April 2008 Volume 8 Number 4
Visit Nature Reviews Immunology online to browse the journal.
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Nature Reviews Immunology Poster on innate immunity: sensing and signalling
The innate immune system is the first line of defence against invading
pathogens. Detection of such pathogens is a complex business, involving
several families of pattern-recognition receptors and an array of signalling
molecules.
This poster provides an overview of the components and networks involved
in pathogen sensing and signalling in the innate immune system.
Access the Poster FREE online!
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This month's FEATURED article:
Evolutionary struggles between NK cells and viruses
Lewis L. Lanier
p259 | doi:10.1038/nri2276
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bquu0EG
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From the editors
p239 | doi:10.1038/nri2313
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bquv0EH
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RESEARCH HIGHLIGHTS
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Antiviral immunity: Re-routing the interferon response through B cells
p240 | doi:10.1038/nri2305
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bquw0EI
Innate immunity: TLR4 signalling
p241 | doi:10.1038/nri2301
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqux0EJ
IN BRIEF
Allergy | Regulatory T cells | T cells
p241 | doi:10.1038/nri2310
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bquy0EK
Tumorigenesis: A marked CARD
p242 | doi:10.1038/nri2306
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bquz0EL
T-cell development: Galectin-1: the decision maker
p242 | doi:10.1038/nri2309
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqu10E7
IN THE NEWS
Awakening the thymus in adults
p242 | doi:10.1038/nri2312
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqu20E8
IN BRIEF
T cells | Innate immunity | HIV
p243 | doi:10.1038/nri2311
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqu30EA
Apoptosis: Killing neutrophils the cathepsin way
p244 | doi:10.1038/nri2298
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqu40EB
Innate immunity: Detecting DNA via the inflammasome
p244 | doi:10.1038/nri2307
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqu50EC
Apoptosis: BIM and FAS: the ultimate death squad
p245 | doi:10.1038/nri2300
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqu60ED
Myeloid development: How microRNAs manage myeloid cells
p246 | doi:10.1038/nri2299
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqu70EE
T-cell activation: Polarity and CRTAM: a matter of timing
p246 | doi:10.1038/nri2308
http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bqu80EF
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REVIEWS
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T-cell quality in memory and protection: implications for vaccine design
Robert A. Seder, Patricia A. Darrah and Mario Roederer
p247 | doi:10.1038/nri2274
Multiparameter flow cytometry can not only assess the phenotype and magnitude of a T-cell response, but based on effector function, its quality. As discussed here, the quality of a T-cell response is crucial for defining protective cellular immunity, and has great implications for vaccine design.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvA0EP
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvB0EQ
Evolutionary struggles between NK cells and viruses
Lewis L. Lanier
p259 | doi:10.1038/nri2276
Natural killer (NK) cells are known to provide a first line of defence against viruses. Here, Lewis Lanier highlights the receptors and effector mechanisms used by NK cells in the protection against viruses and discusses how, reciprocally, viruses have evolved strategies to avoid activation of these cells.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0Bquu0EG
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvC0ER
Cis interactions of immunoreceptors with MHC and non-MHC ligands
Werner Held and Roy A. Mariuzza
p269 | doi:10.1038/nri2278
In addition to conventional interactions between receptors and ligands on opposing cells (trans interactions), some MHC-class-I-specific receptors interact with their ligands on the same cell (cis interactions). Here, the structural characteristics and functional outcome of cis interactions are discussed.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvD0ES
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvE0ET
How dying cells alert the immune system to danger
Hajime Kono and Kenneth L. Rock
p279 | doi:10.1038/nri2215
To avoid potential damage to the host, an inflammatory response is rapidly mobilized on detection of intracellular signals that are released from dying cells. Much has been learned about these 'danger' signals, but several key issues remain unresolved, as discussed by the authors.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvF0EU
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvG0EV
Uncertainty in the niches that maintain haematopoietic stem cells
Mark J. Kiel and Sean J. Morrison
p290 | doi:10.1038/nri2279
Maintenance of haematopoietic stem cells occurs in niches, but much discussion still surrounds the precise site and nature of these niches. Here, Mark Kiel and Sean Morrison review various niche models that are compatible with the recent published data.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvH0EW
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvI0EX
DNA polymerases in adaptive immunity
Jean-Claude Weill and Claude-Agnes Reynaud
p302 | doi:10.1038/nri2281
The development of a diverse B-cell repertoire depends on genetic rearrangement and hypermutation at the B-cell receptor (BCR) loci. This Review describes which DNA polymerases might be involved in these DNA transactions and therefore contribute to BCR diversity.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvJ0EY
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvK0EZ
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PERSPECTIVE
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SCIENCE AND SOCIETY
Conquering sexually transmitted diseases
Michael N. Starnbach and Nadia R. Roan
p313 | doi:10.1038/nri2272
In this Perspective article, Michael Starnbach and Nadia Roan discuss the public-health and social impact of sexually transmitted diseases, raising several questions that need to be addressed before these diseases can be conquered.
Abstract: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvL0Ea
Article: http://ealerts.nature.com/cgi-bin24/DM/y/ejqW0Xztnp0Hjd0BqvM0Eb
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