Signaling Gateway - 10 March 2008
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0M40Ex
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Signaling Update is a one-stop online resource designed to keep you
in touch with the latest and most exciting research in cell
signaling. New content is uploaded every Friday.
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This alert is sponsored by Invitrogen
Be sensitive. Be adaptable. Be ahead.
Invitrogen's Adapta(TM) Universal Kinase Assay Kit.
Study difficult targets like lipid kinases with higher sensitivity
and reduced interference using the Adapta(TM) Universal Kinase Assay Kit.
Find out how to reach your difficult targets:
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0Bpgn0EL
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In Signaling Update this week:
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Featured Article
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PLATELET AGGREGATION: KINDLIN' INTEGRIN ACTIVATION
The platelet protein Kindlin-3 activates integrins by binding to
their cytoplasmic beta tails upon blood vessel injury, thus allowing
efficient platelet aggregation and preventing blood loss.
Original research paper: Nature Medicine 14, 325-330 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0vP0E7
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Molecule Pages
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The Molecule Pages: A comprehensive, relational, signaling database.
Each week we highlight an expert-authored, peer-reviewed Molecule Page.
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0HIE0EO
Vav2
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgB0Eb
Vav2 works as a guanosine nucleotide exchange factor (GEF) that
activates different members of the Rho/Rac family of GTPases. The
activity of Vav2 is tightly regulated by upstream protein tyrosine
kinases, protein tyrosine phosphatases and, possibly, intracellular
second messengers. Vav2 has been shown to be important for the
assembly of cytoskeletal responses, the activation of serine/threonine
kinase cascades and the induction of gene transcription events.
Also published this week:
Vav3
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgC0Ec
Search the Molecule Pages
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BUuz0EK
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Selected Updates
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ALLERGY AND ASTHMA: WHAT 'DRIVES' IL-4 VERSUS IL-13 SIGNALLING?
The way in which the IL-4Ralpha-IL-13Ralpha1 receptor heterodimer
affects different responses to IL-4 versus IL-13 has now been
explained by both structural and kinetic data.
Original research paper: Cell 132, 259-272 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgD0Ed
VACCINES: TBK1 MEDIATES DNA VACCINE IMMUNOGENICITY
TANK-binding kinase 1 (TBK1) mediates the adjuvant effect of
DNA-based vaccines by increasing their immunogenicity independently
of the Toll-like receptor signaling pathway.
Original research paper: Nature 451, 725-729 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgE0Ee
TUMOUR SUPPRESSORS: WHERE TO BEGIN?
Biallelic loss of the tumor suppressor Neurofibromatosis type 1 (Nf1)
promotes tumorigenesis in differentiated Schwann cells, but not in
neural crest stem cells.
Original research paper: Cancer Cell 13, 129-140 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgF0Ef
More Updates:
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0vO0E6
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Research Library
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IDENTIFICATION OF A SEROTONIN/GLUTAMATE RECEPTOR COMPLEX IMPLICATED
IN PSYCHOSIS
Nature 452, 93-97 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgG0Eg
A CORE KLF CIRCUITRY REGULATES SELF-RENEWAL OF EMBRYONIC STEM CELLS
Nature Cell Biology 10, 353-360 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgH0Eh
NOTCH SIGNALING MAINTAINS BONE MARROW MESENCHYMAL PROGENITORS BY
SUPPRESSING OSTEOBLAST DIFFERENTIATION
Nature Medicine 14, 306-314 (2008)
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgI0Ei
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Signaling News
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NATURE NEWS: EPILEPSY DRUG SAVES RATS FROM SEIZURES
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgJ0Ej
The anticonvulsant drug ethosuximide, which blocks T-type calcium
channels, is used to control epileptic seizures. Scientists have now
shown that ethosuximide can also suppress the development of seizures
in a rat model, and thus halt progression of the disease.
More News
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0Crw0Eo
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Gateway Updates
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THE CELL MIGRATION GATEWAY - MARCH UPDATE
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0ll80EM
The Cell Migration Update is a comprehensive FREE online resource to
keep you abreast of the latest findings in the field.
This month's update features:
Germ cell migration: CXCR7 clearing the way
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpGp0Ep
Integrin phosphorylation: An ON and OFF switch
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpkW0E1
Sign up receive the monthly table of contents e-alert for the
Cell Migration Update.
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BJrg0El
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Signaling Job of the Week
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Scientist
Employer: Advanced Cell Technology
Location: Worcester, MA
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BpgL0El
A Scientist or Senior Research Associate position in the field of
cellular reprogramming and stem cell research is available at
Advanced Cell Technology. The successful candidate will reprogram
adult somatic cells into multipotent and pluripotent stem cells, and
study their differentiated derivatives.
More Jobs:
http://ealerts.nature.com/cgi-bin24/DM/y/ejcM0Xztnp0H2W0BnjC0Ed
To advertize a job in this spot, please contact Naturejobs.
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