Signaling Gateway - 20 March 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0M40E3
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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The Profinia(TM) Protein Purification System from
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yielding purified samples in as little as 30 minutes.
For more information, visit:
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqne0EP
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In Signaling Update this week:
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Featured Article
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ERYTHROPOEISIS: Rac AND mDia CARt OUT THE NUCLEUS
The small GTPases Rac1 and Rac2 regulate mDia2 to promote asymmetric
cell division and enucleation in developing erythrocytes.
Original research paper: Nature Cell Biology 10, 314-321 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0vP0ED
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0HIE0ET
CD2
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqnf0EQ
CD2 is a cell-surface receptor molecule that is expressed on nearly
all thymocytes, T lymphocytes and natural killer cells, and was one
of the first adhesion molecules to be implicated in T-cell
recognition. The cytoplasmic tail of CD2 associates with several
downstream signaling proteins, but its ability to signal still seems
to be dependent on the presence of other signaling receptors, such as
the T-cell receptor complex.
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0BUuz0EP
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Selected Updates
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INNATE IMMUNITY: NEW ROLE FOR CATHEPSIN K
The lysosomal cysteine protease cathepsin K regulates TLR9 signaling,
and affects both the resorption of bone by osteoclasts and the
release of pro-inflammatory cytokines.
Original research paper: Science 319, 624-627 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqng0ER
METABOLISM: THE IMPORTANCE OF POLARITY
Loss of the serine/threonine kinase LKB1 disrupts pancreatic acinar
cell polarity, which contributes to the development of
gastrointestinal neoplasms and confers a high risk of pancreatic
cancer.
Original research paper: Mol. Cell. Biol. 28, 2414-2425 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqnh0ES
NEURODEGENERATIVE DISEASE: IN THE PINK
Expression of PTEN-induced kinase 1 (PINK1) protects neurons from the
neurotoxic effects of mitochondrial toxins, suggesting a potential
mechanism by which mutations in PINK1 might lead to Parkinson's
disease.
Original research paper: Proc. Natl Acad. Sci. USA 105, 1638-1643
(2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqni0ET
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0vO0EC
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Research Library
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SCFbeta-TRCP CONTROLS ONCOGENIC TRANSFORMATION AND NEURAL
DIFFERENTIATION THROUGH REST DEGRADATION
Nature 452, 370-374 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqnj0EU
INHIBITION OF Arp2/3-MEDIATED ACTIN POLYMERIZATION BY PICK1 REGULATES
NEURONAL MORPHOLOGY AND AMPA RECEPTOR ENDOCYTOSIS
Nature Cell Biology 10, 259-271 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqnk0EV
MicroRNA Mirn140 MODULATES PDGF SIGNALING DURING PALATOGENESIS
Nature Genetics 40, 290-298 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqnl0EW
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Signaling News
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NATURE NEWS: 222 NIH GRANTS, 22 RESEARCHERS
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqg70EW
Two hundred scientists received six or more grants each from the US
National Institutes of Health (NIH) in 2007. Nature News lists the
twenty-two investigators that were supported by eight or more
grants, and highlights a day in the life of a researcher with eleven
NIH grants.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Crw0Et
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Gateway Updates
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THE FUNCTIONAL GLYCOMICS GATEWAY - MARCH UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0BKHW0Et
The Functional Glycomics Gateway is a comprehensive FREE online
resource to keep you abreast of the latest findings in the field.
This month's update features:
Drug development: Sweet talk to receptors
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0BqCS0EO
Dendritic cell receptors: Keeping it in the family
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0BqCT0EP
Sign up to receive the monthly table of contents e-alert for the
Functional Glycomics Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0BJYw0Eh
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Signaling Job of the Week
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Assistant Professor
Employer: University Medical Centre St. Radboud
Location: Nijmegen, The Netherlands
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0Bqnm0EX
An assistant professor position as available at UMC St. Radboud to
study T-cell signaling. The successful applicant will characterize
differences in signal transduction between T-cell subtypes at the
single cell level. State-of-the-art equipment including optical
tweezers and microcontact printing facilities will be available for
these studies.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0BnjC0Ei
To advertise a job in this spot, please contact Naturejobs.
http://ealerts.nature.com/cgi-bin24/DM/y/ejoF0Xztnp0H2W0vqs0Ef
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