008)
March 2008
SAN FRANCISCO — A cost-effective and readily available source of stem
cells — human fat — may eventually enhance rates of human spine
fusion, based on results of a study presented at the American Academy
of Orthopaedic Surgeons 75th Annual Meeting, here.
Researchers from several U.S. spine centers evaluated the efficacy of
using adipose-derived stem cells (ADSC) transduced with BMP-2 in an
athymic rat posterolateral fusion model. They found fusion results
were better in these animals (group 1) vs. those in four other groups
of animals treated with such other approaches as ADSCs alone, various
doses of BMP-2 alone and ADSCs treated with osteogenic medial and
exogenous BMP-2.
"ADSCs are promising as cellular delivery agents," particularly since
we saw bone formation in unfavorable areas, said Wellington K. Hsu,
MD, of Middleton, Wisc., who presented the results.
One interesting finding: Group 1 animals who had BMP delivered to the
surgical site via stem cells even achieved fusions at proximal levels
that investigators did not prepare during surgery.
Investigators objectively assessed new bone formation using micro-CT
scans.
Hsu said potential clinical uses included long segments or multiple
levels that need fusing. Cellular delivery vehicles such as this may
avoid BMP complications and could assist with percutaneous therapies,
he added.
For more information:
Hsu WK, Wang JC, Feeley B, et al. Stem cells from human fat as
cellular delivery vehicles in rodent posterolateral spine fusion
model. #78. Presented at the American Academy of Orthopaedic Surgeons
75th Annual Meeting. March 5-9, 2008. San Francisco.
http://www.orthosup
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StemCells subscribers may also be interested in these sites:
Children's Neurobiological Solutions
http://www.CNSfoundation.org/
Cord Blood Registry
http://www.CordBlood.com/at.cgi?a=150123
The CNS Healing Group
http://groups.yahoo.com/group/CNS_Healing
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