Signaling Gateway - 28 March 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0M40E4
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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In Signaling Update this week:
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Featured Article
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INFLAMMATION: PARSING THE RESPONSE TO SEPSIS
Sepsis-induced coagulation triggers PAR1-S1P3 signaling in dendritic
cells, resulting in systemic inflammation.
Original research paper: Nature advance online publication,
27 February 2008 (doi:10.1038/nature06663)
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0vP0EE
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Selected Updates
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ALLERGY AND ASTHMA: MOTHER KNOWS BEST
The presence of transforming growth factor-beta (TGF-beta) in breast
milk induces regulatory T cells in newborn mice, which helps protect
mice against the development of allergic airway inflammation.
Original research paper: Nature Med. 14, 170-175 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BrQu0EE
SYNAPTIC PLASTICITY: RISE AND SHINE (WE ARE ALL MORNING PEOPLE!)
The cortex and hippocampus of wakeful rats contain increased levels
of GluR1, CaMKII, NR2A and GSK3beta compared to rats that were
allowed to sleep, suggesting that sleep resets neuronal excitability
and facilitates plasticity.
Original research paper: Nature Neurosci. 11, 200-208 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BrQv0EF
ANTICANCER DRUGS: ANTISENSE ANGIOGENESIS INHIBITION
A key transcription factor involved in tumor angiogenesis - inhibitor
of DNA binding 1 (ID1) - has been successfully targeted and inhibited
by using a peptide-conjugated antisense oligonucleotide (PCAO).
Original research paper: Nature Biotech. 26, 91-100 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BrQw0EG
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0vO0ED
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Research Library
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REGULATION OF VEGF-MEDIATED ANGIOGENESIS BY THE Akt/PKB SUBSTRATE
GIRDIN
Nature Cell Biology 10, 329-337 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BrQx0EH
G PROTEIN-COUPLED RECEPTOR P2Y5 AND ITS LIGAND LPA ARE INVOLVED IN
MAINTENANCE OF HUMAN HAIR GROWTH
Nature Genetics 40, 329-334 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BrQy0EI
CaMKII: A BIOCHEMICAL BRIDGE LINKING ACCUMBENS DOPAMINE AND
GLUTAMATE SYSTEMS IN COCAINE SEEKING
Nature Neuroscience 11, 344-353 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BrQz0EJ
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Signaling News
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NATURE NEWS: THE APPEAL OF SUGAR GOES BEYOND TASTE
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BrQ10E5
Mice that lack the Trpm5 ion channel are unable to detect sweet or
bitter tastes. Despite this deficiency, Trpm5-null mice favor sugar
water over unsweetened water, suggesting that mice can detect
calories without relying on their taste buds.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0Crw0Eu
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Gateway Updates
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NEUROSCIENCE GATEWAY - MARCH UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BmlM0Eu
The Neuroscience Gateway is a comprehensive FREE online resource for
news, highlights and research on neuroscience.
This month's update features:
Blood coagulation: Thanks a clot!
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0Bqkv0Ee
Learning: Shivers down your spine
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BpH20Eu
Sign up to receive the table of contents e-alert for the
Neuroscience Gateway Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BmlN0Ev
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Signaling Job of the Week
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Various Positions
Employer: Structural Genomics Consortium
Location: Oxford, United Kingdom
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BrQ20E6
The SGC (Structural Genomics Consortium) at the University of Oxford
has positions available for postdoctoral fellows, research assistants
or visiting scientists/students. Skilled and motivated researchers
with experience in protein expression and biochemistry are encouraged
to apply. Research will focus on integral membrane proteins, protein
kinases and phosphatases, oxidoreductases and metabolic enzymes.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0BnjC0Ej
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ejxz0Xztnp0H2W0vqs0Eg
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